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1                                              Tk neuron activation overcame reduced aggressiveness cau
2                                              Tk-hefu is an artificial peptide designed based on the a
3 ure of the wheat antimicrobial peptide (AMP) Tk-AMP-X2 studied using NMR spectroscopy.
4 fold, and we obtained a number of artificial Tk-hefu peptides showing selective blockage of K(V)1.3 i
5                            Mutations in both Tk and a candidate receptor, Takr86C, suppressed the eff
6 ent any activity against potassium channels, Tk-hefu blocked Kv1.3 channels with similar potency (IC5
7      We used a transgenic rat line, the GFAP-Tk, to selectively eliminate NSCs and assess repercussio
8 s Glt(Ph) from Pyrococcus horikoshii and Glt(Tk) from Thermococcus kodakarensis.
9 mparison of the L- and D-aspartate bound Glt(Tk) structures revealed that D-aspartate is accommodated
10 s of the glutamate transporter homologue Glt(Tk) in complex with photoresponsive transport inhibitors
11     We determined a crystal structure of Glt(Tk) with bound D-aspartate at 2.8 angstrom resolution.
12                       Here, we show that Glt(Tk) transports D-aspartate with identical Na(+): substra
13 imum-likelihood phylogenetic tree using GTDB-Tk-assigned taxonomies.
14 pes simplex virus thymidine kinase gene (HSV-Tk) driven by the mouse GFAP promoter were used to rende
15 topography to suggest mutations and increase Tk-hefu affinity to the K(v)1.3 channel isoform.
16 r or alone, with a minimal thymidine kinase (Tk) promoter, SSRE showed a weak incremental action on t
17 tassium channel blockers, a mutant molecule, Tk-hefu, was engineered by incorporating the functionall
18                   However, in the absence of Tk there was evidence for a strong synergy between SSRE
19                        We verify the mode of Tk-hefu-2 binding to the channel outer vestibule experim
20 uronal activation, whereas overexpression of Tk potentiated it.
21        We redesign the functional surface of Tk-hefu to better match the respective surface of the ch
22                                     Based on Tk-AMP-X2 structural similarity to cone snail and scorpi
23 dies showed that although the parent peptide Tk-AMP-X2 did not present any activity against potassium
24                        The resulting peptide Tk-hefu-2 retains K(v)1.3 selectivity and displays ~15 t
25       We have constructed GenomePlot, a Perl/Tk script with a series of modules that allow us to disp
26         It was developed using Perl and Perl/Tk and implemented on the LINUX operating system.
27    We present here a win32 system based Perl/Tk application for visual comparisons of these variation
28 platform graphical interface written in Perl/Tk.
29    As a result, we have been able to produce Tk-hefu-11 that shows an EC(50) of ~70 nM against K(V)1.
30                          Quite surprisingly, Tk-hefu-11 turns out to block K(V)1.6 with even higher p
31 ns that express the neuropeptide tachykinin (Tk).
32 aged with current versions of Python and Tcl/Tk, which support new tools for NMR peak simulation and
33               It is implemented in C and Tcl/Tk.
34    TopDraw is a simple, freely available TCL/Tk based drawing program designed specifically for the p
35                The program is written in Tcl/Tk and works on any platform that supports the Tcl/Tk to
36 mplemented as a R package based on the R-Tcl/Tk interface and is available for platforms on which R r
37  works on any platform that supports the Tcl/Tk toolkit.
38 xpressed in the nervous system, we hope that Tk-hefu-11 will be useful in studies of K(V)1.6 and its
39 ant residues from kappa-hefutoxin 1 onto the Tk-AMP-X2 scaffold.
40 ays ~15 times greater activity compared with Tk-hefu.
41        We present eLAMP, a PERL script, with Tk graphical interface, that electronically simulates Lo