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1 Tc toxin complexes are virulence factors of many bacteri
2 Tc toxins are composed of three subunits that act togeth
3 Tc toxins are modular toxin systems of insect and human
5 trated for the first time that non-TcO(4)(-) Tc present in the AN-102 tank waste is composed of sever
11 ent and immobilization of technetium-99 ((99)Tc) contained in reprocessed nuclear waste and present i
12 A fully automated and rapid system for (99)Tc monitoring is introduced with the aim to improve hosp
13 l preparation procedure, measurements of (99)Tc concentrations at the fg/g levels with a sensitivity
14 e GAMS setup is used for the analysis of (99)Tc in samples of the seawater reference material IAEA-44
17 for the treatment and immobilization of (99)Tc present in reprocessed nuclear waste streams and cont
18 pected in groundwater after diffusion of (99)Tc through the bentonite constituting the technical barr
20 l composition and speciation of Tc using (99)Tc nuclear magnetic resonance spectroscopy and X-ray abs
42 conventional imaging (CT or MRI, and a (99m)Tc-methylene diphosphonate bone scan) before enrollment.
43 phosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) typically show intense uptake in skeletal metast
44 set (n = 20), we used the imaging agent (99m)Tc-cAbVCAM1-5 to evaluate expression of an inflammatory
45 (99m)Tc(V)) ((99m)Tc-NOET) could allow (99m)Tc-sestamibi to be repurposed to specifically report on
47 dism and inconclusive results at US and (99m)Tc sestamibi scintigraphy were prospectively enrolled.
48 contrast-enhanced mammography (CEM) and (99m)Tc sestamibi-based molecular breast imaging (MBI) in thi
50 enhanced magnetic resonance imaging and (99m)Tc-diethylene-triamine-pentacetic acid-single-photon emi
51 cs of (99m)Tc-MAS3-y-nal-k(Sub-KuE) and (99m)Tc-mas3-y-nal-k(Sub-KuE) ((99m)Tc-PSMA-I&S for imaging a
53 armacokinetics of (99m)Tc-sestamibi and (99m)Tc-NOET in response to mitochondrial perturbation by hyp
54 adiotracers (68)Ga/(177)Lu-PSMA-I&T and (99m)Tc-PSMA-I&S (for i maging and s urgery) are currently su
55 on of (99m)Tc-MAS3-y-nal-k(Sub-KuE) and (99m)Tc-PSMA-I&S in consistently high radiochemical yield and
56 c meal retention between (99m)Tc-SP and (99m)Tc-SC, was found to be comparable at all measured time p
58 embrane potential of (18)F-MitoPhos and (99m)Tc-sestamibi were tested in isolated perfused rat hearts
59 Radiolabeled bisphosphonates such as (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc
60 for carbon monoxide (DLCO), as well as (99m)Tc-macroaggregated albumin PS and SPECT/CT quantificatio
61 found a significant correlation between (99m)Tc-DTPA content in brain and both the discrimination ind
62 as total gastric meal retention between (99m)Tc-SP and (99m)Tc-SC, was found to be comparable at all
65 olus of phenol red or independently by [(99m)Tc]-diethylenetriamine pentaacetic acid scintigraphy, wa
68 re was a dose-dependent loss of cardiac (99m)Tc-sestamibi retention (from 2.3 +/- 0.3 to 0.9 +/- 0.2
70 ation of three novel (99m)Tc complexes ((99m)Tc-1-3) and their corresponding Re complexes (Re-1-3), i
75 nsisting of (99m)Tc-sestamibi SPECT/CT, (99m)Tc-sestamibi/pertechnetate subtraction imaging, and (99m
76 mission computed tomography diagnostic ((99m)Tc complexes) and antiamyloid therapeutic (Re complexes)
78 ipants were randomly assigned to either (99m)Tc-SP or (99m)Tc-SC on the first GES session before cros
79 quivalent to that with generator-eluted (99m)Tc and had no particular features allowing discriminatio
80 e on the indole moiety adjacent to EuK ((99m)Tc-EuK-(SO(3))Cy5-mas(3)) yielded the most promising tra
81 MA)-targeted radiotracers, for example, (99m)Tc-labeled PSMA tracer analogs for radioguided surgery.
82 and kits) were reported, especially for (99m)Tc/(99)Mo generators and (131)I, particularly in Africa,
84 tudy was to develop a second-generation (99m)Tc-labeled PSMA-targeted tracer incorporating a fluoresc
85 es for SN biopsy with indocyanine green-(99m)Tc-nanocolloid or (99m)Tc-nanocolloid with free indocyan
88 led succinimidyl-hydrazinonicotinamide ((99m)Tc-S-HYNIC)-conjugated anti-FAP antibody 28H1 at 2, 5, a
89 ation of either indocyanine green (ICG)-(99m)Tc-nanocolloid (hybrid-tracer group) or (99m)Tc-nanocoll
90 ode (SN) tracer indocyanine green (ICG)-(99m)Tc-nanocolloid generates temporary tattoolike markings a
91 onal superficial 3 or 4 deposits of ICG-(99m)Tc-nanocolloid (0.1 mL each), and in 12 patients additio
92 tic tracer administration of either ICG-(99m)Tc-nanocolloid (hybrid tracer group) or (99m)Tc-nanocoll
97 on with SPECT and fluorescence imaging, (99m)Tc-EuK-(SO(3))Cy5-mas(3) had the most promising properti
99 mitochondrial perturbations that induce (99m)Tc-sestamibi washout, demonstrating proof-of-concept for
101 KuE) and (99m)Tc-mas3-y-nal-k(Sub-KuE) ((99m)Tc-PSMA-I&S for imaging and surgery) were determined usi
103 N-ethoxy-N-ethyldithiocarbamato)nitrido (99m)Tc(V)) ((99m)Tc-NOET) could allow (99m)Tc-sestamibi to b
104 synthesis and evaluation of three novel (99m)Tc complexes ((99m)Tc-1-3) and their corresponding Re co
107 ined by the ex vivo gamma-well assay of (99m)Tc activity were detected by fluorescence mode imaging.
108 ancer (MBC) by (18)F-FDG PET instead of (99m)Tc bone scintigraphy (BS) supports clinically relevant c
110 ual- and triple-isotope combinations of (99m)Tc, (111)In, (123)I, (177)Lu, and (201)Tl were performed
111 he favorable biodistribution profile of (99m)Tc- and (111)In-labeled C2Am, and their ability to produ
113 avenous injection of 385 +/- 125 MBq of (99m)Tc-ADAPT6 was performed, randomized to an injected prote
115 by SPECT/CT imaging after injection of (99m)Tc-DTPA, an imaging marker of blood-brain barrier permea
116 determine the diagnostic performance of (99m)Tc-labeled SPECT MPI compared with (18)F-flurpiridaz PET
117 s were acquired 24 h after injection of (99m)Tc-labeled succinimidyl-hydrazinonicotinamide ((99m)Tc-S
119 (IC50) and internalization kinetics of (99m)Tc-MAS3-y-nal-k(Sub-KuE) and (99m)Tc-mas3-y-nal-k(Sub-Ku
120 stablished, allowing the preparation of (99m)Tc-MAS3-y-nal-k(Sub-KuE) and (99m)Tc-PSMA-I&S in consist
121 il/valsartan induced an early uptake of (99m)Tc-NC100692 (a radiotracer of angiogenesis) and improved
122 s used to measure the in vivo uptake of (99m)Tc-pertechnetate and (123)I in 2 NIS-expressing mouse ti
123 to explore the targeting performance of (99m)Tc-PHC-102 in SPECT in patients with renal cell carcinom
126 study was to estimate the dosimetry of (99m)Tc-PSMA I&S using a hybrid method (sequential gamma-plan
134 this first (to our knowledge) study of (99m)Tc-pyrophosphate cardiac imaging using a novel cadmium-z
135 ID measured by absolute quantitation of (99m)Tc-pyrophosphate were moderately correlated with LVMI an
136 The ischemic to nonischemic ratio of (99m)Tc-RP805 was significantly increased following I/R in sa
140 to characterize the pharmacokinetics of (99m)Tc-sestamibi and (99m)Tc-NOET in response to mitochondri
142 igraphic imaging methods, consisting of (99m)Tc-sestamibi SPECT/CT, (99m)Tc-sestamibi/pertechnetate s
144 aves the way for further evaluation of [(99m)Tc]-1 for imaging AAA and other MMP-12-associated diseas
146 Tc-nanocolloid (hybrid-tracer group) or (99m)Tc-nanocolloid to create a road map that depicted all SN
147 Tc-nanocolloid (hybrid tracer group) or (99m)Tc-nanocolloid to create a roadmap that depicted all sen
148 ndocyanine green-(99m)Tc-nanocolloid or (99m)Tc-nanocolloid with free indocyanine green used as trace
149 scintigraphy with either radioiodine or (99m)Tc-pertechnetate is useful to characterize different for
150 ndomly assigned to either (99m)Tc-SP or (99m)Tc-SC on the first GES session before crossed over to th
152 f LN involvement (LNI) underwent pelvic (99m)Tc-trofolastat SPECT/CT before radical prostatectomy wit
153 the basis of its in vivo performance, [(99m)Tc]-1 was selected for evaluation in murine AAA, where M
154 re widely available alternative to PET, (99m)Tc-labeled FAPIs represent attractive tracers for imagin
155 unclear if the (99m)Tc-sodium phytate ((99m)Tc-SP) is as reliable as the gold-standard (99m)Tc-sulfu
157 d-energy window with cyclotron-produced (99m)Tc was equivalent to that with generator-eluted (99m)Tc
158 n +/- SD) MBq of the cyclotron-produced (99m)Tc-NaTcO4, whereas the age- and sex-matched controls rec
159 Conclusion: Whatever the protocol, (99m)Tc-tilmanocept showed good results in a heterogeneous br
160 The aim of this study was to quantify (99m)Tc-DPD uptake by means of SPECT/CT before (223)Ra and co
161 rrelation between absolute quantitative (99m)Tc-pyrophosphate metrics and traditional measures of car
165 ds: Patients referred for a stress-rest (99m)Tc-sestamibi protocol and positioned in the biker positi
169 SP) is as reliable as the gold-standard (99m)Tc-sulfur colloid ((99m)Tc-SC) for gastric emptying scin
171 te 1 acquired its standard 300-s static (99m)Tc-DMSA studies as 5-frame dynamic studies in 29 childre
173 Results: In the 5 patients studied, (99m)Tc-PHC-102 was well tolerated and no study drug-related
179 mparable to those known for most of the (99m)Tc tracers and was lower than for the (68)Ga-labeled and
182 2% of participating sites limited their (99m)Tc/(99)Mo generator purchases, and 12% of them temporari
187 eveloped pan-MMP inhibitor-based tracer (99m)Tc-RYM1 displays favorable pharmacokinetics for early va
189 s: We studied 72 patients who underwent (99m)Tc-pyrophosphate SPECT/CT using a novel general-purpose
191 ported for renal cortical imaging using (99m)Tc-DMSA, leading to significant reductions in administer
192 ctive power of cell death imaging using (99m)Tc-duramycin with the current gold standard (18)F-FDG fo
195 y, SPECT measurements of MBF made using (99m)Tc-tetrofosmin were compared with PET in the same patien
196 dy, tumor perfusion was accessed using [(99m)Tc]NaTcO(4) and BB2r-targeted uptake evaluated by utiliz
197 hyldithiocarbamato)nitrido (99m)Tc(V)) ((99m)Tc-NOET) could allow (99m)Tc-sestamibi to be repurposed
198 udies are justified to evaluate whether (99m)Tc-ADAPT6 can be used as an imaging probe to stratify pa
199 2 ID/g with 10 mg/kg (p < 0.05)), while (99m)Tc-NOET retention (0.93 +/- 0.16 ID/g) was unaffected.
203 al cerebral blood flow using SPECT with (99m)Tc-labeled hexamethylpropyleneamine oxime ((99m)Tc-HMPAO
204 dual isotope imaging was performed with (99m)Tc-RP805 and (201)Tl along with contrast cineCT to asses
205 regional myocardial MMP activation with (99m)Tc-RP805 and dynamic (201)Tl for determination of myocar
207 Our aim was to describe results with (99m)Tc-tilmanocept in a heterogeneous group of breast cancer
210 tform, we report herein the development of a Tc goat system expressing human polyclonal antibodies in
211 ounterparts), Ce (an actinide analog), Re (a Tc analog), bentonite particles, and fluorescent dye tra
212 oxide like hematite at pH 6.00 +/- 0.07, and Tc(IV) incorporation into magnetite via Fe(III) substitu
213 library of the Tc(I) [fac-Tc(CO)(3)](+) and Tc(II, IV, V, VII) compounds was generated and applied t
216 tudy, we compared the distribution of Th and Tc cell subsets between blood and RM compartments in 62
217 erved similar tissue distributions of Th and Tc cell subsets, although Tc17 cell frequencies in both
219 g to give a magnetically ordered phase below Tc = 105 K, one of the highest reported ordering tempera
220 ium obtained from CD3 bead-isolated T cells (Tc CM) but not from those isolated without CD3 beads.
224 ty of CD4 T helper (Th) and CD8 T cytotoxic (Tc) cell subsets in the rectal mucosa (RM), a major site
227 chnetium-labeled cardiac scintigraphy (i.e., Tc-PYP scan) has been repurposed for the diagnosis of tr
230 e, a spectroscopic library of the Tc(I) [fac-Tc(CO)(3)](+) and Tc(II, IV, V, VII) compounds was gener
233 uptake mechanism involves the reduction from Tc(VII) to Tc(IV) and subsequent inner-sphere complexati
234 ive vaccines, passive countermeasures (e.g., Tc bovine), and as a means to produce more potent DNA-la
236 e recent discovery of a second class of high-Tc materials, Fe-based superconductors, may provide anot
238 lution in the form of poorly soluble hydrous Tc(IV)-oxides or Tc(IV)-sulfides during the development
239 tion due to rapid reoxidation of immobilized Tc, and competing comingled contaminants, e.g., Cr(VI),
242 led contaminants, e.g., Cr(VI), that inhibit Tc(VII) reduction and incorporation into stable mineral
245 bsequent inner-sphere complexation of Tc(IV)-Tc(IV) dimers onto a Fe oxide like hematite at pH 6.00 +
246 gnet applications are still dominated by low-Tc Nb3Sn due probably to cost and processing issues.
247 cer trap line built by genome editing marked Tc-foxQ2 positive neurons, which projected through the p
248 w in atomic detail a fully assembled 1.7-MDa Tc holotoxin complex from Photorhabdus luminescens in th
249 etion of PGE(2), IL-1beta, and IL-6 in MDP + Tc CM-activated monocytes, whereas recombinant GPIbalpha
254 and subsequent inner-sphere complexation of Tc(IV)-Tc(IV) dimers onto a Fe oxide like hematite at pH
256 we compare the architecture and function of Tc toxins with those of anthrax toxin and vertebrate ten
258 These findings emphasize the importance of Tc cattle in the production of nonimmunogenic MAbs and h
262 cells (PBMC) and the sera, respectively, of Tc caprine demonstrated the successful expression of hum
263 d for chemical composition and speciation of Tc using (99)Tc nuclear magnetic resonance spectroscopy
264 We characterized four distinct types of Tc-foxQ2 positive neural progenitor cells based on diffe
265 confirm that SCU-102 represents the optimal Tc scavenger with the highest reported clean-up efficien
266 fferential co-expression with Tc-six3/optix, Tc-six4, Tc-chx/vsx, Tc-nkx2.1/scro, Tc-ey, Tc-rx and Tc
267 m of poorly soluble hydrous Tc(IV)-oxides or Tc(IV)-sulfides during the development of reducing condi
272 l co-expression with Tc-six3/optix, Tc-six4, Tc-chx/vsx, Tc-nkx2.1/scro, Tc-ey, Tc-rx and Tc-fez1.
279 remobilization and were more resistant than Tc(IV) produced via biostimulation with an acetate/lacta
281 shment of herds, therefore complementing the Tc cattle platform in responses to a range of medical ne
286 is objective, a spectroscopic library of the Tc(I) [fac-Tc(CO)(3)](+) and Tc(II, IV, V, VII) compound
289 anism involves the reduction from Tc(VII) to Tc(IV) and subsequent inner-sphere complexation of Tc(IV
290 utralizing antibodies in a transchromosomic (Tc) bovine for use as a passive immunoprophylactic.
291 our previously established transchromosomic (Tc) cattle platform, we report herein the development of
292 MAb), 53C10, isolated from transchromosomic (Tc) cattle exhibits potent neutralization and hemaggluti
293 In the present study, transchromosomic (Tc) cattle were used for the generation of nonimmunogeni
295 tank waste is composed of several low-valent Tc species, including the Tc(I) [fac-Tc(CO)(3)](+) and T
297 line solutions typifying Hanford tank waste, Tc exists as pertechnetate (TcO(4)(-)) (oxidation state
298 lls based on differential co-expression with Tc-six3/optix, Tc-six4, Tc-chx/vsx, Tc-nkx2.1/scro, Tc-e
300 high electronegativities for Mn, Co, Ni, Zn, Tc, Cd, Hg (affected by choice of valence state), and Gd