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1 ly determined cryoEM structure of a complete TCR-CD3 complex.
2 imals could be activated in vivo through the TCR-CD3 complex.
3 e participation of various components of the TCR-CD3 complex.
4 nits are spread apart upon assembly into the TCR-CD3 complex.
5 in CD247 gene encoding for CD3zeta chain of TCR-CD3 complex.
6 insight into the overall organization of the TCR-CD3 complex.
7 gn of immunotherapeutic agents targeting the TCR-CD3 complex.
8 ed by antibody-mediated cross-linking of the TCR/CD3 complex.
9 locked normal T cell stimulation through the TCR/CD3 complex.
10 amma chain replaced the CD3zeta chain in the TCR/CD3 complex.
11 hesion by stimulation of T cells through the TCR/CD3 complex.
12 G3 dimerization and its association with the TCR/CD3 complex.
13 protein that integrates into the endogenous TCR/CD3 complex.
14 NK-activating ligands, class I MHC, and the TCR/CD3 complex.
15 be inaccessible in the more rigid alphabeta TCR/CD3 complex.
16 l for assembly and surface expression of the TCR/CD3 complex.
17 ases the cytolytic function initiated by the TCR/CD3 complex.
18 n contact with slides coated with Abs to the TCR/CD3 complex.
19 subunit to the CD3 signaling subunits of the TCR/CD3 complex.
20 ing of the structure and organization of the TCR/CD3 complex.
21 receptor (TCR) zeta chain, a subunit of the TCR/CD3 complex.
22 l surface receptors, such as the eight-chain TCR:CD3 complex.
23 ransport, and cell surface expression of the TCR:CD3 complex.
24 the ligation-induced down-modulation of the TCR:CD3 complex.
25 T cells through the T cell antigen receptor (TCR)-CD3 complex.
26 ssembly and function of the T cell receptor (TCR)-CD3 complex.
27 t remarkably similar to the T cell receptor (TCR)-CD3 complex.
28 mplex and downmodulates the T-cell receptor (TCR)-CD3 complex.
29 from that delivered by the T cell receptor (TCR)-CD3 complex.
30 tween ZAP70 and the T cell antigen receptor (TCR)/CD3 complex.
31 ered by ligation of Fas and T cell receptor (TCR)/CD3 complex.
32 stinguish between triggered and nontriggered TCR-CD3 complexes.
33 n, CD3deltaepsilon, and CD3zetazeta) to form TCR-CD3 complexes.
34 ombinations of wild-type and mutant ITAMs in TCR-CD3 complexes.
35 tide led to the engagement of less than 1000 TCR/CD3 complexes.
36 mal sequestration and degradation of surface TCR:CD3 complexes.
37 l surface expression of the T-cell receptor (TCR)/CD3 complex, a complex essential to T-cell activati
39 systems have indicated that signals from the TCR/CD3 complex alone are sufficient to induce T cell un
40 cyte activation through the T cell receptor (TCR)/CD3 complex alters the avidity of the cell surface
45 may interact directly or indirectly with the TCR-CD3 complex and influence the signal transduction pr
48 f multiple signaling pathways coupled to the TCR-CD3 complex and to the CD28 costimulatory molecule.
49 ed to TCR mimic antibody complex structures, TCR-CD3 complexes and annotated Class I and II peptide-M
51 dy, we show that the association between the TCR/CD3 complex and a murine LAG3 mutant that cannot dim
54 gnal derived from ligand binding to both the TCR/CD3 complex and IL-1R receptor mediates rapid activa
55 To confirm that PKA-I activation via the TCR/CD3 complex and IL-1R requires antecedent protein ty
56 ly capable of efficient interaction with the TCR/CD3 complex and may couple the TCR/CD3 complex to ot
57 signaling modules are directly linked to the TCR/CD3 complex and that they can be dissociated from ea
58 ion usually require stimulation via both the TCR/CD3 complex and the CD28 costimulatory receptor.
59 e a simple system for the stimulation of the TCR/CD3 complex and the CD28 receptor using substrates w
61 n presenting cells with the T-cell receptor (TCR)/CD3 complex, and triggering a cascade of signaling
62 tanding of the molecular organization of the TCR-CD3 complex, and provides a conceptual framework for
63 on of protein tyrosine kinases, a functional TCR/CD3 complex, and leukocyte-specific tyrosine kinase.
65 tructures of extracellular components of the TCR-CD3 complex are known, the transmembrane (TM) domain
67 ly than controls to activation through their TCR/CD3 complex, as measured by proliferation and induct
68 results firmly establish that the alphabeta TCR-CD3 complex assembled in the ER is monovalent and co
69 zeta in T cell development in vivo but that TCR/CD3 complexes associated with FcR gamma rather than
70 the JCI, evidence is presented that an anti-TCR/CD3 complex autoantibody present in SLE sera can bin
71 may be a uniquely accessible surface in the TCR/CD3 complex, because there is overlap between the bi
72 tures of two distinct full-length alpha/beta TCR-CD3 complexes bound to their pMHC ligand, the cancer
73 e revealed the organization of the alphabeta TCR/CD3 complex, but similar studies regarding the gamma
75 extremely proximal events downstream of the TCR/CD3 complex by focusing on the activation of ZAP-70.
76 refore, we conclude that in primary T cells, TCR/CD3 complexes can be found that are physically and f
77 C class II Ags results in formation of a CD4-TCR/CD3 complex capable of maximal signal transduction.
81 s the antigen receptor, the T cell receptor (TCR)-CD3 complex contains a panel of immunoreceptor tyro
82 a suggest that T cell activation through the TCR/CD3 complex controls CD2 lateral mobility by a Ca2+/
85 regulates expression of the T cell receptor (TCR)-CD3 complex during a specific stage of thymocyte de
86 pse and cytoskeletal changes that occur upon TCR/CD3 complex engagement is still poorly understood.
87 that neonatal T cells activated through the TCR/CD3 complex express CD40L and use it to promote CD86
89 force-induced conformational changes in the TCR-CD3 complex, for dynamically-driven TCR allostery, a
90 ctively, these data shed light on gammadelta TCR/CD3 complex formation and may aid the design of gamm
95 ied CD3+ IEL T cells were stimulated via the TCR-CD3 complex, high proliferative responses and cytoki
96 ty of the membrane-embedded T cell receptor (TCR) - CD3 complex in extensive atomistic molecular dyna
97 pse and associated with the T cell receptor (TCR)-CD3 complex in CD4(+) and CD8(+) T cells, in the ab
98 olocalizes with the T cell antigen receptor (TCR).CD3 complex in antigen-stimulated T cells and is in
99 that engagement of T cell antigen receptor (TCR)/CD3 complex in either Jurkat cells or peripheral bl
100 the ligation of Fas or the T-cell receptor (TCR)/CD3 complex in Emu-IEX-1 mice that direct the gene
101 nd human leukocyte antigen (HLA)-bound human TCR-CD3 complex in nanodiscs that provide a native-like
104 and to characteristic changes throughout the TCR - CD3 complex, in particular in the EC interactions
105 ERK phosphorylation events downstream of the TCR/CD3 complex, in addition to their failure to undergo
106 otal cellular CD3 chains and of cell-surface TCR-CD3 complexes; in contrast, UBASH3A does not affect
107 overed ligands FGL1 and the T cell receptor (TCR)-CD3 complex, including current controversies over t
109 s initiated by conformational changes of the TCR/CD3 complex, induced by a pulling force originating
111 ross-linking of the T cell antigen receptor (TCR)-CD3 complex induces rapid tyrosine phosphorylation
113 Stimulation of the T cell antigen receptor (TCR).CD3 complex induces rapid tyrosine phosphorylation
114 be costimulatory with signaling through the TCR/CD3 complex inducing interleukin 2-dependent thymocy
115 n microscopy to quantify the organization of TCR-CD3 complexes into nanoscale clusters and to disting
117 raction between CD8 and the T cell receptor (TCR)-CD3 complex is constitutive or antigen induced.
121 ng, we established that the T cell receptor (TCR):CD3 complex is required for USSN-induced T cell act
126 ulation and association of FcRgamma with the TCR/CD3 complex is a hallmark of systemic lupus erythema
128 A+ T cells, but not CD45RO+ T cells, via the TCR/CD3 complex is sufficient to confer the ability to p
129 osine phosphorylated upon stimulation of the TCR/CD3 complex is the 120-kDa product of the c-cbl prot
133 luster of differentiation 3 (CD3) molecules (TCR-CD3 complex) is a key component in the primary funct
134 M1 associates with and recruits SHP-1 to the TCR/CD3 complex leading to decreased phosphorylation of
135 of T cells and that cross-linking of the new TCR/CD3 complex leads to a dramatic increase of intracyt
137 , we have examined the in vivo role of a key TCR/CD3 complex molecule zeta-chain in regulating the di
138 ll surface, the T cell receptor for antigen (TCR)-CD3 complex must assemble in the endoplasmic reticu
143 peripheral T lymphocytes do not express the TCR/CD3 complex on their surface due to retention in the
145 employing monoclonal antibodies against the TCR-CD3 complex or soluble peptide antigens are producin
147 ail inhibited or costimulated, respectively, TCR/CD3 complex plus CD28 mediated activation with the i
149 ction between the intracellular regions of a TCR-CD3 complex recognizing its cognate peptide-major hi
152 e concerted motions of the membrane-embedded TCR - CD3 complex revealed in our simulations provide at
155 P MC, but not PLN MC, stimulated through the TCR/CD3 complex suppress proliferation of purified PLN T
156 erve as coreceptors for the T-cell receptor (TCR)/CD3 complex that are engaged coordinately with TCR
157 and expressed the intermediate levels of the TCR-CD3 complex that is characteristic of resting NK1.1+
158 lower threshold of activation through their TCR-CD3 complex that renders them more susceptible to st
159 eads to an increased pool of fully assembled TCR-CD3 complexes that are capable of recycling back to
160 irectly determined using intact radiolabeled TCR-CD3 complexes that were isolated with a sequential,
161 by flow cytometry, we unexpectedly observed TCR/CD3 complexes that contained two TCRs per complex.
163 ecruits the Src kinase p56(Lck) (Lck) to the TCR-CD3 complex to phosphorylate the ITAMs, initiate int
164 mplex while localizing p56(lck) (lck) to the TCR/CD3 complex to facilitate early signaling events.
165 ostimulatory signal that cooperates with the TCR/CD3 complex to induce T cell activation, cytokine pr
167 with the TCR/CD3 complex and may couple the TCR/CD3 complex to other surface components capable of e
168 racellular signaling domains that couple the TCR/CD3 complex to the downstream signaling machinery.
171 urther analyses showed that recycling of the TCR-CD3 complex was impaired, leading to increased lysos
172 Third, the recruitment of ZAP-70 to the TCR/CD3 complex was seen only in animals with an increas
173 e of bivalency among fully assembled, mature TCR/CD3 complexes was sufficient to impact the functiona
175 eads coated with antibodies specific for the TCR-CD3 complex were sufficient to induce T cell polariz
176 k-accessible PRS ("open-CD3"), although most TCR-CD3 complexes were inaccessible to Nck ("closed-CD3"
178 urkat cells, which coexpress PECAM-1 and the TCR/CD3 complex, were INDO-1AM-labeled and then incubate
179 y related components of the T cell receptor (TCR)-CD3 complex which is essential for the assembly and
181 bitory for T cell responses initiated by the TCR/CD3 complex with the inhibition dependent upon the I
182 en Th1 cells were activated only through the TCR/CD3 complex, with or without IL-2 costimulation.