ライフサイエンスコーパス: TCRbeta gene

1 phocytes with biallelic expression of IgH or TCRbeta genes.

2 cant, portion of cells carrying two in-frame TCRbeta genes.

3 establish diversity and allelic exclusion of TCRbeta genes.

4 ression of a fully rearranged and functional TCRbeta gene, and most cells that fail to produce a func

5 s method involves sequencing of TCRalpha and TCRbeta genes, and amplifying functional genes character

6 nmasks the Dbeta1 gene segment, and triggers TCRbeta gene assembly.

7 is study, we demonstrate that a preassembled TCRbeta gene, but not a preassembled DbetaJbeta complex

8 rangement and expression of TCRgammadelta or TCRbeta genes, but whether it is an instructive or a sto

9 go RAG-dependent rearrangement of endogenous TCRbeta genes, driving surface expression of novel TCRs.

10 use bone marrow that have not rearranged the TCRbeta gene; express a variety of genes associated with

11 the assembly and expression of two distinct TCRbeta genes from a single allele.

12 the CDR3 sequence in millions of rearranged TCRbeta genes from T cells of 2 adults.

13 Rbeta rearrangements needed for a productive TCRbeta gene further increased frequencies of ATM-defici

14 g identical rearranged T cell receptor beta (TCRbeta) gene hypervariable regions.

15 new mouse strain that assembles two in-frame TCRbeta genes in an elevated fraction of cells.

16 verning monogenic assembly and expression of TCRbeta genes in individual cells are paramount for unif

17 e that suppress rearrangements of endogenous TCRbeta genes in normal DN cells are engaged by activate

18 xpression of both prerearranged TCRalpha and TCRbeta genes, indicating a critical role for TCR signal

19 ABab-A2 mice which carry human TCRalpha and TCRbeta gene loci and the human leukocyte antigen class

20 the completion of V(D)J recombination at the TCRbeta gene locus.

21 n, Dbeta1 and Dbeta2 DJ rearrangement of the TCRbeta gene may be differentially regulated and thus se

22 T-cell receptor-beta (TCRbeta) genes naturally acquire premature termination c

23 impaired pre-TCR checkpoint with failure of TCRbeta gene rearrangement and increased apoptosis, resu

24 play obligatory roles both before and after TCRbeta gene rearrangement during the alpha/beta lineage

25 thymocyte development under conditions where TCRbeta gene rearrangement is limiting.

26 " scid thymocyte that undergoes a productive TCRbeta gene rearrangement is susceptible to the oncogen

27 as HSA+ CD44low CD25+, in which the bulk of TCRbeta gene rearrangement occurs.

28 among T cell progenitors that have completed TCRbeta gene rearrangement without producing a functiona

29 typical B-cell marker, T-cell receptor beta (TCRbeta) gene rearrangement indicated a T-cell origin.

30 Thymocytes undergoing TCRbeta gene rearrangements are maintained in a low or n

31 SCL and LMO1 and additionally suggests that TCRbeta gene rearrangements may be required for the onco

32 scid malignancies displayed clonal, in-frame TCRbeta gene rearrangements.

33 equences (RSSs) of V31 and V2 help establish TCRbeta gene repertoire and allelic exclusion by stochas

34 with these RSSs and the weak V1 RSS to shape TCRbeta gene repertoire by restricting their Vbeta segme

35 ination signal sequences (RSSs) flanking the TCRbeta gene segments.

36 on of GATA3 leads predominantly to biallelic TCRbeta gene (Tcrb) recombination.

37 d gender-specific V(D)J recombinase-mediated TCRbeta gene usage and coding joint processing at immune

38 TCRbeta gene usage studies of TRAG-3-specific CD4+ T cel

39 activated in immature thymocytes along with TcRbeta gene V(D)J recombination.

40 pression of either a preassembled functional TCRbeta gene (Vbeta1(NT)) or the prosurvival BCL2 protei

41 Here, we show that the T cell receptor-beta (TCRbeta) gene, which acquires in-frame nonsense codons a