ライフサイエンスコーパス: TCRgamma

1 On multivariate analysis of N/F(mut), TCRgamma ABD, and FLASH deletion, only N/F(mut) was an i

2 We have named this protein TCRgamma alternate reading frame protein (TARP).

3 he TCRbeta locus in gammadelta cells and the TCRgamma and delta loci in alphabeta cells were undertak

4 Productive TCRgamma and delta rearrangements rarely occurred in the

5 parable to those of mice transgenic for both TCRgamma and TCRdelta chains, and numbers of alphabeta t

6 no similar information is available for the TCRgamma and TCRdelta loci.

7 oughput TCR-sequencing approach to study the TCRgamma and TCRdelta repertoires of naive ex vivo PBMC,

8 We demonstrate that the lack of TCRgamma and TCRdelta transcripts in the skink are due t

9 t three T-cell receptor (TCR) loci: TCRbeta, TCRgamma and TCRdelta.

10 pression of functionally rearranged TCRbeta, TCRgamma, and TCRdelta chains by means of transgenes.

11 In vivo treatments with anti-TCRgamma antibody enhanced the number of DP thymocytes,

12 induced DP cell development, indicating that TCRgamma can associate with pTalpha and CD3 to form a no

13 g-TCRdelta rearrangements are expressed with TCRgamma, canonically found in the TCRdelta heterodimer.

14 and Vgamma4 genes, located downstream in the TCRgamma Cgamma1 gene cluster, are expressed by the earl

15 Additionally, the fetal TCRgamma chain repertoire is altered, and peripheral Vga

16 avy, T-cell receptor (TCR)alpha, TCRbeta, or TCRgamma chains expressed in a population of lymphocytes

17 Endogenous TCRgamma chains were expressed by IL-7(+/-) but not IL-7

18 number of DP thymocytes, demonstrating that TCRgamma chains were expressed on the cell surface in th

19 ed IL-7 induced sterile transcripts from the TCRgamma constant region in cultured thymocytes from IL-

20 Absence of biallelic TCRgamma deletion (ABD) was seen in 7%, all of which wer

21 allelic dosage was used to detect FLASH and TCRgamma deletions, which were interpreted in conjunctio

22 Interestingly, TCRgamma delta IEL expressed cell surface c-Kit, while t

23 , but an age-dependent decrease in SI and LI TCRgamma delta IEL occurred in c-Kit mutant mice.

24 onstrated that the development of intestinal TCRgamma delta IEL, regardless of location, shares commo

25 ed alleles, supporting a role for functional TCRgamma/delta rearrangements in the gammadelta divergen

26 cell types, including conventional T cells, TCRgamma/delta T cells, regulatory T cells, and NK cells

27 +,CD4+,CD8-, express either TCRalpha/beta or TCRgamma/delta, and produce mainly type 2 cytokines.

28 e CD4+ and expressed either TCRalpha/beta or TCRgamma/delta.

29 containing additional regulatory sequences, TCRgamma expression was down-regulated in DP cells, and

30 T cell development correlated with increased TCRgamma gene rearrangement involving primarily Vgamma1.

31 thymocyte subsets, but only modestly reduces TCRgamma gene rearrangement, while deletion of each elem

32 In-frame TCRgamma gene rearrangements do not appear underrepresen

33 elta genes, which paired with the Vgamma2(+) TCRgamma gene to generate the Vgamma2/Vdelta7(+) skin ga

34 required for embryonic thymocyte production, TCRgamma gene transcription, and Peyer's patch developme

35 oductive rearrangements of both TCRdelta and TCRgamma genes among CD44highCD25+ thymocytes, suggestin

36 Recombinations of TCRgamma genes occur concurrently with TCRdelta and D-Jb

37 ed by the transcriptional down-regulation of TCRgamma genes that normally accompanies DP cell develop

38 ecessary for rearrangement and expression of TCRgamma genes.

39 ccessful identified the absence of biallelic TCRgamma locus deletion (ABD), a characteristic of early

40 lternative protein product is encoded by the TCRgamma locus in cells other than T lymphocytes.

41 this receptor, whereas rearrangement of the TCRgamma locus may require a signal that is not shared b

42 failed to reconstitute rearrangement of the TCRgamma locus or development of gammadelta T cells.

43 In contrast, in alphabeta cells, the TCRgamma locus was almost completely rearranged with a r

44 The RNA originates from an unrearranged TCRgamma locus, and it is initiated within the intronic

45 aluated at diagnosis for deletion within the TCRgamma locus.

46 g is required for V(D)J recombination at the TCRgamma locus.

47 er and C-enhancer regulatory elements at the TCRgamma locus.

48 ally altering histone acetylation within the TCRgamma locus.

49 d expression of T-cell receptor gamma chain (TCRgamma) mRNA in human prostate and have shown that it

50 pecific form of T cell receptor gamma chain (TCRgamma) mRNA in the human prostate and demonstrated th

51 the thymus with the result that TCRalpha and TCRgamma proteins are not expressed in the same cell at

52 Thus, the function of the endogenous TCRgamma/pTalpha is limited by the transcriptional down-

53 Rdelta-/- mice display random proportions of TCRgamma rearranged alleles, supporting a role for funct

54 What prevents these cells from continuing TCRgamma rearrangement and adopting the gammadelta T cel

55 ions by quantitative sequencing and positive TCRgamma rearrangement assays.

56 ne segment, suggesting that ordered waves of TCRgamma rearrangement exist in the adult mouse thymus a

57 sitive quantitative PCR method, we show that TCRgamma rearrangements are present in CD44(+)CD25(+) Pr

58 expression of TCRgammadelta, TCRdelta and/or TCRgamma rearrangements but no complete TCRbeta variable

59 Productive TCRgamma rearrangements do not increase significantly be

60 TCRgamma rearrangements increase significantly from the

61 Using transgenic TCRgamma recombination substrates, we demonstrate that t

62 TCR repertoires in cattle, demonstrating the TCRgamma repertoire to be clonally stratified and essent

63 In these cases, TCRgamma selection is less obvious.

64 , which were interpreted in conjunction with TCRgamma, TCRbeta, and TCRdelta rearrangements.

65 The prostate-specific TCRgamma transcript consists of the Jgamma1.2 and Cgamma

66 The major TCRgamma transcript in prostate has a different size tha

67 r, HsA and 3'E(Cgamma1), severely diminishes TCRgamma transcription, selectively impairs development

68 Mature TCRgamma transcripts were not detected until day 8, sugg

69 at expression of the productively rearranged TCRgamma transgene competitively inhibits alphabeta thym

70 Expression of a TCRgamma transgene in RAG-1-/- mice resulted in the deve

71 er ORF encodes a 13-kDa truncated version of TCRgamma, whereas the shorter alternative reading frame