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1 tion was seen to require TLR2 in addition to TLR10.
2 s a source of ligand for the orphan receptor TLR10.
3 n in chemokine output following silencing of TLR10.
4 and IL-8 were reduced following knockdown of TLR10.
5 om an ancestral gene also shared by TLR6 and TLR10.
6 tion of STAT3 upon Ab-mediated engagement of TLR10.
7  cells, and monocytes constitutively express TLR10.
8                            Variations in the TLR10/1/6 locus appear to be linked with the risk of con
9 ome-wide significant loci, including LCT and TLR10/1/6, related to area-level cohort IMR exposure dur
10 T cell lines, we dissected the regulation of TLR10, a TLR highly expressed in human Treg cells.
11 man mononuclear cells with a monoclonal anti-TLR10 Ab suppressed proinflammatory cytokines released b
12              Upon preincubation with an anti-TLR10 Ab, production of cytokines in pDCs was downregula
13 transfection in human cell lines showed that TLR10 acts as an inhibitory receptor when forming hetero
14                                     Blocking TLR10 after stimulation of peripheral blood mononuclear
15                          The presence of the TLR10 alleles 775L, 369L, or 241H increased interleukin
16                                     However, TLR10, alone or in cooperation with TLR2, fails to activ
17 ning the extracellular recognition domain of TLR10 and the intracellular signaling domain of TLR1, re
18 ynonymous single-nucleotide polymorphisms in TLR10, and functional consequences of the TLR10 SNPs wer
19 esults suggest that human Treg cells express TLR10, and this expression is regulated through a cooper
20 nuclear cells (PBMCs) preincubated with anti-TLR10 antibody and HEK-293 cells overexpressing TLRs wer
21                     After cross-linking anti-TLR10 antibody, no production of IL-1beta and other proi
22 I-related pathogens, and genetic variants in TLR10 are associated with protection against cSSSIs.
23                    The modulatory effects of TLR10 are complex, involving at least several mechanisms
24  4p14, the specific ligands and functions of TLR10 are currently unknown, although it is expressed in
25 everal immune pathways, among them TLR1/TLR6/TLR10, as being shaped by convergent evolution in two hu
26 and skin structure infections (cSSSIs), with TLR10 being the first family member known to have an inh
27 man aortic ECs express TLR3, TLR4, TLR6, and TLR10, but only TLR4 was detected on the EC surface.
28                                     Blocking TLR10 by antagonistic antibodies enhanced proinflammator
29                   Transcriptional control of TLR10 by FOXP3 was determined through luciferase reporte
30                                  Among them, TLR10 (CD290) remains the only TLR family member without
31 t Neandertal ancestry, we find the TLR6-TLR1-TLR10 cluster, which also contains functional adaptive v
32                            Overexpression of TLR10 completely abrogated TLR2-induced interleukin 8 se
33        Three signals (SERPINA1, ZFP36L2, and TLR10) contain predicted deleterious missense variants.
34                       We conclude that human TLR10 cooperates with TLR2 in the sensing of microbes an
35 regulatory factor 7 (IRF7) in pDCs following TLR10 engagement.
36               These results demonstrate that TLR10 functions as a broad negative regulator of TLR sig
37 or example, Toll-like receptor 1 (TLR1)/TLR6/TLR10 gene cluster showed a strong signal of adaptive se
38                        Relevance of FOXP3 to TLR10 gene transcription in primary T cells was establis
39 ediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk.
40                 Our results demonstrate that TLR10 has a functional role within the B cell lineage th
41 regulator of TLR signaling and suggests that TLR10 has a role in controlling immune responses in vivo
42                       Three polymorphisms in TLR10, I775L, I369L, and N241H, were associated with red
43 ort for strong purifying selection acting on TLR10 in B. t. taurus cattle.
44  interrogated the expression and function of TLR10 in human plasmacytoid dendritic cells (pDCs).
45 se a role for TIRAP-dependent TLRs, possibly TLR10 in particular, in the development and/or maintenan
46              This study assessed the role of TLR10 in recognition of cSSSI-related pathogens and whet
47 ogether, these data indicate novel roles for TLR10 in sensing pathogenic infection in both the epithe
48 d pathogens and whether genetic variation in TLR10 influences susceptibility to cSSSIs.
49                                       Murine TLR10 is a disrupted pseudogene, which precludes investi
50 ledge we demonstrate for the first time that TLR10 is a modulatory pattern-recognition receptor with
51                                              TLR10 is a modulatory receptor of innate immune response
52                          We demonstrate that TLR10 is a modulatory receptor with mainly inhibitory ef
53                                              TLR10 is a potential asthma candidate gene because early
54  inhibitory role in B cells, indicating that TLR10 is a potential drug target in autoimmune diseases.
55 e the (to our knowledge) first evidence that TLR10 is constitutively expressed on the surface of huma
56             One major impediment to studying TLR10 is its absence in mice.
57           Phylogenetic analysis reveals that TLR10 is most related to TLR1 and TLR6, both of which me
58                            Among human TLRs, TLR10 is the only family member without a defined agonis
59        Among the 10-member human TLR family, TLR10 is the only remaining orphan receptor without a kn
60                       TOLL-like receptor 10 (TLR10) is the most recently identified human homolog of
61                            A recent study on TLR10 knock-in mice demonstrated its intrinsic inhibitor
62 ctor, which resulted in prompt production of TLR10 mRNA.
63 tion with cSSSI pathogens in the presence of TLR10 neutralizing antibody significantly increased inte
64 by UEC was demonstrated by RT-PCR, with only TLR10 not expressed.
65 We have found that Ab-mediated engagement of TLR10 on primary human B cells suppresses B cell prolife
66 mechanisms mediate the modulatory effects of TLR10: on the one hand, cotransfection in human cell lin
67  SNPs in 11 bovine innate immune genes (TLR1-TLR10, PGLYRP1) for 37 cattle breeds.
68             Furthermore, individuals bearing TLR10 polymorphisms displayed an increased capacity to p
69    Finally, transgenic mice expressing human TLR10 produced fewer cytokines when challenged with a TL
70                       Enhanced expression of TLR10 protein in primary Treg cells was induced in a cal
71 nds of publications on TLRs, the function of TLR10 remains unknown.
72  heterodimers (with TLR1, TLR6, and possibly TLR10) require in addition the adaptor TIRAP, whereas UN
73                                              TLR10 requires TLR2 for innate immune recognition, and t
74                                 Silencing of TLR10 resulted in increased viability of L. monocytogene
75  asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3x10(-21)); 6p21.33 near HLA-C and
76 ular signaling domain of TLR1, revealed that TLR10 senses triacylated lipopeptides and a wide variety
77 tational modeling and mutational analysis of TLR10 showed preservation of the essential TLR2 dimer in
78 genetic analysis showed that TLR1, TLR6, and TLR10 single-nucleotide polymorphisms modulate Y. pestis
79 in TLR10, and functional consequences of the TLR10 SNPs were assessed via in vitro stimulation assays
80                          We report here that TLR10 suppressed the production of an array of cytokines
81 function of pDCs by Ab-mediated targeting of TLR10 that may open a new therapeutic avenue for autoimm
82 ased on the crystal structure of the dimeric TLR10 TIR domain, the first binding site mediates TLR4-T
83 the peak of the lead region are three genes: TLR10, TLR1, and TLR6.
84 and type 1 IFN were measured in the serum of TLR10 transgenic mice compared to nontransgenic mice, bu
85 th either a T independent or T dependent Ag, TLR10 transgenic mice exhibit diminished Ab responses.
86 transgenic littermate controls, monocytes of TLR10 transgenic mice exhibited blunted IL-6 production
87 3, bditTLR4, TLR5, bditTLR7, TLR8, TLR9, and TLR10 upon Abeta stimulation is severely depressed in mo
88 proximity to the transcription start site of TLR10 was established through EMSA and chromatin immunop
89                           We determined that TLR10 was expressed in human Treg cells through quantita
90                               Interestingly, TLR10 was found to be expressed at greater levels in IgM
91                                              TLR10 was found to be predominantly expressed intracellu
92 xtended to TLR3, TLR6, TLR7, TLR8, TLR9, and TLR10, whereas the cellular level of TLR1, TLR2, and TLR
93 esembles closest to the Toll/IL-1R domain of TLR10 with low sequence homology, substantial difference