ライフサイエンスコーパス: TRPV1 channel

1 6-ARD than in the paralogous thermosensitive TRPV1 channel.

2 rough the pore of the noxious-heat-sensitive TRPV1 channel.

3 ng actions of capsazepine independent of the TRPV1 channel.

4 the role of PAR(2), which can sensitize the TRPV1 channel.

5 ld-sensing fibers express the heat-sensitive TRPV1 channel.

6 nfluences the permeability properties of the TRPV1 channel.

7 ent outward rectification, a property of the TRPV1 channel.

8 s the endogenous phosphoinositide regulating TRPV1 channels.

9 le, robust and temporally precise control of TRPV1 channels.

10 hilic compounds act specifically on TRPA1 or TRPV1 channels.

11 s Ca(2+) influx mediated by fly TRPA and rat TRPV1 channels.

12 g was shaped by the distribution of ASIC and TRPV1 channels.

13 he transient receptor potential vanilloid 1 (TRPV1) channel.

14 ansient receptor potential vanilloid type-1 (TRPV1) channel.

15 ve transient receptor potential vanilloid 1 (TRPV1) channel.

16 on transient receptor potential vanilloid 1 (TRPV1) channels.

17 ient receptor potential vanilloid subtype 1 (TRPV1) channels.

18 ng transient receptor potential vanilloid-1 (TRPV1) channels.

19 quires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alp

20 ay, using cells expressing recombinant human TRPV1 channels, 4 antagonized capsaicin-induced Ca(2+) i

21 he transient receptor potential vanilloid 1 (TRPV1) channel, a key target of inflammatory mediators s

22 e long-acting antagonists of mouse and human TRPV1 channels, abolishing activity for >1 h after remov

23 Transient receptor potential vanilloid-1 (TRPV1) channels abound in corneal nerve fibers and respo

24 in-independent endocytic route, triggered by TRPV1 channel activation and Ca(2+) influx through the r

25 However, whether 12(S)-HpETE underlies TRPV1 channel activation during I/R is unknown.

26 Here we report that TRPV1 channel activation is necessary and sufficient to

27 were depressed by either capsaicin, a potent TRPV1 channel activator, or the endogenously released ei

28 However, their effects on TRPV1 channel activity have not been conclusively determ

29 ress whether noradrenaline can down-regulate TRPV1 channel activity in nociceptors and reduce their s

30 ts formation of DAG and negatively regulates TRPV1 channel activity.

31 of transient receptor potential vanilloid 1 (TRPV1) channel activity.

32 Other derivatives also inhibited the TRPV1 channel, albeit with low potency, affording a stru

33 lycerol could also induce heat activation of TRPV1 channels, although with a small-conductance state.

34 creened a venom library for activity against TRPV1 channels and found robust inhibitory activity in v

35 esults reveal a previously unknown action of TRPV1 channels and indicate that the postsynaptic genera

36 TM5-TM6 linker forms the outer vestibule of TRPV1 channels and that AG489 is a pore blocker.

37 into ligand binding and allosteric gating of TRPV1 channels and the relevance of accurate polymodal r

38 he transient receptor potential vanilloid 1 (TRPV1) channel and sphingosine-1-phosphate receptors.SA1

39 r channels, transient receptor potential V1 (TRPV1) channels and acid-sensing ion channels (ASICs) is

40 ion channels (M-type K(+), L-type Ca(2+), or TRPV1 channels) and G protein-coupled receptors coupled

41 volves PKCepsilon signaling to sensitize the TRPV1 channel, and contributes to acute thermal hyperalg

42 the activation and deactivation kinetics of TRPV1 channels, and from the measurements we determined

43 arinic acetylcholine receptor and vanilloid (TRPV1) channels, and the GPIIb integrin.

44 he transient receptor potential vanilloid 1 (TRPV1) channel, another element of the endocannabinoid s

45 3D-QSAR models for human TRPV1 channel antagonists were developed based on compar

46 Transient receptor potential vanilloid 1 (TRPV1) channel antagonists may have clinical utility for

47 ceptors), but the extent to which functional TRPV1 channels are expressed in the CNS is debated.

48 TRPV1 channels are gated by a variety of thermal, chemic

49 While TRPV1 channels are not considered to be mechanically gat

50 TRPV1 channels are polymodal in their function and exhib

51 transcription, and, therefore, modulators of TRPV1 channels are potentially useful in the treatment o

52 Functional TRPV1 channels are present in the human airway epitheliu

53 C-fibers expressing heat-sensitive TRPV1 channels are proposed, for example, to be heat but

54 Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous s

55 potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels are crucial for detecting and transmitti

56 ient receptor potential vanilloid subtype 1 (TRPV1) channels are essential nociceptive integrators in

57 igned to understand the gating mechanisms of TRPV1 channels based on comparisons between the agonist

58 Inhibition of TRPV1 channels by AG489 is strongly voltage-dependent, w

59 C, consistent with inhibition of presynaptic TRPV1 channels by alpha2 adrenergic receptors.

60 prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8

61 We suggest that modulation of TRPV1 channels by dopamine in nociceptive neurons may re

62 We suggest that modulation of TRPV1 channels by noradrenaline in nociceptive neurons i

63 ed transient receptor potential vanilloid 1 (TRPV1) channel by phosphoinositides is complex and contr

64 ed transient receptor potential vanilloid 1 (TRPV1) channels by phosphoinositides is controversial.

65 m of compartment-specific regulation whereby TRPV1 channels can modify synaptic function in the brain

66 The present study tested whether TRPV1 channels contribute to afferent renal nerve activi

67 ed transient receptor potential vanilloid 1 (TRPV1) channel contributes to neurogenic inflammation an

68 5 mum phosphatidylinositol 4,5-bisphosphate, TRPV1 channels demonstrated rapid activation at 33-39 de

69 channels, TRPV4 channels, and AchR channels, TRPV1 channels diffused laterally in the plasma membrane

70 ed transient receptor potential vanilloid 1 (TRPV1) channels excised in a sniffer-patch configuration

71 e report the 3D structure of full-length rat TRPV1 channel expressed in the yeast Saccharomyces cerev

72 Here, we show that lidocaine inhibits TRPV1 channels expressed in Xenopus laevis oocytes, wher

73 ore, 4ONE (100 microm) was shown to activate TRPV1 channel-expressing HEK cells.

74 1)KO animals with no apparent differences in TRPV1 channel expression.

75 with neuropathic pain, is an agonist of the TRPV1 channel found in primary afferent nociceptors and

76 amine toxins, AG489 and AG505, which inhibit TRPV1 channels from the extracellular side of the membra

77 n evokes itch sensation in mice by promoting TRPV1 channel function in dorsal root ganglion neurons a

78 in the murine colon, and associated loss of TRPV1 channel function.

79 domain, which cause an opening of the lower TRPV1 channel gate.

80 e external pore in the allosteric control of TRPV1 channel gating and provide essential constraints f

81 capsaicin entry without directly modulating TRPV1 channel gating.

82 As a sensor for noxious stimuli, TRPV1 channel has been described as a key contributor to

83 interaction of ligands in this region of the TRPV1 channel has not been previously described and the

84 Mice lacking the TRPV1 channel have altered micturition thresholds sugges

85 on of TRPA1 intrinsic characteristics by the TRPV1 channel have not been examined.

86 functional and structural data suggest that TRPV1 channels have two gates within their permeation pa

87 show that external sodium ions stabilize the TRPV1 channel in a closed state, such that removing the

88 activity at the CB(1) receptor maintains the TRPV1 channel in a sensitized state responsive to noxiou

89 The role of the TRPV1 channel in the development of hyperalgesia is esta

90 flash photorelease of vanilloid can activate TRPV1 channels in <4 ms at 22 degrees C.

91 urther, after PKC stimulation, OEA activated TRPV1 channels in cell-free patches suggesting a direct

92 e, AM404, acting on cannabinoid receptors or TRPV1 channels in central nervous system (CNS) neurons.

93 drenaline strongly inhibited the activity of TRPV1 channels in dorsal root ganglia neurons.

94 nce regarding ligand-dependent activation of TRPV1 channels in light of structural data recently obta

95 of Dh, we carried out a comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1

96 We suggest that modulation of presynaptic TRPV1 channels in nociceptive neurons by descending nora

97 hether dopamine can modulate the activity of TRPV1 channels in nociceptive neurons, the effects of do

98 TRPV1 channels in sensory neurons are integrators of pai

99 Activation of TRPV1 channels in sensory neurons results in opening of

100 We conclude that tonic activation of TRPV1 channels in the abdominal viscera by yet unidentif

101 ght activated TRPA1 and, to a lesser extent, TRPV1 channels in the absence of additional photosensiti

102 To address the possible role of TRPV1 channels in the regulation of synaptic transmissio

103 lds for chemical or thermal stimuli, whereas TRPV1 channels in which this region is replaced with a l

104 he transient receptor potential vanilloid 1 (TRPV1) channel in peripheral sensory neurons, thus lower

105 Accordingly, genetic disruption of TRPV1 channels increases islet size whereas CB1R knockou

106 sine residue, Y200, followed by insertion of TRPV1 channels into the surface membrane, explains most

107 The TRPV1 channel is a detector of noxious stimuli, includin

108 The TRPV1 channel is a sensitive detector of pain-producing

109 ing genetically engineered rats in which the TRPV1 channel is rendered non-functional, we have shown

110 nergy transfer interaction between TRPA1 and TRPV1 channels is as effective as for TRPV1 or TRPA1 hom

111 The best known agonist of TRPV1 channels is capsaicin, the pungent component of "h

112 Spatially resolved sensing with TRPV1 channels is demonstrated by imaging a porous membr

113 he transient receptor potential vanilloid 1 (TRPV1) channel is abundantly expressed in peripheral sen

114 he transient receptor potential vanilloid 1 (TRPV1) channel is activated by heat and by capsaicin, th

115 he transient receptor potential vanilloid 1 (TRPV1) channel is an essential component of the cellular

116 he transient receptor potential vanilloid 1 (TRPV1) channel is associated with noxious heat detection

117 he transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat

118 However, the TRPV1 channel itself is not required for the asthmatic-l

119 asured responses from mice lacking TRPA1 and TRPV1 channels known to mediate some trigeminal response

120 a TRPV1 antagonist (AMG0347) confirmed that TRPV1 channels located outside the brain tonically inhib

121 Although TRPA1 and TRPV1 channels may be involved in the scratching respons

122 tered micturition thresholds suggesting that TRPV1 channels may play a role in the detection of bladd

123 lease, suggesting that calcium entry through TRPV1 channels may trigger glutamate release independent

124 ptor Potential Vanilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sen

125 he transient receptor potential vanilloid 1 (TRPV1) channel on the thin fibre afferents evoking the e

126 Altogether, these data suggest TRPV1 channels play distinct roles in renal interoceptio

127 These findings suggest TRPV1 channels play distinct roles in renal interoceptio

128 nnel blocker QX-314 into these axons via the TRPV1 channel pore.

129 The opening of single TRPV1 channels produced sparklets, representing localize

130 our results provide the first evidence that TRPV1 channels regulate cortical excitability to paired-

131 at transient receptor potential vanilloid 1 (TRPV1) channels regulate glutamate release at central an

132 We demonstrate that the recombinant purified TRPV1 channel retains its structural and functional inte

133 scanning of the C terminus of a cysteineless TRPV1 channel revealed a critical region within which an

134 In TRPV1-channel rhodopsin-2 mice, light activation of ExPA

135 box linker of TRPM8 channel with the cognate TRPV1 channel sequences produced functional chimeric cha

136 Hypertonic stress-elicited TRPV1 channel stimulation mediates increases in a proinf

137 vation of OVLT neurons critically depends on TRPV1 channels, studies in TRPV1(-/-) mice suggest that

138 and interactions of known activators of the TRPV1 channel such as capsaicin, in a structural model o

139 TRPV1 channels support the detection of noxious and noci

140 A reduces the excitability of the ubiquitous TRPV1 channel, thereby lowering impulse activity in the

141 found effect on the contribution of ASIC and TRPV1 channels, therefore, altering the neuronal excitab

142 kinase C (PKC) in the immediate proximity of TRPV1 channels to enhance phosphorylation efficiency.

143 ic transient receptor potential vanilloid 1 (TRPV1) channels to trigger a form of LTD resulting from

144 , a region thought to form the outer pore of TRPV1 channels, to identify pore mutations that alter to

145 Unlike the related TRPV1 channel, TRPV2 does not appear to bind either calm

146 store depletion by plasma membrane-localized TRPV1 channels was demonstrated with an ER-localized Ca(

147 The inhibitory effect of noradrenaline on TRPV1 channels was dependent on calcium influx and linke

148 g capsaicin-sensitive and insensitive rabbit TRPV1 channels, we show that antagonists require the sam

149 channels expressed in HEK-293 cells, but not TRPV1 channels, were activated by bath-applied CO(2).

150 ctric field gradients at pores that activate TRPV1 channels when the probe is in the vicinity of the

151 Local inflammation sensitized TRPV1 channels, which increased ocular pain.

152 he transient receptor potential vanilloid 1 (TRPV1) channel, which contributes to pressure sensing an

153 kinase C (PKC), OEA alone directly activated TRPV1 channel with an EC50 of approximately 2 microm at

154 further, and the toxin was found to inhibit TRPV1 channels with a K(i) of 0.3 microM at -40 mV.

155 localized intra-abdominal desensitization of TRPV1 channels with intraperitoneal resiniferatoxin bloc

156 TRPV1 channels with mutations at position 547 were expre

157 te a new form of afferent signaling in which TRPV1 channels within central terminals of peripheral af