ライフサイエンスコーパス: TRA

1 TRA 2 degrees P-TIMI 50 (Trial to Assess the Effects of

2 TRA complications can be categorized as intra- or postpr

3 TRA has become the dominant percutaneous coronary interv

4 TRA use increased from 14.0% to 58.6% in 417 038 PCI pat

5 TRA was a predictor for reduced bleeding (odds ratio=0.2

6 TRA was associated with a reduction in bleeding and tran

7 TRA was independently associated with a 35% reduction in

8 TRA was independently associated with a decreased risk o

9 TRA was independently associated with reduced 30-day mor

10 TRA-1 activity inhibits male development and allows fema

11 TRA-1 binds to sites adjacent to a number of heterochron

12 TRA-1 export requires TRA-1 binding to the tra-2 3' untr

13 TRA-1 patterns rely on nuclear export since treatment wi

14 TRA-1, a member of the Ci/Gli family of transcriptional

15 TRA-1/GLI is best known as a master regulator of sex det

16 TRA-3, an ortholog of CAPN5, has been shown to be involv

17 TRA-F stimulation of Sxl seems to be direct at some poin

18 atode global sexual regulator Transformer 1 (TRA-1), a transcription factor acting at the interface b

19 list of transcription factors includes WT-1, TRA-1, bicoid, the bacterial sigma(70) subunit, STAT1 an

20 In patients with an MMRS <10, TRA was used in 71,771 (43.2%) of 166,083 PCI procedures

21 We identified 184 TRA-1-binding sites in Caenorhabditis elegans, many with

22 Between 2005 and 2007, TRA did not appear to reduce mortality at 1 year (HR=0.8

23 28; P=0.376), whereas between 2008 and 2011, TRA conferred survival benefit at 1 year (HR=0.65; 95% C

24 sess the performance of LI-RADS version 2018 TRA in the evaluation of HCC after ablation.

25 fficient (ADC) in tumor regions for group 3 (TRA-8) and group 4 (TRA-8/Gem) were 21 +/- 9% (mean +/-

26 mor regions for group 3 (TRA-8) and group 4 (TRA-8/Gem) were 21 +/- 9% (mean +/- SE) and 27 +/- 3%, r

27 uripotency, including Oct-4, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, nanog and alkaline phosphatase.

28 ts-Thrombolysis in Myocardial Infarction 50 (TRA 2 degrees P-TIMI 50) was a randomized, double-blind,

29 TRA-1-60(+)), with variable yield (6 to >500 TRA-1-60(+) iPSC colonies per 10 mL blood; n = 6).

30 en 4 (SSEA-4), tumor rejection antigen 1-60 (TRA 1-60), and tumor rejection antigen 1-81 (TRA 1-81) (

31 SSEA-4, tumour-rejection antigen (TRA)-1-60, TRA-1-81, and alkaline phosphatase.

32 SEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9

33 , including Oct-4, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, nanog and alkaline phosphatase.

34 We also identified 78 TRA-1-binding sites in the related nematode Caenorhabdit

35 h Sendai were variably reprogrammed (10%-80% TRA-1-60(+)), with variable yield (6 to >500 TRA-1-60(+)

36 TRA 1-60), and tumor rejection antigen 1-81 (TRA 1-81) (traditional markers of human embryonic stem c

37 that resides among normal hESC colonies as a TRA-1-60(-)/SSEA4(-)/SOX1(+) cell and developed a method

38 omes this retention resulting in export of a TRA-1/tra-2 mRNA complex.

39 d a transgenic mouse expressing the TCR of a TRA-specific T cell that had escaped negative selection.

40 y and aid in estimating an error range of a %TRA value when the uncertainty is not reported.

41 emporal trends in use of transradial access (TRA) for percutaneous coronary intervention (PCI) in ST-

42 ith transfemoral access, transradial access (TRA) for percutaneous coronary intervention is associate

43 Transradial access (TRA) has been associated with reduced access site-relate

44 emic complications after transradial access (TRA) is controversial.

45 Transradial access (TRA) is favored over transfemoral access for performing

46 The transradial access (TRA) site has become the default access site for percuta

47 ementation of the Theory of Reasoned Action (TRA) using artificial-neural networks.

48 stal germline, where MPK-1 is not activated, TRA-1 represses the male fate as NOS-3 functions in tran

49 erred strong transmission-reducing activity (TRA) at a concentration of 200 mug/mL.

50 The transmission-reducing activity (TRA) of these agents is currently determined in the stan

51 ntensity (% transmission reducing activity, %TRA), or in prevalence of infected mosquitoes (% transmi

52 , in patients with abnormal AT results after TRA.

53 is that expression of tissue-restricted Ag (TRA) is a unique feature of thymic epithelium.

54 multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized.

55 iscuous expression of tissue-restricted Ags (TRA) by thymic epithelial cells (TEC).

56 sion of a plethora of tissue-restricted Ags (TRAs) by medullary thymic epithelial cells (mTECs) plays

57 e range of peripheral tissue-restricted Ags (TRAs) by mTECs remain poorly defined.

58 tes the expression of tissue-restricted Ags (TRAs) in thymic epithelial cells.

59 stem (LI-RADS) treatment response algorithm (TRA) is used to assess presumed hepatocellular carcinoma

60 ve four T cell receptor (TCR) chains: alpha (TRA), beta (TRB), gamma (TRG) and delta (TRD).

61 d reproducibility for T cell receptor alpha (TRA) and T cell receptor beta (TRB) TCR chains.

62 (HLA)-DQ6 allele and T-cell receptor alpha (TRA) J24 gene segment and also suggested that in vitro-s

63 ng analysis of TCR-beta (TRB) and TCR-alpha (TRA) rearrangements of CD3(-)CD4(+)CD8(-) immature singl

64 Although TRAs as short as 100 bp seeded new telomeres, these trac

65 In propensity-matched analyses, TRA remained a predictor for survival at 1 year (HR=0.60

66 -2 physically associates with both FEM-1 and TRA-1 in vivo, and cul-2 mutant males share feminization

67 ty to disrupt interactions between HER-1 and TRA-2A-expressing cells, and a localized region on the H

68 tency markers OCT4, SOX2, NANOG, SSEA-4, and TRA-1-60, give rise to derivatives of the three germ lay

69 -4, Nanog, Sox-2, SSEA-4, TERT, TRA-1-60 and TRA-1-81 up to 65h after exposure to ionizing radiation

70 Thus, principles of BLM and TRA frameworks are confounded by the feeding behavior of

71 ressor, FEM-CUL-2 (E3 ubiquitin ligase), and TRA-1 (Gli transcriptional repressor), which acts both i

72 cells were immunopositive for the RPE65 and TRA-1-85.

73 Combining CD30 to SSEA4 and TRA-1-81 in FACS greatly enhanced specificity and effici

74 nd skewed length distribution of the TRB and TRA complementary determining region 3 sequences from SC

75 We investigated the expression of AIRE and TRAs in DS and control thymic tissue using quantitative

76 Anti-TRA-1 antibodies that recognize human pluripotent stem c

77 dies: anti-RPE65 (RPE-specific marker), anti-TRA-1-85 (human cell marker), anti-Ki67 (proliferation m

78 The anti-human DR5 antibody TRA-8 was efficacious in reducing the severity of arthri

79 efficacy of anti-death receptor 5 antibody (TRA-8) combined with gemcitabine was measured using diff

80 hen treated with an anti-human DR5 antibody, TRA-8.

81 (SSEA)-3, SSEA-4, tumour-rejection antigen (TRA)-1-60, TRA-1-81, and alkaline phosphatase.

82 n from endogenous tissue-restricted antigen (TRA)-specific thymocytes.

83 t react weakly to tissue-restricted antigen (TRA).

84 SEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein an

85 lls (DC) present tissue-restricted antigens (TRA) to thymocytes to induce central tolerance, but the

86 g and presenting tissue-restricted antigens (TRA), so that developing T cells can assess the self-rea

87 tissue-restricted peripheral self-antigens (TRA) from the total thymic ectopic TRA repertoire, weake

88 tissue-restricted peripheral self-antigens (TRA), which is in mature medullary thymic epithelial cel

89 ot express potent tumour rejection antigens (TRAs).

90 onal deletion to tissue-restricted antigens (TRAs) requires positive selection and CCR7-mediated migr

91 nce induction to tissue-restricted antigens (TRAs), the outcome of which depends on the context in wh

92 nsive library of tissue-restricted antigens (TRAs).

93 pression of tissue-restricted self antigens (TRAs) in medullary thymic epithelial cells (mTECs) is es

94 of numerous tissue-restricted self-antigens (TRAs) in medullary thymic epithelial cells (mTECs) is es

95 pectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central

96 and model (BLM) and tissue residue approach (TRA)) are based on the established link between uptake,

97 Transradial approach (TRA), when compared with transfemoral, improves the safe

98 by the insertion of a telomere repeat array (TRA) into the host genome, which seeds the formation of

99 NAs are likely to be regulated indirectly by TRA-1.

100 Depletion of pathogenic macrophages by TRA-8 led to significantly reduced clinical scores for a

101 Alternative splicing of fru is regulated by TRA and TRA2 and depends on an exonic splicing enhancer

102 male-specific FRU(M) protein is regulated by TRA, we hypothesized that a fru-derived transgene encodi

103 st methods showed a lower ability to capture TRA than TRB diversity.

104 Our findings characterize TRA expression in mTECs as a coordinated process that mi

105 -wide significant signals for PCT1 (CLEC19A, TRA, GGTA2P, TM9SF2, IFI16, RBMS3), PCT4 (HPVC1) and PCT

106 an oocyst intensity and generates comparable TRA estimates.

107 Some DNA segments containing TRA-1-binding sites drive male-specific expression patte

108 protein degradation mechanisms that control TRA-1 accumulation in the adult, the temporal, sexual, a

109 The regulatory hierarchy that controls TRA-1 is well established, but the downstream effectors

110 2 efficiently acquires secreted mTEC-derived TRAs for cross-presentation on MHC-I.

111 Fe(VI) leading predominantly to N-desmethyl-TRA (ca. 40%), whereas the proposed oxygen transfer prev

112 used, and an agonistic antibody against DR5 (TRA-8) and human recombinant TRAIL were used to ligate D

113 The temperature-dependent function of the Ds-TRA-2(ts2) protein was also evident by the up- and down-

114 lerance and prevents autoimmunity, with each TRA being expressed in only a few mTECs.

115 antigens (TRA) from the total thymic ectopic TRA repertoire, weakens the platform for central toleran

116 Thus, recirculating RTEs encounter TRAs during a transitional developmental stage that faci

117 vention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial.

118 ulation of cells that differentially express TRA.

119 entification of potent and broadly expressed TRAs and effective adjuvants to stimulate a robust and d

120 The transcription factor TRA-1 is the master regulator of somatic sexual differen

121 elegans, the Gli-family transcription factor TRA-1 is the terminal effector of the sex-determination

122 The Gli-like transcription factor TRA-1 of C. elegans promotes female development by repre

123 by studying genetically sensitized females: TRA-F from either maternal or zygotic tra expression sti

124 and compartment syndrome are rare following TRA.

125 was lower than the interreader agreement for TRA category (kappa = 0.71; 95% CI: 0.59, 0.84; P < .01)

126 We also found evidence for TRA-1 feedback regulation of the global sex-determinatio

127 nd sera from malaria-exposed individuals for TRA.

128 with the fog-3 promoter and is required for TRA-1 to bind to fog-3 promoter.

129 We searched for TRA-1 consensus DNA binding sites near genes with sex-en

130 tion is below that of negative selection for TRA.

131 cent cis-elements that are binding sites for TRA-1A and a POU-type homeodomain protein UNC-86 and act

132 Consistent with its SGP function, TRA-1 protein is present in SGPs during embryogenesis an

133 rval=153-399) lives would have been saved if TRA adoption were uniform nationally.

134 pool of Aire(+)mTEC(high), with an improved TRA transcriptome despite aGVHD.

135 In TRA 2 degrees P-TIMI 50--a randomised, placebo-controlle

136 ntify lives saved and lost by differences in TRA adoption.

137 ous MI followed up for 2.5 years (median) in TRA 2 degrees P-TIMI 50 [Thrombin Receptor Antagonist in

138 e-specific TGE-binding factor GLD-1 increase TRA-2 protein expression and inhibit sperm production in

139 lative to AIRE-induced TRA, AIRE-independent TRA are more numerous and show greater splicing complexi

140 o found that AIRE-dependent and -independent TRA present several distinctive features.

141 port that AIRE-dependent versus -independent TRA project nonredundant representations of peripheral t

142 and preferentially included AIRE-independent TRAs.

143 equency of mTECs that express any individual TRA is quite low (>0.4-2%).

144 ntral tolerance induction because individual TRAs are purged from the total repertoire secondary to a

145 In particular, relative to AIRE-induced TRA, AIRE-independent TRA are more numerous and show gre

146 -ST-segment-elevation myocardial infarction, TRA appears to be a predictor for survival.

147 es arising with STEMCCA-loxP were invariably TRA-1-60(+), yielding 5.3 +/- 2.8 iPSC colonies per 20 m

148 Transformation of a 2.6-kb TRA into tetraploid plants resulted in a DNTF efficiency

149 h saline (control), gemcitabine (120 mg/kg), TRA-8 (200 mug), or TRA-8 combined with gemcitabine, res

150 uman Merlin-deficient mesothelioma cell line TRA and in human Merlin-deficient meningiomas.

151 techniques to prevent, identify, and manage TRA complications.

152 Both populations express stem cell marker TRA-1-60 and TNFR2, but only tubular CD133(+) cells expr

153 on of the human pluripotent stem cell marker TRA-1-60 with CD151 and CD166.

154 ing CD133 mRNA and protein, stem cell marker TRA-1-60, and pH3(S10) within 3 hours of treatment.

155 of cells expressing the pluripotency marker TRA-1-81.

156 effective mechanism to noninvasively monitor TRA-8 efficacy.

157 In nematodes, TRA-1 represses the transcription of genes involved in m

158 Nevertheless, TRA-F stimulation of Sxl autoregulation in the gonadal s

159 Finally, no TRA/delta excision circles (TRECs), a marker of TRA/delt

160 dullary TEC, AIRE-driven pGE upregulates non-TRA coding genes that enhance cell-cell interactions (e.

161 wdr-5.2 are redundantly required for normal TRA-1 dependent repression, and this function is indepen

162 , as disruption of binding increases nuclear TRA-1 and female development.

163 0.100 mg (group 3), or 0.200 mg (group 4) of TRA-8 on days 0 and 3.

164 In the absence of TRA-1, the TRE retains tra-2 mRNA in the nucleus.

165 ein TRA-2, and we find that the abundance of TRA-2 is modestly elevated in laf-1/+ females.

166 ans, contributes to temporal accumulation of TRA-1 in the nervous system.

167 ans hermaphrodites by the combined action of TRA-1/Gli, a complex composed of TRA-4/PLZF-like, NASP,

168 gained the greatest benefit from adoption of TRA during PCI.

169 Analysis of TRA expression in individual and small pools of sorted m

170 The binding of TRA-1 to the 3'UTR overcomes this retention resulting in

171 d action of TRA-1/Gli, a complex composed of TRA-4/PLZF-like, NASP, and HDA-1/HDAC, and synMuv B prot

172 of NOS-3, FEM-CUL-2-mediated degradation of TRA-1 and the promotion of membrane organization during

173 duce the proteasome-dependent degradation of TRA-1.

174 ed sequences for the FEM-3-binding domain of TRA-2 for 9 of the same strains.

175 enorhabditis and the FEM-3 binding domain of TRA-2 is itself hypervariable, a key protein-protein int

176 The FEM-3-binding domain of TRA-2 is less polymorphic than FEM-3.

177 ymorphism allowed in FEM-3 and the domain of TRA-2 that binds it, we have examined intraspecific vari

178 f tra-1, we reveal unanticipated dynamics of TRA-1 protein expression in five dimensions: space, time

179 egression was used to quantify the effect of TRA on 30-day mortality and quantify lives saved and los

180 However, there are few data on the effect of TRA on mortality, specifically, in patients with non-ST-

181 Proviral silencing and expression of TRA-1-60, DNMT3B and REX1 can be used to distinguish the

182 on, suggesting the safety and feasibility of TRA across the whole spectrum of AT results.

183 ment exists on the safety and feasibility of TRA across the whole spectrum of AT results.

184 The frequency of TRA compared with transfemoral access for patients under

185 HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to

186 ependent pGE is not limited to generation of TRA.

187 base, we investigated outcomes for growth of TRA in different regions in England and Wales in 448 853

188 This complex controls the level of TRA-1A, a Ci/Gli homolog and master regulator of sex det

189 /delta excision circles (TRECs), a marker of TRA/delta locus rearrangements, were detected in SCID an

190 e speciation of the tertiary amine moiety of TRA, with apparent second-order rate constants of 7.4 (+

191 In total, six OPs of TRA were identified for both oxidants using Qq-LIT-MS, L

192 We show temporal regulation of TRA-1 protein accumulation in somatic tissues with diffe

193 ching was used to assess the relationship of TRA with in-hospital clinical end points of major bleedi

194 ent may be an evolutionarily ancient role of TRA-1/GLI in nematode development.

195 mporal, sexual, and spatial specificities of TRA-1 accumulation during development are regulated tran

196 valuate the thymic expression of a subset of TRA, parathyroid hormone, calcitonin, and thyroglobulin,

197 opic expression of fog-3, a direct target of TRA-1 repression.

198 Other direct targets of TRA-1 are similarly derepressed in the double mutant.

199 d C. elegans large C-terminal truncations of TRA-1 that retain the DNA-binding domain affect sex dete

200 he predicted risk of bleeding and the use of TRA (P<0.001).

201 The use of TRA for PCI in STEMI was associated with a lower rate of

202 The use of TRA has been associated with less bleeding and improved

203 predicted risk of bleeding and actual use of TRA in STEMI.

204 The use of TRA increased over the study period although the growth

205 m spatial distribution of a diverse range of TRAs likely enhance their presentation and encounter wit

206 ividual mTEC expresses a limited spectrum of TRAs, and the frequency of mTECs that express any indivi

207 estine, and environmental stressors shut off TRA-1 expression in the entire non-gonadal soma, suggest

208 The ADC increase at day 3 was dependent on TRA-8 dose level, averaging 6% +/- 3 (standard error of

209 onally, a food signal is required to turn on TRA-1 expression in the intestine, and environmental str

210 gemcitabine (120 mg/kg), TRA-8 (200 mug), or TRA-8 combined with gemcitabine, respectively, on day 0.

211 nstrate that DR5 ligation by either TRAIL or TRA-8 induces two functional outcomes, apoptosis and exp

212 t humoral immune response against 9L TAAs or TRAs in rats immunized s.c. with 9L-IL4 could be demonst

213 revails for O(3) attack resulting in N-oxide-TRA as the main OP (ca. 90%).

214 chanism can explain the formation of N-oxide-TRA, while a one-electron transfer may result in the for

215 bsets of human mTECs expressing a particular TRA coexpress distinct sets of genes.

216 ion of the global sex-determination pathway: TRA-1 binds its own locus and those of multiple upstream

217 ts in the accumulation of mature, peripheral TRA-specific T cells capable of mediating destructive au

218 Pluripotency (TRA-1-81, SSEA3, OCT4, NANOG, SOX2) remained unaffected,

219 since Sxl harbors highly conserved predicted TRA-F binding sites.

220 ytes interacting with intact APCs presenting TRAs.

221 Strategies to prevent TRA complications are essential and include the use of c

222 in 71,771 (43.2%) of 166,083 PCI procedures; TRA was used in 8,655 (40.1%) of 21,559 PCI procedures i

223 former (tra) to make its feminizing product, TRA-F.

224 d that GLD-1 activity is required for proper TRA-1 protein expression in hermaphrodites.

225 ity of the Ca(2+)-regulated calpain protease TRA-3, and the aspartyl protease ASP-4.

226 expression of the sex determination protein TRA-2, and we find that the abundance of TRA-2 is modest

227 in complexes with the transmembrane receptor TRA-2 and the phosphatase FEM-2 in these species.

228 sing an in vitro system in which recombinant TRA/TRA2 could activate the female-specific 5'-splice si

229 and obtained evidence of numerous recurring TRA-co-expression patterns, each present in only a subse

230 L condition results in significantly reduced TRA-1-60 positively expressed cells and decreases plurip

231 L-2 and the FEM proteins negatively regulate TRA-1 protein levels in C. elegans.

232 ZINB model revealed it is better to report %TRA values with a proper error range, rather than observ

233 cell patterns add up to faithfully represent TRAs, is poorly understood.

234 TRA-1 export requires TRA-1 binding to the tra-2 3' untranslated region (3' UT

235 relationship between baseline bleeding risk, TRA utilization, and procedure-related outcomes in patie

236 rug-resistance (MDR) reversal agents (C-seco-TRAs) are noncytotoxic at the upper limit of solubility

237 t tissue-restricted peripheral selfantigens (TRAs) required for effective negative thymic selection.

238 that integrates the sex determination signal TRA-1 and the cell fate determination and survival signa

239 Single TRA-1-60(-)/SSEA4(-)/SOX1(+) cells grown in serum-free m

240 Six TRAs exhibit ability to modulate a wide range of ATP-bin

241 thelial lineages and that expression of some TRAs by mTECs may reflect this activity.

242 Thus, expression of some TRAs by mTECs may represent coordinated gene expression

243 , many with temporal- and/or tissue-specific TRA-1 association.

244 urified IgG from VLP-P47/P47 mice had strong TRA (83-98%) at concentrations as low as 5 mug/mL.

245 inity antibodies, capable of inducing strong TRA at a lower concentration.

246 m using ovalbumin (OVA) as a model surrogate TRA that the de novo production of OVA-specific CD4(+) T

247 ty of recipient Aire(+)mTEC(high) to sustain TRA diversity.

248 ke in Patients With Acute Coronary Syndrome [TRA.CER] [Study P04736AM3]; NCT00527943).

249 , such as Oct-4, Nanog, Sox-2, SSEA-4, TERT, TRA-1-60 and TRA-1-81 up to 65h after exposure to ionizi

250 Here, we present data that TRA-1 is regulated by degradation mediated by a CUL-2-ba

251 rumental variable analysis demonstrated that TRA conferred mortality benefit at 1-year with an absolu

252 ctivity and TUNEL staining demonstrated that TRA-8 rapidly induced apoptosis of macrophages in inflam

253 Our data provide preclinical evidence that TRA-8 is a potential novel biologic agent for rheumatoid

254 tients with an MMRS >/=20, illustrating that TRA was used less in those at highest risk from bleeding

255 Genetic studies have indicated that TRA-1 is negatively regulated by the fem-1, fem-2, and f

256 We propose that TRA-1/GLI and EHN-3 have overlapping roles in regulation

257 In this paper, we show that TRA-1/GLI controls development of the two somatic gonada

258 Studies suggest that TRA may reduce mortality in patients with ST-segment-ele

259 These results suggest that TRA-1 controls sexual dimorphism through a small number

260 ve male-specific expression, suggesting that TRA-1 imposes sex specificity on developmental timing.

261 A new study suggests that TRA expression is a specialized property of terminally d

262 The TRA cohort of patients was stratified into deciles based

263 The TRA subsets aligned along progressive differentiation st

264 findings using LI-RADS version 2018 and the TRA, respectively.

265 ceh-30 is transcriptionally repressed by the TRA-1 transcription factor, the terminal regulator of se

266 rmination in C. elegans is controlled by the TRA-1 zinc finger protein, a Ci/GLI homolog that promote

267 In this context, the TRA-4 protein functions with NASP-1, a C. elegans homolo

268 olled by a 28-nucleotide repeat element, the TRA-2/GLI element (TGE), located in its 3' untranslated

269 n of the conventional TCR loci, encoding the TRA, TRB, TRG and TRD chains, in the opossum Monodelphis

270 between narcolepsy and polymorphisms in the TRA@ (T-cell receptor alpha) locus, with highest signifi

271 utions regulated by the cellular form of the TRA and the class of major histocompatibility complex (M

272 The fate of the TRA-1-60(-)/SSEA4(-)/SOX1(+) neural precursor becomes sp

273 show that SUP-26 regulates the level of the TRA-2 protein through TGE in vivo and binds directly to

274 first documented genetic involvement of the TRA@ locus, encoding the major receptor for HLA-peptide

275 stained brightly for L-selectin and with the TRA-1-81 antibody, which recognizes carbohydrate epitope

276 loping transgenic cells are exposed to their TRA in the thymus, only a fraction of them are eliminate

277 ullary thymic epithelial cells express these TRAs, as do extrathymic epithelial tissues that are not

278 Thus, TRA-1 coordinates sexual development by reinforcing the

279 and RNAi depletion of some genes adjacent to TRA-1-binding sites results in defects in male sexual de

280 We found that clonal deletion to TRA was completely abrogated in the absence of Bim and l

281 study the role of Bim in clonal deletion to TRA, we constructed bone marrow (BM) chimeras using OT-I

282 e existence of a level of self-reactivity to TRA to which the thymus confers no protection and illust

283 easurement of early breast tumor response to TRA-8 treatment, prior to detectable tumor shrinkage, pr

284 cs and oxidation products (OPs) of tramadol (TRA), an opioid, were investigated for its oxidation wit

285 Transfectol (TRA) -SPIO incubation resulted in the highest frequency

286 or 1,795 rare cells expressing either of two TRAs, TSPAN8 or GP2.

287 une 2009, a total of 942 patients undergoing TRA were screened, and 203 were recruited, of whom 83, 6

288 Unexpectedly, TRA-1 also accumulates in a subset of sex-shared neurons

289 rotein pool and also a larger pool of unique TRAs compared with control exosomes.

290 ptor (TCR) for clonal deletion to UbA versus TRA and highlight the profound ability of other toleranc

291 es, 8.3% of the PCI cases were performed via TRA.

292 ,728 PCI procedures, 17,912 (14.6%) were via TRA.

293 Even when TRA expression is restricted to mTECs, DCs still present

294 discussed here, an alternative model-whereby TRA expression is regulated by conserved developmental p

295 wing reductions in mortality associated with TRA use.

296 The mortality benefit with TRA at 1 year was not seen at the low-volume centers (HR

297 Treatment of MTB cells with TRA 3aa and 10a at the MIC caused filamentation and prol

298 ing to the prognostic benefit conferred with TRA.

299 with this, the FEM-3 protein interacts with TRA-2 in each species, but in a strictly species-specifi

300 After encounter with TRAs in the absence of inflammation, RTEs exhibited defe