ライフサイエンスコーパス: Tfh cell

1 ivity are increased in efficient cTfh2-17/GC-Tfh cells.

2 to provide static and dynamic information on Tfh cells.

3 ut-homing alpha4beta7 integrin expression on Tfh cells.

4 elated to an effect on PD-L1(hi) B cells and Tfh cells.

5 the presence of IL-12 and IL-21 to generate TFH cells.

6 -1 included TFR cells in their definition of TFH cells.

7 ulating Tfr cells, leading to suppression of Tfh cells.

8 a cell type with properties of both Treg and TFH cells.

9 tigen uptake and antigen presentation to the Tfh cells.

10 irements for their differentiation: Th17 and Tfh cells.

11 ated interference increased the frequency of TFH cells.

12 and influenced the functional properties of Tfh cells.

13 aring of CTLA-4 and more potent targeting of Tfh cells.

14 tor Bach2 as a central negative regulator of Tfh cells.

15 of public TCRbeta clonotypes in circulating Tfh cells.

16 c germinal center B cell production required Tfh cells.

17 ally and clonally similar to germinal center Tfh cells.

18 er the GCs to control/eliminate HIV-infected Tfh cells.

19 om lymph nodes into the blood as circulating Tfh cells.

20 cell follicles, where they can interact with Tfh cells.

21 in germinal center (GC) T follicular helper (Tfh) cells.

22 s, including defects in T follicular helper (Tfh) cells.

23 ion and accumulation of T follicular helper (TFH) cells.

24 nment, including CD4(+) T follicular helper (Tfh) cells.

25 ncreased recruitment of T follicular helper (TFH) cells.

26 +) T cell subset called T follicular helper (Tfh) cells.

27 ting "help" from follicular helper CD4(+) T (Tfh) cells.

28 en-specific B cells and T follicular helper (Tfh) cells.

29 rafollicular CD4(+) and follicular T helper (Tfh) cells.

30 .8% after therapy), and decreased numbers of Tfh cells (12% +/- 1.3% before therapy vs 8% +/- 0.9% af

31 sting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and

32 In mice, TFH cells accordingly promote B cell infiltration into t

33 T cells did not affect T follicular helper (Tfh) cell accumulation unless IL-6R-deficient T cells we

34 T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal d

35 Added to TFH cell and B-cell cocultures, they inhibited B-cell di

36 ells modulated IL-21 receptor expressions on TFH cells and B cells, and their suppressive activities

37 tion promotes caspase-mediated pyroptosis of Tfh cells and controls the development of pathogenic ICO

38 low numbers of activated T cells, including Tfh cells and decreased amounts of intestinal IgA and IL

39 We first assessed miRNA expression in TFH cells and defined a TFH-specific miRNA signature.

40 nizations, and the putative central roles of Tfh cells and GC in the generation of HIV bnAbs.

41 deficiency induces excessive development of TFH cells and GC responses in a T-cell-intrinsic manner.

42 ficient in IL-13 showed decreased numbers of Tfh cells and germinal center B cells and produced signi

43 ndicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate

44 ETV5 expression is derepressed in Cic null TFH cells and knockdown of Etv5 suppresses the enhanced

45 mas, engages the inhibitory receptor BTLA on Tfh cells and loss of HVEM leads to exaggerated T cell h

46 required for appropriate ICOS expression in Tfh cells and provides a competitive advantage for Tfh a

47 evidenced by reduced expression of CD40L on Tfh cells and reduced B cell proliferation in treated mi

48 e observed the development of IL-4-producing TFH cells and TH2 cells in draining lymph nodes after ai

49 cells, which is essential for the homing of Tfh cells and the development of B cell follicles.

50 ifficulty of quantifying antigen-specific GC Tfh cells and the difficulty of tracking GC in human and

51 This vaccine enhanced the numbers of Tfh cells and the GC responses, resulting in upregulated

52 receptor restricts the expansion of aberrant Tfh cells and the generation of self-reactive antibodies

53 d carry important implications for targeting Tfh cells and/or B cells therapeutically.

54 te interactions between T follicular helper (Tfh) cells and B cells are essential for promoting prote

55 induced higher rates of T follicular helper (Tfh) cells and germinal center (GC) B cells from drainin

56 criptional regulator of T follicular helper (Tfh) cells and germinal center B cells.

57 to the hypothesis that T follicular helper (Tfh) cells and germinal centers (GC) play a critical rol

58 T follicular helper (TFH) cells and infiltrating stromal cells have been show

59 ive abundance of CD4(+) T follicular helper (Tfh) cells and regulatory T cells was selectively decrea

60 y T cells that suppress T follicular helper (Tfh) cells and the generation of high affinity antibody-

61 and a positive correlation between tonsillar TFH-cell and systemic IgG induction after LAIV.

62 owed more robust Id2 expression than that of TFH cells, and depletion of Id2 via RNA-mediated interfe

63 e highly dependent on the activity of CD4(+) Tfh cells, and may be constrained by host tolerance cont

64 frequencies of antigen-specific GC B cells, Tfh cells, and overall antigen-specific Ab after immuniz

65 s share some phenotypic characteristics with TFH cells, and studies that showed that TFH cells are hi

66 B cells, as well as to T follicular helper (TFH) cells, and directly regulates B cells and TFH in a

67 As Tfh cells are also required for the development of plasm

68 ly, our results indicate that IL-4-producing Tfh cells are central orchestrators of the type 2 immune

69 Differentiation and function of TFH cells are controlled by the master gene BCL6, but it

70 Tfh cells are essential for the formation and maintenanc

71 with TFH cells, and studies that showed that TFH cells are highly permissive to HIV-1 included TFR ce

72 en together, our data suggest that, although Tfh cells are more prone to harbor viral DNA, other func

73 rsely, in central regions of GC light zones, Tfh cells are much more static, forming long-lasting con

74 without affecting the protective function of Tfh cells are unknown.

75 T follicular helper (Tfh) cells are a specialized T cell subset that regulate

76 T follicular helper (Tfh) cells are essential for germinal center B cell resp

77 CD4(+) T follicular helper (Tfh) cells are essential for inducing efficient humoral

78 ent view is that CD4(+) T follicular helper (Tfh) cells are the main subset regulating autoreactive B

79 ector T cells including follicular helper T (Tfh) cells are the major producers of TLR7-induced IFN-g

80 evidence suggests that T follicular helper (Tfh) cells are the primary producer of IL-4 in the react

81 This paradox intimates Tfh cells as key pathologic effectors, consistent with a

82 (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4(+) T cells ne

83 work identified PD-1(+) follicular helper T (Tfh) cells as an important cellular compartment for vira

84 for differentiation of T follicular helper (TFH) cells, but not TH1 effectors, elicited by viral inf

85 Abnormal development of follicular helper T (TFH) cells can induce the GC response to self-antigens,

86 Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and

87 lated to that of CD4(+) T follicular helper (TFH) cells, CD8(+) T cell memory precursors and haematop

88 Therapy inhibited excessive accumulation of Tfh cells coexpressing IL-21 and IFN-gamma, and suppress

89 e cytokines showed a significant decrease in Tfh cells compared with in wild-type mice.

90 ession of Aiolos was elevated in Ag-specific TFH cells compared with that observed in non-TFH effecto

91 We further show that human Tfh cells comprise two effector states producing either

92 Here we show that a proportion of human TFH cells contain dense-core granules marked by chromogr

93 Here, we review current understanding of how Tfh cells contribute to the selection of GC B cells, wit

94 route had high Tfh cell counts in lymph nodes but low pTfh cell counts

95 r helper (pTfh) cell counts in blood but low Tfh cell counts in lymph nodes.

96 f tonsillar follicles and influenza-specific TFH-cell (CXCR5+CD57+CD4+ T cell) responses in children,

97 Besides lymphoid tissue-resident Tfh cells, CXCR5(+) circulating Tfh (cTfh) cells have be

98 Genetic depletion of Tfh cells decreased IgE antibody levels and protected mi

99 i) PD-1(hi) circulating T follicular helper (Tfh) cells decreased after rituximab treatment.

100 In these outer regions, Tfh cells demonstrate multiple interactions between each

101 t that deficient activities might impair the TFH cell-dependent control of humoral immunity and might

102 ate cellular responses, but their control of TFH cell-dependent humoral immune responses is unknown.

103 IL-21, a Tfh cell-derived cytokine, provides instructional cues f

104 duction, and autoantibodies, indicating that Tfh cell-derived IL-21 is critical for pathological B ce

105 Additionally, Tfh cell-derived IL-4 was required to maintain the Th2 r

106 T-cell homeostasis and negatively regulates TFH cell development and autoimmunity.

107 e sought to assess the role of Breg cells on TFH cell development and function.

108 upon allergen exposure play a major role in Tfh cell development, IgE Ab production, and initiation

109 r 9 and CD40 activation of B cells prevented TFH cell development.

110 I(hi) dendritic cells that are implicated in Tfh cell development.

111 te interactions, drives T follicular helper (Tfh) cell development in germinal centers (GCs).

112 responses, but inhibits T follicular helper (TFH) cell development.

113 demonstrate that Bach2 critically regulates Tfh cell differentiation and CD4(+) T cell memory.

114 Advances in the understanding of Tfh cell differentiation and function are discussed, as

115 LRBA deficiency reflects impaired control of TFH cell differentiation because of profoundly decreased

116 SFB induced PP Tfh cell differentiation by limiting the access of inter

117 cient regulatory T cells suppressed in vitro TFH cell differentiation in a CTLA4-dependent manner.

118 nd knockdown of Etv5 suppresses the enhanced TFH cell differentiation in Cic-deficient CD4(+) T cells

119 hat older people and aged mice have impaired Tfh cell differentiation upon vaccination.

120 )-specific transcription factor Thpok during Tfh cell differentiation, GC formation, and antibody mat

121 e molecular mechanism underlying the initial Tfh cell differentiation, however, is still incompletely

122 pression of TFH cell motility, alteration of TFH cell differentiation, reduced TFH abundance and supp

123 e, the role of miR-31 is restricted to human TFH cell differentiation, reflecting a species specifici

124 ription factor Bach2 results in preferential Tfh cell differentiation.

125 with Bcl6 to mediate the effect of Thpok on Tfh cell differentiation.

126 g that Etv5 is a critical CIC target gene in TFH cell differentiation.

127 y regulating Id3 to restrain germinal center TFH cell differentiation.

128 dentified activin A as a potent regulator of TFH cell differentiation.

129 , which is known to promote Th1 and suppress Tfh cell differentiation.

130 lyses included in vitro follicular helper T (TFH) cell differentiation and cTFH/naive B-cell cocultur

131 e composed of two distinct areas in terms of Tfh cell distribution and migration.

132 CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage

133 rstand the contribution of these circulating Tfh cells during human immune responses.

134 this article, we summarize the role of human Tfh cells during humoral immune responses and discuss th

135 ortant insights into the development of CD4+ Tfh cells during Plasmodium infection and highlights the

136 nsable for the expansion of antigen-specific Tfh cells during vaccination.

137 IL-21 and IFN-gamma are coexpressed by Tfh cells during viral infections, but transcriptional r

138 ing PD1, TIM3, LAG3, and TIGIT, resulting in TFH cell dysfunction.

139 , we show that in vivo, despite enhanced non-Tfh cell effector functions, the deletion of transcripti

140 sialic acid binding activity, with limiting Tfh cell elicitation a potential constraint to the induc

141 It has long been debated whether Tfh cells exit from lymph nodes into the blood as circul

142 or raptor deletion ameliorates the aberrant TFH cell expansion in mice lacking Def6.

143 helper (TFH) cells, is critical as aberrant TFH cell expansion is associated with autoimmune disease

144 pted as being important for the induction of Tfh cell fate decision, other molecules may play key rol

145 onal induction of Irf4 expression redirected Tfh cell fate trajectories toward those of Teff.

146 In TFH cells, Fgl2 induces the expression of Prdm1 and a pa

147 The possibility of targeting Tfh cells for the treatment of GC-derived lymphomas is d

148 a) demonstrated a more diverse repertoire of TFH cells from female CKO mice than of those from wild-t

149 In contrast, Tfh cells from IL-6R-cKO-infected mice exhibited reduced

150 Circulating Tfh cells from patients with systemic lupus erythematosu

151 This diverted Tfh cells from systemic (non-gut) inflamed sites such as

152 es, which are known to antagonize peripheral Tfh cell function.

153 mulatory signaling in human regulatory T and Tfh cells, further informing on its potential use in dis

154 d to CTLA-4-Ig led to superior inhibition of Tfh cell, germinal center, and DSA responses in vivo and

155 entification of a circulating counterpart of Tfh cells has allowed us to better understand the contri

156 T follicular helper (TFH) cells have been shown to be critically required for

157 ary lymphoid follicles, follicular helper T (TFH) cells have previously been shown to be highly permi

158 nd is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN-gamma production and for promotio

159 ch2 regulates the transcriptional network of Tfh cells in a different way, as in GC B cells.

160 We sought to investigate the roles of TFH cells in allergic immune responses.

161 restingly, OX40 was coexpressed with ICOS on Tfh cells in and around the GC, and ICOS-ICOSL interacti

162 Here we develop mathematical models of Tfh cells in germinal centers to explicitly define the m

163 (AIM) methodology to identify Ag-specific GC Tfh cells in human lymphoid tissue.

164 juvants is a rational approach for enhancing Tfh cells in humans, thereby supporting the long-lived h

165 n are discussed, as are the understanding of Tfh cells in infectious diseases, vaccines, autoimmune d

166 However the role of TFH cells in LAIV-induced immune responses is unknown.

167 , demonstrate an important role of tonsillar TFH cells in LAIV-induced immunity in humans.

168 ir numbers correlating with the magnitude of Tfh cells in lymphoid tissues.

169 thors show that Def6 limits proliferation of TFH cells in mice via alteration of mTORC1 signaling and

170 ne responses and discuss the contribution of Tfh cells in promoting immunity to influenza viruses in

171 Thus, TFH cells in the B cell follicle progressively different

172 This includes discussion of Tfh cells in the human immune system.

173 mount of antigen they capture and present to Tfh cells in the light zone.

174 A great deal has been learned about Tfh cells in the past 10 years, particularly regarding t

175 These findings suggest a role for Tfh cells in the pathogenesis of human T1D and carry imp

176 Despite the central role of Tfh cells in vaccine responses, there is currently no va

177 lity, restricted expansion of antigen-pulsed Tfh cells in vitro, and possessed a unique gene expressi

178 T follicular helper (Tfh) cells in germinal centers of secondary lymphoid org

179 repertoire of different follicular helper T (Tfh) cells in germinal centers.

180 ted B-cell receptors by follicular helper T (TFH) cells in germinal centres.

181 from mucosal sites and T follicular helper (Tfh) cells in lymph nodes are thought to facilitate spec

182 r, naive mice developed T follicular helper (Tfh) cells in their lung draining lymph nodes and produc

183 (+) T cells, especially T follicular helper (Tfh) cells, in HIV-infected lymph nodes.

184 o be selective for Treg, Th1, Th2, Th17, and Tfh cells, including CD194 (CCR4)(+)FOXP3(+) Treg and CD

185 Gene expression analysis revealed that Tfh cells induce Myc expression in light-zone B cells in

186 endritic cells (DCs) in T follicular helper (Tfh)-cell induction, a T-cell subset critically implicat

187 latory OX40L (OX40 ligand)-OX40 axis reduced Tfh-cell induction by control lung cDC2s.Conclusions: In

188 Increased Tfh-cell induction by COPD cDC2s correlated with increas

189 (-) (Tfh1) subset bias was observed among GC Tfh cells infiltrating the pancreas of NOD mice, which w

190 differentiation (CD) 4+ T follicular helper (Tfh) cells interact with B cells in the germinal centers

191 rol naive B and cognate T follicular helper (Tfh) cell interaction and initiation of the GC reaction.

192 the impact of HIV antigenemia on B cells and Tfh cell interactions warrants further exploration.

193 fector cells, as the biological role of a GC Tfh cell is to provide help to individual B cells within

194 on, generating balanced responses of Th1 and Tfh cells is important to induce effective cell-mediated

195 CXCR5(+)PD-1(+)ICOS(+)-activated circulating Tfh cells is increased both in children with newly diagn

196 e regulatory network in GC B cells, Bach2 in Tfh cells is not coexpressed with Bcl-6 at high levels t

197 Kdelta activity in donor T cells that become Tfh cells is required for cGVHD in a nonsclerodermatous

198 stinal helminth infection, IL-4 derived from Tfh cells is required for IgE class switching and plasma

199 lar migratory behavior is performed by human Tfh cells is unclear, as technology to track them in sit

200 However, while preferential infection of Tfh cells is widely thought to create an important viral

201 ranscription factor for T follicular helper (TFH) cells, is critical as aberrant TFH cell expansion i

202 A new T-cell subset, follicular helper T (TFH) cells, is specialized in supporting B-cell maturati

203 ed the interaction between MZB cells and pre-TFH cells, leading to PDL1-mediated suppression of TFH c

204 genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6, Tcf7 and Cxcr5.

205 eukin 2 to CD4(+) T cells, thereby enhancing Tfh cell master regulator Bcl-6 in a dendritic cell-depe

206 Human Breg cells control TFH cell maturation, expand follicular regulatory T cell

207 on stimulated human T cells, characterizing TFH cell maturation.

208 Cytokine production by GC Tfh cells may be intrinsically limited in comparison wit

209 llicular regulatory T cells, and inhibit the TFH cell-mediated antibody secretion.

210 ely impaired CD4(+) T cell memory, including Tfh cell memory.

211 In the outer GC light zones, Tfh cells migrate actively and with a high ability to fo

212 our knowledge, the dynamic behavior whereby Tfh cells migrate in human GC and highlight the heteroge

213 proliferative response of human preexisting Tfh cells more efficiently than belatacept.

214 lls, leading to PDL1-mediated suppression of TFH cell motility, alteration of TFH cell differentiatio

215 GC and highlight the heterogeneity of GC for Tfh cell motility.

216 +) T cells resulted in a marked reduction in TFH cell numbers and IgE antibody levels, but type 2 cyt

217 ays, attended by significant upregulation of Tfh cell numbers that altogether might explain the obser

218 ons between B cells and follicular helper T (Tfh) cells occurring in lymphoid germinal centers.

219 tion expansion of follicular helper T cells (TFH cells) occurs in patients with lupus.

220 found to be polyclonal and related to GFP(-)Tfh cells of Peyer's Patches in TCR repertoire compositi

221 une responses toward antibody production via Tfh cells or inflammation by Teff cells.

222 7-producing Th17 cells, follicular T helper (Tfh) cells, or regulatory T (Treg) cells.

223 Follicular Th (Tfh) cells orchestrate physiological germinal center (GC

224 ), and positive correlations with numbers of Tfh cells (P = .03) and serum levels of cryoglobulin (P

225 4+CXCR5+interleukin 21+ follicular T-helper (Tfh) cells (P < .01).

226 , the transcriptional network sustaining the Tfh cell phenotype and function is still incompletely un

227 Tfh cells play a key role in peanut allergy, and the IL-

228 Each can promote antibody responses but Tfh cells play critical roles during germinal center (GC

229 TFH cells play critical roles in the regulation of IgE a

230 T follicular helper (Tfh) cells play a very important role in mounting a humo

231 essive expansion of the T follicular helper (TFH) cell pool is associated with autoimmune disease and

232 ubsets, including similarity between Th1-Th2-Tfh cell populations and Th17 cells, as well as similari

233 the differentiation of T follicular helper (TFH) cell populations.

234 cluster-independent increase of follicular (TFH) cells potentially driving the known expansion of B

235 As Tfh cells predominantly reside within B cell follicles i

236 ral pathways and genes related to DC-induced Tfh-cell priming.

237 have impeded our understanding of the GC and Tfh-cell processes involved in bnAb generation, includin

238 TFH cells produce high amounts of dopamine and release i

239 T-bet is important for Tfh cell production of IFN-gamma, but not IL-21, and for

240 OX40 deficiency in Tfh cells profoundly impaired the acquisition of germina

241 re efficiently induced key regulators of the Tfh cell program and influenced the functional propertie

242 Here, we examined the mechanisms whereby Tfh cells program the number of GC B cell divisions.

243 Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival

244 ne, high-affinity T cells and XCR1(+) DCs or Tfh cell-prone, low-affinity T cells and SIRPa(+) DCs po

245 Follicular T helper (TFH) cells provide B-cell help and are crucial for gener

246 CXCR5(+) T follicular helper (Tfh) cells provide help to B cells, are essential for th

247 These CD8(+) Tfh cells regulate the germinal center B cell response a

248 riguingly, this suggests that broadening the Tfh cell repertoire by vaccination may speed up the evol

249 ey can be rescued by a large fraction of the Tfh cell repertoire in the germinal center.

250 the Tfh cell response or the breadth of the Tfh cell repertoire markedly facilitates the evolution o

251 ereby modulated antigen presentation and the TFH cell repertoire to contribute to autoimmunity.

252 6 (BCL6; the master transcription factor for Tfh cells) represses HIV infection of tonsillar CD4(+) T

253 We studied antigen-specific CD4+ Tfh cells responding to Plasmodium infection in order to

254 that age-associated defects in the cDC2 and Tfh cell response are not irreversible and can be enhanc

255 With advancing age the GC and Tfh cell response declines, resulting in impaired humora

256 e sought to discover what underpins the poor Tfh cell response in ageing and whether it is possible t

257 ce did not generate an excessive primary CD4 TFH cell response nor an enhanced alloantibody reaction.

258 Increasing either the magnitude of the Tfh cell response or the breadth of the Tfh cell reperto

259 tibody production and antigen-specific B and Tfh cell responses.

260 CoV-2-specific GC B and T follicular helper (Tfh) cell responses as well as LLPCs and MBCs.

261 tem-specific B cell and T follicular helper (Tfh) cell responses in the context of influenza infectio

262 We measured influenza-specific TFH-cell responses after LAIV by flow cytometry and immu

263 ic salivary IgA concentrations and tonsillar TFH-cell responses, and a positive correlation between t

264 Ectopic overexpression of Bach2 in murine Tfh cells resulted in a rapid loss of their phenotype an

265 n CD8 T cells leads to an increase of CD8(+) Tfh cells, resulting in the breakdown of B cell toleranc

266 l center (GC)-promoting T follicular helper (Tfh) cells, resulting in cGVHD.

267 CD8(+) Tfh cells share similar gene signatures with CD4(+) Tfh,

268 C B cells, with a particular emphasis on how Tfh cell signals may contribute to lymphomagenesis.

269 In contrast to PD-1(+) Tfh cells, SIV-enriched CTLA-4(+)PD-1(-) CD4(+) T cells

270 This CTLA-4-dependent inhibition was Tfh cell specific in that CTLA-4 expression by Tfh cells

271 thermore, formation of memory TH1 and memory TFH cells strongly depended on Tcf1 long isoforms.

272 The T follicular helper (Tfh) cell subset of CD4(+) Th cells promotes affinity ma

273 viously included in the follicular helper T (TFH) cell subset, which consists of cells that are highl

274 n of humoral responses: T follicular helper (Tfh) cells support germinal center formation and provide

275 Follicular helper T (TFH) cells support terminal B-cell differentiation.

276 LRBA-deficient TFH cells supported in vitro antibody production by naiv

277 TFH cells supported the sustained production of IgE anti

278 40L and chromogranin B granules at the human TFH cell synapse and increases the synapse area.

279 uately supported Bcl6 and ICOS expression in TFH cells, Tcf1 long isoforms remained important for sup

280 d phenotype and reduced the diversity of the TFH cell TCR repertoire.

281 ly capturing and presenting more peptides to Tfh cells than other lineages of more specific B cells.

282 in mice, we show that OX40 was expressed on Tfh cells that accumulated at the T/B borders in the whi

283 les, we identify a population of circulating Tfh cells that are transcriptionally and clonally simila

284 eA, can induce abnormal T follicular helper (Tfh) cells that are able to kill B cells.

285 nown to be regulated by follicular helper T (TfH) cells, the mechanism by which B cells initially see

286 e P2X7 receptor as a checkpoint regulator of Tfh cells; thus, restoring P2X7 activity in SLE patients

287 encing was performed using TCR-stimulated GC Tfh cells to identify candidate markers.

288 find that TFR cells are more permissive than TFH cells to R5-tropic HIV-1 ex vivo TFR cells expressed

289 by signals delivered by follicular helper T (Tfh) cells to B cells.

290 Interleukin-4 high (IL-4(hi)) FL-TFH cells, unlike FL B cells themselves, triggered CXCL1

291 STAT4, phosphorylated in Tfh cells upon infection, is required for expression of

292 aboration by HIF-deficient in vivo-generated Tfh cells was impaired.

293 h cell specific in that CTLA-4 expression by Tfh cells was necessary and sufficient for the improved

294 l trial of vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an

295 GFP(+)Tfh cells were found to be polyclonal and related to GFP

296 A large number of follicular helper T (Tfh) cells were also detected in draining lymph nodes of

297 could be corrected when follicular helper T (Tfh) cells were induced before macrophage ablation or wh

298 naive T cells to become T follicular helper (Tfh) cells, whereas higher-affinity TCRs promoted the fo

299 y impaired formation of follicular helper T (Tfh) cells, which are essential for humoral immunity.

300 of cognate peptides to follicular helper T (Tfh) cells, which provide survival signals to the B cell