ライフサイエンスコーパス: TM domain

1 absence of a targeting signal other than the TM domain.

2 strates, however, as it stabilized the first TM domain.

3 teracts with SERCA1 at least in part via its TM domain.

4 -helix connected by a disordered loop to the TM domain.

5 stitute a Golgi-targeting signal or a second TM domain.

6 ough specific interactions with the receptor TM domain.

7 esent in ANAC017 just prior to the predicted TM domain.

8 ually strong interhelical interaction in the TM domain.

9 nd aromatic residues along the length of the TM domain.

10 ity connected to the periplasmic exit of the TM domain.

11 ng antibodies than peptides with a monomeric TM domain.

12 among their membrane-embedded alpha-helical TM domains.

13 he interstices between the outer ends of the TM domains.

14 tive orientation, including both soluble and TM domains.

15 t transmembrane (TM) domain and contains six TM domains.

16 eractions formed between TM3 and neighboring TM domains.

17 nique 44-amino acid proteins with randomized TM domains.

18 perfamily are encoded at least partly in the TM domains.

19 the pair of inner helices from the second 6-TM domains.

20 lation of RNF144A through its transmembrane (TM) domain.

21 channel-forming alpha-helical transmembrane (TM) domain.

22 and F-actin via a C-terminal transmembrane (TM) domain.

23 eins containing only a single transmembrane (TM) domain.

24 e of the envelope counterpart transmembrane (TM) domain.

25 ain a predicted alpha-helical transmembrane (TM) domain.

26 main (CD) following the third transmembrane (TM) domain.

27 tial contribution of the TatA transmembrane (TM) domain.

28 24% sequence identity for the transmembrane (TM) domain.

29 e nitrilase domain fused to a transmembrane (TM) domain.

30 presenilin enhancer 2 in the transmembrane (TM) domain.

31 conserved HxxxW motif in the transmembrane (TM) domain.

32 cally predicted to have 30-40 transmembrane (TM) domains.

33 of the recombinant lectin-like domain of TM-TM domain 1 (rTMD1)-in antiangiogenesis were investigate

34 local distortions within the transmembrane (TM) domain 1 and alter TM1 interaction with TM2.

35 mutant transporters, predicts transmembrane (TM) domains 1, 3, 6, and 8 comprise the 5-HT-binding poc

36 angiogenic activity than did the recombinant TM domains 2 and 3.

37 Deletion of the TM domain abolishes its membrane localization and also s

38 to interact with the alphaIIb transmembrane (TM) domain activate single alphaIIbbeta3 molecules in pl

39 In vitro, the predicted TM domain adopts an alpha-helical structure in lipid env

40 ipid environments and can function as a real TM domain, although not as efficiently as the bona fide

41 extended hydrophobic C terminus containing a TM domain and a cytoplasmic tail.

42 formations of a peptide comprising the EphA2 TM domain and a portion of the intracellular juxtamembra

43 ules in platelets by binding to the alphaIIb TM domain and causing separation of the alphaIIbbeta3 TM

44 efore, understanding the extent to which the TM domain and ECL2 conformations are coupled is useful.

45 cteria and archaea, contains only a single 6-TM domain and functions as a tetramer.

46 occurs when the JM domain is linked to FGFR3 TM domain and not simply anchored to the plasma membrane

47 identified a peptide that binds to the PTPRJ TM domain and represents the first example of an alloste

48 n important role for the self-associating L2 TM domain and the conserved GxxxG motifs in the transfer

49 sults suggest a mechanism involving both the TM domain and the DD of p45 to regulate p75-mediated sig

50 is of a MARCH9 fragment encompassing the two TM domains and extracellular connecting loop revealed th

51 horin A (GpA) contain a GxxxG motif in their TM domains and form a homodimer, but the association aff

52 of different factors (primary structures of TM domains and juxtamembrane regions, composition and ph

53 te the interaction of the beta3 and alphaIIb TM domains and maintain the inactive resting conformatio

54 on between the conformational changes of the TM domains and of the intracellular juxtamembrane domain

55 secretion, the molecular distinction between TM domains and signal peptides, and the propensity for h

56 ilized complex consisting of portions of the TM domains and the full cytoplasmic domains.

57 egion (MPER), followed by the transmembrane (TM) domain and a 20-residue cytoplasmic tail.

58 e variants excludes the first transmembrane (TM) domain and contains six TM domains.

59 45 binds p75 through both its transmembrane (TM) domain and DD.

60 t contain one of two possible transmembrane (TM) domain and flanking sequences that either restrict t

61 n by directly binding to MAVS transmembrane (TM) domain and preventing MAVS aggregation.

62 ox2/4) consisting of the Nox2 transmembrane (TM) domain and the Nox4 dehydrogenase (DH) domain showed

63 ily that are composed of four transmembrane (TM) domains and assemble into dimers.

64 ypeptide that contains seven trans-membrane (TM) domains and other motifs that are characteristics of

65 n Cx26, we studied individual transmembrane (TM) domains and the full-length protein.

66 allest separation between the transmembrane (TM) domains and the highest possible phosphorylation, a

67 ween this initial step and activation of the TM domain, and that activation and deactivation follow a

68 pid nanoparticles using natural and designed TM domains, and antibody affinity was measured using imm

69 extracellular (EC) domain, a transmembrane (TM) domain, and an intracellular domain that includes a

70 he extracellular (EC) domain, transmembrane (TM) domain, and EC-TM interface of GLIC.

71 Stabilization of the first TM domain appears to be a key mechanism for high efficie

72 The ArcB and QseC TM domains are both two-helical motifs, whereas the KdpD

73 ceptor contacts within the extracellular and TM domains are critical for the establishment of the unl

74 t share the extracellular and transmembrane (TMD) domains, as well as an intracellular domain known a

75 ansmitting the conformational changes in the TM domains associated with inside-out activation.

76 complete fusion, the role of synaptobrevin's TM domain association in the fusion process remains poor

77 no consensus on the conformation of the APP-TM domain at the biological membrane.

78 es in the conformation of the transmembrane (TM) domain, brought about by changes in interactions of

79 sodium channels revealed the nature of their TM domains but not their C-terminal domains (CTDs).

80 rongly indicate that the proto-oncogenic Neu TM domain can adopt multiple (at least two) oligomeric c

81 first time that class I viral fusion protein TM domains can self-associate as trimeric complexes in t

82 nthetic peptides derived from transmembrane (TM) domains can interact with a full-length GPCR, blocki

83 domain of the chimera with the glycophorin A TM domain causes intramembrane dimerization and conseque

84 re both two-helical motifs, whereas the KdpD TM domain comprises a four-helical bundle with shorter s

85 Ligand binding leads to a change in the TM domain conformation, resulting in increased kinase do

86 The median rmsd of TM domains containing 75-222 residues between predicted

87 Sedimentation equilibrium analysis of TM domains containing these mutations gave higher relati

88 The TM domain contains three highly conserved GxxxG motifs.

89 The ErbB1 TM domain contribution to stability exceeds the change i

90 nker structure, dynamics, and resulting ecto-TM domain coupling of integrin alphaIIb in model constru

91 -TM domain transition and the degree of ecto-TM domain coupling represents an important parameter in

92 While most TM domain deletion constructs remained fusion competent,

93 of construct C8 (a construct that contains a TM domain deletion of eight amino acids from the C termi

94 sment of dimerization heterogeneity of these TM domains demonstrated that 7 of them have a unique dim

95 The elimination of the TM domain did not affect 2-AG or fluorogenic arachidonoy

96 ion at i, i+4 positions at the center of the TM domain dimer eliminates the barrier and stabilizes th

97 nylalanine) in the predicted, tightly packed TM domain dimer interface.

98 s intrinsic to the physical character of the TM domain dimer, with a significant energy barrier separ

99 l change in a tightly bundled transmembrane (TM) domain dimer.

100 ce motifs for RTK dimerization and about how TM domain dimerization in model systems relates to RTK a

101 volve more slowly than do EM domains, though TM domains display increased rate heterogeneity relative

102 tion of exogenous TM peptides may displace a TM domain, disrupting native TM-TM interactions and glob

103 ot hold true for receptors like CD16A, whose TM domains do not contain basic residues.

104 adhering to immobilized ligand, the integrin TM domains do not form homo-oligomers, suggesting that i

105 Dislocation of the TM domain during the natural process of endoplasmic reti

106 Lipid intercalation between the separating TM domains during channel opening would be facilitated i

107 The pathogenic A391E mutation in FGFR3 TM domain emulates the action of fgf2, trapping the FGFR

108 We find that TM domains evolve more slowly than do EM domains, though

109 Peptides incorporating the native HIV TM domain exhibit significantly stronger interactions wi

110 The NS4A TM domain exhibited a strong homotypic interaction that

111 absence of SRP this structure is lost as the TM domain exits the tunnel; however in the presence of S

112 n cell membranes, they are limited to either TM domains expressed in an inverted orientation or captu

113 Sequence-Structure (GRoSS) alignment of the TM domains for all human GPCR sequences is sufficient to

114 reverse orientation, and are limited to only TM domains for proper membrane trafficking and integrati

115 This study addresses whether integrin TM domains form homo-oligomers in mammalian cell membran

116 how that the receptor complex transmembrane (TM) domains form an intimately associated eight-helix bu

117 s, which are coupled with the transmembrane (TM) domains forming the pathway for anion permeation.

118 iophysical methods, we find that the rat Neu TM domain forms strong oligomers and, similar to previou

119 Experiments using TM domains from other receptors, EGFR and FGFR1, failed

120 ct three-dimensional atomic structure of the TM domains from sequences for a set of 23 nonhomologous

121 by replacing this domain with the F protein TM domains from two other paramyxoviruses, Sendai virus

122 A potential hydrogen-bonding role for a TM domain glutamine was also investigated, and it was fo

123 fect on the T3S process, indicating that the TM domain has no sequence-specific function in the assem

124 ated receptor tyrosine kinase transmembrane (TM) domains have been shown to form sequence-specific di

125 ins a V to E mutation at position 664 in the TM domain, have been analyzed to improve our understandi

126 ed variant without N-terminal transmembrane (TM) domain, hDelta29-3-ABHD6, as the most promising prot

127 and causing separation of the alphaIIbbeta3 TM domain heterodimer.

128 eptide containing the Ostbeta transmembrane (TM) domain heterodimerized with Ostalpha, although the r

129 imal external region (MPER) connected to the TM domain: i.e., the missing parts of the EBOV GP2 struc

130 Mutations in F protein transmembrane (TM) domains implicated the TM domain in the fusion proce

131 e canonical hydrophobic groove displaces the TM domain in a competitive manner, allowing BclXL to dis

132 sured the potential dimerization of the NS4A TM domain in a well-characterized two-hybrid TM protein

133 in and reveal a fundamental role of the NS4A TM domain in coordinating HCV RNA replication and virus

134 lecular dynamics simulations of the isolated TM domain in explicit lipid bilayers coupled to thermody

135 ormation, dynamics, and hydration of the BM2 TM domain in lipid bilayers.

136 ort the identification of a function for the TM domain in mediating MAVS self-association.

137 cute respiratory syndrome virus has only one TM domain in micelles, whereas the predicted beta-coil-b

138 as we observe that dimerization of the Neu* TM domain in the Escherichia coli inner membrane strongl

139 in transmembrane (TM) domains implicated the TM domain in the fusion process, but the structural and

140 mbrane (TM) regions revealed that the second TM domain in the proposed 4-TM model of VKOR does not fu

141 ed the NMR structures of mouse and human Fas TM domains in bicelles that mimic lipid bilayers.

142 the participation of mutual rotations of the TM domains in cytokine receptor activation.

143 n 6 ns), illustrating efficient solvation of TM domains in explicit bilayer environments.

144 al evidence for the major role of the C2 and TM domains in oligomerization, underscoring synergy amon

145 ) and helped to elucidate the association of TM domains in the epidermal growth factor family of rece

146 copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expresse

147 copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expresse

148 l domains to their respective transmembrane (TM) domains in transmitting the conformational changes i

149 intracellular (IC) domains and/or within the TM domain influenced receptor activities.

150 embly of the membrane occurred with the syb2 TM domain inserted, as expected from experimental data.

151 FRalpha1-TM, which contains a transmembrane (TM) domain instead of the GPI anchor.

152 ly been shown to dimerize via transmembrane (TM) domain interactions.

153 The lowest energy state of the TM domain is a right-handed dimer structure in which the

154 lizing antibodies can bind the MPER when the TM domain is a three-helix bundle and this presentation

155 Thus, the beta3-integrin TM domain is able to engage in two mutually exclusive in

156 The sequence of the NS4A TM domain is highly conserved, suggesting that it may be

157 p45 with the cysteine 257 of p75 within the TM domain is necessary for p45-p75 heterodimerization.

158 Further evidence shows that the TM domain is required for RNF144A self-association and t

159 ous reports suggested that Cys257 in the p75 TM domain is required for signaling.

160 The TM domain is structurally related to the TMEM16 family o

161 However, the fate of the cleaved p75 TM domain is unknown.

162 ligand pocket located in the transmembrane (TM) domain is occupied, ligand-specific conformational c

163 gomerization, the role of the transmembrane (TM) domains is unknown.

164 ane-proximal linker (LD), and transmembrane (TMD) domains is required and sufficient to trigger fusio

165 ecific sequences in the alpha-helical MARCH9 TM domains make crucial contributions to its ability to

166 A defined coupling of ecto- and TM domains must be essential to allosteric receptor regu

167 antifying the effect of the pathogenic A391E TM domain mutation on the stability of the fibroblast gr

168 actant micelle possesses a "GG kink," in the TM domain near the dynamic hinge located at G37/G38.

169 e region at the interface between the EC and TM domains, near the interlobe groove of NCT, emerges as

170 An L2 double point mutant renders the TM domain nonfunctional and blocks HPV16 infection by pr

171 es, our method can predict structures of the TM domain of beta-barrel membrane proteins of novel topo

172 ution increases helical structure within the TM domain of C55.

173 ly, replacement of the YscD TM domain with a TM domain of dissimilar sequence had no effect on the T3

174 that equivalent F, D, and T residues in the TM domain of FcepsilonR1alpha markedly influence the bio

175 We found that either TM domain of HBsAg could be replaced, resulting in HBsAg

176 embly by replacing the entire first or third TM domain of HBsAg with the transmembrane domain of HIV

177 equired the specific sequence present in the TM domain of human tetherin.

178 The TM domain of Lnt contains eight TM helices which form a

179 r combinatorial peptide library based on the TM domain of Neu (ErbB2) as a model RTK.

180 a domain-swapped trans fashion, whereby the TM domain of one monomer occupies the canonical hydropho

181 Deletion of the single TM domain of Ostbeta abolished interaction with Ostalpha

182 ed tryptophan-asparagine sequence within the TM domain of Ostbeta to alanines did not prevent cell su

183 although not as efficiently as the bona fide TM domain of PDGFR.

184 relies on a conformational change within the TM domain of PhoQ induced by a perturbation in cell memb

185 Therefore, our data demonstrate that the TM domain of RNF144A has at least two independent roles,

186 The TM domain of RNF144A is highly conserved among species.

187 erization motif G(18)X(3)AX(2)G(25) in the N-TM domain of SR-BI contributes substantially to the homo

188 the channel transmembrane (TM) domain to the TM domain of syntaxin 1A to trigger transmitter release.

189 lar, the role of tapasin binding to the core TM domain of TAP1 single chains is mysterious because th

190 infrared spectroscopy show that the isolated TM domain of the active W515K mutant has a helix tilt an

191 interaction of the beta3 TM domain with the TM domain of the alphav-subunit of the integrin alphavbe

192 gest that intersubunit crevices found in the TM domain of the ATP-bound crystal structure are not pre

193 vators suggested that it interacted with the TM domain of the hEPOR.

194 the two conserved interaction motifs in the TM domain of the integrin beta3-subunit.

195 l-of-mean force calculations on the isolated TM domain of the long isoform of DR5.

196 sults show that the specific sequence of the TM domain of the NDV F protein is important for the conf

197 ai virus (SV) and measles virus (MV), or the TM domain of the unrelated glycoprotein (G) of vesicular

198 0 to monitor the functional integrity of the TM domain of these mutant receptors.

199 have identified critical residues within the TM domains of ABCG1 that are both essential for sterol t

200 to 12 A) reveal weak interactions within the TM domains of all three receptors.

201 ar interaction between the extracellular and TM domains of C99(15-55) is enhanced in the micelle envi

202 G380 and A391E mutations in dimerization of TM domains of FGFR3 and their consecutive contributions

203 on was utilized to demonstrate that isolated TM domains of Hendra virus F protein associate in a mono

204 G380R and A391E mutations on dimerization of TM domains of human fibroblast growth factor receptor 3

205 In this study, the TM domains of Neu and the corresponding oncogenic mutant

206 template had low sequence-similarity to the TM domains of the CNG channels, and to reconcile conflic

207 ved region adjacent to the last two putative TM domains of the protein, that when mutated, affects un

208 we report three backbone structures for the TM domains of the three classes of Escherichia coli hist

209 es with known structures: the transmembrane (TM) domain of a bacterial channel, and the cyclic nucleo

210 It is believed that the transmembrane (TM) domain of EphA2 adopts two alternate conformations i

211 f the central residues of the transmembrane (TM) domain of M2 are significantly enhanced by Cu(II), a

212 hydrophobic match between the transmembrane (TM) domain of membrane proteins and the surrounding lipi

213 of specific sequences in the transmembrane (TM) domain of Newcastle disease virus (NDV) fusion (F) p

214 rol delivery from NPC2 to the transmembrane (TM) domain of NPC1.

215 The transmembrane (TM) domain of p75 stabilizes the receptor dimers through

216 The C-terminal transmembrane (TM) domain of Pf1 finds its optimal position in the memb

217 extra interactions in seven-transmembrane (7-TM) domain of Smo due to an additional 2-pyridylmethyl g

218 dentified in the N-terminal transmembrane (N-TM) domain of SR-BI a conserved glycine dimerization mot

219 g site is present in the core transmembrane (TM) domain of TAP1 and is used only by the unassembled s

220 s between subunits within the transmembrane (TM) domain of the ATP-bound structure.

221 However, replacement of the transmembrane (TM) domain of the chimera with the glycophorin A TM doma

222 ously, we have shown that the transmembrane (TM) domain of the F protein, separate from the rest of t

223 A S31N mutation in the transmembrane (TM) domain of the protein has caused widespread amantadi

224 In this study, we align the transmembrane (TM) domains of all experimental GPCR structures to maxim

225 predicting structures of the transmembrane (TM) domains of beta-barrel membrane proteins.

226 the entire extracellular and transmembrane (TM) domains of C99 needed for gamma-secretase processing

227 H9 activity is encoded in the transmembrane (TM) domains of its substrates.

228 ragment encoding the last six transmembrane (TM) domains of PC1 and the C-terminal tail (QIF38), a se

229 Mutations in transmembrane (TM) domains of receptor tyrosine kinases are shown to ca

230 the cytoplasmic tail (CT) and transmembrane (TM) domains of tetherin alone produced its characteristi

231 cated splice variant with six transmembrane (TM) domains of the mouse mu-opioid receptor gene, in enh

232 The transmembrane (TM) domains of viral fusion proteins are typically requi

233 e approximately 3 kcal/mol energy barrier to TM domain opening and the approximately 2 kcal/mol energ

234 virus 5 F (PIV5 F) and either the MPER, the TM domain, or the cytoplasmic tail of the F proteins of

235 d the L2 sequence to multiple transmembrane (TM) domain prediction algorithms.

236 implies a cleavage event close to its single TM domain prior to loading onto the ELVs.

237 peptide with a trimeric, three-helix bundle TM domain recapitulates the binding profile of the nativ

238 These results imply that early TM domain recognition by targeting factors acts to ensur

239 kpoints in the middle and cytosolic extended TM domain regions.

240 alanine substitution in the first of its two TM domains rendered MARCH9 completely unable to alter th

241 Previous transmembrane (TM) domain replacement studies showed that the TM domain

242 tive arginines immediately C-terminal to the TM domain rescued this defect.

243 analyses have indicated that transmembrane (TM) domain residues can affect folding or function of vi

244 such forces to the intravesicular end of the TM domain resulted in tilting motion of the TM domain th

245 specific residues and motifs within MARCH9's TM domains resulted in varying degrees of functional imp

246 as found, and analysis of the Hendra virus F TM domain revealed a heptad repeat leucine-isoleucine zi

247 s both functions contains the transmembrane (TM) domain (roughly residues 22-46) for the amantadine-s

248 In addition to the classic transmembrane (TM) domain, RXFP1 possesses a large extracellular domain

249 The single mutants had a small effect on TM domain separation and cell death, whereas the double

250 he double mutant significantly increased the TM domain separation and more than doubled the sensitivi

251 TM domain with a nondimerizing poly-Leu/Ala TM domain sequence also blocked pilus production but not

252 residue peptide having the IR transmembrane (TM) domain sequence activates IR, but not related growth

253 his association, 140 paramyxovirus F protein TM domain sequences were analyzed.

254 ) domain replacement studies showed that the TM domain serves a critical role in GP64 function.

255 M2 ectodomain and residues 24-36 of the A/M2 TM domain show 85% amantadine/rimantadine sensitivity an

256 e free energy of association reveal that the TM domains show a significant affinity to self-associate

257 s and validated in cytokine receptors by the TM domain structure of the cytokine receptor common subu

258 To evaluate the role of the transmembrane (TM) domain, synthetic MPER-derived peptides were incorpo

259 icantly slower conformational changes in the TM domain (tau (2) ~ 20 ms).

260 Since the TM-domain template had low sequence-similarity to the TM

261 ization and activation path for TpoR via its TM domain that is shared between the small-molecule agon

262 is studies identify critical residues in the TM domains that are important for ABCG1 to alter sterol

263 entifies activation hot-spot residues in the TM domains that get rewired upon activation.

264 YscD has a single transmembrane (TM) domain that connects a small N-terminal cytoplasmic

265 nilins are proteins with nine transmembrane (TM) domains that function as catalytic subunits of the g

266 partic acid residues in their transmembrane (TM) domains that mediate assembly, via interaction with

267 to previous observations for the human ErbB2 TM domain, the oncogenic mutation results in a reduced l

268 TM domain resulted in tilting motion of the TM domain through the membrane with an activation energy

269 equences corresponding to D1R transmembrane (TM) domains TM5 and TM6, which also selectively modified

270 ail (CT) domain or its CT and transmembrane (TM) domains (TMCT) with counterparts from BPIV3 F, with

271 several lines of evidence indicate that the TM domain (TMD) of the receptor plays a central role.

272 halves of P-gp each contain a transmembrane (TM) domain (TMD) with 6 TM segments followed by a nucleo

273 Through a series of studies of the TM domains (TMDs) of immune receptors and viral membrane

274 Drug-binding sites in the transmembrane (TM) domains (TMDs) are connected to the nucleotide-bindi

275 constructs containing immunotags before the TM domain to assess membrane insertion using proteinase

276 ization assay, we show a propensity for this TM domain to self-associate in a GxxxG-dependent manner.

277 rinus includes a flexible region linking the TM domains to a four-helix coiled-coil bundle.

278 lar binding of its C-terminal transmembrane (TM) domain to the canonical hydrophobic groove in a doma

279 s propagated from the channel transmembrane (TM) domain to the TM domain of syntaxin 1A to trigger tr

280 unction, to result in loss of transmembrane (TM) domain, to affect NCSTN substrate recruitment sites,

281 is a conserved uncoupling motif of the ecto-TM domain transition and the degree of ecto-TM domain co

282 o probe the importance of the closed-to-open TM domain transition in the overall energetics of recept

283 iganded dimeric state of FGFR3 by its JM and TM domains via a mechanism that is distinctly different

284 this, a TM peptide homologous to the PIV5 F TM domain was synthesized.

285 When either the CR or TMD domain was deleted, the mutated proteins localized t

286 Mutations in the NS4A TM domain were further examined in the JFH-1 genotype 2a

287 while mutant proteins with the VSV G protein TM domain were less efficiently expressed on cell surfac

288 Mutant proteins with the SV or MV F protein TM domains were expressed, transported to cell surfaces,

289 f pore-lining inner helices from the first 6-TM domains, whereas membrane potential only activates th

290 (15)N chemical shifts of 29 residues of the TM domain, which yielded backbone (phi, psi) torsion ang

291 ogous copies of a six-transmembrane-helix (6-TM) domain, which has no sequence homology to the canoni

292 but because of the unembedded transmembrane (TM) domain, which serves as a dose-dependent degradation

293 Replacement of the VirB10 TM domain with a nondimerizing poly-Leu/Ala TM domain se

294 Finally, replacement of the YscD TM domain with a TM domain of dissimilar sequence had no

295 However, structural studies involving the TM domain with or without the amphipathic helix differed

296 ects of the V(664)E mutation in the isolated TM domain with respect to protein-protein and protein-li

297 rather mediates the interaction of the beta3 TM domain with the TM domain of the alphav-subunit of th

298 --> Leu substitutions) or by replacing the N-TM domain with those from other CD36 superfamily members

299 Here, we describe a conserved TM domain within L2 (residues 45 to 67) and investigate

300 it is not clear whether studies of isolated TM domains yield knowledge that is relevant to full-leng