ライフサイエンスコーパス: Tg mice

1 elia of the digestive tract (K14 HPV49 E6/E7-Tg mice).

2 xpression in the airway epithelium of Scnn1b-Tg mice.

3 between AD-tau, CBD-tau, and PSP-tau in non-Tg mice.

4 sufficient to rescue the memory deficits in Tg mice.

5 om db/db mice and normalized in db/dbhnRNP F-Tg mice.

6 ial remodeling and development of AF in CREM-TG mice.

7 ncreased collagen and glycogen deposition in TG mice.

8 on, and the formation of anti-tau Abs in tau-tg mice.

9 irway hyperresponsiveness in juvenile Scnn1b-Tg mice.

10 mediated gene transfer to the brain of P301S-tg mice.

11 tokines in kidneys of cisplatin-treated MIOX-TG mice.

12 compared with mice not fed feces from REG3A-TG mice.

13 cits and decreased subsequent plaque load in Tg mice.

14 ,25(OH)(2)D(3) in the distal intestine of KO/TG mice.

15 hages in white adipose tissue of wt and AhRR Tg mice.

16 s remained unchanged in the hearts of female Tg mice.

17 al sensory responses in the barrel cortex of Tg mice.

18 lutamate respiration rates were decreased in TG mice.

19 d trabecular bone in control mice but not in Tg mice.

20 pon intracerebral inoculation into young APP tg mice.

21 ated in the lung tissue of C57/BL6J-betaENaC-Tg mice.

22 didymal adipose tissue from both wt and AhRR Tg mice.

23 significantly increased in the Col1a1-Menin-Tg mice.

24 , mucus obstruction, and emphysema in Scnn1b-Tg mice.

25 y to undergo developmental metaplasticity in Tg mice.

26 ses similar to those of PAO1-infected Scnn1b-Tg mice.

27 o, RPTC apoptosis and urinary RPTCs than non-Tg mice.

28 eased expression of IBA1 in the wt and gp120-tg mice.

29 n the hippocampi of TDF-treated wt and gp120-tg mice.

30 ccompanied the increased CAC in Villin-Cld-1-Tg mice.

31 y, learning ability, and memory retention in TG mice.

32 hages following infliximab treatment in hTNF-Tg mice.

33 uced allergen-induced inflammation in Scnn1b-Tg mice.

34 scued NKT cell development in IkappaBDeltaN (tg) mice.

35 female Tsc1 (tg) mice, but not in male Tsc1 (tg) mice.

36 r (stg/stg) but not homozygous tottering (tg/tg) mice.

37 rast, mTORC2 signaling was enhanced in Tsc1 (tg) mice.

38 itracer PET imaging in transgenic APPPS1-21 (TG) mice.

39 the CD4(+) population of Grb2(fl/fl) CD4cre(tg) mice.

40 ncreased in lymphocytes of autoimmune ApoA-I(tg) mice.

41 and autoantibodies were also lower in ApoA-I(tg) mice.

42 renal injury in diabetic Hnrnpf-transgenic (Tg) mice.

43 y using GFP-LC3 and mRFP-GFP-LC3 transgenic (Tg) mice.

44 pithelial Na(+) channel (Scnn1b)-transgenic (Tg) mice.

45 IL-33(KO)/Tg+ mice compared with IL-33(HET)/Tg+ mice.

46 ompared with IL-33 heterozygous (IL-33(HET)) Tg+ mice.

47 (ApoA-I(-/-)) and ApoA-I-transgenic (ApoA-I(tg)) mice.

48 man dipeptidyl peptidase 4 transgenic (hDPP4 Tg+) mice.

49 nses, and delayed bacterial clearance in SHS-Tg(+) mice.

50 We found that in young Tg mice (1 month), LTP is enhanced at the expense of LTD

51 In Tg mice, 2 different strains of hSOD1 aggregates (denote

52 Nox4 transgene but Cre positive; (2) c-hNox4 Tg mice; (3) angiotensin II (AngII)-infused control mice

53 rease in the incidence of lung metastases in Tg mice (33.3%) compared to WT mice (62.5%).

54 were entirely mimicked in young CaMKIIdelta TG mice (6-8 weeks) where no overt cardiac dysfunction w

55 atal Abeta precursor protein transgenic (APP tg) mice, Abeta deposition emerged in HSCs when cultures

56 depletion of C/EBPbeta from human alpha-Syn Tg mice abolishes rotenone-elicited PD pathologies and m

57 oproline, Gly, and Glu) were altered in UCP3 Tg mice across all training and exercise conditions; and

58 n changes in body weight of the WT and Cld-1 Tg mice after being fed with 2.5% DSS were measured ever

59 es the beneficial effects observed in hCOX-2-Tg mice against IRI due to a preconditioning-derived inc

60 lm-grown rather than planktonic PAO1; Scnn1b-Tg mice also cleared infections more slowly than their w

61 Primary tumors isolated from Tg mice also demonstrated reduced total and mitochondria

62 The female Tg mice also failed to develop myocardial hypertrophy.

63 mportantly, T cells from HBZ transgenic (HBZ-Tg) mice also demonstrate enhanced cell proliferation an

64 As compared with IL-33(HET)/Tg+ mice, although the IL-33(KO)/Tg+ mice had significan

65 us of patients with AD and 5XFAD transgenic (TG) mice, an animal model of AD.

66 etention) in old Tg mice compared with young Tg mice and all WT mice.

67 Additionally, saliva collected from TG mice and containing unpurified hNGF was able to signi

68 used and germ-free mice fed feces from REG3A-TG mice and given DSS developed less-severe forms of col

69 the altered remote memory recall in COMT-Val-tg mice and increased PFC dopamine levels.

70 ccessfully purified from the saliva of these TG mice and its identity was verified.

71 sion was also downregulated in c-rel-/- TCL1-Tg mice and RelA Thr505Ala mutant Emu-Myc mice.

72 reated once with brain extract from aged APP tg mice and the culture medium was continuously suppleme

73 Arthritis was induced in 8-week-old male tg mice and their wild-type (WT) littermates.

74 We then evaluated the responses of Tg mice and their WT littermates to the Food and Drug Ad

75 We intranasally infected Scnn1b-Tg mice and wild-type littermates with the laboratory P.

76 itional MIOX-overexpressing transgenic (MIOX-TG) mice and MIOX-knockout (MIOX(-/-)) mice with tubule-

77 ses in the barrel cortex of aged transgenic (Tg) mice and of age-matched non-transgenic littermate co

78 -related mutant human APP (hAPP) transgenic (Tg) mice and patient brains.

79 genic (Club cell 10-kDa protein [CC10]-IL-13 Tg) mice and wild-type littermates were used in this stu

80 ld Alzheimer's disease (AD)-like transgenic (Tg) mice and wildtype (WT) littermates with a single, wh

81 inducible overexpression of IL-13 (CC10-Il13(Tg) mice) and is overexpressed by esophageal eosinophils

82 e-brain uptake of (18)F-GE180 in both WT and Tg mice, and a significant increase in whole-brain uptak

83 ce, cardiac-specific SIRT2 transgenic (SIRT2-Tg) mice, and their respective littermates (8 to approxi

84 fold in the bone tissues of GILZ transgenic (Tg) mice, and this increase is coupled with a significan

85 ent tau strains occurs in nontransgenic (non-Tg) mice, and to investigate whether there are strain-sp

86 ndent dentin mineralization defects in Trps1-Tg mice are a result of downregulation of a group of pro

87 Tsc1 (tg) mice are more tolerant to exhaustive exercises and l

88 whereas Sike-overexpressing transgenic (Sike-TG) mice are protected from hypertrophic stimuli.

89 the human GLUT4 promoter (i.e., transgenic [TG] mice) are resistant to obesity-induced insulin resis

90 er, these results show the promise of Scnn1b-Tg mice as models of early P. aeruginosa colonization in

91 iac function in 2-month-old male transgenic (Tg) mice as evidenced by decreased ejection fraction, st

92 ted, aggregated tau in brain tissue of P301S-tg mice, associated with a decrease in detergent-soluble

93 disease progression in IRF4-deficient Tcl-1 tg mice, associated with a severe downregulation of gene

94 antially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol

95 iments with BAFF-deficient B6.Baff(-/-) Bcl2(Tg) mice, B cell-deficient B6.muMT mice, BAFF-overexpres

96 slocation in WT mice was exacerbated in MIOX-TG mice but absent in MIOX(-/-) mice.

97 Lung metastases were found in 75% of Sulf1-Tg mice but not in wild-type mice.

98 coded mitochondrial enzymes was decreased in TG mice but that mitochondrial number, size, and fatty a

99 ents confirmed that iNKT cells from Valpha14(Tg) mice but not from Vbeta8(Cg) mice were responsible f

100 span increased significantly in female Tsc1 (tg) mice, but not in male Tsc1 (tg) mice.

101 induced in another set of control and hREG3A-TG mice by administration of trinitrobenzene sulfonic ac

102 Scnn1b-Tg mice carried higher bacterial burdens when infected w

103 to wild-type (wt) and GFAP-gp120 transgenic (tg) mice caused peripheral neuropathy, as indicated by n

104 previously found that aging A53T transgenic (Tg) mice closely model PD-like ENS aSyn pathology, makin

105 d patterns of aberrant PAC in stg/stg and tg/tg mice compared to +/+ and stg/+ mice.

106 ked heterogeneous lung function in beta-ENaC-Tg mice compared to wild-type littermate controls; ident

107 capacity were significantly reduced in TWEAK-Tg mice compared with controls.

108 8)F-GE180 (peak-uptake and retention) in old Tg mice compared with young Tg mice and all WT mice.

109 erved dysbiosis in fecal samples from Hol(Tg/Tg) mice compared with feces from wild-type mice; fecal

110 ment, were somewhat exaggerated in IL-33(KO)/Tg+ mice compared with IL-33(HET)/Tg+ mice.

111 in the interictal EEG of both stg/stg and tg/tg mice, compared to +/+ and stg/+ mice.

112 ice, Ednrb(s-l//s-l) mice, and male TashT(Tg/Tg) mice, compared with control mice, but not Ret(9/-) m

113 he pulmonary phenotypes of C57/BL6J-betaENaC-Tg mice, consistent with the characteristics of human CO

114 that chromatin obtained from the adrenals of TG mice containing the intron conversion binds more stro

115 We found that TG mice containing the intron conversion have (a) increa

116 d (c) increased blood pressure compared with TG mice containing WT intron 2.

117 We generated humanized transgenic (TG) mice containing all the introns, exons, and 5'- and

118 ted to the catastrophic loss of insulin, hep-tg mice continued to have significantly lower blood gluc

119 H-2(k/b) double-Tg mice deficient of all endogenous Tcra genes, a defici

120 Compared to controls, IDO1-TG mice demonstrated an 85% reduction in ileal bacteria

121 ted to a controlled cortical impact, SynCav1 Tg mice demonstrated preserved hippocampus-dependent fea

122 TG mice demonstrated significant age-associated increase

123 Regardless of treatment, TG mice demonstrated significantly lower (18)F-FDG uptak

124 id and bisretinoid levels are normal in RBP4-Tg mice, demonstrating that a retinoid-independent mecha

125 CC10-IL-13 Tg mice developed considerable pulmonary tissue remodeli

126 Vpr-Tg mice developed increased liver triglyceride content a

127 etion of Bacteroidetes (Prevotellaceae); the TG mice developed less-severe colitis following administ

128 A higher proportion of NS5A Tg mice developed liver tumors (39%) than mice that did

129 ANA-12-treated Tg mice developed more gut aSyn aggregation as well as c

130 REG3A TG mice developed only mild colonic inflammation after e

131 We found that Tg and KO/Tg mice developed significantly smaller tumors than KO a

132 rast to our expectations, Grb2(fl/fl) CD4cre(tg) mice developed a milder form of EAE.

133 Unexpectedly, T-bet-tg mice died 2 to 3 weeks after infection due to failure

134 ion of collagen-induced arthritis (CIA), tau-tg mice displayed an increased incidence and an earlier

135 Lungs of STC1 Tg mice displayed none of the above changes.

136 In contrast, Diap3-Tg mice displayed worse thresholds than controls.

137 ked mucus obstruction and Th2 responses, SHS-Tg(+) mice displayed a dramatic suppression of these res

138 HuRANKL-Tg+ mice displayed lower limb force and maximal speed, w

139 The A-Tg+ and A-Tg++ mice displayed severe enamel defects in spite of th

140 nnel function in either wild-type (WT) or tg/tg mice does not induce the high-power state.

141 atives in skeletal muscle and plasma of UCP3 Tg mice (e.g., Asp, Glu, Lys, Tyr, Ser, Met) were signif

142 ntly prolonged mean survival times of Hol(Tg/Tg) mice, Ednrb(s-l//s-l) mice, and male TashT(Tg/Tg) mi

143 nthesizing enzyme SMP30 in C57/BL6J-betaENaC-Tg mice, exaggerated pulmonary phenotypes.

144 Already at steady-state conditions, tau-tg mice exhibit peripheral immune activation that is man

145 The female Tsc1 (tg) mice exhibit a higher fat to lean mass ratio at adva

146 These TG mice exhibited a physiologic-like cardiac hypertrophy

147 BMF-Tg mice exhibited higher systolic blood pressure, urinar

148 SynCav1 Tg mice exhibited increased hippocampal expression of Ca

149 hCOX-2-Tg mice exhibited lower grades of necrosis and inflammat

150 Furthermore, lungs from Tg mice exhibited nearly a 15-fold decrease in the avera

151 Whereas the FA-Tg(+) mice exhibited marked mucus obstruction and Th2 re

152 AhRR Tg mice express significantly higher levels of AhRR comp

153 A-Tg mice expressed A-antigen on vascular endothelium and

154 Similar to human placenta, placentas of Tg mice expressed APOL1.

155 We demonstrated that Tg mice expressing AID in the skin spontaneously develop

156 Both patients and Tg mice expressing mutant human SOD1 (hSOD1) develop agg

157 of horses to prions, we produced transgenic (Tg) mice expressing cognate PrP(C) Although disease tran

158 could be shortened, we generated transgenic (Tg) mice expressing guinea pig prion protein (GPPrP).

159 enhancement of cardiac function, transgenic (TG) mice expressing non-phosphorylatable TnI protein kin

160 Moreover, we found that in bones of NO66-TG mice, expression of Igf1, Igf1 receptor (Igf1r), runt

161 by PND22, the SHS-exposed Scnn1b-Tg(+) (SHS-Tg(+)) mice failed to resolve these infections.

162 In hFcgammaRIIB-transgenic (Tg) mice, FcgammaRIIB-blocking antibodies effectively de

163 after the HCFD (6%); only 9% of Tlr4-/- NS5A Tg mice fed HCFD developed liver tumors.

164 ase (eNOS) were significantly greater in the Tg mice fed NC than in WT mice, as they are during pregn

165 Livers from NS5A Tg mice fed the HCFD had increased levels of TLR4, NANOG

166 Conversely TDF protected gp120-tg mice from cognitive dysfunction.

167 al microbiota from REG3A-TG mice protect non-TG mice from induction of colitis.

168 80 metabolites accurately discriminated UCP3 Tg mice from WT when modeled within a specific exercise

169 By 12 weeks, male Tg mice had 22.2% and female Tg mice had 29.6% reduced t

170 12 weeks, male Tg mice had 22.2% and female Tg mice had 29.6% reduced trabecular bone volume (BV) co

171 ncreased number of dying osteocytes and male Tg mice had a trend for more empty lacunae.

172 Mmp20(+/+)Tg mice had decreased enamel organ cadherin levels compa

173 or neither developing in MR1(+/+) Valpha19i-Tg mice had disparate cytokine profiles in response to R

174 wild-type (WT) mice, cisplatin-treated MIOX-TG mice had even greater increases in urea, creatinine,

175 Female Tg mice had increased number of dying osteocytes and mal

176 ata3-tg mice remained resistant, while Gata3-tg mice had lower IFN-gamma and higher IL-4 production w

177 Fecal samples from REG3A-TG mice had lower levels of ROS than feces from control

178 well as constipation, whereas FTY720-treated Tg mice had reduced aSyn aggregation and less constipati

179 Osteogenic cultures from Tg mice had reduced differentiation and mineralization w

180 e Mmp20 expression and showed that Mmp20(+/+)Tg mice had soft enamel.

181 Similarly, MIOX-TG mice had the highest and MIOX(-/-) mice had the lowes

182 MIOX-TG mice had worsening renal functions with kidneys havin

183 ver, in contrast with FA-Tg(+) mice, the SHS-Tg(+) mice had pronounced epithelial necrosis, alveolar

184 Pf4-Lox(tg/tg) mice had a normal number of platelets; however, time

185 compared with IL-33(HET)/Tg+ mice, IL-33(KO)/Tg+ mice had complete absence of bronchoalveolar lavage

186 IL-33(HET)/Tg+ mice, although the IL-33(KO)/Tg+ mice had significantly reduced levels of MUC5AC prot

187 compared with IL-33(HET)/Tg+ mice, IL-33(KO)/Tg+ mice had significantly reduced levels of Th2-associa

188 enic (Tg) mice uncovered that the Pvalb/Gad1 Tg mice have pronounced sensorimotor gating deficits, in

189 Tsc1 (tg) mice have less fibrosis and inflammation in aged as

190 al microbiota occurred after a few months in TG mice heterozygous for REG3A that harbored a wild-type

191 ct metabolites were altered in liver of UCP3 Tg mice highlights that changes in muscle UCP3 activity

192 As compared with IL-33(HET)/Tg+ mice, IL-33(KO)/Tg+ mice had complete absence of bro

193 As compared with IL-33(HET)/Tg+ mice, IL-33(KO)/Tg+ mice had significantly reduced l

194 the axons of the glial lamina of aged E50K(-tg) mice in vivo.

195 -Trps1;Col1a1-Dspp double transgenic (double-Tg) mice in which Dspp was restored in odontoblasts over

196 jury was significantly shorter in Pf4-Lox(tg/tg) mice, indicating a higher propensity for thrombus fo

197 rated aganglionic colon epithelium of Hol(Tg/Tg) mice, inducing production of endogenous GDNF, and ne

198 We believe that APRIL Tg mice infected by Helicobacter species may represent a

199 In contrast, Scnn1b-Tg mice infected with a mucoid CF isolate carried high b

200 Scnn1b-Tg mice infected with nonmucoid early CF isolates mainta

201 ) was modeled by transplanting hearts from A-Tg mice into sensitized or nonsensitized WT mice.

202 CaMKIIdelta TG mice lacking deltaB exhibited more severe HF, eccentr

203 In CatA-TG mice, LV interstitial fibrosis formation was enhanced

204 ta levels and microglia activation in female Tg mice, modestly increased microhemorrhages in 50 cGy i

205 iation potential rendered Grb2(fl/fl) CD4cre(tg) mice more prone to inflammatory diseases, we used th

206 (+/+) and MR1(-/-) TCR Valpha19i-transgenic (Tg) mice, MR1 expression resulted in significantly incre

207 In TICs from NS5A Tg mice, NANOG and pSTAT3 directly interact to activate

208 In this study, we found that aged Tg mice of both sexes expressing human tau proteins harb

209 ersus WT mice, which were improved in ECIRS1 TG mice on normal chow or HF diet.

210 Scnn1b-Tg mice overexpress the epithelial Na(+) channel (ENaC)

211 Here we show that Tg mice overexpressing mutant human aSyn develop ENS pat

212 tected a significant age-related increase in TG mice (P < 0.0001) but did not detect the treatment-in

213 significantly decreased in fat-1 transgenic (TG) mice (P < 0.001), which exhibited decreased cyclooxy

214 f CD4(+) T cells occurred in H-2(k/k) double-Tg mice presenting high levels of the I-E(k)-restricted

215 de cells from L. major-infected BALB/c-CXCR3(Tg) mice produced more interleukin-4 (IL-4) and IL-10 an

216 At longer times both TAC and TG mice progressed to overt HF (at 45 days and 11-13 wee

217 Fecal microbiota from REG3A-TG mice protect non-TG mice from induction of colitis.

218 Wild-type (WT) and TG mice received vehicle or BACE inhibitor (60 mg/kg) st

219 pression of miR-338-5p in the hippocampus of TG mice reduced BACE1 expression, Abeta formation, and n

220 Long term oral FTY720 in Tg mice reduced ENS aSyn aggregation and constipation, e

221 (2+) channels, known to be upregulated in tg/tg mice, reduces the high-power state.

222 Obese Tg mice remained insulin sensitive, had increased glucos

223 In contrast, Gata3-tg mice remained resistant, while Gata3-tg mice had lowe

224 in the distal intestine of VDR null mice (KO/TG mice) results in the normalization of serum calcium a

225 quencing of the glomerular RNAs from msuPAR2-Tg mice revealed a differentially expressed gene signatu

226 The data from young and old Tg mice revealed FTY720-associated neuroprotection and r

227 nalysis of small intestine tissues from IDO1-TG mice revealed increases in secretory cells.

228 d from bigenic NIC-PRMT1 (Tg) and NIC-PRMT6 (Tg) mice revealed a deregulated PI3K-AKT pathway.

229 let-7 transgenic (let-7-Tg) mice show features of nonproliferative DR, including

230 Although hPER3-P415A/H417R-Tg mice showed a mild depression-like phenotype, Per3 kn

231 Moreover, hCOX-2-Tg mice showed a significant attenuation of the IRI-indu

232 EC-Glrx TG mice showed higher levels of VEGF-A in the tumors, in

233 C57/BL6J-betaENaC-Tg mice showed higher survival rates and key pulmonary a

234 Likewise, in vivo studies in GFAP-Tat tg mice showed increased autophagosome accumulation in n

235 In contrast, the GAPDH Tg mice showed resistance to all of these injury-induced

236 art-specific phosphodiesterase 2-transgenic (TG) mice showed a marked reduction in resting and in max

237 ls in draining lymph nodes from BALB/c-CXCR3(Tg) mice showed enhanced Th2 and reduced Th1 cell accumu

238 n level of transgenes, while the D-Tg+ and D-Tg++ mice showed minor to mild enamel defects, indicatin

239 abetic Akita mice +/- insulin implant, Akita Tg mice specifically overexpressing heterogeneous nuclea

240 were attenuated in db/dbhnRNP F-transgenic (Tg) mice specifically overexpressing hnRNP F in their RP

241 Transgenic mice (Tg) mice specifically overexpressing human BMF in RPTCs

242 Moreover, the male Tg mice spontaneously developed myocardial hypertrophy (

243 LB/c Rag2(-/-)Il2rg(-/-)Sirpa(NOD)Alb-uPA(tg/tg) mice, stably engrafted with human hepatocytes (HUHEP

244 Additionally, it offers a validated pair of Tg mice strains for characterizing the effect of shDPP4

245 f filtered air (FA)-exposed Scnn1b-Tg(+) (FA-Tg(+)) mice successfully cleared spontaneous bacterial i

246 kinase B (Akt) and H3K36me3 in bones of NO66-TG mice, suggesting an inverse correlation between NO66

247 lasts, osteoclasts, and marrow adipocytes in Tg mice, suggesting independence of EPO signaling in mat

248 an the hindbrain across the life span of the Tg mice, suggesting that sortilin, at least in part, inh

249 ehydrogenase activity were increased in UCP3 Tg mice, suggestive of a shift in tissue NADH/NAD(+) rat

250 ults demonstrate that expression of GPPrP in Tg mice supports the rapid propagation of BSE and vCJD p

251 Increased ApoA-I in ApoA-I(tg) mice suppressed CD4(+) T and B cell activation witho

252 In the brains of wt and gp120-tg mice, TDF decreased expression of mitochondrial trans

253 production became significantly less in the Tg mice than in WT mice.

254 nificantly higher in the lungs of CC10-IL-13 Tg mice than wild-type animals.

255 is article, we show that tau-transgenic (tau-tg) mice that develop neurodegenerative disease characte

256 However, in contrast with FA-Tg(+) mice, the SHS-Tg(+) mice had pronounced epithelial

257 Here, we utilized betaENaC-transgenic (Tg) mice, the previously established mouse model of seve

258 146a-deficient mice with 2D2 T cell receptor-Tg mice to generate 2D2 CD4 T cells that are deficient i

259 stions, we exposed Scnn1b transgenic (Scnn1b-Tg(+)) mice to SHS from postnatal day (PND) 3-21 and lun

260 Accordingly, Tg-C73A mice and non-Tg mice treated with dasatinib exhibited improved behavi

261 hTNF-Tg mice treated with infliximab demonstrated significant

262 havioral characterization of our transgenic (Tg) mice uncovered that the Pvalb/Gad1 Tg mice have pron

263 entative histological images of WT and Cld-1 Tg mice under DSS and DSS recovery protocol showing rege

264 Despite reduced angiogenesis, EC-Glrx TG mice unexpectedly developed larger tumors compared wi

265 ns and some primates, we created transgenic (Tg) mice using the promoter of nephrin-encoding Nphs1 to

266 s into different brain regions of female non-Tg mice, we demonstrated the induction and propagation o

267 ng Trps1-Tg and Col1a1-Dspp transgenic (Dspp-Tg) mice, we generated Col1a1-Trps1;Col1a1-Dspp double t

268 Intestinal mucus layers from IDO1-TG mice were 2-fold thicker than mucus layers from contr

269 urthermore, fasting acyl carnitines in obese TG mice were decreased, indicating that increased GLUT4-

270 When the Tg mice were fed chow containing IC3, plasma prolactin c

271 When the Tg mice were fed normal chow (NC), plasma prolactin conc

272 Wild-type and nSIRT1OE Tg mice were fed with either control diet (6.2% fat) or

273 However, we found that K14 HPV49 E6/E7-Tg mice were highly susceptible to upper digestive tract

274 Wild-type (WT) and APRIL Tg mice were infected with Helicobacter felis and Helico

275 fore AF onset) and old (TGo, after AF onset) TG mice were investigated by mRNA microarray profiling i

276 Females from both wt and AhRR Tg mice were less sensitive than male mice to acute toxi

277 Furthermore we found that male AhRR Tg mice were protected from high-dose TCDD-induced letha

278 n in response to ATII, whereas PGC-1alpha EC TG mice were protected.

279 A-transgenic (A-Tg) mice were assessed for A-antigen expression by histo

280 nd that T cell numbers in Grb2(fl/fl) CD4cre(tg) mice were normal in the thymus and were only slightl

281 Human TNF transgenic (hTNF-Tg) mice were treated with infliximab after development

282 Accordingly, IL-33 knockout (IL-33(KO)) Tg+ mice were examined and compared with IL-33 heterozyg

283 greater percentages of Treg cells in B6.Bcl2(Tg) mice (which harbor B cells largely independent of BA

284 ng the VE-cadherin promoter to create ECIRS1 TG mice, which elevated pAkt activation and expressions

285 Scnn1b transgenic (Scnn1b-Tg(+)) mice, which recapitulate cystic fibrosis-like muc

286 th human apoprotein A1-transgenic (APOA1 (tg/tg)) mice, which have elevated cholesterol-effluxing hig

287 Treatments of C57/BL6J-betaENaC-Tg mice with a serine protease inhibitor ONO-3403, a der

288 TNF-Tg mice with established disease were randomized to anti

289 TG mice with Hap -6A and -6G were treated with and witho

290 ncreased blood pressure and redox markers in TG mice with Hap-6A of the hAGT gene.

291 ohol Western diet-fed hepatitis C virus NS5A Tg mice with hepatocyte-specific TBC1D15 deficiency or e

292 tion of mast cells, prevented anaphylaxis in Tg mice with mast cells expressing human CD33, and desen

293 Treatment of adult Scnn1b-Tg mice with the IL-1R antagonist anakinra had protectiv

294 Using transgenic (Tg) mice with a neuronal promoter driving expression of

295 tor defect, but not homozygous tottering (tg/tg) mice with a P/Q type calcium channel mutation.

296 ype (WT), Fgf15(-/-) , and Fgf15 transgenic (TG) mice with BA levels modulated by feeding cholestyram

297 Here, we developed transgenic (Tg) mice with forebrain Camk2a-controlled doxycycline-su

298 wal versus differentiation, we bred Six2-TGC(tg) mice with VHL(lox/lox) mice to generate mice with a

299 Immunization of hDPP4 Tg+ mice with a single dose of rAd5-S1/F/CD40L elicited

300 let transcriptome was greatly altered in hep-tg mice, with >2,000 genes differentially expressed vers