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1 TM addresses the shortage of allergy specialists in rura
2 TM also has been used to manage patients with asthma in
3 TM dislocation by the P5A-ATPase establishes an addition
4 TM induced ER stress as expected, as evidenced by activa
5 TM overcomes 2 barriers that patients face when seeking
6 TM stem cells reside in a discrete location of the super
7 TM-induced cytosolic Ca(2+) and membrane electrical osci
8 TMs 3-7 of NPC1 comprise the Sterol-Sensing Domain (SSD)
9 g the experimental DeltaG(asc) values for 36 TM complexes, including dimers of 10 glycophorin A mutan
10 by transfer of reducing equivalents to the 4 TM helix membrane protein DsbB, which transfers reducing
11 SRD5A2 at 2.8 angstrom, revealing a unique 7-TM structural topology and an intermediate adduct of fin
12 rence in time to AF by arm (3-year AF: 81.9% TM v 85.6% No-TM; HR, 0.89 [95% CI, 0.76 to 1.05]; P = .
15 ying autologous or allogeneic ADSCs and ADSC-TM cells as a potential treatment to restore TM structur
16 tation into naive mouse eyes, ADSCs and ADSC-TM cells integrated into the TM tissue, expressed TM cel
19 the triple-alkali perovskites Cs(2)[Alk](+)[TM](3+)Cl(6), where Alk is a group 1 alkali cation and T
21 FM4-64-labeled lipids, but not the analyzed TM proteins, undergo endocytic recycling within a clearl
22 protein modules in both lipid--anchored and TM probes reflect additional complexity in steady state
24 6), where Alk is a group 1 alkali cation and TM is a transition-metal cation, as a class of Cs(2)BB'C
25 se compounds to the mixing of the Alk-Cl and TM-Cl sublattices, leading to materials with small band
28 structure identification, where the average TM-score of the template alignments has over 7.5% increa
30 02 persons tested for SARS-CoV-2 by BinaxNOW TM and RT-PCR in a community setting, rapid assay sensit
34 s, we develop a neuromedium called BrainPhys(TM) Imaging (BPI) in which we optimize the concentration
37 d generation of activated protein C (APC) by TM-thrombin complex and in upregulation of intercellular
42 3 (-/-) triple-mutant [TM] strains [C1q (-/-)TM and C3(-/-) TM, respectively]), with structural kidne
44 mutant [TM] strains [C1q (-/-)TM and C3(-/-) TM, respectively]), with structural kidney changes resem
45 gly, enhanced thrombin activation in C3(-/-) TM mice and reduction of kidney injury following attenua
47 t contains mixtures of organics that chelate TMs and was used in this work to examine the roles of at
50 table atropisomers of various NHC-containing TM complexes were isolated by preparative HPLC on a chir
52 We established that (1) secretion delivers TM proteins and recycled membrane lipids to the same api
53 ion of induced pluripotent stem cell derived TM like cells (iPSC-TM) restores TM cellularity and func
54 as including metal organic framework design, TM-based catalyst design, the trafficking of TM ions in
58 SC-TM stimulates proliferation of endogenous TM cells in perfusion cultured human eyes from aged dono
59 formations of a peptide comprising the EphA2 TM domain and a portion of the intracellular juxtamembra
60 ltimate 3000 Series System tandem Q Exactive(TM) Hybrid Quadrupole-Orbitrap(TM) Mass Spectrometer wer
61 lls integrated into the TM tissue, expressed TM cell markers, and maintained normal IOP, outflow faci
64 the TM2 homodimer from PASP across the full TM region, whereas the fumarate-destabilized linker dime
69 c) in 554 PDB structures of 85 seven-helical TM proteins and identification of stable two-helical fol
70 sosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipo
71 monomer contains nine transmembrane helices (TMs), six of which (TM4-TM9) form a cavity that accommod
72 on, composed of one membrane-spanning helix (TM) and another that penetrates the inner leaflet (IM).
73 tional modifications of transmembrane helix (TM) 6b, which structurally links these two pathways, imp
77 live-cell imaging, we show that homeostatic TM epidermis is distinct from other epidermal sites and
78 duce ocular hypertensive phenotypes in human TM (hTM) cells to cause ocular hypertension, via a yet u
81 ersed in solutions of resistant starch HYLON(TM) VII (HC) or fruit coating Semperfresh(TM) (SC) conta
82 l zymography-based technique, called the IHZ(TM) assay, for the detection of specific protease activi
86 h significant decrease in IOP and changes in TM gene expression, indicating its direct impact on ocul
87 t is poorly understood how the difference in TM helical crossing angles found in the two conformation
89 es (DeltaDeltaG(asc)) caused by mutations in TM helices correlated with experimental changes in the s
92 the solvation free energy of the individual TM ions and reproduces the thermodynamics of TM ion-liga
94 wer than 1% of all cells appeared to be iPSC-TM, but significantly more cells in these eyes were immu
95 potent stem cell derived TM like cells (iPSC-TM) restores TM cellularity and function in human eyes o
98 study demonstrates that transplantation iPSC-TM stimulates proliferation of endogenous TM cells in pe
99 ization and activation path for TpoR via its TM domain that is shared between the small-molecule agon
100 We identified the Piezo1 channel as a key TM transducer of tensile stretch, shear flow and pressur
102 onated radiation profoundly suppressed KLF2, TM, and eNOS levels, subdued APC generation, declined KL
104 etrad is a pH sensor in the center of the M2 TM helix that activates the channel in response to the l
106 esized an oriented, end-to-end anti-ICAM mAb-TM conjugate and found that this therapeutic had the bes
109 r, significantly strong transverse magnetic (TM) polarized emission is recorded, which is ~4 times st
110 cted so that the standard template-matching (TM) observer performs equally well whether or not the no
112 g, whether induced by laminin111 or Matrigel(TM) is inhibited when the astrocytes are first incubated
115 omising the function of trabecular meshwork (TM) cells in the anterior eye, but how these cells sense
116 hanisms of glaucomatous trabecular meshwork (TM) damage and elevation of intraocular pressure (IOP) a
117 glaucoma and is due to trabecular meshwork (TM) damage, which leads to impaired aqueous humor outflo
118 Aberrant remodeling of trabecular meshwork (TM) extracellular matrix (ECM) may induce ocular hyperte
121 om cells located in the trabecular meshwork (TM), the primary structural component of the conventiona
122 randomized clinical trial of text messaging (TM) versus no text messaging (No-TM) at 40 sites in the
123 GUM with traditional targeted metabolomics (TM) as a screening tool in patients with established gen
124 ell-defined optically pure transition metal (TM) complexes bearing C(1)- and C(2)-symmetric N-heteroc
125 Use of late first-row transition metal (TM) complexes provides an excellent platform for the dev
126 ng the thermodynamics of a transition metal (TM) ion assembly be it in proteins or in coordination co
127 ayered structure, while Li/transition metal (TM) ion mixing in the layered phases was detected to ind
128 erein, a series of Li(2) S/transition metal (TM) nanocomposites are synthesized via a lithiothermic r
129 tal-metal (M-M) bonding in transition-metal (TM) complexes across the periods of TM elements, by use
130 mpanion to the traditional transition-metal (TM) redox charge compensation to achieve high capacity i
131 gh-intensity light-induced transition-metal (TM)-catalyzed systems or visible-light-induced photocata
135 Two commercial methods (traditional method - TM and direct method - DM) used to produce shalgams were
137 M2.5)] with the Enhanced Children's MicroPEM(TM) (RTI International), carbon monoxide (CO) with the U
139 educed with conventional (92.9%) and a2 Milk(TM) (78.6%) compared to lactose (sensitivities adjusted
141 loped a second-generation transmission mode (TM) AP-MALDI imaging platform with in-line plasma postio
142 ccuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free mo
143 hat covalent linkers could directly modulate TM protein function and should be considered an integral
144 ngineering demonstrates that the two motifs (TM region and catalytic domain) of NMCR-2 are functional
145 and Sle1.Mfge8 (-/-) C3 (-/-) triple-mutant [TM] strains [C1q (-/-)TM and C3(-/-) TM, respectively]),
154 ve implications not only for the delivery of TM, but also potentially all therapeutics targeted to th
157 or platform has shown the rapid detection of TM in food, which is compared to other methods very sens
158 er for the calculation of the free energy of TM helix association (DeltaG(asc)) in TM alpha-bundles o
161 n-metal (TM) complexes across the periods of TM elements, by use of ab initio valence-bond theory.
164 oordination as well as the thermodynamics of TM ion binding to a protein active site unlike extant mo
165 TM ions and reproduces the thermodynamics of TM ion-ligand coordination as well as the thermodynamics
166 TM-based catalyst design, the trafficking of TM ions in biological systems, and drug design in metall
167 ke more control of their health care, use of TM is likely to increase because a large part of the mov
169 ion, and it is realized that the presence of TMs in Li(2) S matrix can transform electrochemical beha
175 the models with template modeling score (or TM-score, a metric quantifying the similarity of models
176 em Q Exactive(TM) Hybrid Quadrupole-Orbitrap(TM) Mass Spectrometer were matched with the BIOPEP datab
183 olds over the substrate are conserved in P4H-TM, whereas the extensive loop structures that surround
185 nstrated that Ca(2+)-binding affinity of P4H-TM is within the range of physiological Ca(2+) concentra
190 cular, activated FYN was sequestered in PAG1(TM-) cells, suggesting that disruption of FYN localizati
193 ified by droplet digital Crystal Digital PCR(TM) next-generation technology (Stilla Technologies, Vil
194 e locally induced global, opening-permissive TM motions are indispensable for pore opening and requir
196 ected or established CD received the PillCam(TM) Crohn's System as supplementary diagnostic work-up f
199 Here, we tested the ability of Duragen Plus(TM) - a clinical biomaterial used widely in neurosurgica
201 rther tested the ability of the Duragen Plus(TM) matrix to support stem cells engineered using magnet
202 nd to be as satisfied with TM or they prefer TM over in-person visits, but infrequently they do prefe
203 ibition of ATF4-CHOP-GADD34 pathway prevents TM cell death and rescues mouse models of glaucoma by re
206 ved that the signaling lipid PIP(2) promotes TM dimerization, but only in the small crossing angle st
211 ell derived TM like cells (iPSC-TM) restores TM cellularity and function in human eyes obtained from
212 lish a stem cell-based approach to restoring TM function and normalizing IOP, human adipose-derived s
215 alent mAb-TM was superior to monovalent scFv-TM in both pulmonary targeting and lung residence time (
216 he cytoplasmic end of transmembrane segment (TM) 5, which, together with release of the N-terminus bu
219 ON(TM) VII (HC) or fruit coating Semperfresh(TM) (SC) containing a range of salt (NaCl) between 10 an
224 The DsbD functional homolog CcdA is a six-TM-helix membrane protein that provides reducing equival
225 bute to bleeding in CCMs, and plasma soluble TM may represent a biomarker for hemorrhagic risk in CCM
226 distance of the membrane and forms a stable TM homodimer in both the inactive and fumarate-activated
227 eside in a discrete location of the superior TM and generate long-lived clones and committed progenit
230 ne helices in model membranes and shown that TM and IM together reduce the flow of lipids at a region
231 Collectively, these results suggest that TM mechanosensitivity utilizes kinetically, regulatory a
232 the cytosolic Ca(2+) sensing domain and the TM pore and voltage sensing domains is a 15-residue 'C-l
233 reveal a conformational coupling between the TM and JM regions and suggest that PIP(2) might directly
237 fects initially adapted via mutations in the TM, but TM adaptation stalled within about 300 generatio
241 ADSCs and ADSC-TM cells integrated into the TM tissue, expressed TM cell markers, and maintained nor
242 suggest that functional regeneration of the TM may be possible in human eyes with primary open angle
244 several lines of evidence indicate that the TM domain (TMD) of the receptor plays a central role.
245 inhibits the polysulfide dissolution via the TM S bond, effectively addressing the drawbacks of Li(2)
246 oma, the number of cells residing within the TM is markedly decreased and the function of the tissue
250 tective molecules, including thrombomodulin (TM), a surface receptor, and endothelial nitric oxide sy
251 generation, declined KLF2 binding ability to TM and eNOS promoters, enhanced ICAM-1 expression, and d
252 the truncated aptamers was found to bind to TM with four-fold higher affinity (30 nM) compared to th
256 ls of interest, as well as simulated ToxCast(TM) metabolites, totaling 55,450 chemical structures.
257 uroblastoma cell line, Neuro-2a, the ToxCast(TM) chemical library was screened for compounds that imp
261 omain (ECD) relative to its 7-transmembrane (TM) core, forming more extended interactions than other
262 ct lipid, lipid-anchored, and transmembrane (TM) probes in RBL mast cells by imaging fluorescence cor
263 e potassium (BK) channels are transmembrane (TM) proteins that can be synergistically and independent
266 enth member, PC7, is a type-I transmembrane (TM) protein with a 97-residue-long cytosolic tail (CT).
267 rus is a tetrameric, integral transmembrane (TM) protein that plays a vital role in viral replication
270 construct derived from CFTR's transmembrane (TM) helices 3 and 4 (TM3/4) and their intervening loop,
272 cated splice variant with six transmembrane (TM) domains of the mouse mu-opioid receptor gene, in enh
273 labeled lipids and YFP-tagged transmembrane (TM) proteins in tobacco (Nicotiana tabacum) pollen tubes
274 o a dimer, with the first ten transmembrane (TM) helices harboring the transport core and TM11-TM12 h
278 e with a rearrangement of the transmembrane (TM) helix bundle within ~1 ms, while all other receptors
283 en together, the results suggest piston-type TM signaling by the TM2 homodimer from PASP across the f
285 erformance of the sensor was confirmed using TM spiked chicken soup, resulting in a high percentage r
288 ETDRS VA, LL 2.0 ETDRS VA or MNREAD, Ora-VCF(TM) test and Ora-tablet LL 2.0ND reading tests were able
291 as newly developed tests such as the Ora-VCF(TM) test, Ora-tablet reading test, color sensitivity etc
296 oma but neither the mechanisms through which TM cells sense pressure nor their role in aqueous humour