ライフサイエンスコーパス: Toll-like receptor

1 recipient cells via activation of endosomal Toll-like receptors.

2 of melanoma with intratumoral injections of Toll-like receptor 1/2 (TLR1/2) ligand Pam3CSK4 plus i.p

3 ent on the T. gondii mouse profilin receptor Toll-like receptor 11 (TLR11), but the ectopic expressio

4 of differential expression of genes such as Toll-like receptor 15, Toll-like receptor 21, and matrix

5 ly to host cell CD36 and to the complex CD36-Toll-like receptor 2 (TLR-2), but not to TLR-2 alone or

6 Toll-like receptor 2 (TLR2) agonists are lipopeptides po

7 e previously shown to engage human and mouse Toll-like receptor 2 (TLR2) and to inhibit mouse osteobl

8 ferentiation 14 (CD14) and the transmembrane toll-like receptor 2 (TLR2) are important receptors in t

9 Toll-like receptor 2 (TLR2) is an innate immune receptor

10 ssion profile was similar to that induced by toll-like receptor 2 (TLR2) ligand Pam3Cys, but differen

11 Toll-like receptor 2 (TLR2) plays a key role in innate i

12 We have previously demonstrated that toll-like receptor 2 (TLR2) signaling is critical for ne

13 this study, we examined the contribution of Toll-like receptor 2 (TLR2) to host resistance against M

14 stress response was found to be dependent on Toll-like receptor 2 (TLR2), as evident by reduced expre

15 y diminished capacity to stimulate host cell Toll-like receptor 2 (TLR2)-dependent signaling and inte

16 This study investigated responses to Toll-like receptor 2 (TLR2)-driven extracellular signal-

17 ted proteins on the AML-EV surface activated Toll-like receptor 2 as the initiating event of Akt/mTOR

18 is bacterium evade immune recognition by the Toll-like receptor 2 family complex.

19 roteasome proteolysis, by treatment of TLR2 (Toll-like receptor 2)-engaged and TLR7 (Toll-like recept

20 We demonstrate that Toll-like receptor 2-deficient (TLR2(-/-)) mice are resi

21 amroQ mutant exhibited impaired induction of Toll-like receptor 2-dependent inflammatory responses fr

22 universal T helper epitope, and a synthetic toll-like receptor 2-targeting moiety as a possible self

23 age-driven inflammation by modulation of the toll-like receptor 2/6 pathway.

24 atidylglycerol can inhibit the activation of toll-like receptors 2 and 4 of the innate immune system

25 flammasome via caspase-8 and dimerization of Toll-like receptors 2 and 4.

26 vators of the pattern recognition receptors, toll-like receptor-2 (TLR2) and -4 (TLR4).

27 attenuated pro-inflammatory responses toward Toll-like receptor-2 and -4 stimulation.

28 sion of genes such as Toll-like receptor 15, Toll-like receptor 21, and matrix metallopeptidase 1.

29 infection of EECs significantly reduced both Toll-like receptor 3 (TLR3) and TLR4 mRNA expression at

30 ns, we used CRISPR genome editing to disrupt Toll-like receptor 3 (TLR3) function in the human oviduc

31 s nonsynonymous variant (c.2324C > T) in the Toll-like receptor 3 (TLR3) gene resulting in formation

32 )-stimulator of interferon genes (STING) and Toll-like receptor 3 (TLR3) pathways.

33 -1B, which mediates the polarized sorting of Toll-like receptor 3 (TLR3) towards the basolateral side

34 n (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory f

35 The toll-like receptor 3 agonist poly I:C increased expressi

36 ophage pro-inflammatory responses, represses Toll-like receptor 3 and virus-induced expression of IFN

37 Toll-like receptor 3 responses that were unaffected in A

38 reactivation capacity further increased upon Toll-like receptor 3 stimulation with poly(I.C) double-s

39 This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon a

40 testinal macrophages and dendritic cells via toll like receptor 4.

41 r factor kappa B, lipoxygenase-1 (LOX-1) and toll-like receptor 4 (p < 0.05).

42 nd mRNA translation lead to hypothesize that toll-like receptor 4 (TLR4) activation reduced LNP-media

43 DM), which is similar to that induced by the Toll-like receptor 4 (TLR4) agonist lipopolysaccharide.

44 rcentages and sputum cell gene expression of Toll-like receptor 4 (TLR4) and NLRP3 at 4 hours in nono

45 ined to be associated with downregulation of Toll-like receptor 4 (TLR4) expression on the surface of

46 L1 as a critical structural component of the Toll-like receptor 4 (TLR4) immune signal transduction p

47 s, we first evaluated the role of nociceptor Toll-like receptor 4 (TLR4) in OIH and priming induced b

48 tumor necrosis factor-alpha (TNFalpha), and Toll-like receptor 4 (TLR4) in surgically excised specim

49 critical role of innate immune signaling via Toll-like receptor 4 (TLR4) in the pathogenesis of dyspl

50 Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory resp

51 tirely clear, current evidence suggests that Toll-like receptor 4 (TLR4) is a key player in the mecha

52 r advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4) is implicated in COPD.

53 We investigated the role of an endogenous Toll-like receptor 4 (TLR4) ligand, fibronectin-EDA (FN-

54 xamined the effect of innate immune receptor Toll-like receptor 4 (TLR4) on excitability of the hippo

55 ed by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect the

56 mponents such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a rob

57 genes (STING) pathway and an agonist of the Toll-like receptor 4 (TLR4) pathway.

58 driven by microbial-dependent activation of toll-like receptor 4 (TLR4) signaling and subsequent eng

59 -TOF MS), gas chromatography (GC), SDS-PAGE, Toll-like receptor 4 (TLR4) stimulation, and immunoblot

60 In male rats, HMWH also signals via Toll-like receptor 4 (TLR4), and AS-ODN for TLR4 mRNA ad

61 s can be induced by endotoxin stimulation of Toll-like receptor 4 (TLR4), resulting in an ameliorated

62 conditions were previously found to activate Toll-like receptor 4 (TLR4), resulting in expression of

63 The level of toll-like receptor 4 (TLR4), TLR2, and erythropoietin-pr

64 einphagy requires the presence of microglial Toll-like receptor 4 (TLR4), which induces transcription

65 Bile duct cells expressed the LPS receptor, Toll-like receptor 4 (TLR4), which links to activation o

66 production by modulating host immunity in a Toll-like receptor 4 (TLR4)-dependent manner, a signalin

67 rickettsiae activate ASC inflammasome via a Toll-like receptor 4 (TLR4)-dependent mechanism.

68 ors to evaluate the role of various genes in Toll-like receptor 4 (TLR4)-induced necroptosis.

69 ells, and TNFalpha secretion is dependent on toll-like receptor 4 (TLR4).

70 sensing of lipopolysaccharide (LPS) via the toll-like receptor 4 (TLR4).

71 evelopment accelerates after deletion of the Toll-like receptor 4 (TLR4).

72 e the intestine's innate immune response via toll-like receptor 4 (TLR4).

73 effects which are mediated partially through Toll-like receptor 4 (TLR4).

74 these cytokines during bacterial sepsis via Toll-like receptor 4 (TLR4)/MyD88 sensing of lipopolysac

75 Mechanistically, Toll-like receptor 4 (TLR4, LPS receptor)-sphingosine ki

76 cyte-specific deletion of YAP (YAP( KO) ) or Toll-like receptor 4 (TLR4; TLR4( KO) ), and animals wer

77 with glucopyranosyl lipid adjuvant (GLA), a Toll-like receptor 4 agonist, in a squalene-in-water emu

78 s pathway, and monophosphoryl lipid A, and a Toll-like receptor 4 agonist, which synergize to produce

79 These alarmins bind to the Toll-like receptor 4 and prime the nod-like receptor fam

80 nflammatory factors including TNFalpha via a Toll-like receptor 4 and STAT3-dependent mechanism in hu

81 show that upon cancer-induced activation of Toll-like receptor 4 in skeletal muscle, p38beta MAPK ph

82 Although we report that Toll-like receptor 4 is expressed in both excitatory and

83 nate antimicrobial responses was observed in toll-like receptor 4 knockout mice treated with 3-deacyl

84 Toll-like receptor 4 positive (TLR4(+) ) macrophages wer

85 entrain qualitatively different responses to toll-like receptor 4 signaling in vivo.

86 y by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.

87 d an innate immune response by activation of Toll-like receptor 4 signaling to MD2 and CD14, and caus

88 eloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.

89 nd sevoflurane directly target and attenuate Toll-like receptor 4 system.

90 ses both in vivo and in vitro LPS stimulates Toll-like receptor 4, an important mediator of the brain

91 rotein 3 (NLRP3) inflammasome such as NLRP3, Toll-like receptor 4, and interleukin-1beta.

92 in their livers and spleens for months, but Toll-like receptor 4-deficient animals succumbed to thes

93 RI had increased disulfide-HMGB1 and induced Toll-like receptor 4-dependent tumor necrosis factor alp

94 d antagonizing the activation of LPS-induced Toll-like receptor 4-myeloid differentiation factor 2 (T

95 mechanisms by which inflammation - driven by Toll-like receptor 4-regulated cytokines, immune cells a

96 stic cells by anticardiolipin occurs through Toll-like receptor 4.

97 f IL-1R8, diminishing activation mediated by toll-like receptor 4.

98 to Kupffer cells (KCs) and co-localized with toll-like receptor 4.

99 to 10 days and is partially mediated through toll-like receptor 4.

100 ter wall of Gram-negative bacteria, with the Toll-like Receptor 4.

101 entially detected by host receptors like the Toll-like receptor 4/myeloid differentiation factor 2 co

102 LPS is recognized by the Toll-like receptor 4/myeloid differentiation factor-2 (T

103 ating that miR-147 upregulation inhibits the Toll-like receptor 4/NF-kappaB pathway.

104 also exhibits anti-inflammatory effects in a Toll-like Receptor-4 (TLR-4) dependent manner.

105 The lipopolysaccharide (LPS)- toll-like receptor-4 (TLR4) pathway plays an important r

106 ene Expression Array Plates system for genes Toll-like receptor-4 (TLR4), high-mobility group box 1,

107 lls presented increased CD11b activation and toll-like receptor-4 expression.

108 5) increased hypothalamic microglia density, toll-like-receptor-4 (Tlr4), and the inhibitor-NF-kappa-

109 ponsible for this pro-viral activity was the Toll-Like Receptor 5 (TLR5) agonist flagellin.

110 acid epitope in flagellin recognized by the Toll-like receptor 5 (TLR5).

111 response induced by flagellin activation of Toll-like Receptor 5 cell signalling is augmented follow

112 We treated mice topically with the Toll-like receptor 7 (TLR7) agonist imiquimod (IMQ) to a

113 e production, with IRF5 acting downstream of Toll-like receptor 7 (TLR7) and, possibly, retinoic acid

114 Toll-like receptor 7 (TLR7) is an established therapeuti

115 Our previous study demonstrated that Toll-like receptor 7 (TLR7) is essential in the inductio

116 In mice deficient for Toll-like receptor 7 (TLR7), transcribed ERV loci can re

117 Using Toll-like receptor 7 (TLR7)-dependent mouse models of sy

118 that internalize red blood cells develop in Toll-like receptor 7 (TLR7)-driven inflammation.

119 co-delivery of a hydrophobic small-molecule toll-like receptor 7 agonist, imiquimod (IMD), and a hyd

120 The toll-like receptor 7 and 8 (TLR7/8) agonist Resiquimod (

121 Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent

122 on and revealed that IRF5 acts downstream of Toll-like receptor 7 and possibly retinoic acid-inducibl

123 we shed light on a yet unanticipated role of Toll-like receptor 7 in the recognition of MHV68 in a su

124 rticoids impair upstream B cell receptor and Toll-like receptor 7 signaling, reduce transcriptional o

125 LR2 (Toll-like receptor 2)-engaged and TLR7 (Toll-like receptor 7)/TLR8 (Toll-like receptor 8)-engage

126 vaccine that links neoantigen peptides to a Toll-like receptor 7/8 agonist (SNP-7/8a), we show how t

127 We administered the Toll-like receptor 7/8 agonist resiquimod (R848; a synth

128 tides (ASOs) can have opposing activities on Toll-Like Receptors 7 and 8 (TLR7/8), leading to diverge

129 Imiquimod is a topical toll-like-receptor-7 agonist currently used for treating

130 The Toll-like receptor 8 (TLR8) has an important role in inn

131 Toll-like receptor 8 (TLR8) recognizes pathogen-derived

132 an oral selective small molecule agonist of toll-like receptor 8 in clinical development for the tre

133 ngaged and TLR7 (Toll-like receptor 7)/TLR8 (Toll-like receptor 8)-engaged CD14(+) monocytes with ONX

134 Although the well-known Toll like receptor 9 (TLR9) agonist CpGODN has shown pro

135 lites and peptidoglycan into host cells, and Toll-like receptor 9 (TLR9) activation is attributed to

136 pathology, CpG 1018, a Th1-biasing synthetic toll-like receptor 9 (TLR9) agonist was selected as an a

137 Toll-like receptor 9 (TLR9) agonists have gained tractio

138 Toll-like receptor 9 (TLR9) and Phosphatidylinositol-3-k

139 Toll-like receptor 9 (TLR9) is a regulator of disease pa

140 ecific pattern recognition receptors such as Toll-like receptor 9 (TLR9) on the endosomal surface of

141 role for the innate immune-sensing molecule Toll-like receptor 9 (TLR9)(4), and its interaction with

142 osis-induced apoptosis in human PMNs through Toll-like receptor 9 (TLR9)-mediated release of neutroph

143 NA and contributed to pattern recognition by Toll-like receptor 9 (TLR9).

144 ucleotide conjugated to a scavenger receptor/Toll-like receptor 9 agonist (C-miR146a).

145 imulation with a CpG oligodeoxynucleotide, a Toll-like receptor 9 agonist, evokes changes in the cent

146 hage colony-stimulating factor (GM-CSF), the Toll-like-receptor-9 agonist cytosine-guanosine oligodeo

147 vation in human monocytes is mediated by the Toll-like receptor adapter protein SCIMP.

148 quires signaling from the cytokine IL-34 and Toll-like receptor adaptor MyD88, and occurs in coordina

149 Activation of PMs by Toll-like receptor agonists and live bacteria altered le

150 o type I IFNs promoted enhanced responses to Toll-like receptor agonists.

151 ein, we describe an adjuvant consisting of a Toll-like receptor and C-type lectin receptor agonist pa

152 on from human monocytes requires cooperative Toll-like receptor and IFNalpha/beta signaling.

153 show that RNAi depletion of IL-17RD enhances Toll-like receptor and IL-17A signaling in colon adenoca

154 -cDC2s matured in response to cell-intrinsic Toll-like receptor and type 1 interferon receptor signal

155 although it is nonmyeloid lineage, expressed Toll-like receptors and activated the transcription fact

156 Thus, the concerted activation of both Toll-like receptors and C-type lectin receptors is requi

157 aled stable interactions of the vaccine with Toll-Like Receptors and MHC Receptors.

158 distinct features of bona fide RNA sensors, Toll-like receptors and retinoic-acid inducible gene-I (

159 ated with two mRNA modules enriched for TLR (Toll-like receptor) and T-helper cell type 17 (Th17) sig

160 n genes (STING) pathway, rather than through Toll-like receptors, and result in limited systemic cyto

161 oxychloroquine (HCQ), an orally administered Toll-like receptor antagonist widely used in lupus inclu

162 Toll-like receptors are critical in the early detection

163 t of dendritic cell activation, inflammatory/Toll-like receptor/chemokines, and monocyte modules, but

164 acological blockade of mu opioid receptor or Toll-like receptors complex failed to alter, while block

165 SATB1 was positively correlated with toll-like receptors expression, suggesting innate immune

166 It potently amplifies inflammation via Toll-like receptor four and is antimicrobial as part of

167 s reveal a heretofore undescribed role for a Toll-like receptor in skeletal-muscle AMPK activation an

168 the activated phenotype, IFN-alpha inhibited Toll-like receptor-induced cytokine production and monoc

169 ds significantly inhibited the expression of Toll-like receptor-induced inflammatory genes in vitro a

170 -kB ubiquitination and degradation, prevents Toll-like receptor-induced pro-inflammatory cytokine exp

171 phages, expression of LACC1 was required for toll-like receptor-induced uptake of bacteria, which req

172 n of other innate immune pathways, including toll-like receptor, interleukin and chemokine signaling.

173 Liposomal codelivery of tumor antigen and Toll-like receptor ligand to CD169(+) moDCs and Axl(+) C

174 Toll-like receptor ligands in indoor dust act as environ

175 timuli, such as tumor necrosis factor-alpha, Toll-like receptor ligands, and oxidized lipids, primari

176 n immune response in cells activated by RNA, Toll-like receptor ligands, cGAMP, or recombinant interf

177 onse may be further enhanced by inclusion of Toll-like receptor ligands, which many VLPs naturally pa

178 with IL-2, GM-CSF, and eotaxin production to Toll-like receptor ligands.

179 ated with excess adiposity and implicated in toll-like receptor-mediated activation of macrophages-ke

180 e not effector cells, have lost capacity for Toll-like-receptor-mediated cytokine production and do n

181 l microbes induced IL-17B production through Toll-like receptor-Myd88 adaptor signaling.

182 side downstream of immune sensors, including Toll-like receptors, nucleotide-binding oligomerization

183 ry of pattern-recognition receptors, such as Toll-like receptors or IL-1 family receptors.

184 ated by germ line-encoded receptors, such as Toll-like receptors or natural killer receptors, are com

185 ZC3H12A, and genes in the interleukin 17 and Toll-like receptor pathways, under positive selection in

186 eptor for advanced glycation endproducts and Toll-like receptor proteins 2 and 4.

187 asmic reticulum stress, HIF-1 signaling, and Toll-like receptor signaling as enriched after palmitic

188 ical evidence support the role of macrophage Toll-like receptor signaling in maternal anti-SSA/Ro-med

189 ve growth factor signaling and innate immune toll-like receptor signaling in MDD.

190 naling, C-type lectin receptor signaling and Toll-like receptor signaling pathways.

191 ed macrophages at least in part by enhancing Toll-like receptor signaling via the up-regulation of WD

192 erb-b2 receptor tyrosine kinase (Erbb), and Toll-like receptor signaling were enriched in lysates of

193 GE(2) Mechanistically, WDFY1 was involved in Toll-like receptor signaling, and its down-regulation in

194 al substrates of the HOIL-1 E3 ligase during Toll-like receptor signaling.

195 ncomitant cooperation of B-cell receptor and Toll-like receptor signaling; inhibition of both pathway

196 reby pro-inflammatory cytokine responses and Toll-like receptor signalling are inhibited following PL

197 A Toll-like receptor signalling molecule, TRAM, was assess

198 Toll-like receptor signalling through the adaptor molecu

199 ly engaged at ATF3-bound sites that suppress Toll-like receptor signalling.

200 Toll-like receptor stimulated macrophages from KI mice s

201 These glycosphingolipids are found in Toll-like receptor-stimulated dendritic cells (DC) as se

202 w that CH25H is induced by ZIKV infection or Toll-like receptor stimulation.

203 ity towards increased T-cell reactivity upon Toll-like-receptor stimulation.

204 Innate responses to Toll like receptor (TLR) ligation decreased with treatme

205 eractions with the B cell receptor (BCR) and Toll like receptor (TLR) pathways.

206 The Toll like receptor (TLR) signaling pathway was blunted b

207 Toll-like receptor (TLR) 2 recognizes and responds to th

208 PSA-dependent immunomodulation requires the Toll-like receptor (TLR) 2/1 heterodimer in cooperation

209 Upon ex vivo stimulation with Toll-like receptor (TLR) 4 or TLR-2 agonists, monocytes

210 Much of this influence arises from Toll-like receptor (TLR) 4 or TLR2 signalling and, in th

211 urine X chromosome-encoded receptor proteins Toll-like receptor (TLR) 7 and TLR8 reportedly results i

212 onal deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that th

213 When administered with a potent Toll-like receptor (TLR) 7/8 agonist adjuvant, these nan

214 components, such as unmethylated CpG DNA, a Toll-like receptor (TLR) 9 agonist, are known to possess

215 e we describe an aggressive in vivo model of Toll-like receptor (TLR) 9 dysregulation, based on bypas

216 Based on data suggesting that PG can inhibit toll-like receptor (TLR) activation induced by microorga

217 Toll-like receptor (TLR) activation induces inflammatory

218 FN-I amounts produced by pDCs in response to Toll-like receptor (TLR) activation.

219 nging of mice with a nonlethal dose of viral toll-like receptor (TLR) agonist followed by a nonlethal

220 the aggregation of multiple bacteria and the Toll-like receptor (TLR) agonists they produce.

221 on phenotypes, in the absence or presence of Toll-like receptor (TLR) agonists, including lipopolysac

222 In this study, we show that a toll-like receptor (TLR) and C-type lectin receptor (CLR

223 ave characterized the roles of the endosomal Toll-like receptor (TLR) escort protein UNC93B, endosoma

224 fferentially affects peripheral and lymphoid Toll-like receptor (TLR) expression profiles in T cells

225 recognition receptors (PRRs), including the Toll-like receptor (TLR) family are promising targets fo

226 Evidence suggests that stimulation of the Toll-like receptor (TLR) family of PRR may regulate epit

227 At least two members of the Toll-like receptor (TLR) family, TLR7 and TLR9, can reco

228 icated in interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) immune responses.

229 Synthetic Toll-like receptor (TLR) ligands are ideal adjuvants for

230 Pre-DC activation by toll-like receptor (TLR) ligands induces an antiviral st

231 Oral administration of toll-like receptor (TLR) ligands to virally infected ger

232 terologous stimulants (killed pathogens) and Toll-like receptor (TLR) ligands.

233 croptosis by Tumor necrosis factor (TNF) and Toll-like receptor (TLR) ligands.

234 Toll-like receptor (TLR) recruitment to phagosomes in de

235 tive to stimulation by self-antigen, whereas Toll-like receptor (TLR) signaling can reactivate anergi

236 In normal B cells, Toll-like receptor (TLR) signaling cooperates with BCR s

237 of B cell receptor signaling in B cells and Toll-like receptor (TLR) signaling in macrophages.

238 me (MDS) and cell-intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic

239 gnificantly elevated post injury, indicating toll-like receptor (TLR) signaling may be involved in mu

240 tion of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway.

241 nd inflammation-related processes, including toll-like receptor (TLR) signaling, PDGF- and angiotensi

242 Toll-like receptor (TLR) stimulation shifts intracellula

243 Since Toll-like receptor (TLR)-4 can amplify PAF signaling, we

244 Inflammatory receptors, specifically Toll-like receptor (TLR)-4, have been reported to modify

245 The data also showed that toll-like receptor (TLR)-4/myeloid differentiation prima

246 cytoid dendritic cells, where it potentiates toll-like receptor (TLR)-9 activation and IFN-alpha prod

247 oduction in recruited monocytes by enhancing Toll-like receptor (TLR)-induced glycolysis.

248 Toll-like receptor (TLR)-inducible zinc toxicity is a re

249 Herein, we report that levels of the Toll-like receptor (TLR)-related lnc interleukin (IL) 7

250 ell (LC) migration, but also MyD88-dependent Toll-like receptor (TLR)-stimulated DC activation.

251 of select cytokines upon stimulation of the Toll-like receptor (TLR)1-TLR2 heterodimer (referred to

252 Blocking antibodies against Toll-like receptor (TLR)1/TLR2, as well as small interfe

253 he contribution of innate defense receptors, Toll-like receptor (TLR)2, TLR4, and both (TLR2/4) to th

254 ntranasal costimulation with the lipopeptide Toll-like receptor (TLR)2/6 agonist, Pam2Cys (P2C), and

255 LPS stimulation indicates suppression of the Toll-like receptor (TLR)4 pathway.

256 ne-stimulatory drugs such as agonists of the Toll-like receptors (TLR) 7/8 are potent activators of a

257 Toll-like receptors (TLR) are a group of receptors that

258 Toll-like receptors (TLR) trigger the immune system to m

259 ted single nucleotide polymorphisms (SNP) of toll-like receptors (TLR), NOD-like receptors (NLR) and

260 ical specimens and mice deficient in SAA and Toll-like receptors (TLR).

261 Activation of toll-like receptors (TLR1, TLR5, TLR6) and downstream ma

262 In the present study we show that the toll-like receptors TLR2 and TLR4 inhibited the diet-ind

263 component of the Lyn-mediated regulation of Toll-like receptor (TLR2 and TLR4) signaling in dendriti

264 Toll like receptors (TLRs) are critical receptors to res

265 Plasmacytoid dendritic cells (pDCs) express Toll like receptors (TLRs) that modulate the immune resp

266 The Toll-like receptors (TLRs) 7 and 8 play an important rol

267 biological significance of crosstalk between Toll-like receptors (TLRs) and B cell receptors (BCRs) i

268 udy, we demonstrated that gene expression of Toll-like receptors (TLRs) and myeloid differentiation p

269 Toll-like receptors (TLRs) are a class of proteins that

270 Moreover, we show that Toll-like receptors (TLRs) are critical for shaping the

271 Proinflammatory responses induced by Toll-like receptors (TLRs) are dependent on the activati

272 RNA-sensing Toll-like receptors (TLRs) are often described as antivi

273 Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regula

274 Toll-like receptors (TLRs) are the pattern recognition r

275 Toll-like receptors (TLRs) coupled to intracellular sign

276 Toll-like receptors (TLRs) have a crucial role in the re

277 a or their products affect the adult ENS via toll-like receptors (TLRs) in mice.

278 of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for an appropria

279 displayed on the pathogen are recognized by Toll-like receptors (TLRs) on the host cell, it activate

280 Toll-like receptors (TLRs) play a central role in both t

281 Toll-like receptors (TLRs) play a crucial role in the in

282 We sought to investigate the roles that Toll-like receptors (TLRs) play in A. baumannii OMV-medi

283 Innate immune receptors such as toll-like receptors (TLRs) provide critical molecular li

284 Surface-exposed Toll-like receptors (TLRs) such as TLR2 and TLR4 survey

285 with infliximab or infliximab-TNF complexes; toll-like receptors (TLRs) were blocked with antibodies,

286 afety profiles, as well as three agonists of Toll-like receptors (TLRs) with known inflammatory poten

287 ernal administration of agents that activate toll-like receptors (TLRs), a class of pattern recogniti

288 to our understanding of these events are the Toll-like receptors (TLRs), an evolutionarily ancient fa

289 veal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.

290 pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), and produce inflammatory med

291 osis factor superfamily receptors or certain Toll-like receptors (TLRs), caspase-8 initiates cell-ext

292 pathways, including those through endosomal Toll-like receptors (TLRs), Fc gamma receptors (FcgammaR

293 nucleic acid recognition receptors, such as Toll-like receptors (TLRs), play a role in finely progra

294 other innate immune receptors, for example, Toll-like receptors (TLRs), that recognize ligands deriv

295 r, BCAP suppresses inflammatory signaling by Toll-like receptors (TLRs).

296 transcriptional level or via downregulating Toll-like receptors (TLRs).

297 al drivers of such neuroinflammation include toll-like receptors (TLRs).

298 TREM2, PLCgamma2 also signals downstream of Toll-like receptors to mediate inflammatory responses.

299 ith inflammatory responses driven by TNF and Toll-like receptors via NF-kappaB, eicosanoid biosynthes

300 between 12 and 18 h after the activation of Toll-like receptors with proinflammatory stimuli and tha