ライフサイエンスコーパス: TAP1

1 s, and the ER antigen peptide transporter 1 (TAP1).

2 nsporter associated with antigen processing (TAP1).

3 rate that US6 inhibits the binding of ATP by TAP1.

4 y the cytosolic nucleotide binding domain of TAP1.

5 for nucleotide binding relative to wild type TAP1.

6 in C57BL/6 mice with a targeted deletion in TAP1.

7 ing TAP1 and cooperates with p53 to activate TAP1.

8 control groups, we observed a difference in TAP1.

9 biquitination and proteasomal degradation of TAP1.

10 complex, diffuse slowly, as does GFP-tagged TAP1.

11 AP-deficient cells transfected with only rat TAP1.

12 associated genes such as HLA-A/B/C, B2M and TAP1.

13 essential to achieve full stability of human TAP1.

14 s in a stop codon in the catalytic domain of TAP1.

15 SA occurred in TAP1(0) and beta2m(0)/class I-deficient mice with a mixe

16 nsporter associated with antigen processing (TAP1(0)) on a B6,129 background, and HLA-B27-transgenic

17 ncy of alleles for peptide transporter genes TAP1 (0101) and TAP2 (0101) genes as well as tumor necro

18 protein ICP47 to block peptide transport by TAP1/2 and examined the effects of TAP blockade on the p

19 The TAP1/2 complex translocates peptides from the cytosol in

20 s into the endoplasmic reticulum (ER) by the TAP1/2 complex.

21 was evaluated at multilevel in TAP1/2iso and TAP1/2 cotransfected T2 cells, a mutant cell line deplet

22 and LMP7, shark-specific LMP7-like, and the TAP1/2 genes are linked to class I/II.

23 oteolysis, env peptides are retransported by TAP1/2 into the ER, where association with class I occur

24 The impact of TAP1/2 silencing in lung cancer cells using siRNAs and C

25 easome, PSMB8/9/10, and antigen-transporter, TAP1/2, demonstrating that antigen production is essenti

26 ading to the epigenetic silencing of IFNGR1, TAP1/2, ERAP1/2, and MHC-I genes.

27 Studies using TAP1/2-deficient mice and Ag presentation inhibitors ind

28 e cytosol, we analyzed the processing of two TAP1/2-dependent epitopes containing N-linked glycosylat

29 ic CD8+ CTL, the processing pathway required TAP1/2-mediated transport of cytosolic peptides into the

30 on of TAP2iso was evaluated at multilevel in TAP1/2iso and TAP1/2 cotransfected T2 cells, a mutant ce

31 Of the patients with polymorphic TAP1, 36% were positive for HLA-DRB1*0102 (P=.021; P=.14

32 asured by coimmunoisolation of Kb using anti-TAP1 Abs, while only 20% of the Kb heavy chain molecules

33 The reduction in TAP1 abundance decreased peptide antigen translocation i

34 DRB1*1501-DQA1*0102-DQB1*0602 haplotype, the TAP1 allele encoding Ile at residue 333, and the DRB5-01

35 restored after transfection of a functional TAP1 allele.

36 ur findings indicate that mK3 interacts with TAP1 and -2 via their C-terminal domains and with class

37 ation was driven by CpGs associated with the TAP1 and ALDH3A1 genes, findings that were validated in

38 Two previously undescribed antiviral ISGs, TAP1 and BMP2, were further validated.

39 is homologous to p53, is capable of inducing TAP1 and cooperates with p53 to activate TAP1.

40 T. denticola tap1 and flanking DNA were identified, cloned, and seque

41 tively increased the amount of ubiquitinated TAP1 and increased its degradation in the proteasome of

42 ent in the core transmembrane (TM) domain of TAP1 and is used only by the unassembled subunits.

43 The expression of TAP1 and LMP2 are both greatly reduced in IRF-1-deficien

44 E that is essential for the up-regulation of TAP1 and LMP2 by IFN gamma.

45 However, overexpression of Jak1 did increase TAP1 and LMP2 expression independent of IFN-gamma, indic

46 The effects of IFN-gamma on TAP1 and LMP2 expression revealed a loss of up-regulatio

47 these transactivators regulate differential TAP1 and LMP2 gene transcription is not known.

48 The TAP1 and LMP2 genes are central for class I MHC function

49 The TAP1 and LMP2 genes are transcribed from a shared bidire

50 with luciferase reporter constructs for both Tap1 and Lmp2 genes.

51 These findings suggest that the loss of TAP1 and LMP2 induction is a defect in the earliest step

52 Northern blot revealed reduced amounts of Tap1 and Lmp2 mRNA in NOD mice, and 5'-rapid amplificati

53 The role of IRF-1 in the regulation of TAP1 and LMP2 suggests a mechanism for the antiviral pro

54 ported to have abnormally low expressions of TAP1 and LMP2.

55 ular mechanism of IFN gamma up-regulation of TAP1 and LMP2.

56 ptor agonist can rescue expression of Erap1, Tap1 and MHC-I on p53-mutant tumor cells.

57 ly, a lack of association between alleles of TAP1 and TAP2 (approximately 15 kb) has been observed, s

58 rate that the dimerization interface between TAP1 and TAP2 and the tapasin docking sites for PLC asse

59 We show tapasin binding to both TAP1 and TAP2 and to the corresponding nucleotide bindin

60 cal and functional evidence that the NBDs of TAP1 and TAP2 are non-equivalent.

61 Here we show that both TAP1 and TAP2 are phosphorylated under physiological con

62 Thus, the MSRs of both TAP1 and TAP2 are required for binding peptide.

63 he extra N-terminal domain TMD0 of mammalian TAP1 and TAP2 as well as avian TAP2 recruits tapasin.

64 ased upon cotransfection with genes encoding TAP1 and TAP2 but not individual TAP subunits, beta(2)m,

65 TAP1 and TAP2 contain an N-terminal hydrophobic membrane

66 Besides substantial reduction in TAP1 and TAP2 expression, peripheral blood mononuclear c

67 We found that avian and mammalian TAP1 and TAP2 form heterodimeric complexes across taxa.

68 Strikingly, however, only TAP1 and TAP2 from the same taxon can form a functional

69 ng Lymphocytes (TILs) and the APM components TAP1 and TAP2 in 819 baseline/pre-treatment NSCLCs from

70 We have examined the polymorphism in mouse TAP1 and TAP2 in inbred mice.

71 Differences between TAP1 and TAP2 in the nucleotide-binding site may be rela

72 nhibited photocrosslinking of 8-azido-ATP to TAP1 and TAP2 it seems that ICP47 does not prevent ATP f

73 lass I heavy chain, beta2 microglobulin, and TAP1 and TAP2 mRNAs revealed increased expression in a m

74 expressed as individual subunits or domains, TAP1 and TAP2 NBD differ markedly in their nucleotide bi

75 st the possibility of distinct functions for TAP1 and TAP2 NBD during a single translocation cycle.

76 TAP is made up of the TAP1 and TAP2 polypeptides, which each possess a nucleot

77 ER by an MHC-encoded transporter composed of TAP1 and TAP2 protein delivery.

78 TAP1 and TAP2 proteins are also induced rapidly, increas

79 The TAP1 and TAP2 proteins form a heterodimer that transport

80 as deduced from differential labeling of the TAP1 and TAP2 subunits using sICP47 fragments with chemi

81 For these studies, we tagged the TAP1 and TAP2 subunits with enhanced cyan fluorescent pr

82 two nucleotide-binding domains (NBD) in the TAP1 and TAP2 subunits.

83 ey lysine residues in the Walker A motifs of TAP1 and TAP2 suggests that TAP1-mediated ATP hydrolysis

84 associated with antigen-processing subunits TAP1 and TAP2 that were altered at the conserved lysine

85 and Psmb9 and the antigen transporter genes Tap1 and Tap2 The PSMB8 inhibitor ONX-0914 reversed the

86 nsporter associated with antigen processing (TAP1 and TAP2), members of the ABC transporter family th

87 er associated with antigen processing genes (TAP1 and TAP2).

88 Two subunits, TAP1 and TAP2, are necessary and sufficient for peptide

89 Two subunits, TAP1 and TAP2, are required for peptide transport, and A

90 nsporters associated with antigen processing TAP1 and TAP2, DMA and DMB which are involved in editing

91 gen processing (TAP) comprises two subunits, TAP1 and TAP2, each containing a hydrophobic membrane-sp

92 sporter consists of two homologous subunits, TAP1 and TAP2, each of which contains an N-terminal doma

93 s an ABC transporter formed of two subunits, TAP1 and TAP2, each of which has an N-terminal membrane-

94 tructs except T1ctr interacts with wild type TAP1 and TAP2, indicating possibilities for homodimeriza

95 lved in antigen processing and presentation (TAP1 and TAP2, MHC class I and II, CD80), regulators of

96 cating possibilities for homodimerization of TAP1 and TAP2, or of oligomerization of TAP1/TAP2 hetero

97 comprises two structurally related subunits, TAP1 and TAP2, that form stable complexes in endoplasmic

98 by the association of two half-transporters, TAP1 and TAP2, with a typical ABC transporter core that

99 aining just the membrane-spanning regions of TAP1 and TAP2.

100 The TAP transporter is a heterodimer of TAP1 and TAP2.

101 ry (APM), including LMP2 and LMP7 as well as TAP1 and TAP2.

102 ich are located in the N-terminal domains of TAP1 and TAP2.

103 ulates expression of the peptide transporter Tap1 and the aminopeptidase Erap1, which are required fo

104 in the presence of 2 potent TACE inhibitors: TAP1 and TMI-1.

105 lecule, which recruits one MHC I molecule to TAP1 and/or TAP2.

106 ssociated with antigen processing subunit 1 (TAP1) and a proteasome subunit, low molecular weight pro

107 esentation, including beta-2 microglobulin, (TAP1), and TAP2.

108 s in fetal thymus organ cultures (FTOC) from TAP1+ and TAP1- mice.

109 TCR-delta, TAP1, and IL-17RA deficiency specifically affects early

110 in, protein disulfide isomerase A3, tapasin, TAP1, and TAP2.

111 ll line had little or no expression of LMP2, TAP1, and tapasin, critical components of the HLA class

112 Lmp2 and Tap1 are genes located in the MHC class II region, and t

113 curring Asp(668) and Gln(701) alterations of TAP1 are likely to contribute to attenuated catalytic ac

114 Alterations of TAP1 Asp(668) alone or in combination with TAP1 Gln(701)

115 tection is not affected by TCR-delta, MHCII, TAP1, B cell, IL-17RA, or IL-12p35 deficiency, suggestin

116 eeding the mice to (C57BL/6 x B10.D2)F(1) or TAP1(+/-) backgrounds partially restored cytotoxic activ

117 We also report that mouse TAP1 begins 172 amino acids upstream of the previously p

118 e constitutive and TNF-induced expression of TAP1 but are not necessary for the IFN-gamma response.

119 ssociated with antigen processing deficient (TAP1(-/-)), CD8alpha(-/-), perforin(-/-), and CD1d(-/-)

120 Transfection with TAP1 cDNA restores TAP1 protein abundance, HLA class I b

121 L is restored by transfection with wild-type TAP1 cDNA.

122 Incubation of tapasin(-/-) or TAP1(-/-) cells at 26 degrees C decreased susceptibility

123 Alternate MHC-I processing by TAP1-/- cells was enhanced by preincubation at 26 degree

124 recombinational site centromeric to the Lmp2/Tap1 complex by breeding the two strains.

125 cture of the C-terminal ABC ATPase domain of TAP1 (cTAP1) bound to ADP.

126 porter associated with antigen processing 1 (Tap1)-deficient mice with reduced cell surface expressio

127 ass I biosynthesis similar to those found in TAP1-deficient cell lines.

128 TAP1-deficient fibroblasts were more susceptible to VSV

129 In TAP1-deficient mice, both forms undergo carbohydrate pro

130 r hook protein (FlgE) was synthesized in the Tap1-deficient mutant; however, electron microscopy reve

131 s into the T. denticola chromosome, creating Tap1-deficient mutants.

132 ndoplasmic reticulum-golgi transport and was TAP1 dependent.

133 Ag-processing pathway is both proteasome and TAP1 dependent.

134 the erythromycin resistance cassette within tap1 did not terminate fla operon transcription in eithe

135 that of human and mice: DPB/DPA, Ring3, DMB, TAP1, DOB, DRB2, DRA3, DRB1, DRA2, and DRA1.

136 TAP1 downregulation occurred in 24.4% of lung tumors wit

137 T cells were observed in mice deficient for TAP1 due to TEIPP antigen presentation on all body cells

138 Complex formation with TAP1 enhanced the binding affinity of the TAP2 nucleotid

139 cells was found to be associated with a low TAP1 expression and a reduced function of peptide transp

140 are defective in IFN-gamma-induced LMP2 and TAP1 expression, loss of which inhibits presentation of

141 l lines with distinct phenotypes of LMP2 and TAP1 expression.

142 ation of MHC-I-associated genes H2-Q1-10 and Tap1 fter CMV infection.

143 P14 TAP1- FTOC and negative selection in P14 TAP1+ FTOC.

144 positive selection of anti-LCMV CTLs in P14 TAP1- FTOC and negative selection in P14 TAP1+ FTOC.

145 The flexibility in the regulation of the TAP1 gene may reflect its role in maintaining immune sur

146 Because of the proximity of the TAP1 gene to human leukocyte antigen (HLA) class II gene

147 that the peptide transporter encoded by the Tap1 gene within H2g7 is defective, and this contributes

148 fficient for regulating transcription of the TAP1 gene, binding of both factors is required for LMP2

149 hared bidirectional promoter of the Lmp2 and Tap1 genes in the nonobese diabetic (NOD) mouse.

150 llelic exchange incorporated the interrupted tap1 genes into the T. denticola chromosome, creating Ta

151 f TAP1 Asp(668) alone or in combination with TAP1 Gln(701) had only small effects on TAP activity.

152 Computer analysis indicated that Tap1 had no significant membrane spanning regions, sugge

153 s; however, the initial gene of this operon, tap1, has no known function.

154 es share a bi-directional promoter, LMP2 and TAP1 have differential cellular expression.

155 Preferential ATP interaction with TAP1, if occurring in vivo, might polarize the transport

156 a putative promoter, preceding T. phagedenis tap1 in a region of divergent transcription.

157 including Asp(668) in the Walker B region of TAP1 (in place of a highly conserved glutamic acid), and

158 acid), and Gln(701) in the switch region of TAP1 (in place of a highly conserved histidine).

159 t with RRP might be determined by sequencing TAP1, in conjunction with HLA class II genes.

160 nsporter associated with antigen processing (TAP1)-independent but sensitive to inclusion of inhibito

161 the transport cycle such that ATP binding to TAP1 initiates the cycle.

162 porter associated with antigen processing-1 (TAP1), interferon regulatory factor-1 (IRF1), and class

163 is cassette, a second plasmid that contained tap1 interrupted with a modified erythromycin resistance

164 uenced, and a suicide plasmid that contained tap1 interrupted with an erythromycin resistance cassett

165 used by IFN gamma, but still fails to induce TAP1, IRF1, or class I MHC molecules.

166 We propose that treponemal Tap1 is analogous to FliK, which is involved in monitori

167 TAP1 is expressed constitutively.

168 results indicate that nucleotide binding to TAP1 is not a requirement for peptide binding to TAP com

169 Since the mutant TAP1 is significantly impaired for nucleotide binding, t

170 Here we found that TAP1 is strongly induced by p53 and DNA-damaging agents

171 Transporter associated with Ag processing-1 (TAP1) is induced by IFN-gamma more rapidly than is HLA c

172 Mutants TAP1(K544M) and TAP2(K509M) were expressed in insect cel

173 levels of translocation are detectable with TAP1(K544M).TAP2 complexes.

174 ecordings of hippocampal neurons from beta2m/TAP1 knockout (KO) mice, which have reduced MHCI surface

175 Both TAP1 knockout and wild-type DCs showed enhanced cross-pr

176 C class II, beta2-microglobulin (beta2m) and TAP1 knockout mice, the V beta 4-specific T cell stimula

177 TAP1-knockout macrophages were incubated overnight with

178 omplexes also demonstrate that the extent of TAP1 labeling is dependent upon the presence of a functi

179 The Tap1-Lmp2 promoter from NOD mice showed reduced transcri

180 hain promoter activity, while repressing the TAP1/LMP2 promoter.

181 otide polymorphisms (SNPs) in 5 genes (LMP2, TAP1, LMP7, TAP2, and Tapasin) were investigated for ass

182 Tapasin(-/-) and TAP1(-/-) macrophages had decreased MHC-I stability and

183 cells and experiments with tapasin(-/-) and TAP1(-/-) macrophages that characterize alternate MHC-I

184 sing was diminished in both tapasin(-/-) and TAP1(-/-) macrophages.

185 TAP1-/- macrophages exhibited decreases in cell surface

186 lker A motifs of TAP1 and TAP2 suggests that TAP1-mediated ATP hydrolysis is not essential for peptid

187 e strikingly similar to those in beta2 m(-/-)TAP1(-/-) mice, which lack cell surface expression of al

188 nthesized by recombinant vaccinia viruses in TAP1(-/-) mice.

189 thymus organ cultures (FTOC) from TAP1+ and TAP1- mice.

190 er, bone marrow-derived dendritic cells from TAP1-/- mice showed increased antigen presentation by CD

191 Consistent with the above results, TAP1-/- mice were found to have a higher percentage of t

192 The human TAP1 mRNA 3'-UTR contains a 6-mer canonical seeding site

193 the ER stress-associated reduction in human TAP1 mRNA and protein levels could be reversed with an m

194 s for miR-346, we demonstrate that the human TAP1 mRNA is a direct target of miR-346.

195 Altered psmb9, SGK, and Tap1 mRNA levels were also observed in an in vivo model

196 recruitment correlates with a rise in mature TAP1 mRNA.

197 omplex, we generated two chimeras containing TAP1 MSR and TAP2 NBD (T1MT2C) or TAP2 MSR and TAP1 NBD

198 P1 MSR and TAP2 NBD (T1MT2C) or TAP2 MSR and TAP1 NBD (T2MT1C).

199 exes correlates with enhanced binding of the TAP1 NBD-containing constructs to ATP-agarose beads.

200 Inoculation of C57BL/6 mice with TAP1-negative cells produced large and persistent tumors

201 BL/6 mice with mixtures of TAP1-positive and TAP1-negative cells produced tumors composed exclusively

202 Both TAP1-positive and TAP1-negative cells produced tumors in athymic mice, con

203 ells produced tumors composed exclusively of TAP1-negative cells, indicating in vivo selection for ce

204 ression, matched panels of TAP1-positive and TAP1-negative tumor cell lines were generated from a par

205 ient mice, although not in mice deficient in TAP1 or MHC class II expression.

206 NAs are induced rapidly, increasing 20-fold (TAP1) or 10-fold (TAP2) by 12 h, whereas HLA class I mRN

207 porter associated with antigen processing 1 (TAP1) or TAP2.

208 related genes such as beta(2)-microglobulin, Tap1, or Lmp2, but did not affect MHC class II levels.

209 nd an inverted CAAT-like box in the Lmp2 and Tap1 orientations, respectively.

210 Furthermore, we found that by inducing TAP1, p53 enhances the transport of MHC class I peptides

211 tivation of a subset of genes, including the TAP1 peptide transporter and proteasome subunit beta typ

212 FN-gamma and interleukin-6 (IL-6) but not on TAP1, perforin, IL-4, Fas ligand, or inducible nitric ox

213 explain the experimental data available for TAP1-Phe-265.

214 We examined whether a known TAP1 polymorphism in the ATPase domain altered the sever

215 Inoculation of C57BL/6 mice with mixtures of TAP1-positive and TAP1-negative cells produced tumors co

216 Both TAP1-positive and TAP1-negative cells produced tumors in

217 ects in tumor progression, matched panels of TAP1-positive and TAP1-negative tumor cell lines were ge

218 In contrast, TAP1-positive cells did not generate lasting tumors, alt

219 The regulatory elements within the LMP2/TAP1 promoter and the transcription factors that bind th

220 A gamma-activating sequence (GAS) in the TAP1 promoter is necessary for the rapid induction by IF

221 ectants reveals that IFN-gamma activates the TAP1 promoter more rapidly than the HLA-B7 class I promo

222 f268 reduced the activity of psmb9, SGK, and Tap1 promoter-reporter constructs.

223 porter associated with antigen processing-1 (TAP1) promoter was compared in HeLa cells and endothelia

224 how that culture in tobacco extracts reduces TAP1 protein abundance and membrane HLA class I levels.

225 Culture in tobacco extracts reduces TAP1 protein abundance, but not steady-state mRNA abunda

226 Transfection with TAP1 cDNA restores TAP1 protein abundance, HLA class I biosynthesis, and ce

227 The reduction of TAP1 protein occurs within 4 h and is dose-dependent.

228 ut not extracts of other substances, reduces TAP1 protein, but does not reduce expression of HLA clas

229 genes enriched in immune response processes (TAP1, PSMB8, PSMB9, HLA-DQB1, HLA-DQB2, HLA-DMA, and HLA

230 complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P=5.2E-06) seems to derive from l

231 of tapasin binding to the core TM domain of TAP1 single chains is mysterious because this interactio

232 ty at the first nucleotide binding site (the TAP1 site) of TAP complexes.

233 The mutant TAP1 subunit is significantly impaired for nucleotide bi

234 porter subunit TAP2 and reduce levels of the TAP1 subunit, MHC class I molecules, and EBNA1, a protei

235 A-S microsomes associated with the remaining TAP1 subunit.

236 ediated by two C-terminal fragments of human TAP1 (T1c, residues 452-748 and T1ctr, residues 472-748)

237 By contrast, TAP1/T1MT2C and TAP2/T2MT1C complexes, although observed

238 The enhanced translocation efficiency of TAP1/T2MT1C relative to TAP2/T1MT2C complexes correlates

239 The NBD-switched complexes, T1MT2C/T2MT1C, TAP1/T2MT1C, and TAP2/T1MT2C, all translocate peptides,

240 We show that TAP1/T2MT1C, TAP2/T1MT2C, and T1MT2C/T2MT1C complexes bi

241 <0.05) of CD11c, CD40, CCR7 as well as LMP2, TAP1, TAP2 and tapasin than conv. mix-matured DC.

242 sociated with antigen processing (TAP) loci (TAP1, TAP2) were investigated in 100 members of 16 famil

243 inducible APM components low-m.w. protein 2, TAP1, TAP2, and tapasin.

244 = 0.001) up-regulation of the APM components TAP1, TAP2, and tapasin.

245 on of the four genes encoded within the MHC (TAP1, TAP2, LMP2, and LMP7), as well as LMP10, which is

246 molecular weight TAP complexes that contain TAP1, TAP2, tapasin, and class I heterodimers.

247 Thus, TAP1-TAP2 NBD dimers are not fully stabilized by nucleot

248 The TAP heterodimer (TAP1-TAP2) introduces the final component of the MHC cla

249 nsporter associated with antigen processing (Tap1-Tap2).

250 e MHC class I genes in the complex, arranged TAP1-TAP2-UAA-UBA-UCA-UDA-UEA The UAA gene, situated pro

251 exchanged chimeras as well as to a truncated TAP1.TAP2 complex containing just the membrane-spanning

252 otides stabilize the peptide binding site of TAP1.TAP2 complexes against inactivation, and enhanced t

253 The enhanced structural stability of TAP1.TAP2 complexes in the presence of tapasin might exp

254 for peptide transport, and ATP hydrolysis by TAP1.TAP2 complexes is important for transport activity.

255 equired for high affinity peptide binding to TAP1.TAP2 complexes, and in fact, the presence of tapasi

256 Two nucleotide binding sites are present in TAP1.TAP2 complexes.

257 Peptide translocation is undetectable for TAP1.TAP2(K509M) complexes, but low levels of translocat

258 ced nucleotide binding at the TAP2 site upon TAP1/TAP2 complex formation.

259 The TAP1/TAP2 complex is required for peptide translocation

260 tand the role of each structural unit of the TAP1/TAP2 complex, we generated two chimeras containing

261 ssively reduced efficiencies relative to the TAP1/TAP2 complex.

262 whether the two nucleotide-binding sites of TAP1/TAP2 complexes also differed in their nucleotide bi

263 TAP1/TAP2 complexes translocate peptides from the cytoso

264 e binding to a cytosol-accessible surface of TAP1/TAP2 complexes, but the location of the TAP peptide

265 eractions occurring on the cytosolic face of TAP1/TAP2 complexes, we investigated quaternary associat

266 sites with relatively similar affinities in TAP1/TAP2 complexes.

267 n of TAP1 and TAP2, or of oligomerization of TAP1/TAP2 heterodimers on membranes.

268 No such effects were observed for the TAP1/TAP2 interaction or the complex formation between T

269 TAP1/TAP2 NBD interactions appear to contribute at least

270 opsies showed that H-RS cells were uniformly TAP1/TAP2-positive and expressed HLA class I in the majo

271 The TAP1-TAP2iso transporter facilitated the maturation of M

272 Importantly, TAP1-TAP2iso transporters expressed in T2 cells exhibite

273 and cell lines for genetic abnormalities in TAP1 that might have led to an acquired loss of antigen

274 of US6 with TAP stabilizes a conformation in TAP1 that prevents ATP binding and subsequent peptide tr

275 lanking HLA-DNA to RING3 (45 kb), as well as TAP1 to TAP2 (15 kb), by use of independent CEPH haploty

276 study, we map the respective binding site in TAP1 to the polar face of the amphipathic TM helix TM9 a

277 umab arm with immune genes such as CXCL9 and TAP1, together with other potentially relevant biomarker

278 Only IFN gamma increases TAP1 transcription assessed by reporter gene assay.

279 immune system in RRP is by interfering with TAP1 (transporter associated with antigen presentation 1

280 Beta-2 microglobulin and TAP1 (transporter associated with antigen processing 1)

281 esidues involved in peptide binding, such as TAP1-Val-288, TAP2-Cys-213, TAP2-Met-218.

282 onema denticola was utilized to determine if Tap1 was essential for motility.

283 coupled with Western blotting revealed that Tap1 was located in the aqueous phase.

284 nt cytosolic transcription factor, LMP2, and TAP1 was observed.

285 iated antigen peptide transporter subunit 1 (Tap1), was confirmed after transfection of a neuronal ce

286 FlgE and Tap1 were further characterized.

287 duced affinity for nucleotides compared with TAP1, when the two proteins were separately expressed.