ライフサイエンスコーパス: TCR gene

1 ha chain locus, which deletes the introduced TCR gene.

2 al vectors using the well-characterized OT-1 TCR genes.

3 lineage commitment and allelic exclusion of TCR genes.

4 romoting elements are a conserved feature of TCR genes.

5 teins encoded by non-productively rearranged TCR genes.

6 e present paper, we discuss rearrangement of TCR genes.

7 ced by transfection and amplification of the TCR genes.

8 l-specific transcriptional regulation of the TCR genes.

9 ments during the recombinatorial assembly of TCR genes.

10 e "conventional" translocon organization for TCR genes.

11 habeta, that have endogenously prerearranged TCR genes.

12 epair (NER) or transcription coupled repair (TCR) genes.

13 a, gamma, and delta T cell antigen receptor (TCR) genes.

14 xpressed a variety of Vbeta T-cell receptor (TCR) genes.

15 led immunoglobulin (Ig) and T cell receptor (TCR) genes.

16 genomic scale structural detail of marsupial TCR genes, a lineage of mammals used as models of early

17 The action of TdT on mouse TCR genes accounts for approximately 90% of T cell reper

18 Thus, genomic polymorphism of TCR genes (along with the correct HLA alleles) determine

19 hich may explain the increased expression of TCR gene and accelerated transition of CD25(+)CD44(-) (D

20 le to initiate V(D)J recombination in Ig and TCR genes and lack functional T and B lymphocytes.

21 Site-specific mutagenesis of cloned TCR genes and transfection into Jurkat cells were used t

22 ress tumor antigen-specific T-cell receptor (TCR) genes and generated T lymphocytes by coculture with

23 double-negative (DN) thymocytes to assemble Tcrd genes and in CD4(+)CD8(+) double-positive thymocyte

24 llowed by the introduction of tumor-specific TCR genes, and that proved safer and more effective than

25 pressing disease-associated T cell receptor (TCR) genes, and protects the nonobese diabetic (NOD) mou

26 umor cells were CD3(-)/CD56(+); had germline TCR genes; and strongly expressed CD30, epithelial membr

27 echanisms ensuring the ordered expression of TCR genes are critical for proper T cell development.

28 Like Ig genes, TCR genes are formed by somatic rearrangements of noncon

29 uences from different species indicated that TCR genes are highly stable across primates.

30 e show in this work that Vgamma4 and Vgamma6 TCR genes are rearranged, and sterile Vgamma4 and Vgamma

31 Immunoglobulin (Ig) and T cell receptor (TCR) genes are assembled during lymphocyte maturation th

32 locations in T cells, involving a break in a TCR gene, are characteristically associated with either

33 T cell-specific genes, such as TCR genes, are regulated by a T cell enhanceosome consis

34 ed based on TREC levels and T-cell receptor (TCR) genes, as well as analysis of several sequential hu

35 y regulated in developing T cells to mediate TCR gene assembly.

36 xpression of both alpha/beta and gamma/delta TCR genes at an early level of vertebrate phylogeny and

37 f functional, in-frame rearrangements of the TCR genes, but the mechanism that controls the lineage c

38 The ordered assembly of immunoglobulin and TCR genes by V(D)J recombination depends on the regulate

39 Mutations inactivating TCR genes cause increased damage-induced mutagenesis in

40 xtensively using a combination of individual TCR gene cloning, followed by sequence analysis.

41 A chimeric TCR gene, comprising an anti-hapten single-chain Ab vari

42 es, dTregs were retrovirally transduced with TCR genes conferring specificity for H-2K(d) presented b

43 pic analyses of the reconstituted TRBV4-1(+) TCR genes confirmed CD1c-restricted autoreactivity of th

44 Ig and T cell receptor (TCR) genes consist of separate genomic elements, which m

45 approximately 50% of mice with prerearranged TCR genes develop spontaneous T cell lymphomas, which or

46 hermore, the undersized N regions in revised TCR genes distinguish these sequences from those generat

47 Overall, single TCR gene editing represents a clinically feasible approa

48 We developed the TCR gene editing technology that is based on the knockou

49 ould be reproduced in autologous settings by TCR gene-engineered lymphocytes.

50 n HSC engrafted mouse model and a human iNKT TCR gene engineering approach, we demonstrated the effic

51 iNKT cells in mice through T-cell receptor (TCR) gene engineering of hematopoietic stem cells (HSCs)

52 RTEs contained higher levels of signal joint TCR gene excision circles and were more responsive to in

53 TCR genes exhibit greater sequence diversity in individu

54 TCR gene expression was augmented, whereas NK receptor,

55 conserved with respect to V beta and V alpha TCR gene expression.

56 of GATA-3 and limiting GATA-3 regulation of TCR gene expression.

57 te development, the T-cell antigen receptor (TCR) gene expression is controlled by its promoter and e

58 IBM there is a restricted expression of the TCR gene families among the autoinvasive T lymphocytes w

59 D1d, use a restricted albeit distinct set of TCR gene families, and contribute to the early burst of

60 ting hypermethylated sites on members of the TCR gene family.

61 ns for generating potent Ag complex-specific TCR genes for use in the study of T cell interactions an

62 Transgenic NOD mice carrying alphabeta TCR genes from a class I MHC (Kd)-restricted, pancreatic

63 The TCR genes from an autoreactive K14-A(beta)b CD4 hybridom

64 ed transgenic mice expressing the rearranged TCR genes from an encephalitogenic or a nonencephalitoge

65 e efficient identification of tumor-specific TCR genes from diagnostic tumor biopsies, including core

66 unction of T-CD4 T cells in-depth, we cloned TCR genes from T-CD4 T cells and generated transgenic mi

67 eneration sequencing of the T-cell receptor (TCR) genes from blood or prostate tissue was used to qua

68 this obstacle is to mutate T-cell receptor (TCR) genes from naturally occurring T cells to enhance t

69 Both Ig and TCR genes have been defined in most of the major lineage

70 etically primitive vertebrate class in which TCR genes have been identified, is addressed.

71 Thus, while it has been suggested that the TCR genes have been selected by evolution for MHC bindin

72 de addition during V(D)J recombination of IG/TCR genes, here we propose that illegitimate TdT activit

73 re have demonstrated skewed distributions of TCR genes in HIV-infected subjects but cannot directly m

74 aled a public clonotype using TRAV17/TRBV7-3 TCR genes in six out of seven HLA-B*51:01(+) patients.

75 Sequence analysis of TCR genes in Stat5b-CA Treg cells indicated that ectopic

76 elected for TRAV8/TRAJ52 (CATDLNTGANTGKLTFG) TCR genes in Th1 cells and TRBV16/(TRBD1/2)TRBJ1-7 (CGGK

77 ese mice have prerearranged T-cell receptor (TCR) genes in all cells.

78 of immunoglobulin (Ig) and T cell receptor (TCR) genes in B and T cell precursors.

79 of immunoglobulin (Ig) and T-cell receptor (TCR) genes in lymphocytes by V(D)J recombinase is essent

80 of immunoglobulin (Ig) and T cell receptor (TCR) genes in many species that are not commonly studied

81 d1 has a broader expression pattern than the TCR genes, in terms of both tissue and temporal specific

82 After transfer of the P14 TCR genes into HSCs and subsequent reconstitution of irr

83 Redirecting Ag specificity by transfer of TCR genes into PBLs is an attractive method to generate

84 We show that co-transfer of CD3 and TCR genes into primary murine T cells enhanced TCR expre

85 Transducing high-affinity TCR genes into T lymphocytes is an emerging method to im

86 n of tumor antigen-specific T-cell receptor (TCR) genes into lymphocytes redirects T cells to lyse tu

87 Transfer of tumor-specific T-cell receptor (TCR) genes into patient T cells is a promising strategy

88 Successful assembly of TCR genes is followed by surface TCR expression and test

89 issue- and stage-specific assembly of Ig and TCR genes is mediated by a common V(D)J recombinase comp

90 embly of immunoglobulin and T cell receptor (TCR) genes is blocked by defective V(D)J recombination s

91 he transfer of high-avidity T cell receptor (TCR) genes isolated from rare tumor-specific lymphocytes

92 rogenitors in the marrow have rearranged the TCR gene loci, express Valpha and Vbeta genes as well as

93 ass II (MHC II) in mice containing the human TCR gene loci.

94 the immunoglobulin (Ig) and T cell receptor (TCR) gene loci allows for the generation of B and T lymp

95 enetic landscape within the T cell receptor (TCR) gene loci are pivotal for a fundamental understandi

96 activity and functional memory formation of TCR gene modified T cells in vivo.

97 The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient sur

98 NY-ESO-1(+)/HLA-A*02(+) tumor cell lines by TCR gene-modified CD4(+) T cells.

99 ith a loss of target cell specificity of the TCR gene-modified cells.

100 Substitutions that enhance the reactivity of TCR gene-modified T cells to the cognate Ag complex were

101 kade and increases the functional avidity of TCR-gene-modified T cells.

102 Extensive homology to human TCR genes, natural chimerism, and susceptibility to infl

103 enic mice have been made from the rearranged TCR genes of several of these, of which that specific fo

104 two monkeys early after infection expressed TCR genes of the V beta 13 family; 70% of these V beta 1

105 reflect intrinsic limitations of the pool of TCR genes or lipid Ags.

106 that have not successfully rearranged their TCR genes or that express a receptor with subthreshold a

107 rangements, did not sufficiently account for TCR gene organization, which limits secondary rearrangem

108 Rearrangements, expression and signaling of TCR genes play an indispensable role in this development

109 complex (MHC) class II and T-cell receptor (TCR) gene polymorphisms play important roles in rodent s

110 -joining proteins to form a functional Ig or TCR gene product, while the signal ends form a signal jo

111 positive and negative regulatory elements in TCR gene promoters, the promoter activities from 13 huma

112 Cloned cdr2-specific TCR genes provide a clinically relevant means for immuno

113 TCR gene rearrangement and expression are central to the

114 nt as indicated by positive results for both TCR gene rearrangement and flow cytometry was associated

115 erogeneous in developmental potential before TCR gene rearrangement and suggest that in some precurso

116 T cells are a common and natural product of TCR gene rearrangement and thymocyte development.

117 Quantitative RT-PCR assessment of different TCR gene rearrangement events revealed lower levels in M

118 itored indirectly by measuring the levels of TCR gene rearrangement excision circles in peripheral T

119 cular, we now have a better understanding of TCR gene rearrangement in endomysial T cells, regulation

120 , these findings demonstrate that productive TCR gene rearrangement is associated with events that ca

121 No TCR gene rearrangement is observed in G/M cells from non

122 own-regulation of the protein RAG2, on which TCR gene rearrangement obligatorily depends.

123 tromal signals that induce functions such as TCR gene rearrangement reside mainly in the outer half o

124 in all cases and an identical clonal IgH or TCR gene rearrangement was found on PCR analysis of DNA

125 The latter involves RAG re-expression, TCR gene rearrangement, and expression of a novel TCR.

126 tailed, comprehensive computer simulation of TCR gene rearrangement, incorporating the interaction of

127 pment of T cell precursors in the absence of TCR gene rearrangement, recombinase-activating gene-defi

128 se mice are determined by factors other than TCR gene rearrangement.

129 tment is determined before or independent of TCR gene rearrangement.

130 YDbSmcy share an invariant Vbeta8.2-Jbeta2.3 TCR gene rearrangement.

131 e negative, DN) thymocytes is independent of TCR gene rearrangement; however, induction of CD5 surfac

132 ised DNA products of baboon T-cell receptor (TCR) gene rearrangement (signal-joining TCR excision cir

133 previously shown to impair T cell receptor (TCR) gene rearrangement and to cause a partial block in

134 of immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement are reflected in the accessibili

135 cal Ig heavy chain (IgH) or T-cell receptor (TCR) gene rearrangement at initial diagnosis and subsequ

136 excisional DNA products of T-cell-receptor (TCR) gene rearrangement to measure thymic output directl

137 by measuring the excisional DNA products of TCR-gene rearrangement.

138 Further, because TCR gene rearrangements are generally limited to T linea

139 that differ from the mouse are the status of TCR gene rearrangements at the nonexpressed loci, the ti

140 p study of the junctional diversity of these TCR gene rearrangements focuses on characterization of t

141 flow cytometry and by the presence of clonal TCR gene rearrangements in four patients' posttreatment

142 Analysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-through

143 el of lineage commitment in which sequential TCR gene rearrangements may influence alphabeta/gammadel

144 We analyzed the sequences of Ig and TCR gene rearrangements obtained at presentation and rel

145 by polymerase chain reaction analysis of Ig/TCR gene rearrangements, and patients were assigned to a

146 ment expressing a repertoire biased to early TCR gene rearrangements, we developed a mouse model in w

147 circles created by alphabeta and gammadelta TCR gene rearrangements.

148 vival of TN cells and its role in regulating TCR gene rearrangements.

149 me of jawed vertebrates that were capable of TCR gene rearrangements.

150 well as analysis of several sequential human TCR gene rearrangements.

151 studies that have assessed T-cell receptor (TCR) gene rearrangements (GRs) present at different anat

152 based on immunoglobulin/T-cell receptor (Ig/TCR) gene rearrangements and with quantification of IKZF

153 Progenitor cells undergo T cell receptor (TCR) gene rearrangements during their intrathymic differ

154 flow cytometry, and clonal T-cell receptor (TCR) gene rearrangements in two of two pretreatment bloo

155 Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements provide clonal markers useful f

156 sity, as detected by Ig and T-cell receptor (TCR) gene rearrangements, may represent a very useful pr

157 ifs created by quasi-random T cell receptor (TCR) gene rearrangements, with diversity being highest f

158 urface antigens, and clonal T-cell receptor (TCR) gene rearrangements.

159 81/CD42, and all had clonal T-cell receptor (TCR) gene rearrangements.

160 d that T cells expressing introduced CD3 and TCR genes recognized lower concentration of antigen than

161 transition, a survival program is initiated, TCR gene recombination ceases, cells migrate into a new

162 These data indicate a direct role for ATM in TCR gene recombination in vivo that is critical for surf

163 o the definitive process of T cell receptor (TCR) gene recombination, are presently emerging.

164 h Edelta and that might function to regulate Tcrd gene recombination events.

165 cell dataset, scFusion detects the invariant TCR gene recombinations in mucosal-associated invariant

166 versity (D), and joining (J) segments of the TCR genes result in deletion of the intervening chromoso

167 re unable to properly rearrange their Ig and TCR genes, resulting in a severe combined immunodeficien

168 Our data suggest that a TCR gene segment in or linked to this 47-kb region may b

169 recombinase cleavage of RSSs flanking Ig and TCR gene segments in nuclei.

170 The full complement of TCR gene segments is finally known and should prove a va

171 n leading to the inactivation or deletion of TCR gene segments is unknown.

172 ch control chromatin accessibility at Ig and TCR gene segments to the RAG-1/RAG-2 recombinase complex

173 nes was examined to determine whether common TCR gene segments were used preferentially.

174 genes, the random, inexact recombination of TCR gene segments, and the vast array of possible self a

175 The rearrangement of particular Ig and TCR gene segments, however, is tightly regulated with re

176 nded DNA breaks (DSB) adjacent to the Ig and TCR gene segments.

177 oordinated rearrangement of T cell receptor (TCR) gene segments and the expression of either alphabet

178 les immunoglobulin (Ig) and T cell receptor (TCR) gene segments during lymphocyte development.

179 Restricted use of T cell receptor (TCR) gene segments is characteristic of several induced

180 Murine Tcra and Tcrd gene segments are organized into a single genetic l

181 The Tcra/Tcrd locus recombines Tcrd gene segments in CD4(-)CD8(-) double-negative thymo

182 Recombination of murine Tcrd gene segments is known to be regulated, at least in

183 MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a that were derived

184 T cell rearrangement of the T cell receptor (TCR) genes TCRalpha and delta is specifically regulated

185 dity, and the clones utilize a biased set of TcR genes that favor two combinations, Valpha12-beta5.1

186 gions of immunoglobulin and T-cell receptor (TCR) genes, the V(D)J recombination reaction can in prin

187 This work enables the design of safer TCR gene therapies for cancer immunotherapy.

188 ng of TGF-beta signaling blockade to enhance TCR gene therapy against advanced cancers.

189 D8-LV represents a powerful novel vector for TCR gene therapy and other applications in immunotherapy

190 a signaling in TCR-modified T cells enhances TCR gene therapy efficacy in an autochthonous mouse tumo

191 This clinical trial extends the reach of TCR gene therapy for patients with metastatic cancer.

192 generic platform to optimize the efficacy of TCR gene therapy in humans.

193 TCR gene therapy is a promising approach for the treatme

194 However, TCR gene therapy is hindered by the transient presence a

195 In this patient, TCR gene therapy targeting the KRAS G12D driver mutation

196 CRs, which can potentially be used in future TCR gene therapy to treat EBV-associated latency type II

197 To define a safe clinical setting for HMMR-TCR gene therapy, we analyzed transgenic T-cell recognit

198 and were analyzed as therapeutic targets for TCR gene therapy.

199 finity TCRs can then be developed for use in TCR gene therapy.

200 nificant implications for the improvement of TCR gene therapy.

201 T cell receptor (TCR) gene therapy can reconstitute CD8 T cell immunity i

202 T cell receptor (TCR) gene therapy is a potent form of cellular immunothe

203 T cell receptor (TCR) gene therapy is an effective cancer treatment.

204 r-reactive T cell receptors (TCRs), known as TCR-gene therapy (TCR-T), is a promising immunotherapeut

205 CRs, which can potentially be used in future TCR gene-therapy to treat EBV-associated latency type II

206 dition to being CD3(-)/CD56(+) with germline TCR genes, these cells were CD25(+)/CD122(+)/granzyme B(

207 The ability of this anti-gp100 TCR gene to transfer high avidity Ag recognition to engi

208 The transfer of TCR genes to mature T cells to generate tumor-reactive T

209 o simultaneously knockout the two endogenous TCR genes TRAC (which encodes TCRalpha) and TRBC (which

210 l promoter are important for enhancer driven TCRD gene transcription.

211 Similarly to unedited T cells redirected by TCR gene transfer (TCR transferred [TR]), SE T cells eff

212 We here show that it is possible to improve TCR gene transfer by adding a single cysteine on each re

213 redirection of normal T cell specificity by TCR gene transfer can have potential applications in tum

214 an HSCs established durable, high-efficiency TCR gene transfer following long-term transplantation in

215 ificant implications for the optimization of TCR gene transfer immunotherapies widely applicable to c

216 TCR gene transfer in primary T cells resulted in specifi

217 TCR gene transfer installed BOB1 specificity and reactiv

218 TCR gene transfer into a TCR-deficient alpha beta T cell

219 For all three specificities, TCR gene transfer into CD8 T cells resulted in cytokine

220 TCR gene transfer into hematopoietic stem cells (HSCs) i

221 modeling of modified TCR through retroviral TCR gene transfer into Rag(-/-) mice confirmed the biolo

222 Additionally, TCR gene transfer offers unique opportunities to study t

223 However, TCR gene transfer results in competition for surface exp

224 TCR gene transfer to patient PBL can produce CTL with an

225 in cell-based assays and in a mouse model of TCR gene transfer-induced graft-versus-host disease.

226 n of autologous melanoma Ags following gp100 TCR gene transfer.

227 d antimelanoma activity following anti-gp100 TCR gene transfer.

228 d safer and more effective than conventional TCR gene transfer.

229 be efficiently targeted on AML by DeltaNPM1 TCR gene transfer.

230 TCR-gene transfer represents an effective way to redirec

231 n that can be applied for the improvement of TCR-gene transfer-based treatments.

232 TCR gene-transfer in primary T cells resulted in specifi

233 TCR-gene-transfer is an efficient strategy to produce th

234 ome painting analyses showed no evidence for TCR gene translocations in p53-deficient thymomas, altho

235 Clonotypic T cell receptor (TCR) genes undergo ordered rearrangement and expression

236 DR4 transgenic mice and observe biased TRAV6 TCR gene usage across these two citrullinated epitopes w

237 gender-specific developmental differences in TCR gene usage and coding joint processing that could di

238 Presence of dominant clonotypes with limited TCR gene usage for both TCR alpha- and beta-chains in ty

239 TCR gene usage in the response to HA/HLA-DR appears to c

240 Da-reactive T cell Ag fine specificities and TCR gene usage in this model.

241 ost robust T cell responses including biased TCR gene usage patterns.

242 rtheless, our understanding of how differing TCR gene usage results in altered MR1 binding modes rema

243 Analysis of TCR gene usage showed that the predominant V(alpha) segm

244 However, our knowledge of TCR gene usage within the primary intestinal tissue of H

245 ction and analyzed the cellular composition, TCR gene usage, and cytokine production of granuloma-inf

246 Despite this convergent TCR gene usage, structural and functional assays demonst

247 ed from the same subject, but show different TCR gene usage.

248 autoimmune diseases characterized by common TCR gene usage.

249 this study, we analysed the T-cell receptor (TCR) gene usage by endomysial T lymphocytes in three seq

250 Restricted T cell receptor (TCR) gene usage has been demonstrated in animal models o

251 of the differences in their T cell receptor (TCR) gene usage, all these Th1 clones required W144 as t

252 x class II restriction, and T cell receptor (TCR) gene usage.

253 ect to expression of cell surface molecules, TCR gene utilization, binding of tetrameric KdHA complex

254 to determine detailed T cell epitope(s) and TCR genes utilized by Dsg3-specific T cells.

255 and CD103 and display selective usage of the TCR gene Vbeta9.

256 Expression of this TCR gene was confirmed by Western blot analysis, immunoc

257 asic protein (MBP)-specific T cell receptor (TCR) genes, we have previously shown that mice bearing e

258 4(+) T cells engineered with this anti-gp100 TCR gene were Ag reactive, suggesting CD8-independent ac

259 The prerearranged TCR genes were expressed abnormally early in hemopoietic

260 The TCR genes were expressed in CD4+CD8- and CD4-CD8+ (singl

261 TCR genes were isolated from C6VL, a T cell tumor of C57

262 alpha and beta TCR genes were isolated from these clones, and TCR RNA w

263 The transmembrane encoding domains of the TCR genes were replaced by sequences encoding for phosph

264 een years have passed since T-cell receptor (TCR) genes were identified (reviewed in [1]).

265 om Ag-recognition elements such as alphabeta-TCR genes with the desired specificity, or Ab variable d