ライフサイエンスコーパス: TMJ

1 TMJ anatomy and loading area were obtained from magnetic

2 TMJ clicking was the most common clinical symptom.

3 TMJ intra-articular status was determined by 3 blinded,

4 TMJ microtrauma and remodeling can increase expression o

5 TMJ reconstruction with standard alloplastic prosthesis

6 extracellular matrix that may function in a TMJ disc replacement.

7 the FCSC pool and regenerates cartilage in a TMJ injury model.

8 that mice deficient in Gli2 display aberrant TMJ development such that the condyle loses its growth-p

9 Acute TMJ arthritis was diagnosed in 75% of the children by MR

10 JD, representing the subject's most advanced TMJ diagnosis.

11 To assess if estrogens act rapidly to affect TMJ-responsive neurons, we applied 17beta-estradiol (E2)

12 d cartilage thickness significantly affected TMJ disc tractional forces.

13 the prognosis of using standard alloplastic TMJ prostheses for the treatment of TMJ ankylosis in Chi

14 In conclusion, progesterone ameliorated TMJ inflammation through inhibition of NF-kappaB pathway

15 ble working to balancing muscle activity and TMJ reaction ratios during biting to those observed in v

16 HS sulfation is critical for mandibular and TMJ development and allows HS-PGs to exert their roles v

17 , but their possible roles in mandibular and TMJ formation are largely unclear.

18 in the underlying pathology of migraine and TMJ disorders.

19 beneficial in the treatment of migraine and TMJ disorders.

20 is critical for FCSC fate specification and TMJ homeostasis, and reveal that inhibition of the Notch

21 ermal fibroblasts, a mixture of the two, and TMJ disc cells in a scaffoldless tissue-engineering appr

22 ciceptive response of rats with an arthritic TMJ and reduced the amount of the proinflammatory cytoki

23 We employed two different models to assess TMJ-OA.

24 We found that P4 replacement attenuated TMJ inflammation and the nociceptive responses in a dose

25 Longitudinally, 76% of baseline TMJ soft tissue diagnoses and 71% of the baseline hard t

26 o consider the potential association between TMJ remodeling and mandibular repositioning under orthop

27 The correlations between TMJ intra-articular status and TMD impact were 0.05 (95%

28 Bilateral TMJ MR imaging and clinical examination were performed a

29 men with compared to women without bilateral TMJ DD.

30 in women with (+) and without (-) bilateral TMJ disc displacement (DD).

31 Findings of both acute and chronic TMJ disease were detected by MRI in 53% of the patients.

32 predict which patients will develop chronic TMJ pain and degeneration, limiting clinical management.

33 poral mechanistic factors leading to chronic TMJ pain are undefined.

34 In one model, clinical TMJ-OA cartilage from 5 different samples in TMJ-OA cart

35 Average ED for contralateral TMJs was significantly larger ( P = 0.012) by 1.4-fold i

36 Upon surgically creating TMJ OA in miniature pigs, we discovered increased vascul

37 lusion, this study experimentally determined TMJ disc metabolic rates, solute diffusivities, and disc

38 he condyle and in the disk of the developing TMJ.

39 d 800 times more glycosaminoglycans than did TMJ constructs.

40 rient metabolic rates, solute diffusivities, TMJ anatomy, and loading areas, subject-specific finite

41 nsdifferentiation using healthy and diseased TMJ tissues from miniature pigs and humans.

42 ular joint (TMJ) intra-articular disorders ("TMJ intra-articular status"), representing a transition

43 he activating FgfR3(P244R) mutation disturbs TMJ developmental processes, likely by reducing hedgehog

44 erficial niche exhibit Notch activity during TMJ morphogenesis.

45 importance of regulated RTK signaling during TMJ development and suggest multiple skeletal origins fo

46 clinical symptoms were used to classify each TMJ data sample as healthy control ( n = 124) or TMJOA (

47 Tissue engineering TMJ discs has emerged as an alternative approach to over

48 stages of the disease, using an established TMJ OA genetic mouse model deficient in 2 extracellular

49 However, evaluating TMJ pathology in mice using standard histologic methods

50 nificant shear loads onto the fibrocartilage TMJ disc during jaw motion.

51 nd tissue defects in young bgn(-/0)fmod(-/-) TMJ subchondral bone are likely attributed to increased

52 reduced type I collagen in bgn(-/0)fmod(-/-) TMJ subchondral bone.

53 were three-fold higher in bgn(-/0)fmod(-/-) TMJs than in WT.

54 ted from 3-week-old WT and bgn(-/0)fmod(-/-) TMJs with an intact cartilage/subchondral bone interface

55 ifferentially expressed in bgn(-/0)fmod(-/-) TMJs, including 5 genes involved in osteoclast activity/

56 ease in RANKL/OPG ratio in bgn(-/0)fmod(-/-) TMJs.

57 t biglycan and fibromodulin are critical for TMJ subchondral bone integrity and reveal a potential ro

58 agnosed JIA were prospectively evaluated for TMJ arthritis.

59 t the pig may be a suitable animal model for TMJ bioengineering efforts.

60 Our data indicate that Prg4 is needed for TMJ disc integrity and function and that its absence lea

61 ne integrity and reveal a potential role for TMJ subchondral bone turnover during the initial early s

62 examination are not sufficient to screen for TMJ disease.

63 for further study as an anabolic therapy for TMJ-OA.

64 od can serve as a primary screening tool for TMJ pathology, before proceeding to complicated, time co

65 coming limitations of current treatments for TMJ disorders.

66 s in tissue stiffness and ultrastructure for TMJ components is critical to understanding joint functi

67 igh-resolution CBCT (radiomics) markers from TMJ OA patients and controls.

68 nges in the tissue engineering of functional TMJ discs.

69 wever, the pathological mechanisms governing TMJ OA are poorly understood.

70 with a chamber in the exact shape of a human TMJ was designed for controllable perfusion throughout t

71 d vasculature, while isolated diseased human TMJ cells exhibited marked increased in vasculature mark

72 centration ranges for unloaded healthy human TMJ discs were 0.6 to 4.0 mM, 0.9 to 5.0 mM, and 0% to 6

73 evant TMJ OA large animal models or in human TMJ tissues and cells.

74 her, LOXL2 has beneficial functions in human TMJ-OA cartilage implants and promotes gender-specific a

75 n networks and extracellular matrix in human TMJ-OA cartilage implants in vivo.

76 oromandibular joint (TMJ) and to model human TMJ disease.

77 Pathological human TMJ tissues also exhibited increased vasculature, while

78 hallenges of in vivo measurements, the human TMJ disc extracellular nutrient environment under load,

79 ile and compressive) properties of the human TMJ disc, and also discs from the cow, goat, pig, and ra

80 supply and metabolism for the in vivo human TMJ disc.

81 dalities with clinical potential to identify TMJ OA early, and future directions for clinical managem

82 tion and for the long-term goal of improving TMJ disorder treatment strategies.

83 number, and enhanced osteoclast activity in TMJ subchondral trabecular bone of UAC-treated rats.

84 electrical and solute transport behaviors in TMJ discs under mechanical loading and aids in the under

85 leviating oxidative stress-related damage in TMJ chondrocytes.

86 To assess the requirement for Ddr2 in TMJ development, studies were undertaken to compare wild

87 Chronic disability in TMJ osteoarthritis (OA) increases with aging, and the ma

88 hat a reduction in FcgammaRIII expression in TMJ tissues would reduce the nociceptive and inflammator

89 inhibition of ectopic cartilage formation in TMJ disease.

90 the crucial role of sprouty (Spry) genes in TMJ development.

91 ll death and severe functional impairment in TMJ chondrocytes, and warrant in vivo testing to explore

92 -AR signal-mediated subchondral bone loss in TMJ osteoarthritisis associated with increased RANKL sec

93 a higher peak induction of MMP9 and MMP13 in TMJ fibrocartilaginous cells than knee meniscus cells to

94 , little is known about the role of Notch in TMJ development and disease.

95 f the temporal bone, with important roles in TMJ functions.

96 TMJ-OA cartilage from 5 different samples in TMJ-OA cartilage plugs were implanted subcutaneously in

97 upport the idea that Wnt5a/Ror2 signaling in TMJ subchondral BMSCs enhanced by UAC promoted BMSCs to

98 At study inception, TMJ disk displacement was observed in 31% of asymptomati

99 Inceptive TMJ status was maintained after 15 years in 91% (43 of 4

100 omandibular joint (TMJ) disorders, including TMJ osteoarthritis (TMJ-OA).

101 or crossbite (UAC) was established to induce TMJ degeneration in rats.

102 Using a TNF-alpha-induced TMJ inflammatory arthritis mouse model, we found that th

103 on in nociception was comparable to an intra-TMJ injection of 15d-PGJ2.

104 However, intra-TMJ injections are painful.

105 poro-mandibular or temporomandi-bular joint (TMJ), a highly specialized synovial joint that permits m

106 tive remodelling of temporomandibular joint (TMJ) and to determine associated mechanisms.

107 thritis (OA) of the temporomandibular joint (TMJ) and to explore the role of stromal cell-derived fac

108 y used to study the temporomandibular joint (TMJ) and to model human TMJ disease.

109 Temporomandibular joint (TMJ) ankylosis is a refractory disease that is difficult

110 s, but its roles in temporomandibular joint (TMJ) are unclear.

111 We selected the temporomandibular joint (TMJ) condylar bone as our tissue model, because of its c

112 l zone niche in the temporomandibular joint (TMJ) condyle.

113 he preponderance of temporomandibular joint (TMJ) degenerative disorders in women and their early ons

114 he mutation affects temporomandibular joint (TMJ) development and growth.

115 but their roles in temporomandibular joint (TMJ) development are unknown.

116 -engineering of the temporomandibular joint (TMJ) disc aims to provide patients with TMJ disorders an

117 gitudinal course of temporomandibular joint (TMJ) disc displacement (DD) and degenerative joint disea

118 nt of patients with temporomandibular joint (TMJ) disc displacement without reduction (DDwoR), but th

119 The temporomandibular joint (TMJ) disc is a heterogeneous fibrocartilaginous tissue p

120 The temporomandibular joint (TMJ) disc nutrient environment profoundly affects cell e

121 The temporomandibular joint (TMJ) disc plays a critical role in normal function of th

122 ional forces on the temporomandibular joint (TMJ) disc predispose tissue fatigue.

123 The temporomandibular joint (TMJ) disc, a fibrocartilaginous structure between the ma

124 ransport in porcine temporomandibular joint (TMJ) discs using the electrical conductivity method.

125 Temporomandibular joint (TMJ) disorders are often associated with development of

126 onic low back pain, Temporomandibular Joint (TMJ) disorders are the second most common musculoskeleta

127 uency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing th

128 east one symptom of temporomandibular joint (TMJ) disorders, including TMJ osteoarthritis (TMJ-OA).

129 ogy of migraine and temporomandibular joint (TMJ) disorders.

130 the hypothesis that temporomandibular joint (TMJ) eminence shapes develop ideally to minimize joint l

131 the consequences on temporomandibular joint (TMJ) growth and organization over age.

132 Temporomandibular joint (TMJ) inflammation is closely associated with oxidative s

133 advanced stages of temporomandibular joint (TMJ) intra-articular disorders ("TMJ intra-articular sta

134 The temporomandibular joint (TMJ) is a complex hinge and gliding joint that induces s

135 The temporomandibular joint (TMJ) is a specialized synovial joint essential for the f

136 The temporomandibular joint (TMJ) is the synovial joint of the craniofacial complex a

137 s) derived from the temporomandibular joint (TMJ) mandibular condyle that generates cartilage anlagen

138 usly shown in a rat temporomandibular joint (TMJ) model that injection of 15d-PGJ2 into the rat TMJ c

139 Temporomandibular joint (TMJ) osteoarthritis (OA) is a degenerative disease of th

140 gy and treatment of temporomandibular joint (TMJ) osteoarthritis (TMJOA) remain complex and unclear.

141 bone remodeling in temporomandibular joint (TMJ) osteoarthritis.

142 seek treatment for temporomandibular joint (TMJ) symptoms, typically occurring with anterior disc di

143 ive response of the temporomandibular joint (TMJ) to mandibular advancement, while others have report

144 affecting the human temporomandibular joint (TMJ), but the underlying molecular mechanisms remain obs

145 tive changes in the temporomandibular joint (TMJ).

146 ulations in the rat temporomandibular joint (TMJ).

147 nd in the arthritic temporomandibular joint (TMJ).

148 ke lesions in mice temporomandibular joints (TMJs), displaying as subchondral trabecular bone loss.

149 In temporomandibular joints (TMJs), the disc and condylar cartilage function as load-

150 milar for soft tissue diagnoses and the left TMJ.

151 long-term pain and invasive procedures, like TMJ replacement.

152 nal nutrient profiles in unloaded and loaded TMJ discs (unloaded, 0% strain, 20% strain).

153 nases may together contribute to E2-mediated TMJ fibrocartilage loss.

154 each proteinase individually to E2-mediated TMJ matrix loss but noted a significant compensatory rec

155 very of LOXL2 is anabolic to human and mouse TMJ condylar cartilage in vivo and evaluate the protecti

156 pontaneously in proteoglycan 4 (Prg4) mutant TMJ discs without further invasive procedure.

157 ion is required for completion of post-natal TMJ growth and organization.

158 iant fibrocartilaginous matrix in the native TMJ disc.

159 intermediate zone, reminiscent of the native TMJ disc.

160 emonstrate that DDR2 is necessary for normal TMJ condyle development and homeostasis and that these D

161 equation model estimated the association of TMJ intra-articular status with the latent measure TMD i

162 Analysis of primary cultures of TMJ articular chondrocytes from wild-type and Ddr2(slie/

163 a) characterized individual-specific data of TMJ stress-field mechanics to determine ED (ED = W/ Q mJ

164 that MRI is preferable for the detection of TMJ disease in new-onset JIA.

165 conductivity, as well as ion diffusivity, of TMJ discs was determined under confined compression with

166 nificant implications for the improvement of TMJ therapeutics.

167 l brainstem site for synaptic integration of TMJ sensory signals, while recording single neuron activ

168 complex to influence sensory integration of TMJ-related information.

169 ng pathways is critical for the integrity of TMJ development and for the maintenance of cellular orga

170 ay led to a dramatic and progressive loss of TMJ articular integrity and osteoarthritis-like changes.

171 f E2 but not P4 caused a significant loss of TMJ collagen and glycosaminoglycans, which was accompani

172 buting to the development and maintenance of TMJ pain.

173 future directions for clinical management of TMJ OA are reviewed in the context of evidence in the fi

174 potentially alter the clinical management of TMJ OA by defining new drugs that target angiogenesis or

175 e technique, previously validated markers of TMJ pain or nociception (specifically, meal duration and

176 dependent manner in the synovial membrane of TMJ.

177 Models of TMJ intra-articular status other than ours (normal struc

178 ed to determine differences in prevalence of TMJ symptoms among the three examination times.

179 Prevalence of TMJ symptoms did not change significantly between examin

180 lagen interactions during the progression of TMJ-OA.

181 tive data on the biomechanical properties of TMJ condylar cartilage.

182 ults showed that the transport properties of TMJ discs were region-dependent.

183 turnover during the initial early stages of TMJ OA disease in this model.

184 ole in joint function may guide our study of TMJ pathologies, including disc displacement.

185 ly, the osteoblast activity in the tissue of TMJ subchondral trabecular bone of these UAC-treated rat

186 oplastic TMJ prostheses for the treatment of TMJ ankylosis in Chinese patients with severe mandibular

187 the effect of E2 on the targeted turnover of TMJ fibrocartilage matrix via E2-induced matrix metallop

188 cal loading and aids in the understanding of TMJ pathophysiology related to tissue nutrition.

189 Conceptualizing worsening of TMJ intra-articular disorders as 4 stages and characteri

190 Analysis of TMJs from newborn Ddr2(slie/slie) mice revealed a develo

191 essed and activated in the articular zone of TMJs but not knee joints.

192 larly in light of psychosocial influences on TMJ pain.

193 , acute activity of the trigeminal nerve, or TMJ tissue degeneration and/or damage, the temporal mech

194 Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease that affects both cart

195 Temporomandibular joint osteoarthritis (TMJ OA) leads to permanent cartilage destruction, jaw dy

196 y of temporomandibular joint osteoarthritis (TMJ-OA) and is promoted through dysfunctional biochemica

197 MJ) disorders, including TMJ osteoarthritis (TMJ-OA).

198 Two primary outcomes (TMJ pain intensity and maximum mouth opening) and a numb

199 increased osteoclast activity and an overall TMJ subchondral trabecular bone loss in the UAC-treated

200 e significantly upregulated in miniature pig TMJ tissues relative to donor matched knee meniscus fibr

201 Porcine TMJ discs (n = 187) received a 10-N vertical static load

202 Porcine TMJ discs were compressed between an axially translating

203 tion and lactate production rates of porcine TMJ discs were measured under varying tissue culture con

204 tation creep tests were performed on porcine TMJ condylar cartilage at 5 different regions-anterior,

205 ntact area were performed on 8 adult porcine TMJs at 5 different regions (anterior, posterior, centra

206 ential direct and indirect roles to preserve TMJ structural and cellular integrity over post-natal li

207 Primary TMJ synoviocytes were treated with TNF-alpha or IL-1beta

208 asia (Cho/+) mice, which develop progressive TMJ-OA due to a point mutation in the Col11a1 gene, were

209 lic responses in Cho/+ mice with progressive TMJ-OA, suggesting its merit for further study as an ana

210 A-adrenergic signal in chondrocytes promotes TMJ degenerative remodelling by chondrocyte-mediated pro

211 Previous quantitative TMJ characterization studies examined either the human o

212 The impact of PLGA MP concentration on rat TMJ function was quantified via computerized meal patter

213 odel that injection of 15d-PGJ2 into the rat TMJ can provide antinociceptive relief against a subsequ

214 15d-PGJ2 cream for 15min directly on the rat TMJ skin did not induce any significant antinociceptive

215 able for intra-articular delivery to the rat TMJ, a finding that has significant implications for the

216 y (within 10 minutes) and reversibly reduced TMJ-evoked neural activity at the Vc/C(1-2) region.

217 ical evidence and various theories regarding TMJ growth modification are discussed.

218 investigate the role of Notch in regulating TMJ development and FCSC fate.

219 erentiation or vasculature in human-relevant TMJ OA large animal models or in human TMJ tissues and c

220 ession of hard tissue diagnoses in the right TMJ occurred in 15.2% of subjects (95% CI, 10.5% to 20.8

221 llenge from formalin injection into the same TMJ.

222 he fact that a reliable animal model of such TMJ diseases is not available.

223 represent a compensatory response to sustain TMJ movement and function.

224 advancement, while others have reported that TMJ adaptive responses are non-existent and negligible.

225 The results suggest that TMJ disc homeostasis may be vulnerable to pathological l

226 Although the TMJ disc has been well-characterized under tension and c

227 their mandibular ramus was elongated by the TMJ prosthesis and 2 patients were combined with Le Fort

228 Unlike appendicular articular cartilage, the TMJ has two distinct functions as the synovial joint of

229 Thus, we characterized the TMJ phenotype in wild-type and Prg4 -/- mouse littermate

230 UC 0.870, and F1-score 0.823 to diagnose the TMJ OA status.

231 ent an efficient approach to engineering the TMJ disc graft with anisotropic scaffold microstructure,

232 oparticle-based drug delivery system for the TMJ.

233 region, to modulate sensory signals from the TMJ region.

234 to dynamic behavior, perhaps implicating the TMJ disc as a structure primarily exposed to predominant

235 entified in this screen were examined in the TMJ and compared with those of other synovial joints, in

236 ated by type I and III collagen found in the TMJ and other fibrocartilages, has been associated with

237 icking anisotropic collagen alignment in the TMJ disc and corresponding mechanical properties.

238 ssive strain impeded solute transport in the TMJ disc.

239 ify changes in gene expression levels in the TMJ during early stages of the disease, using an establi

240 ine measures; follow-up was performed in the TMJ Impact Project.

241 n of an osteoarthritis-like condition in the TMJ in the Col1-IL-1betaXAT mouse model resulted in up-r

242 L-1beta) and IgG content was measured in the TMJ tissue by enzyme-linked immunosorbent assay.

243 FcgammaRIII expression in the TMJ tissue was assayed by immunocytochemistry or Western

244 RNA reduced the amount of FcgammaRIII in the TMJ tissues, and the transcript was cleaved in a manner

245 s behind the various tissues involved in the TMJ's normal growth and maturation.

246 the articular eminence/glenoid fossa in the TMJ, and fusion of the articular disc.

247 in conjunction with arthritic changes in the TMJ, assessed by histopathologic and immunohistochemical

248 , and interpreting nociceptive inputs in the TMJ, particularly in light of psychosocial influences on

249 cytes into osteoblasts and osteocytes in the TMJ.

250 s or agonists were injected locally into the TMJ area of UAC rats.

251 Cs (GFP-BMSCs) were weekly injected into the TMJ region for 4, 8, and 12 wk.

252 tructs were expected to appear most like the TMJ disc constructs.

253 ed to guide bony mass removal and locate the TMJ prosthesis (Biomet, USA).

254 nflammatory signaling in OA cartilage of the TMJ and knee joint, induces chondroprotective and regene

255 tion of the joint, and many disorders of the TMJ are a result of disc dysfunction.

256 The main components of the TMJ are the mandibular condyle, the glenoid fossa of the

257 The ultrastructure of the TMJ disc and cartilage is different from that of hyaline

258 t than the corresponding contact area of the TMJ disc.

259 The OA cartilage of the TMJ displays a synchronous increase in SDF-1 and RANTES

260 for cellular and molecular evaluation of the TMJ during its adaptive response to biomechanical forces

261 s adaptive remodeling or degeneration of the TMJ following discectomy.

262 njected into the superior joint space of the TMJ in rats.

263 e genetic program for the development of the TMJ remains poorly understood.

264 Fundamentally, OA of the TMJ was induced by unilateral anterior crossbite in mice

265 resulting from inflammatory arthritis of the TMJ, and siRNA has the potential to be an effective trea

266 rol related to inflammatory disorders of the TMJ.

267 subchondral bone loss in mice with OA of the TMJ.

268 towards degraded cartilage in mice OA of the TMJ.

269 olecular framework for future studies of the TMJ.

270 the reasons for its targeted effects on the TMJ but not other joints remain poorly understood.

271 we performed micro-tribometry testing on the TMJ disc and condylar cartilage to obtain their region-

272 ut the effect of orthopedic treatment on the TMJ, it is necessary that we understand the biologic bas

273 fore, the study objective was to predict the TMJ disc nutrient environment under loading conditions u

274 bly, our work provides the evidence that the TMJ condyle and disc develop independently of the mandib

275 differences were noted, indicating that the TMJ forms via a distinct molecular program.

276 study provides evidence to suggest that the TMJ in higher order species are in fact vascularized.

277 ologically and biochemically superior to the TMJ disc and dermal fibroblast constructs, and their com

278 structs would produce matrix relevant to the TMJ disc, but the mixture constructs were expected to ap

279 highly expressed in muscles attached to the TMJ, including the lateral pterygoid and temporalis musc

280 brocartilage matrix turnover targeted to the TMJ.

281 degenerative mechanisms associated with the TMJ disc.

282 lage stem cells (FCSCs) localized within the TMJ condyle superficial zone niche that regenerate carti

283 se, we discovered FCSCs localized within the TMJ superficial niche exhibit Notch activity during TMJ

284 The TMJs of all patients were imaged with MRI and US within

285 ficantly greater degenerative changes in the TMJs of 3- and 10-mo-old Ddr2(slie/slie) mice as compare

286 ic as well as asymptomatic, maintained their TMJ status during 15 years.

287 ransdifferentiation, which may contribute to TMJ pathogenesis.

288 s, the mechanisms by which E2 contributes to TMJ degenerative disorders and the reasons for its targe

289 The articular and neural contributors to TMJ pain, imaging modalities with clinical potential to

290 by the addition of hydrogen peroxide (HO) to TMJ-derived chondrocyte cultures.

291 that these DDR2 functions are restricted to TMJ fibrocartilage and not seen in the hyaline cartilage

292 a transition from normal joint structure to TMJ disc displacement with and without reduction (DDwR a

293 erapies, including tissue-engineering toward TMJ disc regeneration.

294 The challenges of managing and treating TMJ OA are due, in part, to a limited understanding of t

295 may be a new therapeutic target for treating TMJ osteoarthritis.

296 stimated potential for cartilage fatigue via TMJ energy densities (ED) and jaw muscle duty factors (D

297 When TMJ -OA is induced using a surgical instability model, l

298 er fibrocartilages, has been associated with TMJ degeneration, but its role in normal joint developme

299 hondrocyte function contextually linked with TMJ-OA.

300 int (TMJ) disc aims to provide patients with TMJ disorders an option to replace diseased tissue with

301 ales in each of two groups, with and without TMJ disc displacement.