ライフサイエンスコーパス: TGFbeta

1 gnal, often transforming growth factor-beta (TGFbeta).

2 promoted by p38 MAPK activation initiated by TGFbeta.

3 production in SA fibroblasts in response to TGFbeta.

4 ed mRNA transcript levels of MCP-1, Cx43 and TGFbeta.

5 ession changes in secreted MMP-1, MMP-3, and TGFbeta.

6 ese genes showed H3K9ac enrichment following TGFbeta.

7 er of signaling networks composed of EGF and TGFbeta.

8 ed by combinations including the blockade of TGFbeta.

9 increase the expression of MMP-1, MMP-3, and TGFbeta.

10 (DeltaABD) abrogated migratory responses to TGFbeta.

11 y shown that full-length MAGP-1 binds active TGFbeta-1 and some BMPs.

12 ility to interact with TGFbeta-1, and active TGFbeta-1 did not bind fibrillin in the absence of MAGP-

13 alysis to measure the kinetics of the MAGP-1-TGFbeta-1 interaction, we localized the TGFbeta- and BMP

14 th factor activity experiments revealed that TGFbeta-1 retains signaling activity when complexed with

15 MAGP-1 retained the ability to interact with TGFbeta-1, and active TGFbeta-1 did not bind fibrillin i

16 specific for binding active, but not latent, TGFbeta-1.

17 tivation of transforming growth factor-beta (TGFbeta), a pro-fibrotic mediator that is pivotal to the

18 overexpression antagonized GLI2 induction by TGFbeta, a known activator of GLI2 in cancer cells.

19 Independent of its kinase activity, the TGFbeta-activated kinase 1 (TAK1) mediates LMP1 signalin

20 alpha(5) subunits, which, in turn, enhanced TGFbeta activation, as evidenced by increased phosphoryl

21 However, the role of TGFbeta/Activin-like ligands in disc growth control rema

22 TGFbeta also activates fibroblasts and induces extracell

23 The cascade of BMP9-HOXD3-TGFbeta also affects Notch signaling and angiogenesis th

24 ation on tumour cells and 2) upregulation of TGFbeta and activated stroma.

25 ng pathways and muscle endurance centered on TGFbeta and fibrosis pathways in muscle.

26 e scientific rationale for the evaluation of TGFbeta and PD1 co-blockade in the clinical setting, thi

27 were needed to explain the crosstalk between TGFbeta and pro-inflammatory signalling pathways.

28 eflect defective kinase signaling, including TGFbeta and several receptor tyrosine kinase pathways.

29 1alpha mediates HSC activation downstream of TGFbeta and that its role depends on activation of a sig

30 TGFbeta and UPR signaling pathways are tightly intertwin

31 erior patterning uncovered components of the TGFbeta and Wnt signalling pathways as regulators of the

32 e, we found transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) signal tra

33 tion of the transforming growth factor beta (TGFbeta) and fibroblast growth factor (FGF) signalling p

34 Transforming Growth Factor Beta (TGFbeta) and insulin-like growth factor-1 (IGF-1) are kn

35 , including transforming growth factor beta (TGFbeta) and LIF interleukin-6 family cytokine (LIF) sig

36 tor Twist1, transforming growth factor beta (TGFbeta), and YAP activation appeared to modulate stiffn

37 e lesions overexpress a fibrogenic cytokine, TGFbeta, and an oncogene, ERBB2, accompanied by the occu

38 rongly interacting pathways (focal adhesion, TGFbeta, and Hippo, respectively).

39 Tumors with high AXL, TGFbeta, and JAK1 signaling concomitantly displayed CD13

40 testing of PDOs, identifies continuous AXL, TGFbeta, and JAK1-STAT3 signal activation in select tumo

41 GFR, VEGF, insulin/IGF/MAPKK, FGF, Hedgehog, TGFbeta, and PI3K signaling pathways.

42 GP-1-TGFbeta-1 interaction, we localized the TGFbeta- and BMP-binding site in MAGP-1 to a 19-amino ac

43 pathogenic processes and the contribution of TGFbeta- and BMP-regulated signaling pathways to disease

44 Furthermore, we identify TGFbeta as an important mediator of T cell exclusion.

45 sed the synthesis of CCL/CXCL chemokines and TGFbeta-associated signals.

46 x of latent transforming growth factor beta (TGFbeta at the surface of cardiac PW1(+) cells.

47 Accordingly, disruption of either the GARP/TGFbeta axis or its activated Smads/YAP/TAZ complex abro

48 es 7 latent transforming growth factor beta (TGFbeta)-binding protein-like (TB) domains and mediates

49 ession of genes related to Notch signalling, TGFbeta/BMP antagonists, a downregulation of genes relat

50 nockout mouse models, we disrupted canonical TGFbeta/BMP signaling in either maturing basal VSNs (bVS

51 However, disruption of TGFbeta/BMP signaling turned a normally beneficial Enter

52 uorescently labeled Enterobacter showed that TGFbeta/BMP-exerted control operated primarily in the an

53 tion of the transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) signaling syst

54 kinase and transforming growth factor-beta (TGFbeta)/bone morphogenetic protein (BMP) signalling and

55 The (FSF)TGFbeta(CA) allele consists in a transgene encoding a co

56 The (FSF)TGFbeta(CA) allele was created to generate this model, a

57 phenotype despite the correct expression of TGFbeta(CA) transgene in fibroblasts.

58 onstitutively active mutant form of TGFbeta (TGFbeta(CA)) under the control of a Frt-STOP-Frt (FSF) c

59 [Fsp1-Flpo; (FSF)TGFbeta(CA)] animals do not present any obvious phenotyp

60 This [Fsp1-Flpo; (FSF)TGFbeta(CA)] model is highly pertinent for future studie

61 the genetically-engineered [Fsp1-Flpo; (FSF)TGFbeta(CA)] mouse model.

62 This discovered cross-talk between TGFbeta/CD73 on myeloid cells and TGFbeta signaling on f

63 ed by activating mutations in the type I BMP/TGFbeta cell surface receptor ACVR1, which over-activate

64 tivating mutations in the genes encoding the TGFbeta cell surface receptors (TGFBR1/ALK5 and TGFBR2)

65 the effects of increased microenvironmental TGFbeta concentration in vivo, we developed a conditiona

66 ct of increased microenvironmental bioactive TGFbeta concentrations in mice bearing Cre-dependent gen

67 rferons and transforming growth factor-beta (TGFbeta) cytokines.

68 C cells via transforming growth factor-beta (TGFbeta)-dependent Drosophila mothers against decapentap

69 cription of transforming growth factor beta (TGFbeta)-dependent genes and thereby promote growth and

70 hibition, and lineage tracing, we elucidated TGFbeta-dependent and TGFbeta-independent mechanisms und

71 on (EMT), followed by the establishment of a TGFbeta-dependent autocrine loop that sustains EMT.

72 at SMAD2 and mTOR signaling are required for TGFbeta-dependent Igf-1 expression in myofibroblasts; (4

73 miR-186 that inhibits growth, spreading, and TGFbeta-dependent immune escape mechanisms in neuroblast

74 Furthermore, PD-L1 knockdown decreased the TGFbeta-dependent induction of extracellular matrix prot

75 n endocytic-based mechanism able to generate TGFbeta-dependent regulatory loops conferring cellular p

76 ells in the PATS show an enrichment of TP53, TGFbeta, DNA-damage-response signalling and cellular sen

77 by incorporating model error that shifts the TGFbeta doses associated with the state transitions and

78 ed synthetic experiments for a wide range of TGFbeta doses, investigating different cell steady-state

79 thogenesis remain poorly understood, and the TGFbeta downstream effectors responsible for hereditary

80 , further implicating ANGPT2 as an important TGFbeta downstream mediator of AVM formation.

81 es IGF-1R activation is essential to support TGFbeta-driven profibrotic myofibroblast functions and e

82 s provide support for targeting PDGFRbeta in TGFbeta-driven renal fibrosis.

83 USP27X was upregulated by TGFbeta during EMT and was required for TGFbeta-induced

84 As a result, TGFbeta enables cancer cell invasion and dissemination,

85 luorescence (TIRF) microscopy, we found that TGFbeta enhanced the assembly and disassembly rates of p

86 TGFbeta excludes immune cells from tumors, and TGFbeta i

87 ferative response and benefit from increased TGFbeta expression and autocrine TGFbeta signalling thro

88 f PDGFRbeta is also associated with enhanced TGFbeta expression and mTORC1 activation in the kidney c

89 of GDF11/ActRIIB/Alk5 shows that, across the TGFbeta family, different mechanisms regulate type I rec

90 The transforming growth factor beta (TGFbeta) family is a highly conserved group of proteins

91 volving IL-12p70 for IL-21 and activin A and TGFbeta for CXCL13.

92 the surface of tumor cells, which activates TGFbeta from a latent precursor.

93 These data demonstrate a mechanism of TGFbeta immunosuppression through inhibition of CXCR3 in

94 naling axis involving integrin activation of TGFbeta in CSCs promotes enhanced tumorigenesis through

95 model (Flpo/Frt system) expressing bioactive TGFbeta in fibroblasts, a cell population present in the

96 regulating the tumor suppressor function of TGFbeta in liver carcinogenesis.

97 a critical mediator for apoptotic EV-induced TGFbeta in macrophages.

98 (1) documents the upregulation of IGF-1 via TGFbeta in myofibroblasts and fibrotic lung tissue, as w

99 ating the increase in IGF-1 transcription by TGFbeta in pulmonary fibroblasts; (3) determines that SM

100 in cancer and unveils critical functions of TGFbeta in the metastatic process.

101 y arterial hypertension, whereas the role of TGFbeta in the pathophysiology of CTEPH is unknown.

102 ey point is the model-dependent abundance of TGFbeta in the tumor, which controls the variable suscep

103 more, our study shows that neutralization of TGFbeta in vivo leads to remodeling of CAF dynamics, gre

104 TGFbeta increased phosphorylation of the PI 3-kinase-int

105 Here, we show that TGFbeta increased the catalytic loop phosphorylation of

106 tracing, we elucidated TGFbeta-dependent and TGFbeta-independent mechanisms underlying tendon regener

107 interreceptor interactions that are seen for TGFbeta, indicating that Alk5 binding to GDF11 is more d

108 ose and glutamine carbon into the TCA cycle, TGFbeta induced the biosynthesis of proline from glutami

109 PP) mediate transforming growth factor beta (TGFbeta)-induced breast cancer cell migration and invasi

110 eraction of transforming growth factor-beta (TGFbeta)-induced canonical signaling with the noncanonic

111 th predictions from a computational model of TGFbeta-induced EMT, can reconstruct the cell state and

112 ge-independent growth, and responsiveness to TGFbeta-induced EMT.

113 d by TGFbeta during EMT and was required for TGFbeta-induced expression of Snail1 and other mesenchym

114 f IGF-1 in the initiation and progression of TGFbeta-induced fibrogenesis and IPF have remained unexp

115 was associated with a parallel reduction in TGFbeta-induced fibrosis, caused by a BAMBI-mediated red

116 TGFbeta-induced genes CCR7, TGFbeta1 and EGR3 showed sim

117 nthesis acts as a redox vent, preventing the TGFbeta-induced increase in mitochondrial glucose and gl

118 lized to the adhesions, LPP was required for TGFbeta-induced increases in cell migration and adhesion

119 functional interaction between SHCA and LPP, TGFbeta-induced LPP localization to cellular adhesions d

120 ed phosphorylation of PRAS40 is required for TGFbeta-induced mesangial cell hypertrophy and fibronect

121 was highly effective at inhibiting basal and TGFbeta-induced migration of HaCaT keratinocytes and, fu

122 TLR4 null and EDA null mice blocked Ad5.TGFbeta-induced ocular hypertension.

123 , the enhanced synthesis of proline supports TGFbeta-induced production of matrix proteins.

124 TGFbeta induces the differentiation of hepatic stellate

125 In the current study, we found that TGFbeta induces the expression of the immunoinhibitory m

126 Fbeta excludes immune cells from tumors, and TGFbeta inhibition improves the efficacy of cytotoxic an

127 f E. coli, the nematode's neurons signal via TGFbeta-insulin/IGF1 relay to target tissues to repress

128 TGFbeta is a key upstream regulator of T cell reprogramm

129 As TGFbeta is causal to various fibroproliferative disorder

130 Transforming growth factor beta (TGFbeta) is a multipotent immunosuppressive cytokine.

131 Transforming growth factor-beta (TGFbeta) is a potent inducer of this cellular transition

132 Transforming growth factor (TGFbeta) is a secreted factor, which accumulates in tiss

133 Transforming growth factor-beta (TGFbeta) is an enigmatic protein with various roles in h

134 lymph node, transforming growth factor-beta (TGFbeta) is required for differentiation of skin-recruit

135 netic deletion of TGFbeta1 in platelets (Plt.TGFbeta-KO) or TGFbeta type II receptors in endothelial

136 , suggesting that the MAGPs compete with the TGFbeta large latent complex for binding to microfibrils

137 ing peptides that reduce systemic macrophage TGFbeta levels and help ameliorate HO.

138 neonatal tenocytes for recruitment and that TGFbeta ligand is positively regulated in tendons.

139 increasing TGFBR3 protein that can sequester TGFbeta ligands.

140 ceptors (Alk1/Alk5), a shift that results in TGFbeta losing its protective role in cartilage homeosta

141 sults define a novel signaling mechanism for TGFbeta-mediated fibrous differentiation in sclerotome.

142 SMAD3 ChIP-seq and ATAC-seq suggested that TGFbeta-mediated H3K9ac occurs through SMAD signaling, w

143 of KAT2A or H3K9ac inhibition prevented the TGFbeta-mediated increase in FN1 and SERPINE1.

144 are mated to fertile males, indicating that TGFbeta-mediated postpartum endometrial repair is critic

145 on (H3K27ac), and was associated with global TGFbeta-mediated transcription.

146 in vitro, showed elevated activation of the TGFbeta mediator, SMAD3.

147 Our findings indicate that targeting TGFbeta might be a promising strategy to overcome T cell

148 Thus, pursuing TGFbeta noncanonical signaling, we identified how TGFbet

149 riments showed that the repressive effect of TGFbeta on chondrocytes treated with a pro-inflammatory

150 otein beta (C/EBPbeta), which is crucial for TGFbeta- or IRE1alpha-mediated LX-2 activation.

151 mportant insights into the regulation of the TGFbeta pathway and its change from an antitumorigenic t

152 These data establish the TGFbeta pathway as a novel candidate biomarker and thera

153 stosis and consolidate the importance of the TGFbeta pathway in skeletal disorders.

154 identify potential biological targets of the TGFbeta pathway involved in AVM formation, we performed

155 Finally, TGFbeta3 and other TGFbeta pathway members were elevated in SDS patient blo

156 The genes associated with TGFbeta pathway were enriched in Hdac10 KO tumor cells,

157 the central transcriptional mediator of the TGFbeta pathway, Smad4.

158 mors suggests minimal effect of Tgifs on the TGFbeta pathway.

159 stoma (MYCN and AURKA) and components of the TGFbeta pathway.

160 ations in 4 transforming growth factor beta (TGFbeta) pathway members, including the central transcri

161 ator of the transforming growth factor-beta (TGFbeta) pathway.

162 ity via the transforming growth factor beta (TGFbeta) pathway.

163 pmental pathways (e.g. the Wnt, Hedgehog and TGFbeta pathways), Hippo signalling is a 'jack of all tr

164 roblasts by transforming growth factor-beta (TGFbeta) play a critical role in wound healing.

165 TGFbeta plays a crucial role in the tumor microenvironme

166 Transforming growth factor beta (TGFbeta) potently activates hepatic stellate cells (HSCs

167 Instead, TGFbeta promotes cartilage degradation which correlates

168 Here, we show that TGFbeta promotes protein translation at least in part by

169 ches (PPs), transforming growth factor-beta (TGFbeta) promotes IgA induction in activated B cells tha

170 However, the mechanism by which TGFbeta protects against pro-inflammatory responses and

171 e effectiveness of therapies combining EPHA2-TGFbeta-PTGS2 pathway inhibitors with anti-tumor immunot

172 ases in collagen, alpha-smooth muscle actin, TGFbeta receptor 1, and the transcription factor Snail.

173 The flow-responsive TGFbeta receptor Acvrl1 is required for addition of endo

174 ectal cancer models in cell type-conditional TGFbeta receptor I (ALK5) knockout mice, we interrogate

175 ta noncanonical signaling, we identified how TGFbeta receptor I achieves mTORC1 activation through PD

176 Because endocytosis of TGFbeta receptor II (TbetaRII), in response to TGFbeta s

177 wever, the specific target downstream of the TGFbeta receptor involved in the noncanonical signaling

178 Lastly, we demonstrate type I TGFbeta receptor kinase inhibition abrogates VehM-/GIM-

179 The type I TGFbeta receptor TGFbetaRI (encoded by Tgfbr1) was ablat

180 We discovered that ablation of the TGFbeta receptor, TGFBR2, in retinal microglia of adult

181 ogenitor populations, defects ameliorated by TGFbeta-receptor and IL-6 inhibition, respectively.

182 TGFbeta reduced endogenous TFII-I binding to the INR and

183 TGFbeta reduces CXCR3 expression, and increases binding

184 TGFbeta reduces MHC-I expression in ovarian cancer cells

185 A TGFbeta-regulated miRNA network acted as upstream regula

186 TGFbeta released by cancer cells, stromal fibroblasts an

187 Thus, competition between T cells for active TGFbeta represents an unappreciated selective pressure t

188 tumours comprising cancer cells that are not TGFbeta responsive.

189 y TFII-I as a novel repressor of a subset of TGFbeta-responsive genes through the regulation of RNAPI

190 Finally, blocking TGFbeta restores the production of IFNalpha by activated

191 erefore hypothesize that, in the presence of TGFbeta, SHCA promotes the formation of small, dynamic a

192 cancer cell plasticity regulated by SOX2 and TGFbeta signaling affects EGFR-TKI tolerance and lung ca

193 , we report that cross-talk between SOX2 and TGFbeta signaling affects lung cancer cell plasticity an

194 This study unveils TGFbeta signaling and a network of four miRNAs as upstre

195 IX1 overexpression and reversed SIX1-induced TGFbeta signaling and EMT.

196 w concentrations of dexamethasone suppressed TGFbeta signaling and enhanced adipogenesis, at least in

197 cancer microenvironment, including elevated TGFbeta signaling and immune checkpoint expression, as w

198 duced production of collagen due to impaired TGFbeta signaling and increased expression of matrix met

199 evealed that AXL inhibition suppressed SMAD4/TGFbeta signaling and induced JAK1-STAT3 signaling to co

200 y, functional recovery depended on canonical TGFbeta signaling and loss of function is due to impaire

201 alphavbeta6, induces prolonged inhibition of TGFbeta signaling and reduces lung collagen deposition a

202 such as beta2SP, are important mediators of TGFbeta signaling and regulate gene expression to suppre

203 o stimulate metastasis through activation of TGFbeta signaling and subsequent induction of epithelial

204 Prostaglandin E2 (PGE2) disrupts TGFbeta signaling and suppresses myofibroblast different

205 erived cell lines revealed downregulation of TGFbeta signaling and upregulation of differentiation pa

206 BMP and TGFbeta signaling are instrumental in vascular disease s

207 neonatal tendon regeneration, we identified TGFbeta signaling as a major molecular pathway that driv

208 pe of cross talk between endothelial BMP and TGFbeta signaling as mediated by HOXD3.

209 ic approach to control dysfunctional BMP and TGFbeta signaling by regulating HOXD3.

210 in Hdac10 KO tumor cells, and activation of TGFbeta signaling contributed to SOX9 induction in Hdac1

211 In the setting of TGFbeta signaling deficiency, gemcitabine and anti-PD-1

212 igh BMP activity further results in enhanced TGFbeta signaling due to induction of TGFbeta1 and its r

213 d for LTM formation requires the addition of TGFbeta signaling during Trial 2.

214 hat glucocorticoids restrain cell-autonomous TGFbeta signaling in ASCs to facilitate adipogenesis and

215 ng a continuous and cell autonomous role for TGFbeta signaling in cell fate maintenance.

216 e in vivo and identify an essential role for TGFbeta signaling in maintenance of the tendon cell fate

217 Similarly, pharmacologic blockade of TGFbeta signaling in normal mice boosted the pre-EPO mod

218 results show a functional role for canonical TGFbeta signaling in tendon regeneration and offer new i

219 To examine the role of TGFbeta signaling in tenocyte function the TGFbeta type

220 indicate that MAGP-1 plays an active role in TGFbeta signaling in the ECM.

221 y is to determine if HOXD3 modulates BMP and TGFbeta signaling in the endothelium.

222 differentiated cell fate and a key role for TGFbeta signaling in these processes.

223 indicate a cross-talk between autophagy and TGFbeta signaling in TM cells.

224 y show that the combination of chemotherapy, TGFbeta signaling inhibition, and immune checkpoint bloc

225 We show that TGFbeta signaling is directly required in neonatal tenoc

226 lk between TGFbeta/CD73 on myeloid cells and TGFbeta signaling on fibroblasts can contribute to ECM r

227 TGFbeta signaling on fibroblasts is decreased in breast

228 Reduced TGFbeta signaling on fibroblasts was associated with the

229 dings, adenosine significantly downregulated TGFbeta signaling on fibroblasts, an effect regulated by

230 tumor model, we discovered that deletion of TGFbeta signaling on myeloid cells (PyMT/TGFbetaRII(LysM

231 together, our studies reveal a new role for TGFbeta signaling on myeloid cells in tumorigenesis.

232 We previously demonstrated that TGFbeta signaling on myeloid cells regulates expression

233 human cancers, indicating that a functional TGFbeta signaling pathway is required for evading tumori

234 ancer, such as dysregulation in the KRAS and TGFbeta signaling pathways, have failed to improve survi

235 How TGFbeta signaling to microglia influences pathological r

236 IPF lung and reduces downstream pro-fibrotic TGFbeta signaling to normal levels.

237 ays downstream of the upregulated miRNAs and TGFbeta signaling via SMADs and Notch signaling as pathw

238 ted in End.TGFbetaRII-KO mice, and activated TGFbeta signaling was present in vessel-rich areas of CT

239 f ERK1/2 in HUVECs in vitro to activation of TGFbeta signaling, EndMT, suppression of eNOS, and induc

240 essed germ cells (NFkappaB response, TNF and TGFbeta signaling, Hif1alpha and Myc genes).

241 an endogenous role for PD-L1 in profibrotic TGFbeta signaling, TGFbeta stimulated-human lung fibrobl

242 In the absence of TGFbeta signaling, there was an accumulation of LZ GC B

243 Despite the tumor-suppressive role of TGFbeta signaling, transcriptome profiling of colon tumo

244 on and mucus clearance and the regulation of TGFbeta signaling, which promotes fibrotic remodeling.

245 derwent genetic or pharmacologic ablation of TGFbeta signaling.

246 es GDF11 signaling, but has little impact on TGFbeta signaling.

247 action and transforming growth factor beta (TGFbeta) signaling via miRNA in breast cancer as pathway

248 TGFbeta signalling has key roles in cancer progression:

249 n-canonical activation of NF-kappaB, reduced TGFbeta signalling in airways, and induced regeneration

250 highlight a concentration-dependent role for TGFbeta signalling in the maintenance and activation of

251 rein, we introduce the mechanisms underlying TGFbeta signalling in tumours and their microenvironment

252 The repression of TGFbeta signalling is therefore considered a prerequisit

253 Inhibition of TGFbeta signalling leads to reversal of age-associated H

254 feration and differentiation, and in IGF and TGFbeta signalling pathways.

255 m increased TGFbeta expression and autocrine TGFbeta signalling through effects on gene expression, r

256 nment, and observe up-regulation of IL-6 and TGFbeta signalling-induced gene expression in aged bone

257 ntiation program is mediated by induction of TGFbeta signalling.

258 The transforming growth factor beta (TGFbeta) signalling pathway regulates a range of importa

259 wever, their roles are relatively unknown in TGFbeta/SMAD signaling.

260 relaxation upregulated PLOD2 expression via TGFbeta-SMAD2 signaling, forming a feedback loop between

261 We propose that TGFbeta/SMAD3 inhibition may represent an actionable the

262 Pharmacological inhibition of the TGFbeta/SMAD3 signalling axis was sufficient to inhibit

263 previous CAF activation, which involved the TGFbeta/Snail1 signaling axis.

264 ays include transforming growth factor-beta (Tgfbeta), sonic hedgehog (Shh), wingless-integrated site

265 Targeting of the integrin alphavbeta6-TGFbeta-SOX4 pathway therefore provides therapeutic oppo

266 for PD-L1 in profibrotic TGFbeta signaling, TGFbeta stimulated-human lung fibroblast-derived PD-L1 i

267 n the Panc1 cell line blocked the process of TGFbeta-stimulated EMT.

268 pharmacological inhibitor and siRNAs blocked TGFbeta-stimulated phosphorylation of proline-rich Akt s

269 s SOX2-mediated cell plasticity regulated by TGFbeta stimulation and epigenetic control affects EGFR-

270 TGFbeta stimulation caused widespread changes in histone

271 TGFbeta stimulation downregulated SOX2 and induced epith

272 Functionally, TGFbeta stimulation promoted HSCs to express tumor-promo

273 Fbeta receptor II (TbetaRII), in response to TGFbeta stimulation, is a prerequisite for TGF signaling

274 ations and transcriptional changes following TGFbeta stimulation.

275 was sufficient to raise the amount of total TGFbeta stored in the ECM of cultured cells, suggesting

276 ines of the transforming growth factor beta (TGFbeta) superfamily with potential therapeutic applicat

277 We found that the source of TGFbeta -supporting Trm cells was autocrine.

278 How TGFbeta supports the bioenergetic cost of matrix protein

279 oding a constitutively active mutant form of TGFbeta (TGFbeta(CA)) under the control of a Frt-STOP-Fr

280 igenetic activation mechanisms downstream of TGFbeta that mediate transcription of fibrogenic signals

281 valis augmented secretion and bioactivity of TGFbeta through glycoprotein A repetitions predominant (

282 g cytokine, transforming growth factor beta (TGFbeta) to induce collagen production.

283 ased promoter methylation of the profibrotic TGFbeta transcription factor SMAD3 compared with ADC-TAF

284 traditional pathways of activation, such as TGFbeta (transforming growth factor beta) and AngII (ang

285 graphical cues with the profibrotic agonist, TGFbeta (transforming growth factor beta), additively up

286 TGFbeta (transforming growth factor-beta) signaling muta

287 hat is downregulated in neuroblastoma and in TGFbeta-treated NK cells represses oncogenic proteins in

288 Recombinant TGFbeta treatment in PREX1 overexpressing corneal cells

289 At the same time, TGFbeta treatment led to Smad2/3-dependent dysregulation

290 increased RNAPII SerP2 in the gene body post-TGFbeta treatment.

291 s NETosis in an Akt-dependent manner through TGFbeta type I receptor kinase ALK5.

292 formed protein complexes with SMAD3 and the TGFbeta type I receptor.

293 th age there is a change in the ratio of two TGFbeta type I receptors (Alk1/Alk5), a shift that resul

294 f TGFbeta signaling in tenocyte function the TGFbeta type II receptor (Tgfbr2) was targeted in the Sc

295 of TGFbeta1 in platelets (Plt.TGFbeta-KO) or TGFbeta type II receptors in endothelial cells (End.TGFb

296 Transforming growth factor beta (TGFbeta) upregulates cholangiocyte-derived signals that

297 However, when the active-TGFbeta was limited or when new T cell clones were recru

298 targets of transforming growth factor-beta (TGFbeta) were dysregulated in SDS hematopoietic stem cel

299 ating into myofibroblasts in the presence of TGFbeta when tested in 3D collagen model mimicking the s

300 volved in embryonic development, such as BMP-TGFbeta, WNT, Notch, HIF1alpha, TWIST1 and HOX family ge