ライフサイエンスコーパス: TCRgammadelta

1 all of which were CD4(+)CD8(-)TCRalphabeta(+)TCRgammadelta(-).

2 lta form of the T-cell receptor for antigen (TCRgammadelta).

3 TCRalphabeta(+)CD4(-)CD8(-) cells co-express TCRgammadelta.

4 rangements, with diversity being highest for TCRgammadelta.

5 stics of extrathymic populations, expressing TCRgammadelta(+) (28%), the CD8alphaalpha homodimer (11%

6 Nonetheless, TCRgammadelta also displays nonclonotypic innate respons

7 ltaneous expression in progenitor cells of a TCRgammadelta and a pre-TCR on alphabeta/gammadelta line

8 t, in theory, could simultaneously express a TCRgammadelta and a pre-TCR.

9 rs analyzed two poorly understood receptors, TCRgammadelta and B-cell receptors (BCR), in allograft r

10 aseline with which to compare the effects of TCRgammadelta and BCR deficiency.

11 birth where they develop into unconventional TCRgammadelta and TCRalphabeta lymphocytes in a process

12 esponses mediated by DCs and IL-17-producing TCRgammadelta(+) and CD4(+) Th17 T cells following TLR7

13 Interestingly, a large proportion of the TCRgammadelta(+) and CD8alphaalpha(+)TCRalphabeta(+) gut

14 8(+) T cells and macrophages, and subsets of TCRgammadelta(+) and NK1.1(+) T cells.

15 alent in WT, T-deficient (TCRalphabeta(-/-), TCRgammadelta(-/-)), and Toll-like receptor 4 (TLR4)-def

16 Graft survival was extended in the TCRgammadelta- and BCR-deficient mice.

17 Anti-TCRgammadelta antibody-induced gammadelta T-cell depleti

18 a specific anatomic site indicates that for TCRgammadelta, as for immunoglobulin, conformation is as

19 in a small fraction of cells in wt mice, the TCRgammadelta can drive the differentiation of alphabeta

20 Thus, TCRgammadelta can make innate and adaptive responses wit

21 D3+/CD5+ (approximately 1-5%), and NKR-P1dim/TCRgammadelta+/CD3+/CD5+ (approximately 0.5-2%).

22 tages (CD4+ [P <= .01], CD8+ [P <= .01], and TcRgammadelta (CD4-CD8-) [P <= .001]) was found in unnva

23 her than B lymphocytes, then TCRalphabeta or TCRgammadelta, CD4 or CD8, and Th1 or Th2 lineage.

24 in the intraepithelial lymphocyte CD8alpha(+)TCRgammadelta(+)/CD8alpha(+)TCRalphabeta(+) ratio.

25 We have previously described a murine TCRgammadelta cell clone, TgI4.4, that is reactive to he

26 habeta development is normal, as are NKT and TCRgammadelta cell production.

27 ated that although IL-7 was not required for TCRgammadelta cell proliferation, it was required to pro

28 A subset of TCRgammadelta cells and CD161-expressing thymocytes expr

29 Although TCRgammadelta cells are absent from IL-7(-/-) mice, TCRg

30 Therefore, TCRgammadelta cells are capable of recognizing a variety

31 ures that are capable of being recognized by TCRgammadelta cells are unclear.

32 in addition to TCRVgamma gene rearrangement, TCRgammadelta cells differentiating from late fetal live

33 airway inflammation, clusters of B cells and TCRgammadelta cells in lung tissue, increased serum IgE

34 In contrast, the numbers of TCRgammadelta cells in other tissues of TCRgammadelta-tr

35 had similar numbers of fetal thymus-derived TCRgammadelta cells in their skin.

36 orm of gI suggests that HSV-1 recognition by TCRgammadelta cells in vivo is not limited by cell-speci

37 n addition, the recent descriptions of human TCRgammadelta cells recognizing mycobacterium-derived lo

38 Thus, fetal TCRgammadelta cells required IL-7 for TCR rearrangement,

39 es in developmental requirements for IL-7 by TCRgammadelta cells were noted and were linked to deriva

40 adelta cells are absent from IL-7(-/-) mice, TCRgammadelta cells were restored to the thymus and peri

41 of numerous antigenic ligands recognized by TCRgammadelta cells, detailed information concerning the

42 alpha-/- mice selectively lack CD8alphaalpha TCRgammadelta cells, whereas IL-2Rbeta-/- mice show a si

43 ing some but not all of the TCRalphabeta and TCRgammadelta cells-expressed the CD43 S7(-) reactive de

44 HIV-1 infection induced depletion of CD4(+) TCRgammadelta cells.

45 on of specific pathogens, as is the case for TCRgammadelta cells.

46 required to prolong the life span of mature TCRgammadelta cells.

47 ) cells and the generation of atypical CD8(+)TCRgammadelta(+) cells.

48 Hypo lungs also had increased IL-17A(+) and TCRgammadelta(+) cells.

49 Thymic CD27+IFN-gamma+CCR9+alpha4beta7+TCRgammadelta+ cells migrate to the periphery, particula

50 Distinct T-cell populations, including TCRgammadelta+ cells, expressing activation markers and

51 Consistent with this, skin-resident TCRgammadelta+ cells, known as dendritic epidermal T cel

52 al lymphocytes that are commonly enriched in TCRgammadelta+ cells.

53 share an unconventional phenotype with their TCRgammadelta(+) counterparts.

54 red with their TCRalphabeta(+)CD8beta(+) and TCRgammadelta(+) counterparts.

55 ight genes that were at higher levels in the TCRgammadelta-deficient group, suggesting that these rec

56 re expressed at lower levels in the BCR- and TCRgammadelta-deficient groups, respectively.

57 CD8- or TCRgammadelta-deficient mice were not protected from thr

58 at tape stripping induces IL-1-, IL-23-, and TCRgammadelta(+)-dependent upregulation of cutaneous Il1

59 vel was high and clonality was detected in a TCRgammadelta expressing tumor.

60 orcine gammadelta T cells have two levels of TCRgammadelta expression.

61 poietic cells), anti-CD3 (lymphocytes), anti-TCRgammadelta (gammadeltaT cells), anti-IL-15ralpha (cel

62 We show here that TCRgammadelta gene rearrangements are suppressed in TCRa

63 r T cells containing productively rearranged TCRgammadelta genes have additional requirements for IL-

64 ere are two CD3gammaepsilon dimers for every TCRgammadelta heterodimer.

65 scent approaches to determine the valency of TCRgammadelta heterodimers and CD3gammaepsilon dimers in

66 w TCRgammadelta(med) cells can be induced to TCRgammadelta(hi) but only under IL-2 influence.

67 ls are mostly CD2(+)CD8(-) and CD2(+)CD8(+), TCRgammadelta(hi) cells are highly enriched for CD2(-)CD

68 Moreover, TCRgammadelta(hi) cells can generate TCRgammadelta(med)

69 permanently reconfigures the tissue-resident TCRgammadelta(+) IEL compartment in CeD.

70 ery of both TCRalphabeta(+)CD8alphaalpha and TCRgammadelta(+) IEL is constructed differently than oth

71 We also show that iCD8alpha IEL but not TCRgammadelta(+) IEL, TCRbeta(+) IEL, or intestinal epit

72 le TCRalphabeta(+)CD8alphaalpha IEL resemble TCRgammadelta(+) IEL, they are a unique population of ce

73 We observed that TCRgammadelta IELs exhibit unique microbiota-dependent l

74 iological Vgamma4(+)/Vdelta1(+) subset among TCRgammadelta(+) IELs.

75 we investigated the functional attributes of TCRgammadelta+ IELs isolated from intestinal biopsies of

76 demonstrate that human small intestinal CD8+TCRgammadelta+ IELs may have regulatory potential in cel

77 iduals on GFD have a higher frequency of CD8+TCRgammadelta+ IELs that express the inhibitory NK recep

78 owing infection, represents up to 15% of the TCRgammadelta(+) iIELs, and is dependent on the MHC clas

79 ural killer T cells, CD8+ T lymphocytes, and TCRgammadelta intraepithelial lymphocytes.

80 Thus, the development of signature, murine TCRgammadelta(+) intraepithelial lymphocytes (IEL) in gu

81 and/or maintenance of gammadelta T cells and TCRgammadelta(+) intraepithelial lymphocytes.

82 zation of tissue-resident V(gamma)5V(delta)1 TCRgammadelta+ intraepithelial T cells and Langerhans ce

83 Clarity requires a better understanding of TCRgammadelta itself, not only through identification of

84 duce CD4+Foxp3+ regulatory T cells, although TCRgammadelta+LAP+ cells do not themselves express Foxp3

85 TCRgammadelta+LAP+ cells express antigen presentation mo

86 Identification of TCRgammadelta+LAP+ regulatory cells provides an avenue f

87 Here, we propose that thymic TCRgammadelta-ligand engagement versus ligand-independen

88 TCR)-negative and strikingly associated with TCRgammadelta lineage T-ALLs, as defined by expression o

89 innate, T cell receptor (TCR)alphabeta, and TCRgammadelta lineages, expand in early tumors.

90 Whereas TCRgammadelta(med) cells are mostly CD2(+)CD8(-) and CD2

91 reover, TCRgammadelta(hi) cells can generate TCRgammadelta(med) cells but never the opposite.

92 he only exception is the thymus, where a few TCRgammadelta(med) cells can be induced to TCRgammadelta

93 ar mechanisms of costimulation revealed that TCRgammadelta-mediated activation of NFAT and JNK is req

94 Coculture of sorted TCRgammadelta+NKG2A+ IELs, IL-15-stimulated TCRalphabeta

95 n productive rearrangement and expression of TCRgammadelta or TCRbeta genes, but whether it is an ins

96 a(+) intraepithelial T cells that are either TCRgammadelta(+) or TCRalphabeta(+).

97 ances the expansion of natural IELs that are TCRgammadelta+ or TCRalphabeta+CD8alphaalpha+ to shape t

98 ed gammadelta T cells and their fetal thymic TCRgammadelta precursors, and it is the most abundantly

99 genic receptor is expressed relatively late, TCRgammadelta rearrangements occur normally such that TC

100 viral gene expression independent of a basal TCRgammadelta signal, neither tonic TCR triggering nor t

101 rapid antimicrobial response independent of TCRgammadelta signaling, and may produce IFN-gamma in a

102 TCR ligands, but also by correlating thymic TCRgammadelta signalling with commitment to gammadelta e

103 ction from gammadelta T cells in response to TCRgammadelta stimulation.

104 haalpha(+)TCRalphabeta(+)and CD8alphaalpha(+)TCRgammadelta(+) subsets that exist in the absence of IL

105 epithelial lymphocytes (IELs) expressing the TCRgammadelta survey the intestinal epithelium to limit

106 ligand leads to greater numbers of Th17 and TCRgammadelta T cells and exacerbated development of pso

107 bitors reduced IFN-gamma production by human TCRgammadelta T cells and IL-17 and IFN-gamma production

108 ic effector Th2 cells and was independent of TCRgammadelta T cells and IL-22.

109 n linked with IL-17 production characterizes TCRgammadelta T cells as an efficient first line of defe

110 TCRgammadelta T cells were the major IL-17-producing pop

111 fied in vitro as NK cells, CD8+ T cells, and TCRgammadelta T cells.

112 ceptor alphabeta [TCRalphabeta] T-LGL and 12 TCRgammadelta T-LGL).

113 el, the expansion of a CD8alphabeta(+)CD94(-)TCRgammadelta(+) T cell subset within the iIEL populatio

114 n, promoted the expression of IL-17A in both TCRgammadelta(+) T cells and CD4(+) Th17 cells.

115 Therefore, suppression of intestinal TCRgammadelta(+) T cells by Treg cells maintains enteric

116 later waves in the adult and constitute most TCRgammadelta(+) T cells in secondary lymphoid tissue.

117 xpressed by the earliest waves of developing TCRgammadelta(+) T cells in the fetal thymus, destined f

118 These results suggest that TCRgammadelta(+) T cells may play a role in the liver pa

119 s activation and proliferation of intestinal TCRgammadelta(+) T cells observed in PDK1-deficient mice

120 and/or HBV) or nonviral hepatitis contained TCRgammadelta(+) T cells that could be expanded in vitro

121 This dysregulation of intestinal TCRgammadelta(+) T cells was attributable to a reduction

122 Conversely TCRgammadelta(+) T cells were normal in the VDR KO mice.

123 TCRgammadelta(+) T cells were responsible for the inflam

124 torspira: Leptospira stimulation of purified TCRgammadelta(+) T cells, obtained from 8-day cultures o

125 al controls had no preferential expansion of TCRgammadelta(+) T cells.

126 IFN-gamma and TNF-alpha production by liver TCRgammadelta(+) T cells.

127 fected individuals contained high numbers of TCRgammadelta(+) T cells.

128 ion is dependent on both TCRalphabeta(+) and TCRgammadelta(+) T cells.

129 ) increase in the number of peripheral blood TCRgammadelta(+) T cells.

130 Surprisingly, none of these liver TCRgammadelta(+) T-cell lines could recognize any of the

131 Liver TCRgammadelta(+) T-cell lines from HCV-infected individu

132 IL-17-producing T cell receptor gammadelta (TCRgammadelta) T cells share characteristic features wit

133 Th1 or Tc1 cytokine production and CD8+ and TCRgammadelta+ T cell-mediated GVHD, but abrogates GVL.

134 oportions of other T cell subsets, including TCRgammadelta+ T cells and some TCRalphabeta+ T cell sub

135 receptor-alphabeta (TCRalphabeta)+ and CD4-8-TCRgammadelta+ T cells.

136 it reduced numbers of the IEL subpopulations TCRgammadelta(+), TCRbeta(+)CD4(+), TCRbeta(+)CD4(+)CD8a

137 lineage T-ALLs, as defined by expression of TCRgammadelta, TCRdelta and/or TCRgamma rearrangements b

138 nt clonotypic heterodimers (TCRalphabeta and TCRgammadelta) that define the alphabeta and gammadelta

139 anti-Thy1.2 mAb, indicating that CD4(-)CD8(-)TCRgammadelta(+)Thy1.2(+)NK1.1(-) cells (gammadelta T ce

140 CD31 expression on TCRgammadelta thymocytes is very similar to that of CD4

141 The number of TCRgammadelta thymocytes was 10-fold reduced in TCRgamma

142 TCRgammadelta thymocytes were productively infectable by

143 percentages of both CD4-CD8- thymocytes and TCRgammadelta+ thymocytes suggest that pTalpha plays a c

144 notion that TCRalphabeta can substitute for TCRgammadelta to permit a gammadelta lineage choice and

145 to the thymus and periphery by expression of TCRgammadelta transgenes.

146 re importantly, DN2 and DN3 progenitors from TCRgammadelta transgenic mice have strong biases for opp

147 gammadelta thymocytes was 10-fold reduced in TCRgammadelta-transgenic IL-7(-/-) embryos; however, adu

148 ng in neonatal thymus, thymus cellularity of TCRgammadelta-transgenic IL-7(-/-) mice dropped signific

149 TCRgammadelta-transgenic IL-7(-/-) mice were generated t

150 s of TCRgammadelta cells in other tissues of TCRgammadelta-transgenic IL-7(-/-) mice were not complet

151 transgenic IL-7(-/-) embryos; however, adult TCRgammadelta-transgenic IL-7(-/-) or IL-7(+/-) mice had

152 tial of single thymocytes from wild-type and TCRgammadelta-transgenic mice at two sequential early de

153 ere expressed by IL-7(+/-) but not IL-7(-/-) TCRgammadelta-transgenic mice, providing direct support

154 as increased proportions of CXCR3-expressing TCRgammadelta +Vdelta2+ cells.