ライフサイエンスコーパス: TH

1 TH is highly regulated, notably by phosphorylation of se

2 TH receptors act primarily to repress these programs whe

3 TH-ir EGFP(Vgat) neurons were distributed throughout the

4 TH-MYCN tumors were found to resemble immune infiltratio

5 MX concentration (mg/g) as; TB (0.13-0.38), TH (0-0.55), C (7.14-11.20).

6 wed retention time (min) of 1.51 (TB), 1.81 (TH), 2.30 (C) with r(2) values (0.980-0.988).

7 age MX (mug/mL) was as; TB (14.73 +/- 20.9), TH (32.05 +/- 55.5), C (121.87 +/- 32.3).

8 tion of KORs from dopamine neurons using AAV-TH-cre in KOR(loxP) mice prevented pain-induced aversive

9 The degree of cooling required to achieve TH may therefore act as a biomarker of injury severity.

10 Our findings indicate that REST activates TH expression and thereby protects neurons against Mn-in

11 The T4 metabolite TETRAC was the most active TH on PPARgamma with nanomolar potency and binding affin

12 We found that either acute TH treatment or blocking TH production before resection

13 in Xenopus laevis before, during, and after TH-dependent metamorphosis.

14 dition, neonatal hyperoxia promoted allergic TH responses to house dust mite exposure.

15 e is selective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaffected.

16 pheral blood for IgG4-expressing B cells and TH subsets.

17 gic enzymes (COMT, DBH, DDC, MAOA, MAOB, and TH), dopamine receptors (DRD1, DRD2, DRD3, DRD4, and DRD

18 reduction of TH-expressing cells in SN, and TH mRNA/protein levels in midbrain/striatum.

19 Thyroid hormone (TH) and TH receptors (TRs) alpha and beta act by binding to TH r

20 al association cortex, parahippocampal areas TH / TF, the ventral posterior midline, and lateral pari

21 s response is selective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaffected.

22 To assess TH involvement, Wistar rats were treated with alpha-meth

23 d thus require less active cooling to attain TH.

24 e observed pattern of colocalization between TH-ir and EGFP(Vgat) , we first performed Nissl-based pa

25 0.94; P = .037), with no difference between TH and TL.

26 d that either acute TH treatment or blocking TH production before resection significantly but differe

27 owing short-day photoperiod exposure in both TH+ and SST+ neurons at 1 and 3 months while an overall

28 t 12 months and completely abolished in both TH+ and SST+ neurons by 18 months.

29 other avian species, the expression of both TH and DARPP-32 was highest in the house crow striatum.

30 helium is juxtaposed to two sources of brain THs, the cerebrospinal fluid and vasculature, this proge

31 e hypothesize that this obesity is caused by TH(+) cell loss or altered phenotype in key compartments

32 nstrate cooperative regulation of cyp27c1 by TH receptors and a requirement for thrb in red cone fate

33 DNA and leads to complete loss of canonical TH action.

34 d tyrosine hydroxylase-immunopositive cells (TH cells) modulate visually driven signals as they flow

35 ication for BDE-99 interfering with cellular TH signaling during O4(+) cell formation.

36 glia (DRG), there is an increase in CGRP(+), TH(+), and Iba1(+) (macrophage) labeling, but no increas

37 At the ankle there is increased CGRP(+), TH(+), and GAP-43(+) fiber synovial innervation.

38 Circulating TH cells from infected children were attenuated in their

39 xplored integrated signaling among classical TH 2 cytokines (IL-4, IL-5, and IL-13), which together w

40 ery few GHRH neurons were found to coexpress TH- and GH-induced pSTAT5.

41 er of Type III Dio (Dio3), which deiodinates TH inner rings through a selenocysteine (Sec) residue, r

42 tac3a cells were located in areas with dense TH fibers.

43 uperior cervical ganglion, these PSG-derived TH neurons were clearly evident forming a network around

44 rstand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2) and diffu

45 and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy

46 licular lymphomas were classified as HGBL-DH/TH- BCL2 compared with zero of 50 in the DHITsig-negativ

47 ectively; P < .001), irrespective of HGBL-DH/TH- BCL2 status.

48 HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2) and diffuse large B-cell lymphoma (DLBCL) morp

49 rboring MYC and BCL2 rearrangements (HGBL-DH/TH- BCL2).

50 Validating the association with HGBL-DH/TH- BCL2, 11 of 25 DHITsig-positive-transformed follicul

51 ed by a gene expression signature of HGBL-DH/TH- BCL2.

52 and BCL2 and/or BCL6 rearrangements (HGBL-DH/THs) include a group of diffuse large B-cell lymphomas (

53 ight that FISH fails to identify all HGBL-DH/THs, while revealing a range of other genetic mechanisms

54 had significantly better RFS and OS than did TH (RFS hazard ratio, 0.32; 95% CI, 0.14 to 0.71; P = .0

55 However, discrete TH-ir signals colocalized with EGFP(Vgat) neurons, which

56 e for Chx10 or GAD2 and ~70% of dopaminergic TH-positive neurons.

57 vity of ventral tegmental area dopaminergic (TH(VTA)) neurons, as well as from more global maladaptat

58 lopment, the expression of key dopaminergic (TH) and serotonergic (Tph2, SERT, and Pet-1) genes, and

59 mperature between 33 and 34 degrees C during TH compared to neonates with a favourable outcome.

60 servo-controlled mattress temperature during TH and short-term outcome.

61 ooling to maintain target temperature during TH.

62 ival and physiology by manipulating both egg TH levels and post-hatching nest temperature in wild pie

63 Importantly, endogenous TH is required during this transition for the functional

64 and beta-cells become targets of endogenous TH signaling during the larval-to-juvenile transition.

65 tion against these variants should eradicate TH.

66 d to the hypothalamus in the ARA-where every TH-ir neuron expressed EGFP(Vgat) .

67 Evofosfamide (TH-302) is a hypoxia-activated DNA-crosslinking prodrug

68 We found that exogenous TH precociously activates the beta-cell differentiation

69 pinal afferent nerve endings did not express TH, and lacked the cylindrical morphology around blood v

70 -tissue-resident macrophages did not express TH.

71 to alter GH secretion and neurons expressing TH are located in several brain areas containing GH-resp

72 Finally, TH-MYCN transgenic mice were administered cyclophosphami

73 ) induced similar defects by decreasing fish TH levels and affecting their sensory development.

74 Patterns of immunoreactivity for TH and DARPP-32 in "limbic" areas such as the hippocampu

75 Whereas immunoreactivity for TH was higher in the vocal control region Area X compare

76 nd recognition and may hold implications for TH and PPAR pharmacology.

77 ished as the canonical or type 1 pathway for TH action.

78 neurons and their forebrain projections for TH did not reveal any major changes in staining intensit

79 o single TH nuclear receptor is required for TH-mediated induction of cyp27c1 but that deletion of al

80 ific responses to TH, and assessed roles for TH receptors.

81 This response is selective for TH 2 immunity as TH 1 and TH 17 immunity is largely unaf

82 Ablation of GH receptor (GHR) from TH cells or in the entire brain markedly increased GH pu

83 et of FoxO1, and the FoxO1-Dio2 axis governs TH-induced hypertrophic growth of neonatal cardiomyocyte

84 pital, Dana-Farber Cancer Institute, Harvard TH Chan School of Public Health, Harvard Medical School,

85 cribed individual-based transmission hazard (TH) model and assessed its utility for analyzing data fr

86 stroke) and diffusion of the trailing head (TH) that contributes in propelling the motor by 16 nm ha

87 ns contribute to the expression of T helper (TH) lineage-defining factors is unknown.

88 lin, glucagon, adipocytokines, and T-helper (TH) 1-, 2-, and 17- associated cytokines in patients wit

89 d with persistent pro-inflammatory T-helper (TH)2 and TH17 responses.

90 netic diseases such as transverse hemimelia (TH), a congenital developmental abnormality characterize

91 prognostic impact of a tumor heterogeneity (TH) index on clinical outcomes, using mutational profile

92 Thyroid hormone (TH) and TH receptors (TRs) alpha and beta act by binding

93 tablish links between these thyroid hormone (TH) disrupting molecular events and adverse outcomes rel

94 in a rat model, induced by thyroid hormone (TH) disruption during gestation.

95 d box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morpho

96 Thyroid hormone (TH) regulates diverse developmental events and can drive

97 Thyroid hormone (TH) signaling plays an important role in the regulation

98 for chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets.

99 s that can compete with the thyroid hormone (TH) thyroxine (T4) for binding to transthyretin (TTR).

100 activating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter 8 (MCT8) cau

101 concentration of the active thyroid hormone (TH) triiodothyronine through regioselective deiodination

102 physiologically similar to thyroid hormone (TH)-regulated metamorphosis in anuran amphibians.

103 to highlight the role that thyroid hormones (TH) play in sensory development and determining anti-pre

104 re, we investigate whether thyroid-hormones (TH) and their receptors (TR) coordinate the larval recru

105 her maternally transferred thyroid hormones (THs) exert context-dependent effects on offspring surviv

106 Thyroid hormones (THs) operate numerous physiological processes through mo

107 of low-exposure POPs with thyroid hormones (THs) remains unclear.

108 een individuals living in temporary housing (TH) and those living in other types of accommodation (no

109 How TH cells acquire pathogenicity and communicate with myel

110 To learn how TH elicits seemingly opposite responses in cells having

111 To better understand how TH controls these processes, we analyzed the phenotype o

112 tional domains: an N-terminal T hydroxylase (TH) homologous to the 5-methylcytosine hydroxylase domai

113 , quantified levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT) mRNA using quantitati

114 Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA.

115 nd 38% of oxytocin and tyrosine hydroxylase (TH) cells, respectively, were responsive to GH in the PV

116 om modulation of brain tyrosine hydroxylase (TH) expression and dopamine biosynthesis.

117 l models by recovering tyrosine hydroxylase (TH) from the TH-negative dormant dopaminergic neurons, s

118 cer targets the nearby tyrosine hydroxylase (TH) gene responsible for dopamine synthesis.

119 itu hybridization with tyrosine hydroxylase (TH) immunochemistry for better characterization of PSST1

120 techolaminergic marker tyrosine hydroxylase (TH) in developing murine and human submandibular glands.

121 of 32 kDa (DARPP32) or tyrosine hydroxylase (TH) in tissue sections of adult mouse striatum.

122 ce experiments against tyrosine hydroxylase (TH) or dopamine transporter (DAT).

123 ocytochemistry against tyrosine hydroxylase (TH) or glutamate decarboxylase (GAD) to systematically c

124 tional activity at the tyrosine hydroxylase (TH) promoter, which is mediated by the interaction with

125 in cells that express tyrosine hydroxylase (TH), a compartment where PPGL is known to originate.

126 amate neurons in which tyrosine hydroxylase (TH), and thus DA biosynthesis, was conditionally ablated

127 ther the expression of tyrosine hydroxylase (TH), the rate limiting enzyme in dopamine catalysis, cou

128 tiserum raised against tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis

129 dy the distribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of catech

130 gly, fibers expressing tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, wer

131 notype, which includes tyrosine hydroxylase (TH), vesicular monoamine transporter 2, and the norepine

132 em, it was absent from tyrosine hydroxylase (TH)-expressing cells, but tac3a cells were located in ar

133 Although tyrosine hydroxylase (TH)-immunoreactive neurons in NPPa are hypophysiotropic,

134 demonstrated >300,000 tyrosine hydroxylase (TH)-positive grafted cells per side with normalized stri

135 ic function, including tyrosine hydroxylase (TH).

136 ne-synthesizing enzyme tyrosine hydroxylase (TH).

137 d by the expression of tyrosine hydroxylase (TH).

138 of antibodies against tyrosine hydroxylase (TH; the first enzyme in the synthesis of catecholamines)

139 he number of dopamine (tyrosine hydroxylase, TH+) and somatostatin (SST+) neurons in the paraventricu

140 n each neuron, we determined if hypothalamic TH-immunoreactive (ir) neurons express vesicular glutama

141 Therapeutic hypothermia (TH) at 33.5 degrees C for 72 h is the only therapy to da

142 Treatment with therapeutic hypothermia (TH) improves the long-term neurodevelopmental outcome of

143 an extensive filigree of TH-immunoreactive (TH-ir) arborizations in the appendage neuromeres, as wel

144 Reciprocal histone acetylation in TH+ and SST+ neurons indicates the importance of studyin

145 trong presence of EGFP(Vgat) fluorescence in TH-ir neurons across all brain regions, but the most str

146 Ablation of GHR in TH cells increased the hypothalamic expression of Ghrh m

147 ppressed MYCN-driven neuroblastoma growth in TH-MYCN homozygous transgenic mice and MYCN gene-amplifi

148 This increase in TH occurred equally in both diabetes-susceptible and dia

149 Histone acetylation increased in TH+ neurons and decreased in SST+ neurons following shor

150 s robust at 1 and at 3 months but reduced in TH+ neurons at 12 months and completely abolished in bot

151 ceiving IN + FUS had significantly increased TH immunoreactivity in the treated hemisphere compared t

152 e IGF2 enhancer is associated with increased TH protein levels.

153 , stimulates TH transcription, and increases TH mRNA and protein levels in dopaminergic cells.

154 cyte growth and remodeling and intracellular TH homeostasis.

155 vely), key enzymes involved in intracellular TH metabolism.

156 zebrafish with mutations in the three known TH nuclear receptor transcription factors (thraa, thrab,

157 Likewise, TH and NPY were colocalized in noradrenergic nerves thro

158 t costimulatory molecule expression, limited TH-polarizing cytokine production, and significant cell

159 provide compelling support for AOPs linking TH disruption to impaired AC inflation in fish.

160 neural marker PGP 9.5 and sympathetic marker TH by computerized image analysis.

161 sine hydroxylase (sympathetic neuron marker; TH), calcitonin gene-related protein (peptidergic nocice

162 er, the specific mechanism by which maternal TH insufficiency results in this birth defect remains un

163 In melanophores, TH drives terminal differentiation, limiting final cell

164 photoperiods demonstrated elevated midbrain TH expression levels, specifically during perinatal deve

165 itionally, 8%, 49% and 75% of neuroendocrine TH, TRH and CRH neurons, and 67%, 32% and 74% of nonneur

166 genitor cells, and increased addition of new TH(+) neurons in populations that constitutively add new

167 sulfate metabolites of PCBs 11 and 52 had no TH activity; but 4-OH PCB 52 had higher potency than the

168 living in other types of accommodation (non-TH) five years after the 2011 Great East Japan Earthquak

169 e TH group (n = 2,372) compared with the non-TH group (n = 5,119) using discrete-time logit models st

170 receptor (RXR) by classical and nonclassical THs as another molecular activity of THs.

171 s, and 67%, 32% and 74% of nonneuroendocrine TH, TRH and CRH neurons were responsive to GH in the PVH

172 EGFP(Vglut2) neurons were not TH-ir.

173 e visualized TH target tissues using a novel TH-responsive reporter line and found that both alpha- a

174 However, 87 +/- 1.6% NPPa TH-immunoreactive neurons were surrounded by TRH-immunor

175 Nevertheless, less than 50% of TH-expressing neurons in the hypothalamus were found to

176 study, we showed that between 50% and 90% of TH-expressing neurons in the periventricular, paraventri

177 A vast abundance of TH-ir somata were located in the opisthosomal neuromeres

178 nstrate that the transcriptional activity of TH is modulated by the cellular redox state, and daily r

179 ances ERG proliferation, but not addition of TH(+) neurons.

180 On the background of TH 2 inflammation, we have demonstrated that innate immu

181 pulations judging from the colocalization of TH immunoreactivity and PSST6 expression but not with PS

182 servations suggest a potential connection of TH and PPAR signaling through overlapping ligand recogni

183 Therefore, we examined the consequence of TH excess and deprivation on the efficiently regeneratin

184 me the detailed developmental time course of TH-expressing neurons during murine salivary gland devel

185 cell differentiation; specific depletion of TH from the culture medium completely blocked terminal e

186 was performed for simultaneous detection of TH with nitric oxide synthase, choline acetyltransferase

187 nalysis, and then mapped the distribution of TH-ir EGFP(Vgat) neurons onto atlas templates from the A

188 ntil now, very little data on the effects of TH disruption on inflation of the anterior chamber (AC)

189 port that while there is modest expansion of TH(+) glomus cells in the carotid body upon SDHC loss, P

190 and SMARCA4 are necessary for expression of TH and selection against these variants should eradicate

191 l mass, we detected an extensive filigree of TH-immunoreactive (TH-ir) arborizations in the appendage

192 The PFB-induced increase of TH in the basal ganglia of the NGR was documented by imm

193 hough our data show a complex inheritance of TH, we predict that homozygous variants in WNT7A and SMA

194 ted by continuing limits in our knowledge of TH signaling in important life stages and tissues, such

195 gf2 enhancer deletion disrupts the levels of TH protein and striatal dopamine, and induces transcript

196 Both approaches led to loss of TH expression in VTA glutamate neurons and loss of DA re

197 Moreover, pharmacologic modulation of TH activity rescues the changes in feeding initiation du

198 pallial regions based on a larger number of TH-positive "baskets" of fibers around neurons in this r

199 Furthermore, explicit pairing of TH(VTA) neuronal activation with a forepaw stimulus of a

200 and demonstrates that a transient period of TH perturbation is sufficient to induce a congenital abn

201 Perturbation of TH signaling can lead to abnormal brain development, cog

202 ontrolling the intensity and polarization of TH emission.

203 The PSG therefore provides a population of TH-expressing neurons prior to the arrival of the postga

204 D patients shows a significant population of TH-negative/DDC-positive dormant neurons surrounded by n

205 impairment of motor functions, reduction of TH-expressing cells in SN, and TH mRNA/protein levels in

206 on molecular and physiological regulation of TH signaling and associated adverse outcomes.

207 REST relieved Mn-induced repression of TH promoter activity, mRNA, and protein levels and also

208 ll, our data highlight an unexplored role of TH availability in modulating the cardiac regenerative o

209 Here we demonstrate an essential role of TH during terminal human erythroid cell differentiation;

210 te that selective optogenetic stimulation of TH(VTA) neurons enhanced cerebral blood volume signals i

211 assical THs as another molecular activity of THs.

212 available to interrogate chemical effects on TH signaling.

213 Stimulating either mCbN afferents or TH neurons augments IPSCs and suppresses EPSCs in Chx10

214 closely associated with DRD2 in DARPP32- or TH-immunopositive cells, respectively.

215 to evaluate the relative impact from IR- or TH-induced regulation.

216 In colorectal cancer patients, TH index values also correlated significantly with clini

217 The first pattern (TH-positive, DAT-positive, ZsGreen-positive) was found i

218 The second pattern (TH-positive, DAT-negative, ZsGreen-positive) was found i

219 The third pattern (TH-positive, DAT-negative, ZsGreen-negative) was found i

220 consumption and environmental footprint per TH mined is expected to decrease.

221 ration in tissue homogenates and the percent TH-immunoreactive area in the NPPa.

222 pend on dimerization of its lipid-binding PH-TH module on the cell membrane, we performed long-timesc

223 ar dynamics simulations of membrane-bound PH-TH modules and observed that they dimerized into a singl

224 ing pleckstrin homology and Tec homology (PH-TH) module of Bruton's tyrosine kinase (Btk).

225 t multiple sites, and that the effects of PH-TH mutations on dimer stability were consistent with the

226 not capable of dimerization through their PH-TH modules.

227 ice, lower levels of DRD2 and phosphorylated TH were observed, when compared to wild-type littermates

228 current paradigm that in vivo physiological TH action is mediated exclusively via regulation of gene

229 l underlying physiological responses (plasma TH levels, oxidative stress and mitochondrial density).

230 dopaminergic [tyrosine hydroxylase-positive (TH(+))] neurons.

231 ce for context-dependent effects of prenatal THs related to postnatal temperature on growth, survival

232 DAergic Rit2-KD did not affect presynaptic TH and DAT protein levels in females, nor was TH was aff

233 Treatment with hypoxia-activated prodrug TH-302 potently reduces NEPC tumor growth.

234 d with TRH (0.5-2 muM) significantly reduced TH concentration in tissue homogenates and the percent T

235 Ps at low levels might be related to reduced THs.

236 hin the ARA ontology of gray matter regions, TH-ir neurons localized primarily to the periventricular

237 inding protein/p300 and thereby up-regulated TH expression.

238 signaling in dopaminergic neurons regulates TH expression and feeding initiation via the downstream

239 We found that this Delta-JDBD domain retains TH activity in vitro but displays a 15-fold lower appare

240 , while in retinal pigment epithelium (RPE), TH regulates expression of a cytochrome P450 enzyme, cyp

241 We found that no single TH nuclear receptor is required for TH-mediated inductio

242 in principal neurons but did occur in small, TH-negative cells presumed to be interneurons and in a f

243 This is associated with a loss of spinal TH(+) axons, as well as permanent deficits in shoaling a

244 us sites in the TH gene promoter, stimulates TH transcription, and increases TH mRNA and protein leve

245 fted cells per side with normalized striatal TH-immunoreactive fiber innervation and bidirectional sy

246 In summary, TH neurons that do not express DAT or DBH are required f

247 ion improved when they received supplemental TH.

248 m community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiati

249 Finally, we tested TH-MYCN mice as a feasible model for immunotherapy, usin

250 erred from the data: L-triiodothyronine, TH, TH receptor, and triiodothyronine (reverse) were inferre

251 We show that TH promotes maturation of both cell types but in distinc

252 The TH group showed a significantly higher odds ratio (OR) f

253 The TH index tended to be increased in high pathological sta

254 The TH loss depends on reduced dopaminergic neuronal firing

255 The TH-MYCN transgenic mouse is a promising in vivo model fo

256 conclusion, deep sequencing to determine the TH index could serve as a promising prognostic indicator

257 ecovering tyrosine hydroxylase (TH) from the TH-negative dormant dopaminergic neurons, some of which

258 residue has been proposed to function in the TH form as a general acid in RNA synthesis and as a gene

259 hat REST binds to RE1 consensus sites in the TH gene promoter, stimulates TH transcription, and incre

260 ted the odds ratio of new onset of DM in the TH group (n = 2,372) compared with the non-TH group (n =

261 Integration of the TH index with genomic and clinical features could improv

262 to model choice, although the ability of the TH model to accurately describe transmission of influenz

263 development resulted in specific loss of the TH-positive neurons from the PSG, and subsequent branchi

264 x revealed a distinctive binding mode of the TH.

265 REST binding to the TH promoter recruited the epigenetic modifier cAMP-respo

266 s of MX i.e. Theobromine (TB), Theophylline (TH) and Caffeine (C), with application in commercial tea

267 Thus, TH signaling coordinately regulates both spectral sensit

268 The precise roles of the TL/TH in RNA synthesis and hydrolysis remain unclear.

269 ients were randomly allocated to THL, 120 to TH, and 67 to TL.

270 ptors (TRs) alpha and beta act by binding to TH response elements (TREs) in regulatory regions of tar

271 p linking impaired swim bladder inflation to TH disruption.

272 owed immunoreactivity to dopamine but not to TH.

273 Survivors relocated to TH appeared to be at an increased risk of new onset DM.

274 d pigment cell-lineage specific responses to TH, and assessed roles for TH receptors.

275 nitor niche may be especially susceptible to TH disruption.

276 pontaneous neuroblastomas (NB) in transgenic TH-MYCN mice; (ii) orthotopic xenografts of a drug-resis

277 S2 and 9464D), and a spontaneous transgenic (TH-MYCN) murine model of neuroblastoma, comparing histol

278 astuzumab plus lapatinib (THL), trastuzumab (TH), or lapatinib (TL).

279 inferred from the data: L-triiodothyronine, TH, TH receptor, and triiodothyronine (reverse) were inf

280 ntered in coral-reefs, impairs A. triostegus TH-levels, transformation, and grazing activity, hence d

281 er of outcome in infants with HIE undergoing TH.

282 ifferent functional strategies that underpin TH pleiotropy.

283 We visualized TH target tissues using a novel TH-responsive reporter l

284 tic approaches to show a causal role for VTA TH neurons in two forms of relapse to alcohol-seeking: r

285 eurons, we identified medial and lateral VTA TH neuron activity profiles during self-administration,

286 Next, we used optogenetic inhibition of VTA TH neurons to show distinct causal roles for VTA subregi

287 Then, using gCaMP fiber photometry of VTA TH neurons, we identified medial and lateral VTA TH neur

288 H and DAT protein levels in females, nor was TH was affected in males; however, DAT was significantly

289 a total of 169, 154 and 2863 genes that were TH-responsive (FDR < 0.05) in the tilapia cerebellum, th

290 act primarily to repress these programs when TH is limiting.

291 transporter (vGAT), then determined whether TH-ir neurons colocalized with native EGFP(Vglut2) - or

292 However, whether TH-expressing neurons are required to regulate GH secret

293 ults reveal the molecular mechanism by which TH functions during red blood cell formation, results th

294 the ventral tegmental area (VTA), along with TH transcription, are highly disrupted following chronic

295 uctions revealed that Ank-G colocalized with TH only at the AIS.

296 tes with moderate or severe HIE treated with TH were included in the present study.

297 rominated dibenzo-p-dioxins and furans, with THs [total (L)-thyroxine (TT(4)), total 3,3',5-triiodo-(

298 In xanthophores, TH promotes accumulation of orange carotenoids, making t

299 PCR, and immunohistochemistry to assess YY1, TH, GLAST, and GLT-1 levels.

300 In zebrafish, TH has opposite effects on neural crest derived pigment