ライフサイエンスコーパス: Tg mouse

1 D4(+) TCR transgenic mouse model system (ABM-tg mouse).

2 T cell deficiency observed in IkappaBDeltaN (tg) mouse.

3 eurons in the nigra of A53T transgenic (A53T-Tg) mouse.

4 a model of AD, the APPswe/PS1DE9 transgenic (Tg) mouse.

5 vivo, we generated an aP2-WISP2 transgenic (Tg) mouse.

6 b CD4 hybridoma were cloned to produce a TCR Tg mouse, 2-2-3.

7 A triple transgenic (Tg) mouse (3xTg-AD) was reported to develop Abeta plaque

8 surface expression of gp96 in a transgenic (Tg) mouse (96tm-Tg) conferred hyperresponsiveness to LPS

9 We used the tottering (tg/tg) mouse, a faithful animal model of EA2, to dissect th

10 , oxidation, and covalently linked dimers in tg mouse Abeta provides an explanation for the differenc

11 cnn1b gene, betaENaC protein) in transgenic (Tg) mouse airways dehydrates mucosal surfaces, producing

12 Dystrophic neurites in plaques of PDAPP tg mouse and AD formed synapses and contained many dense

13 orm of nitric oxide synthase (iNOS) from VCP TG mouse and by pharmacological inhibition of iNOS in is

14 that repression of Spry2 expression in TCL1-tg mouse and human B-cell lymphomas and cell lines is as

15 We used the Scnn1b-Tg mouse as a model of CF lung disease and determined ef

16 as significantly increased in the db/db eNOS-Tg mouse, as serum alanine aminotransaminase (ALT) level

17 n isoforms in BASE strain-infected humanized Tg mouse brains are different from those from the origin

18 no-associated virus particles in mutant hAPP Tg mouse brains decreases synaptic Abeta levels and amel

19 leukin (IL) 1beta and TNFalpha mRNA in gp120-tg mouse brains.

20 Similar to AD, neuritic plaques in PDAPP tg mouse contained a dense amyloid core surrounded by an

21 physiological environment of the BDC-2.5 TCR-Tg mouse, despite being apparently "naive" in surface ph

22 The transgenic Myo-Tg mouse develops hypertrophy and HF as a result of over

23 In intact heart study, the P2X4 receptor TG mouse exhibited significantly elevated basal cardiac

24 To address this issue, we developed a Tg mouse expressing a single-chain, membrane-bound anti-

25 f basal autophagy, we generated an inducible Tg mouse expressing autophagy-related 7 (Atg7), a critic

26 A transgenic (Tg) mouse expressing human IL-15 was generated to define

27 ite of Ag deposition acts to protect the TCR-Tg mouse from EAE.

28 ressing in L3-L5 DRG, T10-L1 DRG, NG/JG, and TG mouse ganglion neurons.

29 restoring the functional properties of LCAT-Tg mouse HDL and promoting the hepatic uptake of HDL-CE.

30 and regenerative pathways and found that the Tg mouse heart undergoes myocyte loss and regeneration,

31 The tamoxifen-treated TG mouse hearts also exhibited better functional recover

32 BC levels in the mitochondrial fractions of TG mouse hearts but no increase in alpha BC levels in an

33 t ischemia followed by reperfusion, the MKK6 TG mouse hearts exhibited significantly better functiona

34 muscles from the right ventricle of NTG and TG mouse hearts expressing ssTnI and measured isometric

35 age, tetracycline-transactivating factor/V1A-TG mouse hearts had reduced cardiac function, cardiac hy

36 n TG than non-transgenic (NTG) mouse hearts, TG mouse hearts were morphologically and functionally si

37 apillary muscle fibers from non-TG (NTG) and TG mouse hearts were used to measure tension, ATPase act

38 sible mechanisms of cardioprotection in MKK6 TG mouse hearts.

39 to their beta-TM counterparts in transgenic (TG) mouse hearts causes a depression in both +dP/dt and

40 cardiac fibre bundles from three transgenic (TG) mouse hearts in which 50, 92 and 6 % of the native c

41 were made in muscle fibers from transgenic (TG) mouse hearts that expressed a mutant alpha-Tm (Tm(H2

42 these roles, we have developed a transgenic (Tg) mouse in which all B lymphocytes produce only the me

43 cts, we generated Mecp2(WT_EGFP) transgenic (TG) mouse in which MeCP2 (endogenous plus TG) is mildly

44 issue, we generated a TGF-beta1-transgenic (Tg) mouse in which TGF-beta is linked to the IL-2 promot

45 nd beta-cell proliferation, were enhanced in TG mouse islets, without changes in Akt phosphorylation

46 iate their rapid degradation, was reduced in TG mouse islets.

47 We have generated a transgenic (Tg) mouse [keratin-14 (K14)-survivin] with skin expressi

48 Here, we developed a new TG mouse line in which the -800-base pair Rosa26 promote

49 A TG mouse line secreting high levels of hNGF protein in i

50 ed with green fluorescent protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau misloca

51 Foxa proteins, we used the T-77 transgenic (TG) mouse line in which the -3-kb transthyretin (TTR) pr

52 We previously developed a transgenic (TG) mouse line in which the ubiquitous Rosa26 promoter w

53 and its function, we generated a transgenic (TG) mouse line that expressed a recombinant chimeric cTn

54 of nephron number reduction in the Six2TGC(+/tg) mouse line.

55 Our Tg mouse lines also revealed a predominance of intracell

56 A-DRA-IE alpha was not detectable in several Tg mouse lines by flow cytometric analysis.

57 These 2 Tg mouse lines provide relatively rapid models to study

58 to tumorigenesis in vivo, we have generated Tg mouse lines that express human CR-1 under the transcr

59 anges were detected in the eyes of the other Tg mouse lines.

60 Transgenic (Tg) mouse lines (Dct-Survivin) were generated with melan

61 ission of human prions to 18 new transgenic (Tg) mouse lines expressing 8 unique chimeric human/mouse

62 Transgenic (Tg) mouse lines that express chimeric mouse-human prion

63 Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical

64 first intron construct, and four transgenic (TG) mouse lines were established.

65 Transgenic (TG) mouse lines were generated in which the luciferase r

66 thways relevant to the development of Scnn1b-Tg mouse lung pathology.

67 In this study, we used the MMTV-Neu-Tg mouse mammary tumor model to identify potential new s

68 is also observed in a number of transgenic (Tg) mouse mammary tumors.

69 gland-specific PELP1-expressing transgenic (Tg) mouse (MMTVrtTA-TetOPELP1).

70 isease manifestations in both the A53TalphaS Tg mouse model and the adeno-associated virus-transduced

71 Thus, myocytes from the alpha-MyHC TG mouse model display many morphological and functional

72 ments led to spatial memory improvement in a Tg mouse model of AD Alzheimer disease .

73 erved as early as 2 months of age in the 3 x Tg mouse model of AD, whereas no such induction of LRP1B

74 help explain the LV dysfunction seen in this TG mouse model of FHC.

75 ly in the disease pathogenesis in the YAC128 Tg mouse model strengthens the argument for a causative

76 In this study, we generated an AT-1 Tg mouse model that selectively overexpresses human AT-1

77 n maintaining CD8(+) T cell homeostasis in a Tg mouse model that specifically overexpresses a dominan

78 These results indicate that in a tg mouse model, overexpression of either wild-type hsp27

79 study, a constitutive TSC1 transgenic (Tsc1 (tg) ) mouse model was generated and characterized.

80 disease in the setting of HIV, a transgenic (Tg) mouse model [CD4C/HIV-negative regulator factor (Nef

81 y roles of Ser282 we generated a transgenic (TG) mouse model expressing cardiac myosin binding protei

82 oncentration were performed in a transgenic (Tg) mouse model expressing human CETP.

83 igenesis in vivo using the established HPV16(tg) mouse model for cervical squamous cell carcinoma.

84 ically evaluated by generating a transgenic (TG) mouse model in which the SLN to sarco(endoplasmic)re

85 KT cell function, we generated a transgenic (Tg) mouse model in which thymocytes and peripheral T cel

86 idespread CNS delivery in an APP-transgenic (tg) mouse model of AD.

87 T mutant human alphaS transgenic (A53TalphaS Tg) mouse model of alpha-synucleinopathy, we show that d

88 y in tauopathies, we generated a transgenic (Tg) mouse model of astrocytic tau pathology by expressin

89 wing a tolerogenic signal, a TCR-transgenic (Tg) mouse model of collagen-induced arthritis was develo

90 human P301S tau-expressing transgenic (P301S-tg) mouse model of frontotemporal dementia/tauopathy.

91 We modified a transgenic (TG) mouse model of inducible FXN depletion that permits

92 We created a transgenic (Tg) mouse model of lifelong excess synaptic Glu release

93 The human TNF transgenic (hTNF-Tg) mouse model of RA displays a chronic, progressive di

94 h a knock-in (KI) and a myogenic transgenic (TG) mouse model of SBMA.

95 We recently generated a transgenic (Tg) mouse model of tau pathology in astrocytes by expres

96 pools in our new inducible rNLS8 transgenic (Tg) mouse model of TDP-43 proteinopathy and found striki

97 to assess Abeta deposition in a transgenic (Tg) mouse model overexpressing Abeta-protein precursor.

98 Using a transgenic (Tg) mouse model overexpressing Sulf1 (Sulf1-Tg), we asse

99 lymphocytes (iIELs) using the 2C transgenic (Tg) mouse model specific for a peptide antigen (Ag) pres

100 cytes (IELs), we utilized the 2C transgenic (Tg) mouse model specific for a peptide self Ag presented

101 demonstrate this, we developed a transgenic (TG) mouse model that exhibits an inappropriate overexpre

102 re regulated, we generated an Ig transgenic (Tg) mouse model that expresses an Ig that binds alpha3(I

103 ept was recently challenged by a transgenic (Tg) mouse model that lacks circulating antibody but stil

104 ed this question using a H chain transgenic (Tg) mouse model that lacks secreted Ig (mIg), and thus d

105 Recently, we developed a transgenic (Tg) mouse model that overexpress myotrophin (a 12-kDa pr

106 We used a Tlr7 transgenic (tg) mouse model to investigate the cellular and molecula

107 ific human CysLT2R (EC-hCysLT2R) transgenic (TG) mouse model using the Tie2 promoter/enhancer.

108 cific TCR/hLa neo-self-Ag double-transgenic (Tg) mouse model was developed and used to investigate ce

109 (T1D), we previously designed a transgenic (tg) mouse model where the viral nucleoprotein (NP) gene

110 ion (I/R) injury, we generated a transgenic (TG) mouse model with cardiac-specific overexpression of

111 ogic hypertrophy, we generated a transgenic (TG) mouse model with cardiac-specific overexpression of

112 We have generated a SALL4 transgenic (SALL4B Tg) mouse model with pre-leukemic MDS-like symptoms that

113 ts of ss-3 type HPV49 in a novel transgenic (Tg) mouse model, using a cytokeratin K14 promoter to dri

114 Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells fro

115 nditional mammary gland-specific transgenic (TG) mouse model, we show that miR-22 enhances mammary gl

116 alpha-syn in the mThy1-alpha-syn transgenic (tg) mouse model, which resembles the striato-nigral and

117 uced in cardiac myocytes using a transgenic (TG) mouse model.

118 of the HY-T-cell receptor (TCR) transgenic (Tg) mouse model.

119 nt diabetes mellitus (IDDM) in a transgenic (tg) mouse model.

120 induces SCZ-like phenotypes in a transgenic (Tg) mouse model.

121 took advantage of the OT-II TCR-transgenic (Tg) mouse model.

122 We generated a transgenic (Tg)-mouse model expressing a dominant negative-(DN)-RARa

123 c potential, with structural and transgenic (Tg) mouse modeling and cell-free prion amplification.

124 Using HCV Tg mouse models and patients with HCC, we isolated CD133

125 ctivity, and might be useful in the study of Tg mouse models for other neurodegenerative illnesses.

126 Rosa26-FoxM1b mice with both TRAMP and LADY TG mouse models of prostate cancer.

127 While several transgenic (Tg) mouse models have recapitulated aspects of AD-like A

128 We found that some transgenic (Tg) mouse models of AIDS also develop accumulation of ma

129 Transgenic (Tg) mouse models of Alzheimer's disease have served as v

130 Transgenic (Tg) mouse models of autoimmunity have been used to expre

131 HTT) isolated from the brains of transgenic (Tg) mouse models of HD and humans with HD using an amylo

132 intraventricularly in newborn AD transgenic (tg) mouse models of SPs (PDAPP(+)/(-)), both SPs and NFT

133 Transgenic (Tg) mouse models overexpressing amyloid precursor protei

134 storically used first-generation transgenic (Tg) mouse models that overexpress proteins linked to fam

135 ifficulties with hapten-specific transgenic (Tg) mouse models that yield relatively large numbers of

136 We used HIV transgenic (Tg) mouse models to study MDSC, namely, CD4C/Nef Tg mice

137 T-cell receptor transgenic (TCR-tg) mouse models with direct CD4 alloreactivity will hel

138 (M83) and wild-type (M20) alphaS transgenic (Tg) mouse models.

139 Male TG mouse myocytes had higher [Ca(2+)](i) after 30 minute

140 d [Ca2+]i and [Na+]i in isolated transgenic (TG) mouse myocytes overexpressing the Na+-Ca2+ exchanger

141 This TCR-tg mouse, named 4C, was selected for reactivity against

142 amyloid precursor protein (hAPP) transgenic (Tg) mouse neurons.

143 previously characterized a novel transgenic (Tg) mouse on the IL-2Rbeta-/- genetic background (Tg-/-

144 and protein were detected in all transgenic (TG) mouse ovaries at levels far higher than in other tis

145 in solubility between human AD and the APP23 tg mouse plaques.

146 Thus, our double-Tg mouse provides a novel model in which to study epista

147 Thus double Tg mouse provides a novel model to study epistatic inter

148 This Tg mouse provides a valuable tool to study mechanisms by

149 ung disease model (i.e., Scnn1b-Tg-positive [Tg+]) mouse, remain unclear.

150 gene into the Nur77(tg) (Nur77(tg);Valpha14(tg)) mouse rescued iNKT cell development up to the early

151 the target tissue, which may explain the GAD-tg mouse's usual disease incidence.

152 human pregnancy, the mouse (including CYP3A4-tg mouse) seems to be an excellent animal model to deter

153 and clinical disease in the BAFF-Tg and non-Tg mouse sets.

154 , hypertrophic fibres from Mtn(-/-)/Errgamma(Tg/+) mouse showed satellite cell deficit which unexpect

155 of cystathionine gamma-lyase (alpha-MHC-CGL-Tg mouse) significantly limits the extent of injury.

156 ne diseases, we have generated a transgenic (Tg) mouse strain ectopically expressing DRAK2 via the lc

157 The transgenic (tg) mouse strain tg(Grm1)EPv develops spontaneous melano

158 gen stimulation by engineering a transgenic (Tg) mouse strain with CD8(+) T cells capable of augmente

159 ely used MHC class I-restricted TCRalphabeta Tg mouse strains and compared it with that in non-Tg mic

160 Both Tg mouse strains elicited, in an apparently Fas-independ

161 al tolerance, we established two transgenic (Tg) mouse strains expressing different levels of membran

162 ociated heart pathology in the P2X4 receptor TG mouse suggests a novel physiologic role of the P2X4 r

163 on-targeted Cav-1-overexpressing transgenic (Tg) mouse [synapsin-driven Cav-1 (SynCav1 Tg)] and subje

164 PG-TCR-Tg mouse T cells cultured with antigen-loaded DCs showed

165 Rapid evolution in transgenic (Tg) mouse technology now permits cell-specific and tempo

166 cell lines from the BDC-2.5 TCR transgenic (Tg) mouse that exhibit a Th2 cytokine phenotype in vitro

167 We developed a transgenic (Tg) mouse that expresses TGF-beta under control of the I

168 lished mouse model of EA2, the tottering (tg/tg) mouse, to examine the potential therapeutic utility

169 f the L-VDCC alpha(1) subunit in transgenic (Tg) mouse ventricles resulted in marked blunting of the

170 ng CaMKIIdeltac-overexpressing (CaMKIIdeltac-Tg) mouse ventricles.

171 (SS)) were significantly decreased in p90RSK-Tg mouse ventricular myocytes.

172 er report in which T cells obtained from the Tg mouse were cultured for 1 wk under Th2-promoting cond

173 ith cardiac-specific Gsalpha overexpression (TG mouse), which exhibits enhanced postsynaptic beta-adr

174 A TCR-tg mouse with direct CD4 specificity in the widely used

175 By crossing this TCR Tg mouse with mice expressing the kappa chain of mAb 36-

176 By using a transgenic (TG) mouse with cardiac-specific overexpression (3.5-fold

177 Transgenic (Tg) mouse with cardiomyocyte-specific overexpression of

178 this problem by developing a TCR-transgenic (Tg) mouse with CD4 T cells that respond to a common Ag i