ライフサイエンスコーパス: TRP channel

1 lammation in-vivo that involve more than one TRP channel.

2 portant role in the activation of Drosophila TRP channels.

3 explain the large temperature sensitivity of TRP channels.

4 ared and unique features compared with other TRP channels.

5 sensitivity common to other thermosensitive TRP channels.

6 alling components, such as STIM proteins and TRP channels.

7 ividual cells expressing genetically encoded TRP channels.

8 crease in the calcium flow through activated TRP channels.

9 aM-induced regulatory mechanism of canonical TRP channels.

10 which is reminiscent of other heat-activated TRP channels.

11 aled as pivotal for allosteric activation in TRP channels.

12 ies that are important for the activation of TRP channels.

13 tion of cysteine residues on multiple Ca(2+) TRP channels.

14 ical modulation exhibited by TRPV1 and other TRP channels.

15 families of sensory proteins--rhodopsins and TRP channels.

16 ne lipids modulate other "receptor-operated" TRP channels.

17 lgesic properties, at least in part, via the TRP channels.

18 rations sufficient for activation of sensory TRP channels.

19 indeed forms the main intracellular gate in TRP channels.

20 f TRPV2 and may play a similar role in other TRP channels.

21 l for modulation of TRPM8 and possibly other TRP channels.

22 nown ligand and lipid binding sites in other TRP channels.

23 ide with the expression or function of other TRP channels.

24 mental evidence supporting this mechanism in TRP channels.

25 29 ankyrin repeats, the largest number among TRP channels.

26 ive engineered transient receptor potential (TRP) channels.

27 tor of certain transient receptor potential (TRP) channels.

28 expression of transient receptor potential (TRP) channels.

29 the opening of transient receptor potential (TRP) channels.

30 ct upstream of transient receptor potential (TRP) channels.

31 odulates other transient receptor potential (TRP) channels.

32 ported Brivido Transient Receptor Potential (TRP) channels.

33 Here, we identified mucolipin TRP channel 1 (TRPML1) as the key lysosomal Ca2+ channel

34 This change is detected by mucolipin TRP channel 3 (TRPML3), a transient receptor potential c

35 Thermal transient receptor potential (TRP) channels, a group of ion channels from the transien

36 Transient receptor potential (TRP) channels, a superfamily of ion channels, can be div

37 Various TRP channels act as polymodal sensors of thermal and che

38 Transient receptor potential (TRP) channels act as sensors for a range of stimuli as d

39 hannels, facilitates better understanding of TRP channel activation, and provides insights into the m

40 cuss the thermodynamic foundations of thermo-TRP channel activation.

41 fects of chloroform or the VGA isoflurane on TRP channel activation.

42 ells and measured ATP release in response to TRP channel activation.

43 of 5,6-EET to transient receptor potential (TRP) channel activation in nociceptor neurons and its co

44 ich is finally unmasked as a potent flatworm TRP channel activator.

45 TRP channel agonists anandamide and (-)menthol were foun

46 nd response to transient receptor potential (TRP) channel agonists.

47 s is regulated by a thermosensitive membrane TRP channel and the DAF-16/FOXO transcription factor, bu

48 ral architecture for this major subfamily of TRP channels and a well-defined calcium-binding site wit

49 coveries were made, few would have suspected TRP channels and astrocytes could contribute significant

50 Recent findings, however, put TRP channels and astrocytes in the spotlight, describe t

51 Here I discuss the recent developments on TRP channels and astrocytes that have made us aware of t

52 These findings suggest that when TRP channels and GPCRs are co-expressed in the same tiss

53 cantly deviates from the structures of other TRP channels and has a unique 2-fold symmetrical rose-sh

54 st distinct roles of resolvins in regulating TRP channels and identify RvD2 as a potent endogenous in

55 suggest that most structural elements within TRP channels and Kv channels are not sufficiently relate

56 diovascular system, and interactions between TRP channels and other proteins involved in mechanoelect

57 erone and provide a mechanistic link between TRP channels and their GPCRs during biosynthesis and tra

58 ficity for TRPM3 compared with other sensory TRP channels, and blocked PregS-induced intracellular fr

59 ture analysis unveiled the modular design of TRP channels, and electrophysiological experiments condu

60 Macrophages express at least 3 different TRP channels, and the properly balanced activation of al

61 a drug that targets two functionally-related TRP channels, and thus can be used to combat isoforms of

62 mediated by a transient receptor potential (TRP) channel, and RT-PCR was used to confirm expression

63 bited by PIP2; where does PIP2 interact with TRP channels; and is the mechanism of modulation conserv

64 e is a transition from AP to CP, after which TRP channel antagonism is ineffective, and thus (3) that

65 e, and thus (3) that early intervention with TRP channel antagonists may attenuate the transition to

66 ine and were antagonized by the nonselective TRP channel antagonists Ruthenium Red and gadolinium, bu

67 ium that was abolished by preincubation with TRP channel antagonists.

68 oform of phospholipase C, but TRPA1 or other TRP channel are not required.

69 TRP channels are activated by a variety of stimuli, incl

70 poral resolution of neuronal activation when TRP channels are activated by ambient temperature variat

71 tion with and without Ca(2+) bound, although TRP channels are believed to be tetramers.

72 thesis that in low extracellular calcium the TRP channels are dilating, and as a consequence open cha

73 emonstrate that 26 out of 28 currently known TRP channels are expressed in the IVD on the mRNA level,

74 Furthermore, several TRP channels are expressed on immune cells.

75 Mammalian TRP channels are grouped into six subfamilies (TRPC, TRP

76 Thermal TRP channels are important for thermal sensation and noc

77 Our findings show that several TRP channels are involved in colour-driven behaviour in

78 of the core functional features of metazoan TRP channels are present in Cr-TRP1, suggesting that bas

79 the driving force for Ca(2+) entry, and some TRP channels are required for proliferation and migratio

80 Functional TRP channels are tetrameric complexes consisting of 4 po

81 The Transient Receptor Potential (TRP) channels are a family of cationic ion channels wide

82 hether sensory transient receptor potential (TRP) channels are a molecular target for apomorphine.

83 Transient receptor potential (TRP) channels are a superfamily of broadly expressed ion

84 Transient receptor potential (TRP) channels are abundant in the brain where they regul

85 Transient receptor potential (TRP) channels are activated by environmental particulate

86 Transient Receptor Potential (TRP) channels are emerging as essential cellular switche

87 cts to humans, transient receptor potential (TRP) channels are key transducers of thermal, chemical a

88 ts to mammals, transient receptor potential (TRP) channels are known mediators for cellular sensing.

89 Transient receptor potential (TRP) channels are members of a large family of ion chann

90 Transient receptor potential (TRP) channels are polymodal cell sensors responding to d

91 Transient receptor potential (TRP) channels are polymodal signal detectors that respon

92 Transient receptor potential (TRP) channels are polymodal signal detectors that respon

93 Most transient receptor potential (TRP) channels are regulated by phosphatidylinositol-4,5-

94 Transient receptor potential (TRP) channels are sensors for a wide range of cellular a

95 Transient receptor potential (TRP) channels are the key sensory transducers that confe

96 The transient receptor potential (TRP) channels are unique cellular sensors that are widel

97 Human genetics point to three additional TRP channels as plausible therapeutic targets: TRPC6 in

98 licate certain transient receptor potential (TRP) channels as a therapeutic target along with metabot

99 el sharing key features present in mammalian TRP channels associated with sensory transduction.

100 ously unknown proteins, which we have named "TRP channel-associated factors" (TCAFs), as new TRPM8 pa

101 e opportunity to explore ionic conduction in TRP channels at atomic detail.

102 bilateria and transient receptor potential (TRP) channels before the origin of animals.

103 of TRPA1, TRPV1, TRPC3 or TRPC6, nor by the TRP channel blocker Ruthenium Red.

104 Moreover, ruthenium red (a general TRP channel blocker), BTP2 (a general TRPC channel inhib

105 y phospholipase C (PLC) and Ca(2+)-permeable TRP channels, but the function of endoplasmic reticulum

106 m (Ca(2+)) and transient receptor potential (Trp) channels, but not sodium (Na(+)) channels or ligand

107 ight-sensitive transient receptor potential (TRP) channel by modulating the levels of dihydrosphingos

108 neuron excitability via actions on multiple TRP channels can contribute to the anti-inflammatory eff

109 Na(+) /Ca(2+) exchanger, but not TRP channels, can also facilitate STOC production.

110 a schistosome transient receptor potential (TRP) channel, christened SmTRPM(PZQ), present in parasit

111 These data indicate that often occurring TRP channel complexes regulate diversity in neuronal sen

112 We identified the first heteromeric TRP channels composed of subunits from 3 different TRP s

113 Transient Receptor Potential (TRP) channels constitute a family of multimodal ion chan

114 Furthermore, recent evidence shows that TRP channels contribute to the progression and survival

115 nnels, such as transient receptor potential (TRP) channels, contribute to changes in Ca(2+) by modula

116 This suggests that cross-sensitization of TRP channels contributes to enhanced pain sensitivity in

117 We conclude that targeting TRP channels could pave the way for much needed therapie

118 Transient receptor potential (TRP) channels couple various environmental factors to ch

119 ructure of the transient receptor potential (TRP) channel crTRP1 from the alga Chlamydomonas reinhard

120 in freshly isolated mouse tissues and led to TRP channel-dependent release of proinflammatory neurope

121 Together, this study indicates that TRP channel dephosphorylation is a regulatory process th

122 hysiology that transient receptor potential (TRP) channel dephosphorylation at a specific site is a f

123 We find that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment

124 tors, metabotropic glutamate receptor 5, and TRP channels did not prevent this short-term inhibition.

125 The TRP channel dilation mechanism may play important roles

126 depends on the transient receptor potential (TRP) channels dTRPA1 and Pyrexia, and is also timed by t

127 mational changes in the outer pore region of TRP channels during activation.

128 is known about the folding and transport of TRP channels during biosynthesis.

129 PP2, a member of the polycystin subfamily of TRP channels encoded by the PKD2L1 gene, is an exception

130 Here, we review the emerging evidence that TRP channels, especially TRPCs, are critical regulators

131 l vanilloid 5) is a unique calcium-selective TRP channel essential for calcium homeostasis.

132 k for better understanding algae biology and TRP channel evolution.

133 so robustly activated by CFA1, whereas other TRP channels expressed by airway sensory neurons and lun

134 and excitation-contraction coupling; hence, TRP channels expressed in the heart most likely coordina

135 In this study, we investigated functional TRP channel expression in human odontoblast-like cells a

136 hat the zinc-finger protein ZBTB20 regulates TRP channels expression in nociceptors.

137 nociception and pain sensation by modulating TRP channels expression in nociceptors.

138 TRPV5 is unique within the large TRP channel family for displaying a high Ca(2+) selectiv

139 opposing effects chloroform has on different TRP channel family members, the findings of this study p

140 TRPA1, a member of TRP channel family, is specifically activated by natural

141 ere, we found that a member of the canonical TRP channel family, TRPC3, is highly expressed in MRGPRD

142 eature of this transient receptor potential (TRP) channel family member.

143 ed the role of transient receptor potential (TRP) channel family members in mediating chloroform acti

144 members of the transient receptor potential (TRP) channel family of nonselective cation channels.

145 associate with transient receptor potential (TRP) channel family proteins to form functionally import

146 ist-binding site from that found in TRPV1, a TRP channel from a different subfamily.

147 Our study provides a structure of a TRP channel from a micro-organism and a structural frame

148 we examine the effect of several ligands on TRP channel function and the evidence regarding their me

149 tudies to establish the mechanistic basis of TRP channel function.

150 lueprint for understanding unique aspects of TRP channel function.

151 r, and recent discoveries are revealing that Trp channels function as transducers for both.

152 ducing thermosensitivity can be critical for TRP channel functional diversification, facilitating the

153 echanisms whereby chemical ligands impact on TRP channel gating are poorly understood.

154 re present in Cr-TRP1, suggesting that basic TRP channel gating characteristics evolved early in the

155 We suggest that TRP channel gating is accompanied by large changes in mo

156 rk for investigating the structural basis of TRP channel gating mechanisms and pharmacology, and, des

157 First, we screened mutants for 18 TRP channel genes (including all TRPV orthologs) and fou

158 ubunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an

159 TRP channels have been associated with cell proliferatio

160 Several TRP channels have been implicated in Drosophila auditory

161 Although these TRP channels have been intensively studied, little is kn

162 TRP channels have emerged as key biological sensors in v

163 Gain-of-function mutations in TRP channels have not been previously implicated in dopa

164 Transient receptor potential (TRP) channels have been implicated as sensors of diverse

165 Polymodal transient receptor potential (TRP) channels have been shown to integrate mechanical, c

166 al properties and the mechanism of action in TRP channels, high-resolution three-dimensional structur

167 only very small numbers of K(+), Ca(2+) and Trp channel homologues.

168 ing evidence demonstrates important roles of TRP channel in controlling vascular function including e

169 This review focuses on the role of TRP channels in a few surgically important disease proce

170 TRP channels in brown and white adipogenesis from human

171 expressed wild-type or specifically mutated TRP channels in human embryonic kidney cells and used ca

172 This study supports the importance of TRP channels in IVD homeostasis and pathology and their

173 We expressed mammalian or snake TRP channels in light-insensitive retinal cones in a mou

174 tability and messenger RNA expression of the TRP channels in NG and DRG pancreatic neurons.

175 determine the mRNA and protein expression of TRP channels in non-degenerated and degenerated human IV

176 tional and non-transcriptional regulation of TRP channels in odontoblasts.

177 AP (AP), we studied the involvement of these TRP channels in pancreatic inflammation and pain-related

178 hat chemosensing of this dietary molecule by TRP channels in the endothelium promotes arterial relaxa

179 However, developmental roles for TRP channels in the establishment of neuronal connectivi

180 dependent cannabinoid signaling, the role of TRP channels in the modulation of monoaminergic signalin

181 by microOR activation, much more than other TRP channels in the same compartment, like TRPV1 and TRP

182 ral functional transient receptor potential (TRP) channels in live cells and in real time.

183 f transient receptor potential ion channels (TRP channels) in health and disease.

184 1), one member of the vanilloid subfamily of TRP channels, in the pathophysiology of asthma.

185 sodium, cofired to agonists of nocisensitive TRP channels, including capsaicin, mustard oil, and noxi

186 finity, and specificity for TRPV5 over other TRP channels, including its close homologue TRPV6.

187 d to cilia and further investigated ENKUR, a TRP channel-interacting protein identified in the cilia

188 .SIGNIFICANCE STATEMENT TRPM8 is a polymodal TRP channel involved in cold temperature sensing, thermo

189 m of temperature-dependent gating of thermal TRP channels involving an intracellular region assembled

190 Activation of TRP channels is verified by using genetically encoded fl

191 TRPV subset of transient receptor potential (TRP) channels is heat activated and proposed to be respo

192 id 4 (TRPV4), a Ca(2+)-permeable osmomechano-TRP channel, is highly expressed in articular chondrocyt

193 nction of NompC, a putative mechanosensitive TRP channel, is not only required for fly locomotion, bu

194 an homologue of the Drosophila photoreceptor TRP channel, is predominantly expressed within the outer

195 tage-dependent manner but, unlike many other TRP channels, is permeable to monovalent cations only.

196 ed that diverse types of channels, including TRP channels, K(2P) channels, MscS-like proteins, and DE

197 the de-orphanization of natural products as TRP channel ligands may leverage their exploration as vi

198 or understanding the differential actions of TRP channel ligands, with important ramifications for TR

199 eveal a previously unrecognized function for TRP channels, link calcium signaling to longevity, and,

200 These neurons received TRP channel M8 (TRPM8)-positive DRG inputs as well as no

201 In mammals, temperature-sensitive TRP channels make membrane conductance of cells extremel

202 Finally, we foresee that TRP channels may be explored for the selective pharmacod

203 r findings indicate that temperature-sensing TRP channels may not contain a specialized heat-sensor d

204 Pharmacologic activation or blockade of TRP channels may offer new treatment options in surgical

205 Thermal TRP channels mediate temperature transduction and pain s

206 that distinct transient receptor potential (TRP) channels mediate allodynia and hyperalgesia downstr

207 innervating the inflamed paw, and augmented TRP channel-mediated calcium responses, both in the cell

208 Tiotropium failed to modulate other TRP channel-mediated responses.

209 oints for designing natural product-inspired TRP channel modulators.

210 cs dictate that opening of these specialized TRP channels must involve an unusually large conformatio

211 ession or cellular localization of TRPA-1, a TRP channel needed in OLQ and IL1 neurons for touch beha

212 The transient receptor potential (TRP) channel NOMPC is important for mechanosensation-rel

213 implicates the transient receptor potential (TRP) channels NOMPC, NANCHUNG, and INACTIVE, but not the

214 ontribution of transient receptor potential (TRP) channels, notably TRPV4, in volume regulation after

215 The skin expresses abundant TRP channels of different subtypes, which play an essent

216 Transient receptor potential (TRP) channels of multiple subclasses are expressed in th

217 R(2) activates transient receptor potential (TRP) channels of nociceptive neurons to induce neurogeni

218 Because several of these TRP channels on macrophages are temperature sensitive, t

219 chemotaxis that link receptor activation to TRP channel opening and Ca2+ signaling.

220 trimeric G protein, phospholipase Cbeta, the TRP channel, or the Na(+)/Ca(2+) exchanger did not influ

221 iated by TMC-1 and to a lesser extent by the TRP channel OSM-9.

222 f the nematode transient receptor potential (TRP) channel OSM-9.

223 dritic neurons, requires rhodopsin 7 and the TRP channel Painless, and is independent of the clock.

224 ent luciferase assay, we characterize a GPCR-TRP channel pair, angiotensin II receptor type 1 (AT1R),

225 The mechanism by which TRP channels participate in pruritogen-induced scratchin

226 Although TRP channels permeate many different cations, they are m

227 The transient receptor potential (TRPs) channels persist scarcely explored as targets, des

228 ciliary ultrastructure, localization of the TRP channel PKD-2 and the kinesin-3 KLP-6, and velocity

229 lcium compartment regulated by a heteromeric TRP channel, PKD1L1-PKD2L1, in mice and humans.

230 by a subset of taste cells that express the TRP channel PKD2L1 and its partner PKD1L3, however the m

231 Transient receptor potential (TRP) channels play a significant role in taste perceptio

232 Our results show that a TRP channel plays a role in regulating growth factor sig

233 bsequently interferes with expression of the TRP channel polycystin-2 (PKD2).

234 omeric complex formed by PKD1L3 and TRPP3, a TRP channel protein.

235 How TRP channels reciprocally regulate GPCR signaling is les

236 trafficking of transient receptor potential (TRP) channels remain poorly understood, and identifying

237 Transient receptor potential (TRP) channels represent interesting molecular target str

238 Although transient receptor potential (TRP) channel research has vastly increased our understan

239 Transient receptor potential (TRP) channels respond to various chemical and physical s

240 the global genetic disruption of individual TRP channels result in phenotypes associated with impair

241 Yvc1p channel, a homologue of the mammalian TRP channels, revealed that the channel is activated by

242 Although TRP channels seem to be absent in plants, C. reinhardtii

243 cterization of a C. reinhardtii version of a TRP channel sharing key features present in mammalian TR

244 In particular, TRP channels showing high levels of expression in sensor

245 el ligands, with important ramifications for TRP channel structure-function analysis and pharmacology

246 The recent proliferation of published TRP channel structures provides a foundation for underst

247 lignment of the transmembrane domains of 120 TRP channel structures.

248 bonds and the girdle are seen in many closed TRP channel structures.

249 o identify the Transient Receptor Potential (TRP) channel subfamily M (Trpm) as a critical channel th

250 nding pocket that is highly conserved across TRP channel subtypes and accounts for all aspects of cal

251 ng that nyctalopin is acting as an accessory TRP channel subunit critical for proper channel localiza

252 recently that mutant mice lacking a specific TRP channel subunit, TRPC5, exhibited decreased innate f

253 ltiple genes encoding homologues of K(+) and Trp channel subunits, and genes encoding novel homologue

254 Although other TRP channels, such as TRPV4, are expressed in primary af

255 nsory neurons and expression of itch-related TRP channels suggest no change in sensory transduction b

256 on S6, have been recently reported for other TRP channels, suggesting an evolutionarily conserved mec

257 se the possibility that other members of the TRP channel superfamily are also regulated by caspase-me

258 sion of both TRPC6 and TRPC7, members of the TRP channel superfamily, also essentially eliminated the

259 ubfamily M member 3 (TRPM3), a member of the TRP channel superfamily, was recently identified as a no

260 ubgroup of the transient receptor potential (TRP) channel superfamily whose members have important ro

261 First, we identify TRP channels that function in the fly antenna to mediate

262 V6 is a member of the vanilloid subfamily of TRP channels that is permeable to cations and highly sel

263 nilins and the transient receptor potential (TRP) channels that are distributed across ER/SR membrane

264 nilins and the transient receptor potential (TRP) channels that are distributed across ER/SR membrane

265 humans, which express many K(+), Ca(2+) and Trp channels, the genomes of pathogenic fungi encode onl

266 l activation, allowing temperature-sensitive TRP channels to function as polymodal nociceptors.

267 We targeted TRP channels to human retinas, which allowed the postmor

268 rties by using transient receptor potential (TRP) channels to activate or ablate specific neuronal po

269 (+), Na(+), or transient receptor potential (TRP) channels to cross-react with intracellular Ca(2)(+)

270 use vanilloid transient receptor potential (TRP) channels to integrate light-evoked signals with amb

271 The ability of transient receptor potential (TRP) channels to sense and respond to environmental and

272 es a G-protein, phospholipase Cbeta, and the TRP channel, TRPA1.

273 canonical (C) transient receptor potential (TRP) channel TRPC3 were present in both popliteal and fi

274 utation in the transient receptor potential (TRP) channel TRPC3.

275 Transient receptor potential (TRP) channels TRPC3 and homologous TRPC6 are expressed o

276 netically, the transient receptor potential (TRP) channels Trpm, NompC, and Polycystic kidney disease

277 An exception is the genetic ablation of the TRP channel TRPM7, which results in early embryonic leth

278 epertoire of ion channels, which include the Trp channel Trpm8 and potassium channel Kcnk9, that are

279 annels Na(V)1.8 and Na(V)1.9, as well as the TRP channel Trpm8, have been shown to contribute to cold

280 Recently, the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been identified as mo

281 s of Kv2.1 with corresponding regions of two TRP channels, TRPM8 and TRPV1.

282 domain Ca(2+) transients are mediated by the TRP channel TrpML, stimulated by reactive oxygen species

283 nts expressing transient receptor potential (TRP) channels TRPV1 and TRPA1 are thought to be required

284 The transient receptor potential (TRP) channels TRPV1 and TRPA1 have each been associated

285 nction of TRPM3 and two other heat-activated TRP channels (TRPV1 and TRPA1) in sensory neurons innerv

286 py to determine the structure of a mammalian TRP channel, TRPV1, at 3.4 A resolution, breaking the si

287 vanilloid (V) transient receptor potential (TRP) channel TRPV4 can be rapidly recorded and character

288 (2+)-selective transient receptor potential (TRP) channels TRPV5 and TRPV6 play vital roles in calciu

289 or inputs from transient receptor potential (TRP) channel V1 (TRPV1)-positive dorsal root ganglion (D

290 Functional expression of TRP channels was determined with reverse transcription p

291 -TyrR) and the transient receptor potential (TRP) channel Water witch (Wtrw), and astrocytes in turn

292 Antagonists of the two TRP channels were administered at different times to blo

293 Effects of nitro-oleic acid (OA-NO2) on TRP channels were examined in guinea-pig dissociated dor

294 TRP channels were first identified as membrane proteins

295 t function and activation of the highlighted TRP channels will have to be determined in future studie

296 TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread e

297 As TRP channels with specific subunit compositions may have

298 In contrast, replacement of portions of TRP channels with those of Kv2.1 consistently yielded no

299 be replaced by the analogous regions of both TRP channels without abolishing voltage-activation.

300 TRP channels work as sensors for a wide range of cellula