ライフサイエンスコーパス: Toll-like receptor 4

1 testinal macrophages and dendritic cells via toll like receptor 4.

2 s, an event triggered by the innate receptor Toll-like receptor 4.

3 lowing binding of growth factor receptors or Toll-like receptor 4.

4 ccharides through Toll-like receptors, e.g., Toll-like receptor 4.

5 dapter molecule 1, toll-like receptor 2, and toll-like receptor 4.

6 nflammation in ALD through activation of the Toll-like receptor 4.

7 stic cells by anticardiolipin occurs through Toll-like receptor 4.

8 nism remarkably similar to that of mammalian Toll-like Receptor 4.

9 nd to enhance fibroblast CCN2 expression via Toll-like receptor 4.

10 f IL-1R8, diminishing activation mediated by toll-like receptor 4.

11 to Kupffer cells (KCs) and co-localized with toll-like receptor 4.

12 to 10 days and is partially mediated through toll-like receptor 4.

13 ter wall of Gram-negative bacteria, with the Toll-like Receptor 4.

14 eta1 integrin and the innate immune receptor toll-like receptor 4.

15 ury triggering the macrophage activation via Toll-like receptor 4.

16 s blunted by incubation with an inhibitor of Toll-like receptor 4.

17 The levels of mRNA for Toll-like receptors 4, 5, and 9 also largely decreased i

18 60 adjuvanted with nanoparticle-encapsulated Toll-like receptor 4/7/8 (TLR4/7/8) agonists, administer

19 Chemical inhibition or genetic deletion of Toll-like receptor 4, a pattern recognition receptor res

20 t PTX sensitizes mice to HA independently of Toll-like receptor 4, a purported receptor for PTX, and

21 otein (CRP) at baseline and months 4 and 16; toll-like receptor-4 activated monocyte production of pr

22 anscriptional rate of CXCL8 and TNF-alpha to Toll-like receptor 4-activating signals.

23 investigates the mechanisms linking CFTR to toll-like receptor 4 activity.

24 ts demonstrate that the use of the synthetic Toll-like receptor 4 agonist glucopyranosyl lipid A in s

25 ated the immune response elicited by a novel Toll-like receptor 4 agonist vaccine adjuvant, glucopyra

26 with glucopyranosyl lipid adjuvant (GLA), a Toll-like receptor 4 agonist, in a squalene-in-water emu

27 s pathway, and monophosphoryl lipid A, and a Toll-like receptor 4 agonist, which synergize to produce

28 engineered liposomes carrying the synthetic Toll-like receptor-4 agonist, CRX-601.

29 Additionally, we found a significant toll-like receptor 4/alpha4beta1-dependent enrichment in

30 ses both in vivo and in vitro LPS stimulates Toll-like receptor 4, an important mediator of the brain

31 reduced lipopolysaccharide activation of the toll-like receptor 4 and increased survival times compar

32 astrocytic GAP43 expression was mediated by Toll-like receptor 4 and nuclear factor-kappaB (NF-kappa

33 These alarmins bind to the Toll-like receptor 4 and prime the nod-like receptor fam

34 nflammatory factors including TNFalpha via a Toll-like receptor 4 and STAT3-dependent mechanism in hu

35 at induction of IP-10 by MRP8/MRP14 required Toll-like receptor 4 and TRIF but not MyD88.

36 identified two innate immune cell receptors, Toll-like receptor 4 and type 1 interferon receptor (IFN

37 innate immune signaling components including Toll-like receptor-4 and type I IFNs.

38 rotein 3 (NLRP3) inflammasome such as NLRP3, Toll-like receptor 4, and interleukin-1beta.

39 Intracellular adhesion molecule 1, Toll-like receptor 4, and macrophage inflammatory protei

40 on of IL-33 in DCs is dependent on FcRgamma, Toll-like receptor 4, and phosphoinositide 3-kinase.

41 so improved the level of HA receptors (CD44, Toll-like receptor-4, and receptor for HA-mediated motil

42 In particular, aged neutrophils engage Toll-like receptor-4- and p38 MAPK-dependent pathways to

43 f immune inhibitory receptors on T cells via Toll-like receptor 4 binding to CD14(+) monocytes.

44 ube and network formation in the presence of Toll-like receptor 4 blockade but not in the presence of

45 Information on gene expression of toll-like receptor 4, catalase, and tumor necrosis facto

46 ood monocytes and 30% lower monocyte surface Toll-like receptor 4, compared with those with high expr

47 ts a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of

48 in their livers and spleens for months, but Toll-like receptor 4-deficient animals succumbed to thes

49 failed to induce depressive-like behavior in Toll-like receptor 4-deficient mice and in mice harborin

50 RI had increased disulfide-HMGB1 and induced Toll-like receptor 4-dependent tumor necrosis factor alp

51 ll-derived Fn-EDA exacerbates stroke through Toll-like receptor-4 expressed on hematopoietic cells.

52 with healthy controls (p = 0.0002), whereas Toll-like receptor 4 expression was decreased compared w

53 evated hepatic stellate cell-derived TnC and Toll-like receptor 4 expression was observed in the diet

54 Dectin-1, Toll-like receptor 2, and Toll-like receptor 4 expression; regulatory T cell (Treg

55 lls presented increased CD11b activation and toll-like receptor-4 expression.

56 In the brain, levels of RAGE and Toll-like receptor 4, glial fibrillary acidic protein an

57 n end products (RAGE) messenger RNA, but not toll-like receptor 4 in hippocampal microglia.

58 show that upon cancer-induced activation of Toll-like receptor 4 in skeletal muscle, p38beta MAPK ph

59 amplified platelet response to the agonists; Toll-like receptor 4 inhibitor blunted this effect.

60 Although we report that Toll-like receptor 4 is expressed in both excitatory and

61 nate antimicrobial responses was observed in toll-like receptor 4 knockout mice treated with 3-deacyl

62 ter P. aeruginosa infection in wild-type and toll-like receptor 4 knockout mice treated with 3-deacyl

63 ity to inhibit lipopolysaccharide binding to toll-like receptor-4, leading to reductions in mitogen-a

64 f mice with either protein formulated with a Toll-like receptor 4 ligand (TLR4L)-containing adjuvant

65 effect of liver inflammation induced by the Toll-like receptor 4 ligand lipopolysaccharide (LPS) wit

66 lipopolysaccharide (LPS), a proinflammatory Toll-Like Receptor 4 ligand.

67 primes the cell for an enhanced response to toll-like receptor 4 ligands.

68 They share regulatory function downstream of Toll-like receptor 4/LPS in mast cells, through regulati

69 ibitor of LPS, blocking the formation of the Toll-like receptor 4/MD-2/LPS complex.

70 and subsequent sustained bacteremia leads to Toll-like receptor 4-mediated hyperinflammation and leth

71 rass pollen or mite allergens to enhance the Toll-like receptor 4-mediated proallergic properties of

72 s) of this new class of small-molecule mouse Toll-like receptor 4 (mTLR4) agonists.

73 Moreover, Toll-like receptor 4 mutant mice (C3H/HeJ) with high-fat

74 d antagonizing the activation of LPS-induced Toll-like receptor 4-myeloid differentiation factor 2 (T

75 entially detected by host receptors like the Toll-like receptor 4/myeloid differentiation factor 2 co

76 LPS is recognized by the Toll-like receptor 4/myeloid differentiation factor-2 (T

77 ediated by the cluster of differentiation 14/Toll-like receptor 4/myeloid differentiation protein 2 (

78 ly inhibited lipopolysaccharide binding to a toll-like receptor-4/myeloid differentiation factor 2 fu

79 ating that miR-147 upregulation inhibits the Toll-like receptor 4/NF-kappaB pathway.

80 ation by the innate immune system, including Toll-like receptor 4, nuclear factor kappa-light-chain-e

81 and bicarbonate secretion, up-regulation of toll-like receptor 4/nuclear factor kappa light-chain-en

82 T cells and Toll-like receptor 4 on B cells were important in the ge

83 Inhibition of PKR or NE or neutralization of Toll-like receptor 4 or 2(TLR4 or TLR2) prevented the de

84 nd SseK3 suppress TNF-alpha-induced, but not Toll-like receptor 4- or interleukin-induced, NF-kappaB

85 r factor kappa B, lipoxygenase-1 (LOX-1) and toll-like receptor 4 (p < 0.05).

86 Toll-like receptor 4 positive (TLR4(+) ) macrophages wer

87 tion of MMP-1 and COX-2 was mediated through Toll-like receptor-4, possibly through thrombin-induced

88 mechanisms by which inflammation - driven by Toll-like receptor 4-regulated cytokines, immune cells a

89 l a novel function of CFTR as a regulator of toll-like receptor 4 responses and cell polarity in bili

90 ine kinase self-activates and phosphorylates toll-like receptor 4, resulting in activation of nuclear

91 In vitro studies found enhanced Toll-like receptor 4 signaling activated by TnC, promoti

92 Overall, these studies suggest TnC/Toll-like receptor 4 signaling as an important regulator

93 The penta-acylated LOS exhibits reduced toll-like receptor 4 signaling but does not affect N. go

94 arly postnatal inflammatory stimuli activate toll-like receptor 4 signaling in astrocytes and promote

95 entrain qualitatively different responses to toll-like receptor 4 signaling in vivo.

96 ng low-status-associated polarization of the Toll-like receptor 4 signaling pathway toward a proinfla

97 gen species production and activation of the Toll-like receptor 4 signaling pathway.

98 y by increasing sirtuin 1 and inhibiting the Toll-like receptor 4 signaling pathway.

99 nown that lipopolysaccharide (LPS)-activated toll-like receptor 4 signaling pathways play a crucial r

100 d an innate immune response by activation of Toll-like receptor 4 signaling to MD2 and CD14, and caus

101 lls, relied on innate immune sensing through toll-like receptor 4 signaling, and ultimately depended

102 gram-negative bacterial products in situ via Toll-like receptor 4 signaling, contributing to genital

103 ipopolysaccharide (LPS) stimuli through CD14/Toll-like receptor 4 signaling.

104 eloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.

105 nd sevoflurane directly target and attenuate Toll-like receptor 4 system.

106 es of TAK-242, a small molecule inhibitor of Toll-like receptor 4, that primarily reacted with a sing

107 Interestingly, a direct activator of toll-like receptor 4, the bacterial cell wall component

108 fter infection with Y. pestis, influenced by Toll-like receptor 4-TIR-domain-containing adapter-induc

109 NA levels were assessed by real-time PCR and Toll like receptor 4 (TLR-4) protein expression by Weste

110 t into atherosclerotic lesions and inhibited toll-like receptor 4 (TLR 4)-initiated proinflammatory m

111 the present study is to examine the level of Toll-like receptor 4 (TLR-4), interleukin-18 (IL-18), an

112 increase in TJ permeability was mediated by toll-like receptor 4 (TLR-4)/MyD88 signal-transduction p

113 also exhibits anti-inflammatory effects in a Toll-like Receptor-4 (TLR-4) dependent manner.

114 livery system, and simultaneously, activated Toll-Like Receptor-4 (TLR-4) on APCs to release chemokin

115 In this work, human Toll-Like Receptor-4 (TLR-4), a protein responsible for

116 different human-compatible adjuvants (alum, Toll-like receptor 4 [TLR-4] agonist glucopyranosal lipi

117 Additionally, the activation of toll like receptor 4 (TLR4) induced by LPS showed no alt

118 This activation is through the toll like receptor 4 (TLR4)/myeloid differentiation prim

119 mor necrosis factor alpha (TNFA) (n = 6) and toll-like receptor 4 (TLR4) (n = 3).

120 ng number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, th

121 In this study we hypothesized that Toll-like receptor 4 (TLR4) activation and subsequent in

122 Toll-like receptor 4 (TLR4) activation by bacterial infe

123 ponses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopo

124 nd mRNA translation lead to hypothesize that toll-like receptor 4 (TLR4) activation reduced LNP-media

125 cell (DC) response to C. jejuni LOS through Toll-like receptor 4 (TLR4) activation.

126 DM), which is similar to that induced by the Toll-like receptor 4 (TLR4) agonist lipopolysaccharide.

127 immune stimulation, such as treatment with a Toll-like receptor 4 (TLR4) agonist, enhanced bacterial

128 In primary rat cardiomyocyte cultures Toll-like receptor 4 (TLR4) agonist- or PKCepsilon/CN-de

129 g stimulation by lipopolysaccharide (LPS) of Toll-like receptor 4 (TLR4) and by poly(I.C) of TLR3 but

130 iated mainly by leukocytes that express both Toll-like receptor 4 (TLR4) and Fc gamma receptors (Fcga

131 e microbiota, hematopoietic cell deletion of Toll-like receptor 4 (TLR4) and inactivation of the IL-1

132 with a decrease in the expression of mucosal toll-like receptor 4 (TLR4) and its adaptor myeloid diff

133 LPS-induced ACSL1 expression is dependent on Toll-like receptor 4 (TLR4) and its adaptor protein TRIF

134 ring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic pro

135 rcentages and sputum cell gene expression of Toll-like receptor 4 (TLR4) and NLRP3 at 4 hours in nono

136 emic low-dose morphine (LDM) share action at Toll-like receptor 4 (TLR4) and signaling via protein ki

137 hat expression of the innate immune receptor Toll-like receptor 4 (TLR4) and the extracellular matrix

138 Here we identify endothelial Toll-like receptor 4 (TLR4) and the gut microbiome as cr

139 f innate immune signaling systems, including toll-like receptor 4 (TLR4) and the interleukin-1beta (I

140 the combination of synthetic small-molecule Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent

141 show here that the combination of synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent

142 uvant comprised of two synthetic ligands for Toll-like receptor 4 (TLR4) and TLR7.

143 ntigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in p

144 (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been show

145 The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for

146 further implicate the innate immune receptor toll-like receptor 4 (TLR4) as an underlying mechanism m

147 Identification of Toll-like receptor 4 (TLR4) as one of the most abundant

148 Recognition of lipopolysaccharides (LPS) by Toll-like receptor 4 (TLR4) at the plasma membrane trigg

149 Upon activation, Toll-like receptor 4 (TLR4) binds adapter proteins, incl

150 Surprisingly, disruption of the Toll-like receptor 4 (TLR4) but not TLR2 signaling resto

151 Stimulation of Toll-like receptor 4 (TLR4) by bacterial lipopolysacchar

152 evels of NF-kappaB in human embryonic kidney Toll-like receptor 4 (TLR4) cells and murine embryonic f

153 Our results show that Toll-like receptor 4 (TLR4) drives breast cancer cell gr

154 ined to be associated with downregulation of Toll-like receptor 4 (TLR4) expression on the surface of

155 Similarly, Toll-like receptor 4 (TLR4) has been implicated in breas

156 L1 as a critical structural component of the Toll-like receptor 4 (TLR4) immune signal transduction p

157 Ps) induced NF-kappaB activation mediated by Toll-like receptor 4 (TLR4) in a glycoprotein (GP)-depen

158 MA with wild-type lipid A to stimulate human Toll-like receptor 4 (TLR4) in a reporter cell line.

159 Increased expression and activity of toll-like receptor 4 (TLR4) in chronic infectious and in

160 Increasing evidence points to a key role for toll-like receptor 4 (TLR4) in chronic pain states of so

161 LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-bi

162 ing studies indicate a sex-dimorphic role of Toll-like receptor 4 (TLR4) in driving neuropathic pain.

163 m gene knockout studies supports the role of Toll-like receptor 4 (TLR4) in intestinal inflammation a

164 LPS-mediated activation of Toll-like receptor 4 (TLR4) in macrophages results in th

165 e 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species.

166 cal role for the lipopolysaccharide receptor toll-like receptor 4 (TLR4) in NEC development through i

167 s, we first evaluated the role of nociceptor Toll-like receptor 4 (TLR4) in OIH and priming induced b

168 Recent evidence implicates toll-like receptor 4 (TLR4) in opioid analgesia, toleran

169 tumor necrosis factor-alpha (TNFalpha), and Toll-like receptor 4 (TLR4) in surgically excised specim

170 critical role of innate immune signaling via Toll-like receptor 4 (TLR4) in the pathogenesis of dyspl

171 Polymorphisms in toll-like receptor 4 (TLR4) induce an aberrant immune re

172 Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory resp

173 Our findings demonstrate that LPS induces Toll-like receptor 4 (TLR4) internalization in corneal e

174 Toll-like receptor 4 (TLR4) is a critical component of i

175 Toll-like receptor 4 (TLR4) is a key mediator of innate

176 SIGNIFICANCE STATEMENT: Toll-like receptor 4 (TLR4) is a key mediator of innate

177 Toll-like receptor 4 (Tlr4) is a key mediator of pro-inf

178 tirely clear, current evidence suggests that Toll-like receptor 4 (TLR4) is a key player in the mecha

179 Toll-like receptor 4 (TLR4) is a pattern recognition mol

180 Toll-like receptor 4 (TLR4) is an innate immune receptor

181 r advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4) is implicated in COPD.

182 Mechanistically, we report that Toll-Like Receptor 4 (TLR4) is required, at least in par

183 While Toll-like receptor 4 (TLR4) is responsible for all the h

184 Innate immune system activation via Toll-like receptor 4 (TLR4) leads to inflammation and ox

185 The Toll-like receptor 4 (TLR4) ligand endotoxin triggers ro

186 n enhanced sensitivity of macrophages to the Toll-like receptor 4 (TLR4) ligand lipopolysaccharide (L

187 We investigated the role of an endogenous Toll-like receptor 4 (TLR4) ligand, fibronectin-EDA (FN-

188 morphine binds to the innate immune receptor toll-like receptor 4 (TLR4) localized primarily on micro

189 Here, we show that Toll-like receptor 4 (TLR4) mediates cancer-induced musc

190 To test the hypothesis that toll-like receptor 4 (TLR4) mediates proinflammatory pol

191 xamined the effect of innate immune receptor Toll-like receptor 4 (TLR4) on excitability of the hippo

192 ed by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect the

193 eria activates plasma membrane signaling via Toll-like receptor 4 (TLR4) on host cells and triggers i

194 mponents such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a rob

195 rs of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells.

196 rs of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells.

197 ow that GOS is recognized by and upregulates Toll-like receptor 4 (TLR4) on RAW264.7 macrophages, fol

198 either bacterial lipopolysaccharide through Toll-like receptor 4 (TLR4) or leukocyte cytokine IFN-ga

199 The toll-like receptor 4 (TLR4) pathway is known to be invol

200 interacts with rapid kinetics to engage the Toll-like receptor 4 (TLR4) pathway, leading to the prod

201 genes (STING) pathway and an agonist of the Toll-like receptor 4 (TLR4) pathway.

202 tumor necrosis factor alpha (TNF-alpha) and Toll-like receptor 4 (TLR4) pathways, and resulted in co

203 entiation revealed that binding of S100A9 to Toll-like receptor 4 (TLR4) promotes activation of p38 m

204 Toll-like receptor 4 (TLR4) promotes vascular inflammato

205 As part of the innate immune system, Toll-like receptor 4 (TLR4) recognizes bacterial cell su

206 driven by microbial-dependent activation of toll-like receptor 4 (TLR4) signaling and subsequent eng

207 Using Toll-like receptor 4 (TLR4) signaling in macrophages as

208 recently discovered the presence of multiple Toll-like receptor 4 (TLR4) signaling intermediates in l

209 In the liver, IRF3 is activated via Toll-like receptor 4 (TLR4) signaling or the endoplasmic

210 otential vanilloid subtype 1 (TRPV1) through Toll-like receptor 4 (TLR4) signaling.

211 During bacterial infections, Toll-like receptor 4 (TLR4) signals through the MyD88- a

212 -TOF MS), gas chromatography (GC), SDS-PAGE, Toll-like receptor 4 (TLR4) stimulation, and immunoblot

213 re, we provide evidence that immune receptor toll-like receptor 4 (TLR4) supports OL lineage cell spa

214 emonstrate that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4) through its N terminal and m

215 Conversely, the ability of Toll-like Receptor 4 (TLR4) to activate NFkappaB in resp

216 flammatory endocytosis pathway that delivers Toll-like receptor 4 (TLR4) to endosomes.

217 that ragweed pollen extract (RWPE) requires Toll-like receptor 4 (TLR4) to stimulate CXCL-mediated i

218 ced by reduced proinflammatory responses via Toll-like receptor 4 (TLR4) to the hypoacylated LPS.

219 ent of Gram-negative bacteria that activates Toll-like receptor 4 (TLR4) to trigger proinflammatory r

220 300b, and its adaptor DAP12, associated with Toll-like receptor 4 (TLR4) upon LPS binding, thereby en

221 Binding of MfP to Toll-like receptor 4 (TLR4) was determined by co-immunop

222 WD-fed Toll-like receptor 4 (TLR4)(-/-) mice did not exhibit my

223 osis factor alpha (TNF-alpha) or blocking of Toll-like receptor 4 (TLR4), (v) was absent in TLR4-knoc

224 as a consequence of sequential activation of toll-like receptor 4 (TLR4), a receptor for endotoxin, a

225 data suggest that the innate immune receptor Toll-like receptor 4 (TLR4), along with its coreceptor m

226 In male rats, HMWH also signals via Toll-like receptor 4 (TLR4), and AS-ODN for TLR4 mRNA ad

227 -NS5A in liver up-regulate the expression of Toll-like receptor 4 (TLR4), and develop liver tumors co

228 hat can lyse bacteria, suppress signaling by Toll-like receptor 4 (TLR4), and enhance signaling to do

229 of normal human monocytes, primarily through Toll-like receptor 4 (TLR4), and suppressed phytohemaggl

230 o found to bind TRAM, an adaptor protein for Toll-like receptor 4 (TLR4), and thereby impact both vir

231 nses invoked by IL-1beta, TNF-alpha, and LPS/Toll-like receptor 4 (TLR4), but not TRIF-dependent poly

232 In the ALHS, we tested for a gene [Toll-like Receptor 4 (TLR4), encoding the endotoxin rece

233 d not require T-cell-intrinsic expression of toll-like receptor 4 (TLR4), interleukin-1 receptor (IL-

234 ith the immunosurveillance receptor complex, Toll-like receptor 4 (TLR4), on microglial cells to init

235 ytoplasm and downregulated the expression of toll-like receptor 4 (TLR4), receptor for advanced glyca

236 s can be induced by endotoxin stimulation of Toll-like receptor 4 (TLR4), resulting in an ameliorated

237 conditions were previously found to activate Toll-like receptor 4 (TLR4), resulting in expression of

238 with lipopolysaccharide (LPS), the ligand of Toll-like receptor 4 (TLR4), reveals previously unobserv

239 ssociated lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4), stimulating production of t

240 The level of toll-like receptor 4 (TLR4), TLR2, and erythropoietin-pr

241 gle study revealed a new complex composed of Toll-like receptor 4 (TLR4), TLR6, and CD36 induced by f

242 Toll-like receptor 4 (TLR4), together with MD-2, binds b

243 ediated activation of TRPC1 was dependent on Toll-like receptor 4 (TLR4), which induced endoplasmic r

244 einphagy requires the presence of microglial Toll-like receptor 4 (TLR4), which induces transcription

245 Bile duct cells expressed the LPS receptor, Toll-like receptor 4 (TLR4), which links to activation o

246 olecules and innate immune receptors such as Toll-like receptor 4 (TLR4), which recognizes the lipid

247 sma G-CSF levels and neutrophil numbers in a Toll-like receptor 4 (TLR4)- and myeloid differentiation

248 del of PHH, we demonstrate that IVH causes a Toll-like receptor 4 (TLR4)- and NF-kappaB-dependent inf

249 Although Toll-like receptor 4 (TLR4)- and nucleotide-binding olig

250 In PRR analyses, whereas Toll-like receptor 4 (TLR4)- and SIGNR1-deficient vagina

251 one was sufficient to induce meningitis in a Toll-like receptor 4 (TLR4)-CXCL2-dependent manner.

252 production by modulating host immunity in a Toll-like receptor 4 (TLR4)-dependent manner, a signalin

253 Disease was linked to a Toll-like receptor 4 (TLR4)-dependent mechanism of IAP d

254 rickettsiae activate ASC inflammasome via a Toll-like receptor 4 (TLR4)-dependent mechanism.

255 EL induced PTX3 expression by activating the Toll-like receptor 4 (TLR4)-dependent pathway via nuclea

256 ors to evaluate the role of various genes in Toll-like receptor 4 (TLR4)-induced necroptosis.

257 ct ligations or sham surgeries on C57BL/6 or toll-like receptor 4 (TLR4)-knockout mice to induce live

258 in LPS activates innate immunity through the Toll-like receptor 4 (TLR4)-MD-2 complex on host cells.

259 Single inhibition of the Toll-like receptor 4 (TLR4)-MD2 complex failed in treatm

260 ages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX)

261 f opioids, and we recently demonstrated that Toll-like receptor 4 (TLR4)-mediated neuroinflammation i

262 Toll-like receptor 4 (TLR4)-mediated signaling was asses

263 ue damage and expressed by tumors, activates toll-like receptor 4 (TLR4)-mediated sterile inflammatio

264 pid Lipid A, initiates the activation of the Toll-like Receptor 4 (TLR4)-myeloid differentiation fact

265 s in cultured myenteric neurons that express Toll-like receptor 4 (TLR4).

266 e the intestine's innate immune response via toll-like receptor 4 (TLR4).

267 effects which are mediated partially through Toll-like receptor 4 (TLR4).

268 ll understood, FNIII EDA is known to agonize Toll-like receptor 4 (TLR4).

269 antimicrobial peptides and signaling through Toll-like receptor 4 (TLR4).

270 amaged epidermal keratinocytes and driven by Toll-like receptor 4 (TLR4).

271 age-associated molecular pattern to activate Toll-like receptor 4 (TLR4).

272 ells, and TNFalpha secretion is dependent on toll-like receptor 4 (TLR4).

273 sensing of lipopolysaccharide (LPS) via the toll-like receptor 4 (TLR4).

274 evelopment accelerates after deletion of the Toll-like receptor 4 (TLR4).

275 ated predominantly via the membrane receptor Toll-like receptor 4 (TLR4).

276 these cytokines during bacterial sepsis via Toll-like receptor 4 (TLR4)/MyD88 sensing of lipopolysac

277 Dimerization of Toll-like receptor 4 (TLR4)/myeloid differentiation fact

278 Palmitate activated the Toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-ka

279 A3 are transcriptional targets of S100A4 via Toll-like receptor 4 (TLR4)/nuclear factor-kappaB signal

280 Mechanistically, Toll-like receptor 4 (TLR4, LPS receptor)-sphingosine ki

281 tor cluster-of-differentiation 14 (CD14) and Toll-like receptor 4 (TLR4; essential for the LPS respon

282 cyte-specific deletion of YAP (YAP( KO) ) or Toll-like receptor 4 (TLR4; TLR4( KO) ), and animals wer

283 In mechanistic experiments, inhibition of toll-like receptor-4 (TLR4) and the receptor for advance

284 Toll-like receptor-4 (TLR4) and type 1 interferon recept

285 the present study was to assess the role of Toll-like receptor-4 (TLR4) in mediating the inflammator

286 The lipopolysaccharide (LPS)- toll-like receptor-4 (TLR4) pathway plays an important r

287 of this process, inducing the activation of toll-like receptor-4 (TLR4) signaling and endoplasmic re

288 Toll-like receptor-4 (TLR4) was recently found to be exp

289 ene Expression Array Plates system for genes Toll-like receptor-4 (TLR4), high-mobility group box 1,

290 vate the host repair program orchestrated by Toll-like receptor-4 (TLR4).

291 ir of UVB-induced DNA damage is regulated by Toll-like receptor-4 (TLR4).

292 botic activity and is known to interact with Toll-like-receptor 4 (TLR4).

293 5) increased hypothalamic microglia density, toll-like-receptor-4 (Tlr4), and the inhibitor-NF-kappa-

294 resistant to Fas-mediated apoptosis ex vivo, Toll-like receptor 4(TLR4)-ligation restored Fas-sensiti

295 Thus, TRIF signaling (likely downstream of Toll-like receptor 4, TLR4) serves as one of the microbi

296 Activation of ERK signaling, downstream of toll-like receptor 4, was essential to the mitogenic eff

297 The NMDA-R and Toll-like receptor-4 were not required for proinflammato

298 also attenuated proinflammatory signaling by Toll-like receptor 4, which has a central role in Ad pat

299 A member of the toll-like receptor family, toll-like receptor 4, which is known to contribute to di

300 d macrophages (BMDM) upon stimulation of the Toll-like receptor 4 with Kdo2-Lipid A (KLA) and stimula