ライフサイエンスコーパス: Tat protein

1 least 1000-fold more toxic than recombinant Tat protein.

2 h transactivation of the HIV promoter by the Tat protein.

3 a cell-penetrating peptide derived from the TAT protein.

4 those observed for peptides derived from the Tat protein.

5 human immunodeficiency virus type I (HIV-1) Tat protein.

6 tion (CHIPDeltaU-box), was unable to degrade Tat protein.

7 n sequence from human immunodeficiency virus TAT protein.

8 similar to those of the ungulate lentiviral Tat protein.

9 s for deleterious mutations elsewhere in the Tat protein.

10 PTD) derived from the human immunodeficiency TAT protein.

11 erase II is strongly stimulated by the viral Tat protein.

12 onal repression by DRB and activation by the Tat protein.

13 human immunodeficiency virus type 1 (HIV-1) Tat protein.

14 n elongation complexes is inhibited by HIV-1 Tat protein.

15 ed cells were treated with exogenously added Tat protein.

16 n in the presence of either DRB or the HIV-1 Tat protein.

17 Vpu also expressed a functional single-exon Tat protein.

18 es capable of neutralizing the effect of the Tat protein.

19 oter of HIV-1 that is activated by the HIV-1 Tat protein.

20 fection with HIV-1, in part due to the HIV-1 Tat protein.

21 physical interaction between MED14 and HIV-1 Tat protein.

22 direct effects of viral proteins such as the Tat protein.

23 annels in the response of microglia to HIV-1 Tat protein.

24 transactivation, along with stabilization of Tat protein.

25 orescence microscopy of Texas Red-conjugated TAT proteins.

26 for transcriptional activation by lentivirus Tat proteins.

27 o the translocon, FRET was observed for both Tat proteins.

28 e and HIV-1 transactivator of transcription (Tat) protein.

29 g the HIV-1 transactivator of transcription (Tat) protein.

30 dies examined the ability of two variants of Tat protein (1-100 nM), Tat 1-72 and Tat 1-86, to produc

31 Treatment of rat microglia with HIV-1 Tat protein (200 ng/ml) resulted in pro-inflammatory mic

32 s cellular defense, HIV-1 has evolved in its Tat protein a suppressor of RNA silencing (SRS) function

33 he human immunodeficiency virus type 1 (HIV) Tat protein, a potent activator of HIV gene expression,

34 l region of the human immunodeficiency virus Tat protein, a protein transduction domain known to ente

35 demonstrate that highly divergent lentiviral Tat proteins activate transcription from their cognate L

36 Treatment with HIV-tat protein activated NF-kappa B, degraded I kappa B alp

37 wnstream of the MyD88 and TRIF pathways, the Tat protein activated the protein kinase C (PKC) betaII

38 As the HIV-1 Tat protein activates the overall expression of the huma

39 Human immunodeficiency virus, type 1 (HIV-1) Tat protein activates transcription from the HIV-1 long

40 s basal HIV gene expression and that the HIV Tat protein activates transcription independently of the

41 uman immunodeficiency virus, type 1 (HIV-1), Tat protein activates viral gene expression through prom

42 T-tg or C57BL/6J mice; however, induction of Tat protein after the extinction of CPP also produced re

43 by vGPCR was greatly increased by the HIV-1 Tat protein, although Tat alone had little effect on NF-

44 ransduction domain (PTD) embedded in the HIV TAT protein (amino acids 47-57) has been shown to succes

45 study was to determine whether and how HIV-1 Tat protein, an immunosuppressive viral factor, induces

46 PI3K-dependent inhibition required the viral Tat protein and a trans activation response region eleme

47 ar cofactor cyclin T1, which binds the viral Tat protein and activates the RNA polymerase II transcri

48 We found HIV-Tat protein and IL-17-expressing mononuclear cells in th

49 ble to that of the RNA-binding domain of the Tat protein and inhibited protein binding to the RNA.

50 uction of NO production by recombinant HIV-1 Tat protein and inhibition of RSV-tat-induced NO product

51 anges conformation in response to binding of Tat protein and of a variety of peptidic and small molec

52 e suggest a model where CycT1 interacts with Tat protein and positions the protein complex to make co

53 The HIV-1 Tat protein and several small molecules bind to HIV-1 tr

54 M) of the human immunodeficiency virus (HIV) Tat protein and TAR RNA is essential for Tat activation

55 ccount for the specificity between the HIV-1 Tat protein and TAR RNA.

56 Novel systems using Tat protein and the GHOST cell line were developed to te

57 cture, termed TAR RNA, in concert with HIV-1 Tat protein and these positive and negative elongation f

58 protein transduction domain (PTD) of the HIV/TAT protein and transduced pancreatic islets ex vivo wit

59 ciates with the human immunodeficiency virus Tat protein and with the transactivation response elemen

60 We quantified the secreted Tat proteins and measured their uptake by TZM-bl cells,

61 man immunodeficiency virus 1-transactivator (Tat) protein and linked to the mitochondrial targeting s

62 V replication, with associated production of Tat protein, and C. parvum infection synergistically inc

63 with the human immunodeficiency virus type 1 Tat protein, and Drosophila mof, a gene essential for ma

64 s have documented the neurotoxic property of Tat protein, and Tat has therefore been proposed to cont

65 observed that neuronal cultures treated with Tat protein are protected from Tat-mediated cytotoxicity

66 ysiology of M. smegmatis and homologs of the TAT proteins are also present in the genome of Mycobacte

67 and simian immunodeficiency virus (HIV/SIV) Tat proteins are specified by two coding exons.

68 Our results demonstrate that Tat protein associates with RNA polymerase II complexes

69 ndicating that penetrating property of HIV-1 Tat protein attributes to synaptic damage.

70 ptide mimic of the RNA-binding domain of BIV Tat protein based on a designed beta-hairpin scaffold.

71 d, however, by immunization with inactivated Tat protein before vaccination with the bicistronic gp12

72 tides from the carboxy terminus of the HIV-1 Tat protein bind to the apical stem-loop region of TAR R

73 The arginine-rich RNA-binding domains of the Tat proteins bind to their cognate transactivation respo

74 At the HIV-1 promoter, the viral Tat protein binds simultaneously to the nascent TAR RNA

75 Our previous studies showed that HIV-1 Tat protein binds to PP1 through the Tat Q(35)VCF(38) se

76 This minimal hybrid mutant hCycT1-Tat protein bound TAR RNA as well as human and murine P-

77 NF-kappa B, AP-1, JNK, and apoptosis by HIV-tat protein but has minimal or no role in activation of

78 h protein-protein interaction with the HIV-1 Tat protein can also activate cad transcription.

79 The HIV Tat protein can be endocytosed by surrounding uninfected

80 HIV-1 Tat protein can damage the synaptic membranes contributi

81 Here we show that HIV-1 Tat protein can directly promote KSHV transmission.

82 In cultured cells, the HIV-1 Tat protein can induce the expression of the cytokines i

83 HIV-1 Tat protein can penetrate cell membrane freely and secre

84 ch as HIV-1 Transactivator of Transcription (Tat) protein can activate microglia is thus of paramount

85 Specific HIV proteins, such as Tat protein, can contribute to the dysfunction of tight

86 Administration of recombinant HIV-1 Tat protein caused a 13-fold increase in HERV-K (HML-2)

87 piCCT1 has a region of similarity to the HIV Tat protein cell-transduction domain, we tested whether

88 RNA polymerase II, is regulated by the HIV-1 Tat protein, CK2, TFIIB, and the large subunit of TFIIF

89 in vitro biochemical assays with recombinant Tat protein confirmed that TR1 targets two disulfide bon

90 The recombinant HIV-1 Tat protein contains a small region corresponding to res

91 cause HIV-1 Transactivator of Transcription (Tat) protein continues to be present despite antiretrovi

92 HIV-1 Tat protein contributes to HIV-neuropathogenesis in seve

93 The HIV-1-encoded Tat protein controls transcription elongation by increas

94 The Tat protein controls transcription in lentiviruses such

95 We discovered that HIV-Tat protein could be transported along anatomical pathwa

96 Hence we examined if Tat protein could directly activate T cells.

97 Additionally, the rate of Tat protein degradation as measured by cycloheximide (CH

98 Using an HIV-1 Tat protein-derived peptide to mediate rapid and efficie

99 exposure of cultures to a deletion mutant of Tat protein devoid of amino acids 31-61 (Tat Delta31-61)

100 The human immunodeficiency virus Tat protein directly associates with CycT1 to utilize Cy

101 Moreover, the CycT1 complex formed by each Tat protein displays a distinct RNA target specificity t

102 pendent on the same cellular cofactor as the Tat proteins encoded by other lentiviruses, is neverthel

103 Tat protein, encoded by one of the HIV-1 regulatory gene

104 ne composition in the proper function of the Tat protein export pathway.

105 uorum-sensing and uncover a function for the Tat protein export system in the production of secreted

106 The Tat protein export system translocates folded proteins a

107 TAT peptides derived from the HIV-1 TAT protein facilitate intracellular delivery of protein

108 ly proposed a two-step model where the viral Tat protein first preassembles at the promoter with an i

109 The pretreatment of human monocytes with Tat protein for 10 to 30 min suffices to irreversibly en

110 d to the nontoxic transduction domain of the tat protein from human immunodeficiency virus type 1 (ta

111 recently identified inhibitors of the viral Tat protein from the bovine immunodeficiency virus (BIV)

112 In this study, we demonstrate that Tat proteins from representative HIV-1 subtype E isolate

113 Brief exposure (10 min) to each variant of Tat protein (>1 nM) markedly increased levels of intrace

114 athione peroxidase, NK-lysin/granulysin, HIV Tat protein, H(2)O(2), lipid hydroperoxides, vitamin K,

115 The human immunodeficiency virus (HIV) Tat protein has a critical role in viral transcription,

116 The human immunodeficiency virus (HIV)-Tat protein has been implicated in the neuropathogenesis

117 The HIV-1 Tat protein has been reported to exert an adverse effect

118 human immunodeficiency virus type 1 (HIV-1) Tat protein has been reported to transactivate several c

119 ddition, our results indicate that the alpha-TAT protein has functions that require acetyltransferase

120 findings are particularly important because Tat protein has recently been detected in the brain of H

121 ated that a TAT peptide derived from the HIV TAT protein has the ability to transduce peptides or pro

122 HIV-1 transactivator of transcription (Tat) protein has been shown to induce the production of

123 Several HIV-1-derived proteins including the Tat protein have been shown to transcriptionally repress

124 In marked contrast, bovine lentiviral Tat proteins have evolved a high-affinity TAR interactio

125 The virally encoded Tat protein hijacks positive transcription elongation fa

126 human immunodeficiency virus type 1 (HIV-1) Tat protein (hTat) activates transcription initiated at

127 Here the specific interaction between Tat protein, human cyclin T1, and HIV-1 TAR RNA was anal

128 eterminants of TAR recognition by: (i) viral Tat proteins, (ii) an innovative lab-evolved TAR-binding

129 Here we report that synthetic HIV-1 Tat protein, immobilized on a solid substrate, up-regula

130 ndent on the presence of both HAT domain and Tat proteins, implying that Tat influences the transcrip

131 P-expressing plasmid decreased the levels of Tat protein in a dose-dependent manner, without affectin

132 ese effects, we constitutively expressed HIV-Tat protein in astrocytes.

133 Recently, we showed the presence of Tat protein in brains of patients with HIV-1 encephaliti

134 an elongation block that is overcome by HIV Tat protein in conjunction with P-TEFb.

135 gain a better understanding of the roles of Tat protein in HIV-1 neuropathogenesis, we attempted to

136 whole organism to support a critical role of Tat protein in HIV-1 neuropathogenesis.

137 nly further highlights the importance of HIV Tat protein in HIV/neuroAIDS, but also presents a new st

138 wn to suppress transcriptional activation by Tat protein in human cells with an IC(50) of approximate

139 n the activation of transcription by the HIV Tat protein in human cells.

140 ctivation, we explored the role of the HIV-1 Tat protein in inducing the expression of these endogeno

141 Inclusion of recombinant Tat protein in the boosting phase along with the Env pro

142 nterferes with transcriptional activation by Tat protein in vitro and in HeLa cells.

143 R is not required for binding by recombinant Tat protein in vitro, suggesting that the loop region ac

144 L response to autologous virus Env, Gag, and Tat proteins in three patients, and investigated the ext

145 We show here that HIV type 1 (HIV-1) Tat protein, in combination with anti-CD3/CD28 mAbs, pro

146 mbinant biologically active HIV-1-associated Tat protein increased FasL expression in the cytoplasm o

147 cryptosporidiosis, we found that recombinant Tat protein increased TLR4 mRNA expression in both uninf

148 HIV-1 Tat protein increases synaptic dopamine (DA) levels by d

149 itioned media from astrocytes or recombinant Tat protein inhibited NPC proliferation and migration an

150 In this study, we show that the HIV-1 Tat protein interacts with rapid kinetics to engage the

151 in the brain, or by injection of recombinant Tat protein into the brain, which may cause secondary st

152 human immunodeficiency virus type 1 (HIV-1) Tat protein is a key pathogenic factor in a variety of a

153 The HIV-1 Tat protein is a potent neurotoxin produced during HAND

154 eptide from the Jembrana disease virus (JDV) Tat protein is a structural "chameleon" that binds bovin

155 efore, this study analyzed whether the HIV-1 Tat protein is able to activate these two pathways separ

156 g domain of the Jembrana disease virus (JDV) Tat protein is able to recognize two different TAR RNA s

157 l repeat (LTR) promoter element by the viral Tat protein is an essential step in the HIV-1 life cycle

158 Human immunodeficiency virus (HIV)-1 Tat protein is an important pathogenic factor in HIV-ass

159 The Tat protein is essential for HIV type 1 (HIV-1) replicat

160 human immunodeficiency virus type 1 (HIV-1) Tat protein is essential for viral replication and stimu

161 The human immunodeficiency virus Tat protein is essential for virus replication and is a

162 that the bovine immunodeficiency virus (BIV) Tat protein is fully able to bind to BIV TAR both in viv

163 mmunodeficiency virus (HIV) infection, HIV-1 Tat protein is known to synergize with psychostimulant d

164 deregulation of neuronal functions by HIV-1 Tat protein is miRNA-dependent.

165 The HIV-1 Tat protein is one of the proteins present in HIV that a

166 n of the bovine immunodeficiency virus (BIV) Tat protein is shown to bind specifically to its target

167 We report here that the HIV Tat protein is strongly immunosuppressive, both immediat

168 The HIV-1 Tat protein is translated from the early spliced mRNA an

169 The transactivator of transcription (Tat) protein is essential for efficient HIV type 1 (HIV-

170 we showed that neurotoxic factors other than Tat protein itself were present in the supernatant of Ta

171 nd, unlike human papillomavirus E6 and HIV-1 TAT proteins, LANA did not reduce TIP60 stability.

172 Since the nuclear presence of Tat protein leads to alteration of host gene expression,

173 ion with HIV-1 or stimulation with the HIV-1 Tat protein leads to the activation of K111 proviruses.

174 TLR4 pathway with rapid kinetics, the HIV-1 Tat protein leads to the engagement of both the MyD88 an

175 TLR4 pathway with rapid kinetics, the HIV-1 Tat protein leads to the engagement of both the MyD88 an

176 HIV-tat protein, like TNF, activates a wide variety of cellu

177 hat the HIV transactivator of transcription (Tat) protein manipulates the intrinsic toggling of HIV's

178 These data indicate that the HIV-1 Tat protein may act as a protocytokine by causing the re

179 Hence, Tat protein may induce autophagosome and lysosome fusion

180 tion of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine t

181 y virus type 1 (HIV-1) potent transactivator Tat protein mediates pleiotropic effects on various cell

182 To characterize the mechanism by which HIV-1 Tat protein modulates human brain microvascular endothel

183 ned whether exposure of susceptible cells to Tat protein of HIV could result in the production of sel

184 The Tat protein of human immunodeficiency virus (HIV) is ess

185 The Tat protein of human immunodeficiency virus type 1 (HIV-

186 The Tat protein of immunodeficiency viruses is the main acti

187 ation to define the interactions between the Tat proteins of Escherichia coli at molecular-level reso

188 at transactivation assay, where we expressed Tat proteins of HIV-1 clade B (Tat-B) or C (Tat-C) or th

189 Asparagine is prevalent in Tat proteins of viruses in clades A, C, and D, which are

190 Here we investigated the effects of the Tat protein on enteric neuronal excitability, proinflamm

191 the KS-promoting factor TNF-alpha, the HIV-1 Tat protein, or the human herpesvirus 8 protein ORF74, w

192 The transacting activator of transduction (TAT) protein plays a key role in the progression of AIDS

193 e 1 (HIV-1) transactivator of transcription (Tat) protein possesses a unique membrane-transduction pr

194 f Tat and respond similarly to extracellular Tat protein produced during infection.

195 nding to the same site as arginine 52 of the Tat protein, rather than to the neomycin binding site.

196 The viral Tat protein recruits human Super Elongation Complex (SEC

197 The viral Tat protein recruits human super elongation complexes (S

198 human immunodeficiency virus type 1 (HIV-1) Tat protein recruits positive transcription elongation f

199 human immunodeficiency virus type-1 (HIV-1) Tat protein regulates transcription by stimulating RNA p

200 HIV-1 Tat protein regulates transcription elongation by bindin

201 Tat protein released from HIV-infected blood-borne leuko

202 ed with a variant TAR able to bind all three Tat proteins replicate efficiently with any of the prote

203 LTR) promoter element by the essential viral Tat protein requires recruitment of positive transcripti

204 demonstrated that exposure of HUVECs to HIV Tat protein resulted in induced expression of cell adhes

205 domain from the human immunodeficiency virus TAT protein, results in delivery of the biologically act

206 position 31, found in >90% of HIV-1 clade C Tat proteins, results in a marked decrease in IL-10 prod

207 Analysis of different Tat proteins revealed that the 101-amino-acid SF2 HIV-1

208 component of the twin-arginine translocase (Tat) protein secretion pathway and likely forms a secret

209 The HIV-1 Tat protein selectively recruits P-TEFb as part of a sup

210 found that treatment of DCs with whole HIV-1 Tat protein significantly upregulated the level of expre

211 Our results also show that HIV-1 Tat protein stimulated DSIF and RNA pol II phosphorylati

212 ealthy or HIV-1-infected patients with HIV-1 Tat protein stimulated the expression of PD-L1.

213 The HIV type 1 (HIV-1) Tat protein stimulates transcription elongation by recru

214 The HIV-1 Tat protein stimulates viral gene expression by recruiti

215 FP-SsrA or upon overexpression of the native Tat proteins SufI and CueO.

216 cein-labeled TAR RNA and a rhodamine-labeled Tat protein synthesized through solid-phase chemistry.

217 uction was achievable, as minimum amounts of Tat protein, synthesized following application of a shor

218 n domain of the human immunodeficiency virus TAT protein (Tat), an Angiopep peptide (Ang-2), and the

219 ll membrane transduction domain of the HIV-1 Tat protein (TAT-C24WT).

220 treatment with a CRMP2 peptide fused to HIV TAT protein (TAT-CBD3) blocked neuronal death following

221 udy the interaction between PTD of the HIV-1 Tat protein (TAT-PTD; residues 47-60 of Tat, fluorescent

222 g domain of the human immunodeficiency virus Tat protein (Tat-srIkappaBalpha).

223 to the HIV transactivator of transcription (TAT) protein (TAT-CBD3) decreased neuropeptide release f

224 Compared to HIV-1-subtype-B and its Tat proteins(Tat.B), HIV-1-CRF02_AG and Tat.AG significa

225 ed to the protein transduction domain of HIV-TAT protein (TATFLAGVHL-peptide) to facilitate entry int

226 An 11-residue basic domain of the HIV-1 tat protein, termed the tat transduction domain (TTD), h

227 element is regulated by the essential viral Tat protein that binds to the viral TAR RNA target and r

228 netrating peptide (CPP) conjugate of the HIV TAT protein that is fused to an aminoterminal sequence o

229 immunodeficiency virus (SIVmnd), also encode Tat proteins that activate transcription via RNA targets

230 ty is seen in viral replication assays using Tat proteins that rely on CycT1 for TAR binding but are

231 upporting HIV-1 transactivation by the viral Tat protein, the AFF4-SEC is more important for HSP70 in

232 ed by the human immunodeficiency virus (HIV) Tat protein to activate elongation of the integrated pro

233 tion complex (SEC) used by the viral encoded Tat protein to activate HIV transcription.

234 mbrana disease virus (JDV) utilize the viral Tat protein to activate viral transcription.

235 These studies link the HIV-1 Tat protein to cell cycle-specific biological functions.

236 in concert with these factors and the HIV-1 Tat protein to ensure that viral transcription is induce

237 fused to the polybasic sequence from the HIV Tat protein to facilitate entry into cells.

238 conjugation of peptides derived from the HIV TAT protein to membrane-impermeant molecules has gained

239 protein, called the TAT peptide, enables the TAT protein to penetrate cell membranes.

240 Binding of the HIV tat protein to the TAR (transactivating response region)

241 continues to synergize normally with the HIV Tat protein to transactivate the HIV long terminal repea

242 at is responsible for the inability of these Tat proteins to produce high IL-10 levels in monocytes d

243 report that binding of HIV-1 transactivator (Tat) protein to low-density lipoprotein receptor-related

244 and is the site of interaction of the HIV-1 Tat protein together with host cellular factors.

245 th versions of these peptides containing HIV-Tat protein transduction and mammalian mitochondrial tar

246 The TAT protein transduction domain (PTD) has been used to d

247 or-associated Ag (OVA) that contains the HIV TAT protein transduction domain (PTD) was readily engine

248 r uptake of the human immunodeficiency virus TAT protein transduction domain (PTD), or cell-penetrati

249 ass IA PI3K adaptor subunit, fused to an HIV-TAT protein transduction domain (TAT-Deltap85) concentra

250 nto mice of dnRas, which was fused to an HIV-TAT protein transduction domain (TAT-dnRas).

251 When fused to the HIV-TAT protein transduction domain and delivered as a prote

252 d recombinant fusion proteins containing the TAT protein transduction domain and either wild-type Sur

253 ptide was redesigned to TSB2 that includes a TAT protein transduction domain and shortened to 14 aa.

254 een fluorescent protein or dnRas lacking the TAT protein transduction domain did not block airway inf

255 esults provide insight into the mechanism of TAT protein transduction domain transduction.

256 56 to 76 amino acid (aa) region and the HIV Tat protein transduction domain, and this peptide marked

257 is fused to the human immunodeficiency virus TAT protein transduction domain.

258 directed mutagenesis and fused downstream of TAT protein transduction domain.

259 tor, p16INK4a that contained an NH2-terminal TAT protein transduction domain.

260 a physiological role for nuclear RACK1, the Tat protein transduction system was used to transduce RA

261 The transactivator of transcription (TAT) protein transduction domain is an 11-amino acid pos

262 we used the transactivator of transcription (TAT) protein transduction domain to deliver human FXN pr

263 e effect of transactivator of transcription (TAT) protein transduction of the apoptosis repressor wit

264 The twin-arginine (Tat) protein translocase is a highly unusual protein tra

265 Current models for Tat protein transport are also discussed.

266 drical structures that may correspond to the Tat protein transport channel.

267 omponents of the thylakoid deltapH-dependent/Tat protein transport machinery was analyzed in vitro.

268 te the mechanism and energetics of bacterial Tat protein transport, we developed an efficient in vitr

269 protein (GFP)-tagged constructs to study the Tat protein transporter and Rieske Tat substrates in Syn

270 Our results demonstrate that HIV-1 Tat protein upregulates PD-L1 expression on MoDCs throug

271 ophobic domain may play an important role in Tat protein uptake and be useful for intracellular deliv

272 The viral trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM

273 The viral Tat protein utilizes Cyclin T1 to activate proviral tran

274 HIV-1-derived TAT protein variants contain a transmembrane domain, whi

275 By detection of the Tat protein, virus transmission can be detected in high-

276 Here, we demonstrate that the Cv-pdg-NLS-TAT protein was delivered to repair-proficient keratinoc

277 Based on the intrinsic disordered nature of Tat protein, we focused our attention on host cell E3 ub

278 The colored Tat proteins were easily visible during purification, en

279 n domain of the human immunodeficiency virus TAT protein, were tested in in vitro and in vivo experim

280 ion of human immunodeficiency virus requires Tat protein which activates elongation of RNA polymerase

281 Replication of HIV-1 requires the Tat protein, which activates elongation of RNA polymeras

282 Replication of HIV requires the Tat protein, which activates elongation of RNA polymeras

283 opolysaccharide (LPS) and the neurotoxic HIV Tat protein, which cause dopamine neuronal toxicity afte

284 utlined various strategies for detecting the Tat protein, which helps transcribe the virus and enhanc

285 cy virus (HIV)-1 genes is activated by HIV-1 Tat protein, which induces phosphorylation of the C-term

286 This is mediated in part through the HIV-1 Tat protein, which is secreted by the infected cells and

287 by the human immunodeficiency virus, type 1 Tat protein, which is secreted by virally infected cells

288 Here, we report that the HIV-1 Tat protein, which is secreted from virus-infected cells

289 HIV Tat protein, which is the transactivator of transcriptio

290 ide (Abeta1-6A2V), linked to the HIV-related TAT protein, which is widely used for brain delivery and

291 HIV-infected macrophages release Tat protein, which may act directly on neurons to cause

292 HIV-1 transcription is activated by HIV-1 Tat protein, which recruits cyclin-dependent kinase 9 (C

293 V-1) transcription is regulated by the viral Tat protein, which relieves a block to elongation by rec

294 human immunodeficiency virus type 1 (HIV-1) Tat protein, which was able to restore the 7SK-binding a

295 V-1) replication requires the interaction of Tat protein with the human cyclinT1 (hCyclinT1) subunit

296 1 (HIV-1) requires specific interactions of Tat protein with the trans -activation responsive region

297 1 (HIV-1) requires specific interactions of Tat protein with the trans-activation responsive region

298 expression that requires the interaction of Tat protein with the trans-activation responsive region

299 ciency virus (HIV) tat and boosting with the Tat protein would elicit protection against SHIV(89.6P).

300 to membrane translocation signals from HIV-1 tat protein (YGRKKRRQRRRPP-LRK(5)H, DT-2) or Drosophila