ライフサイエンスコーパス: TDI

1 TDI achieved integrated signals of 10(6) counts at a sig

2 TDI e' was nonlinearly associated with incident HF or de

3 TDI exposure elevated IL-4, IL-5, IL-13, and IFN-gamma m

4 TDI for BPA were 0.03-0.07 ug kg(-1) day(-1) (children)

5 TDI indices increased with administration of dobutamine

6 TDI indices were also studied serially in 8 mice before

7 TDI is known to arise because of five different mutation

8 TDI measures reflect directional and incremental alterat

9 TDI was performed in 10 healthy mice to measure endocard

10 TDI-015051 also inhibited viral replication in primary s

11 TDI-8414 showed nanomolar antiparasitic activity, no tox

12 TDI-SFC combines the high spectral resolution of spectra

13 , the rats were exposed to 60 ppb of 2,4-2,6-TDI vapor for 2 h.

14 gy, we have configured a CCD to operate in a TDI mode to detect single double-stranded DNA molecules

15 gnificantly increased 12, 24, and 48 h after TDI exposure.

16 re removed 1, 12, 24, 48, 72, and 96 h after TDI treatment and prepared for SP immunocytochemistry an

17 al epithelium is transiently increased after TDI exposure, suggesting that TDI inhalation not only ca

18 rcorrelation coefficients were >0.89 for all TDI parameters (P < 0.001).

19 cess patients exhibited lower values for all TDI parameters compared with weaning failure patients, e

20 3 versus 3.36 +/- 2.40 cm/s (P < 0.001); and TDI-maximal relaxation rate, 3.64 +/- 2.02 versus 10.25

21 Two-dimensional Doppler and TDI echocardiography were performed simultaneously with

22 mitral inflow, pulmonary venous inflow, and TDI of the mitral annulus were obtained.

23 xation velocity, velocity-time integral, and TDI-derived maximal relaxation rate were assessed during

24 nous flow velocities were also measured, and TDI was used to acquire Ea and Aa.

25 days with or without a 2-wk rest period and TDI challenge.

26 ts, diaphragmatic excursion, thickening, and TDI parameters of peak contraction velocity, peak relaxa

27 a major reaction target for TDI in vivo, and TDI-albumin reaction products have been proposed to serv

28 -1), the total daily intake of inorganic As (TDI-iAs) exceeds the previous provisional tolerable dail

29 ice, the total daily intake of inorganic As (TDI-iAs) in 29% of the cases exceeds the previous WHO re

30 s and methods for monitoring and attenuating TDI.

31 pite PDI of the average consumers were below TDI, special attention should be paid in high consumers

32 f 16 layers, with strong pai-overlap between TDI moieties, observed by small- and wide-angle X-ray sc

33 amine the temporal/dose relationship between TDI-induced rhinitis and asthma.

34 bsequent challenge with 50 parts per billion TDI vapor resulted in robust up-regulation of Ab product

35 consecutive weekdays to 50 parts per billion TDI vapor showed elevated total serum IgE and increased

36 identify the sites of albumin conjugation by TDI vapors, modeling the air/liquid interface of the lun

37 es and strain rate (SR) could be obtained by TDI in mice and whether these indices accurately quantif

38 The CCD/TDI approach allowed increasing sample throughput by a f

39 gitudinal dyssynchrony was assessed by color TDI for time to peak velocity (2 sites in all and 12 sit

40 Mid-LV M-mode and two-dimensional color TDI images were recorded during control and inotropic mo

41 ups and peptide backbone identified compound TDI-8414.

42 ny of the population groups when the current TDI value for BPA of 4 mug/kg bw/day was used as toxicol

43 XR activation, CYP2C9 inhibition, and CYP3A4 TDI, several compounds were advanced into in vivo target

44 reduce time-dependent inhibition of CYP3A4 (TDI) by members of this structural class.

45 We describe a unique flow cytometer (TDI-SFC) for the immunophenotyping of low-abundance cell

46 compound and demonstrate that a derivative, TDI-011536, is an effective blocker of Lats kinases in v

47 Diaphragmatic TDI-derived parameters differentiate patients who fail a

48 ods: In 20 healthy volunteers, diaphragmatic TDI was performed to assess the pattern of diaphragmatic

49 two terrylene-3,4:11,12-bis(dicarboximide) (TDI) derivatives 1 and 2, which crystallize into two dis

50 Exposure to toluene diisocyanate (TDI), an industrially important crosslinking agent used

51 of irritants, such as toluene diisocyanate (TDI), stimulates substance P (SP) release from periphera

52 rize a murine model of toluene diisocyanate (TDI)-induced rhinitis.

53 errylene-3,4:11,12-bis(dicarboximide) dimer (TDI(2)), in which the two TDI molecules are directly lin

54 dMRI-, TDI- and PLI-images showed these striae to intersect the

55 Conventional and tissue Doppler (TDI) echocardiography, systemic and hepatic hemodynamics

56 ex (arterial and venous) and tissue Doppler (TDI) traces were obtained in each pacing mode with a Viv

57 peak atrial longitudinal strain), elevated E/TDI-e', and worsened left atrial strain rate components

58 Results suggest that the elevated TDI scores in the relatives of persons with schizophreni

59 initially reduced TD velocities establishes TDI as a reliable method for early identification of HCM

60 In further experiments, TDI indices were compared with dP/dt(max) and with sonom

61 below the values established by the EFSA for TDI.

62 ARIC-based reference limits for TDI e' (4.6 and 5.2 cm/s for septal and lateral TDI e',

63 en identified as a major reaction target for TDI in vivo, and TDI-albumin reaction products have been

64 (T(1)) were studied at room temperature for TDI(2) aligned in 4-cyano-4'-pentylbiphenyl (5CB), a nem

65 on with fluorescence quenching detection (FQ-TDI) assay is based on the observation that the intensit

66 lele frequencies estimated by the kinetic FQ-TDI assay correlated well with known allele frequencies,

67 The kinetic FQ-TDI assay is highly accurate and reproducible both in ge

68 ted to newer diastolic indexes measured from TDI and CMM in SHF.

69 on, and wind speed), we established a Global TDI Suitability Score aimed at pinpointing species and r

70 Changes in segmental and global TDI data were not related to an elevated post-race HR, a

71 via intracoronary alcohol injection and had TDI and SRI pre- and postablation.

72 ological conditions, habitat types, and high TDI species diversity.

73 tients had fewer teeth (P <0.001) and higher TDI (P <0.05).

74 opithecidae, and Indridae showed the highest TDI values, suggesting their suitability for TIR-drone s

75 Thanatophoric dysplasia type I (TDI) is a lethal human skeletal growth disorder with a p

76 hreshold, discrimination and identification, TDI).

77 he purpose of this study was to determine if TDI inhalation affects intraneuronal levels of SP and pr

78 and thanatophoric dysplasia types I and II (TDI and TDII), which are caused by different mutations i

79 of dMRI data provided track density imaging (TDI) maps to investigate white matter at a smaller resol

80 and super-resolution track-density imaging (TDI) maps.

81 Also, track density imaging (TDI) of 68 white matter parcels were generated using fib

82 Recently, tissue Doppler imaging (TDI) and myocardial strain rate (SR) have emerged as imp

83 inal dyssynchrony by tissue Doppler imaging (TDI) and radial dyssynchrony by speckle-tracking strain

84 astolic function via tissue-Doppler imaging (TDI) as well as Doppler flow variables before and after

85 Tissue Doppler imaging (TDI) by depicting local myocardial motion can potentiall

86 Tissue Doppler imaging (TDI) can record the mitral annular velocity.

87 Tissue Doppler imaging (TDI) is a novel echocardiographic method to quantify reg

88 Tissue Doppler imaging (TDI) is a novel method of color-coding myocardial veloci

89 Rationale: Tissue Doppler imaging (TDI) is an echocardiographic method that measures the ve

90 variables, including tissue Doppler imaging (TDI) parameters and strain rate analysis, in 262 patient

91 ic modality based on tissue Doppler imaging (TDI) that allows quantitative assessment of regional myo

92 ocardiography (2DE), tissue Doppler imaging (TDI), and 3-dimensional echocardiography (3DE) in subjec

93 lor M-mode (CMM) and tissue Doppler imaging (TDI), and of right ventricular (RV) function.

94 er echocardiography, tissue Doppler imaging (TDI), and strain rate imaging.

95 lic velocity (Ea) by tissue Doppler imaging (TDI), T(E-Ea), which is well related to the time constan

96 nd showed elevated E/tissue Doppler imaging (TDI)-e', markedly diminished peak atrial longitudinal st

97 ies measured by tissue Doppler (TD) imaging (TDI) recently were shown to be decreased in subjects who

98 diastolic measures (tissue Doppler imaging [TDI] e', E/e', and left atrial size) with concomitant N-

99 chocardiography (eg, Tissue Doppler Imaging [TDI] S-wave R=0.52, P<0.001) and conventional cardiovasc

100 Changes in TDI peak systolic velocity were correlated with changes

101 Changes in TDI peak velocity from multiple mid-LV sites also correl

102 Predicted significant increases in TDI indices occurred with dobutamine: peak systolic velo

103 -lead optimization of RU-0415529 resulted in TDI-015051 with a dissociation constant (K(d)) of 61 pM

104 Doppler imaging-derived modalities including TDI velocities, strain, and SR are currently being used

105 plate-directed dye-terminator incorporation (TDI) assay, has been developed for mutation detection an

106 howed elevated total serum IgE and increased TDI-specific IgG titers.

107 Results included elevated PIBI, increased TDI, and two or more sites with >/= 6 mm or deeper perio

108 den index (PIBI) and the total dental index (TDI) were calculated.

109 Number of teeth, total dental index (TDI), and periodontal inflammatory burden index were cal

110 h utilizing a novel Thermal Detection Index (TDI) to evaluate the potential of TIR drones for primate

111 subjects, using the Thought Disorder Index (TDI).

112 ost-dose FEV1, and Transition Dyspnea Index (TDI) focal score, all measured at week 26 in the intenti

113 us; or (4) iron dextran total dose infusion (TDI).

114 causing CYP3A4/5 time-dependent inhibition (TDI) and found key modifications to mitigate the TDI.

115 iated with CYP3A4 time-dependent inhibition (TDI).

116 , eRF1 acts as a GTP dissociation inhibitor (TDI) for eRF3, promoting efficient ribosomal recruitment

117 Tolerance of daily intake (TDI) for DMP were 2.50-2.94 ug kg(-1) day(-1) (children)

118 en, would exceed the tolerable daily intake (TDI) of 0.1mg/kg bw/day.

119 itude lower than the tolerable daily intake (TDI) reported by the European Food Safety Authority (EFS

120 for the HI based on tolerable daily intake (TDI) values (considered as potential adverse antiandroge

121 al Protection Agency Tolerable Daily Intake (TDI) values and the EFSA Reference Doses (RfD) (e.g., fo

122 ily intake (PDI) and tolerable daily intake (TDI).

123 d in the human diet (tolerable daily intake -TDI- values were not exceeded).

124 a CCD operated in time-delayed integration (TDI) for improved duty cycle and sensitivity.

125 camera operated in time-delayed integration (TDI) mode as a means for increasing the throughput of an

126 e' (4.6 and 5.2 cm/s for septal and lateral TDI e', respectively) were substantially lower than guid

127 Mean TDI focal scores at week 26 were 1.71 for BDP/FF/GB and

128 Boxers showed a mean TDI score of 32.5 compared to 35.1 of non-boxing control

129 Diastolic longitudinal segmental and mean TDI data were altered post-race such that the mean E'/A'

130 The mean TDI scores were significantly higher in schizophrenic th

131 In contrast, using the new TDI value for BPA of 0.04 ng/kg bw/day, proposed by EFSA

132 osed to workplace-relevant concentrations of TDI vapor via inhalation for 4 h/day for 12 days with or

133 We recently reported the discovery of TDI-015051, a first-in-class small-molecule inhibitor of

134 tion spectroscopy reveals that excitation of TDI in the G-quadruplex results in symmetry-breaking cha

135 s suggest an important and expanding role of TDI in amyloid infiltration of the heart.

136 the recent literature addressing the role of TDI velocities, strain, and SR in the diagnosis and asse

137 ive insights into the species selectivity of TDI-8304, resistance to it, and the collateral sensitivi

138 rescent beads to optimize synchronization of TDI clocking with the sheathed-cell velocity and to impr

139 asured noninvasively in mice with the use of TDI.

140 We recently developed a macrocyclic peptide, TDI-8304, that is highly selective for Pf20S over human

141 th those recently described for liquid phase TDI, especially in domains IIA and IIIB of albumin.

142 Vapor phase TDI was found to react with human albumin in a dose-depe

143 Measurements of longitudinal plane TDI myocardial diastolic velocities at five sites on the

144 el was independently associated with reduced TDI-s'/TDI-e', worse global atrio-ventricular strains (g

145 ased fiber tractography and super-resolution TDI mapping reveals abnormal fiber projections in nodula

146 independently associated with reduced TDI-s'/TDI-e', worse global atrio-ventricular strains (global l

147 when dyssynchrony was negative using 12-site TDI and radial strain (p < 0.001 vs. both positive).

148 hen both longitudinal dyssynchrony by 2-site TDI (> or =60 ms) and radial dyssynchrony (> or =130 ms)

149 T1 yield in films of 1, where the pi-stacked TDI molecules are rotated by 23 degrees along an axis pe

150 a single guanine moiety to terrylenediimide (TDI)-a chromophore with a large extended pai-surface-pro

151 ed by EDI calculations which were lower than TDI for all legislated Fusarium mycotoxins.

152 y associated with resistance, including that TDI-8304 binds beta2 and beta5 in wild type Pf20S as wel

153 We further show that TDI-8304 kills P. falciparum as quickly as chloroquine a

154 The present model shows that TDI inhalation induces immune-mediated allergic rhinitis

155 ncreased after TDI exposure, suggesting that TDI inhalation not only causes SP release but also incre

156 The TDI showed a significant regression pattern (Cox: hazard

157 The TDI-derived strain rate showed minimal dyssynchrony in A

158 The TDI-derived strain rate showed worsened ventricular dyss

159 The TDI-SFC could potentially be used in any application req

160 in drinking water is above 10 mug L(-1), the TDI-iAs exceeds the previous PTDI for all the participan

161 rs; 29 female [29.3%]; 70 male [70.7%]), the TDI was significantly correlated with OS (r = -0.34; P <

162 e used to assess the association between the TDI and OS.

163 periments were conducted by immobilizing the TDI dye molecules in a polystyrene film.

164 and found key modifications to mitigate the TDI.

165 we report the successful application of the TDI assay to detect mutations in the cystic fibrosis tra

166 ts as having lower or higher OS based on the TDI (log-rank test = 4.52; P = .03).

167 -month cutoff) OS was predicted based on the TDI computed in the discovery cohort (accuracy = 87%).

168 These findings indicate that the TDI is a reliable presurgical outcome predictor that may

169 sumption is a significant contributor to the TDI-iAs, supplying water with an As concentration at the

170 In contrast, when the TDI molecules are slip-stacked along their N-N axes in f

171 This TDI-SFC format allowed the CCD shutter to remain open du

172 s study, we characterize the effect of three TDI mutations, Arg248Cys, Ser249Cys, and Tyr373Cys, on F

173 ential of Terahertz Time-Domain Imaging (THz-TDI) as a tool to perform non-invasive 3D analysis of an

174 beta6 subunit, A117D, confers resistance to TDI-8304, yet enhances both enzyme inhibition and anti-p

175 slation and tethering and may be superior to TDI for regional function analysis.

176 yanate (4,4'-MDI), (iv) toluenediisocyanate (TDI), and (v) oligo(ethylene) ([C2H4O]n) as well as p-to

177 ructurally characterized along with tribromo-TDI.

178 arboximide) dimer (TDI(2)), in which the two TDI molecules are directly linked at one of their imide

179 of the molecular interactions that underlie TDI.

180 examined regional myocardial function using TDI and SRI in a unique clinical model of a small, discr

181 We examined eight sheep using TDI in apical four-chamber views to evaluate the LV free

182 d interface plays an important role in vapor TDI conjugation and, thus, could influence biological re

183 Sites of vapor TDI conjugation to albumin were quantitatively limited c

184 gnetic nanoparticles (Fe(3)O(4@)betaCD-Vinyl-TDI) as sorbent in magnetic u-SPE was developed for the

185 a later date, we sought to determine whether TDI predicts the subsequent evolution of the HCM phenoty

186 ation rate was significantly correlated with TDI-maximal relaxation rate.Conclusions: Diaphragmatic t

187 -resolution cryo-EM structures of Pf20S with TDI-8304, of human constitutive proteasome with TDI-8304

188 -8304, of human constitutive proteasome with TDI-8304, and of Pf20Sbeta6(A117D) with WLW-vs that give

189 tion rate) were recorded simultaneously with TDI.Measurements and Main Results: In terms of reproduci

190 dy was to evaluate endocardial velocity with TDI as a method of objectively quantifying alterations i