ライフサイエンスコーパス: Toll-like receptor 7

1 ence of RNA, presumably for interaction with Toll-like receptor 7.

2 highly conserved cysteine residue (Cys98) on Toll-like receptor-7.

3 ne ligand-2, gasdermin-D, interleukin-1beta, toll-like receptor 7/ 8, and IL-17A by 6.4-, 1.6-, 2.0-,

4 rial (CRM), admixed with the novel lipidated toll-like receptor 7/8 (TLR7/8) agonist INI-4001 adsorbe

5 Small-molecular Toll-like receptor 7/8 (TLR7/8) agonists hold promise as

6 d RNA of HIV-1 encodes multiple uridine-rich Toll-like receptor 7/8 (TLR7/8) ligands that induce stro

7 cal intravital microscopy, we show that upon Toll-like receptor 7/8 (TLR7/8)-mediated inflammation of

8 -201 cells, can be activated by the specific Toll-like receptor 7/8 activator, R848, to release TNFal

9 otosensitizer (pyropheophorbide-a, PA) and a Toll-like receptor 7/8 agonist (resiquimod, R848), into

10 vaccine that links neoantigen peptides to a Toll-like receptor 7/8 agonist (SNP-7/8a), we show how t

11 ccine that links tumor antigen peptides to a Toll-like receptor 7/8 agonist (SNP-7/8a), we treated tu

12 application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely us

13 to monitor response to immunotherapy with a toll-like receptor 7/8 agonist in orthotopic syngeneic e

14 H505 envelope (Env) trimer formulated with a Toll-like receptor 7/8 agonist induced potent HIV-1 poly

15 tivated SARS-CoV-2 vaccine formulated with a toll-like receptor 7/8 agonist molecule adsorbed to alum

16 ammatory conditions, exposure of APCs to the Toll-like receptor 7/8 agonist R848 increases nanocluste

17 We administered the Toll-like receptor 7/8 agonist resiquimod (R848; a synth

18 al cytotoxic payload and an immunoregulating Toll-like receptor 7/8 agonist to the CD276 mAb.

19 in early life via synergistic engagement of Toll-like Receptor 7/8 and the C-type lectin receptor Mi

20 Activation of Toll-like receptor 7/8 by means of topical application o

21 d tumor necrosis factor responses of pDCs to Toll-like receptor 7/8 stimulation and intact/total prov

22 among LVRs, both at rest and in response to Toll-like receptor 7/8 stimulation by R848, were subopti

23 We show that activation of pDCs through Toll-like receptor 7/8 suppresses ILC2-mediated AHR and

24 (stimulator of interferon genes) and TLR7/8 (toll-like receptor 7/8) as drivers of LMP7 expression in

25 ed mRNA delivery, but also endowed LNPs with Toll-like receptor 7/8-agonistic activity, which signifi

26 Overall, we identified imidazopyrimidine Toll-like receptor-7/8 adjuvants that act in synergy wit

27 thways at basal and stimulated states with a Toll-like Receptor-7/8 agonist.

28 Administration of an agonist to toll-like receptor-7/8, a receptor expressed primarily o

29 patients, following in vitro stimulation of Toll-like receptors 7/8.

30 ed with three immunostimulatory agonists for Toll-like receptors 7/8/9 (TLR7/8/9) and stimulator of i

31 d produced significantly less IFN-alpha upon Toll-like receptor 7/9 (TLR7/9) engagement than controls

32 Nucleic acids from microbes are sensed by Toll-like receptors 7/9 (TLR7/9), which are selectively

33 On treatment with the toll-like receptor 7 agonist imquimod (IMQ), Trim32 knoc

34 Toll-like receptor agonists like the Toll-like receptor 7 agonist R848 induce DC maturation a

35 polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well

36 e isolated from whole blood, stimulated with Toll-like receptor 7 agonist, and analyzed by means of e

37 co-delivery of a hydrophobic small-molecule toll-like receptor 7 agonist, imiquimod (IMD), and a hyd

38 Imiquimod is a topical toll-like-receptor-7 agonist currently used for treating

39 blood IFN-stimulated gene signature in SLE, Toll-like receptor 7 agonists, but not IFN-alpha, up-reg

40 article (CDNP) formulation encapsulating the Toll-like receptor 7 and 8 (TLR7/8) agonist R848 (CDNP-R

41 very system for vaccines adjuvanted with the toll-like receptor 7 and 8 (TLR7/8) agonist R848.

42 The toll-like receptor 7 and 8 (TLR7/8) agonist Resiquimod (

43 Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent

44 nal screening effort identified a pyrimidine Toll-like receptor 7 and 8 dual agonist.

45 rge amounts of type 1 interferon (IFN) after Toll-like receptor 7 and 9 engagements.

46 nterferon-alpha in response to SIV and other Toll-like receptor 7 and 9 ligands ex vivo.

47 on and revealed that IRF5 acts downstream of Toll-like receptor 7 and possibly retinoic acid-inducibl

48 Through pattern recognition receptors (Toll-like receptor 7 and retinoic acid-inducible gene 1)

49 ing recombinant Sm-p80 protein formulated in Toll-like receptor 7 and Toll-like receptor 9 agonists,

50 ce interferon alpha following stimulation of Toll-like receptor 7 and upregulation of interferon-stim

51 r-associated factor 6 (TRAF6) as part of the Toll-like receptor-7 and -9 (TLR7/9) innate immune signa

52 y to produce type I IFN after challenge with Toll-like receptor-7 and -9 ligands, or murine cytomegal

53 pting aptamer-like roles by interacting with Toll-like receptors 7 and 8 (TLR7 and TLR8) via specific

54 tides (ASOs) can have opposing activities on Toll-Like Receptors 7 and 8 (TLR7/8), leading to diverge

55 Toll-like receptors 7 and 8 (TLRs) have emerged as key t

56 Toll-like receptors 7 and 8 are involved in modulating t

57 re inhibited by ligation of Fc receptors and Toll-like receptors 7 and 8 in a PKCbeta-dependent manne

58 an-pD-PLGA-NP@R848 released R848 to activate Toll-like receptors 7 and 8, following dual-reprograming

59 B cells and plasmacytoid dendritic cells via Toll-like receptors 7 and 9 suggested that agents that b

60 ferentiation and T cell activation, activate Toll-like receptor 7, and are linked to neurodegeneratio

61 ficiency in FcgammaRIIB or overexpression of Toll-like receptor 7 are protected from death caused by

62 We investigated Toll-like receptor 7-deficient (Tlr7(-/-)) and myeloid d

63 Furthermore, when formulated with a toll-like receptor 7-dependent (TLR7) agonist recently d

64 innate immune cells sustains interferon- and toll-like receptor 7-dependent B1a cell expansion and au

65 I interferons in a Toll-like receptor 3- and Toll-like receptor 7-dependent manner.

66 us sensing occurred in endosomes via a MyD88-Toll-like receptor 7-dependent mechanism and stimulated

67 spectively, retaining the ability to trigger Toll-like receptor 7 exclusively, and expanded human all

68 Toll-like receptor 7 expression in cortical neurons was

69 ce was associated with an increase in B cell Toll-like receptor 7 expression, increased serum levels

70 cells both in vivo and in vitro, leading to Toll-like receptor 7 hyporesponsiveness and impaired IFN

71 Ankara (MVA) boost) and stimulation of TLR7 (Toll-like receptor 7) improves virologic control and del

72 nt with the known neurodegenerative role for toll-like receptor 7 in neurons.

73 we shed light on a yet unanticipated role of Toll-like receptor 7 in the recognition of MHV68 in a su

74 tive orally active small molecule agonist of Toll-like receptor 7--in chimpanzees with chronic HBV in

75 macytoid dendritic cell (pDC) activation via Toll-like receptor 7, inducing type I IFN and inflammato

76 ABCs and demonstrated that signaling through Toll-like receptor 7 is crucial for development of this

77 et al. used mouse models to demonstrate that Toll-like receptor 7 is required for the generation of a

78 Because a major function of Toll-like receptor 7 is to induce type I interferons (IF

79 However, despite large amounts of Toll-like receptor 7-mediated IFN-alpha, produced by pDC

80 it, colony stimulating factor 3 receptor and toll-like receptor 7 mRNA expression increases in the th

81 The small molecule GS-9620 activates Toll-like receptor 7 signaling in immune cells of chimpa

82 l replication, direct cell-cell contact, and Toll-like receptor 7 signaling, and we show that the act

83 rticoids impair upstream B cell receptor and Toll-like receptor 7 signaling, reduce transcriptional o

84 less IFNalpha than healthy control pDCs upon toll-like receptor 7 stimulation ex vivo (P < .0001).

85 , where the nucleic acid components activate Toll-like receptor 7 (TLR-7) or TLR-9.

86 otypes and clinical phenotypes, and assessed Toll-like receptor 7 (TLR-7)-stimulated MIF production i

87 so show that HIV-1-induced IKpDC depended on Toll-like receptor 7 (TLR7) activation.

88 ol-containing oil-in-water emulsion; AS37, a Toll-like receptor 7 (TLR7) agonist adsorbed to alum; Cp

89 Provision of CD40-specific antibody, Toll-like receptor 7 (TLR7) agonist and interleukin-2 (I

90 Imiquimod is a synthetic Toll-like receptor 7 (TLR7) agonist approved for the top

91 We treated mice topically with the Toll-like receptor 7 (TLR7) agonist imiquimod (IMQ) to a

92 molecule immune response modifier that is a Toll-like receptor 7 (TLR7) agonist induces IL-12 and TN

93 s that have been activated with IL-2 and the Toll-like receptor 7 (TLR7) agonist resiquimod (called 2

94 od is a topical immune response modifier and Toll-like receptor 7 (TLR7) agonist that induces the imm

95 ibody (bNAb) administration, together with a Toll-like receptor 7 (TLR7) agonist, enhanced virologic

96 with vesatolimod, an investigational, oral, toll-like receptor 7 (TLR7) agonist, leads to sustained

97 eport that intravenous administration of the Toll-like receptor 7 (TLR7) agonist, R848 in combination

98 Small molecule Toll-like receptor 7 (TLR7) agonists have been used as v

99 Pteridinone-based Toll-like receptor 7 (TLR7) agonists were identified as

100 use in plasmacytoid DC (pDC) stimulated with Toll-like receptor 7 (TLR7) agonists, Erk1/2 activation

101 Toll-like receptor 7 (TLR7) agonists, in combination wit

102 This research examined the roles of Toll-like receptor 7 (TLR7) and autophagy in IFN-alpha p

103 ues report that platelets express functional TOLL-like receptor 7 (TLR7) and contribute to host survi

104 se include endosomal recognition through the Toll-like receptor 7 (TLR7) and cytosolic recognition th

105 e maturation of dendritic cells (DC) through Toll-like receptor 7 (TLR7) and its adaptor molecule MyD

106 e plasmacytoid dendritic cells (pDC) through Toll-like receptor 7 (TLR7) and its adaptor molecule, My

107 luenza genomic RNA and signaling by means of Toll-like receptor 7 (TLR7) and MyD88.

108 on pattern-recognition receptors, including Toll-like receptor 7 (TLR7) and retinoic acid inducible

109 acid-binding innate immune receptors such as Toll-like receptor 7 (TLR7) and TLR9 have been implicate

110 In lupus, Toll-like receptor 7 (TLR7) and TLR9 mediate loss of tol

111 IRF-5 is activated by Toll-like receptor 7 (TLR7) and TLR9 via the MyD88 pathw

112 e production, with IRF5 acting downstream of Toll-like receptor 7 (TLR7) and, possibly, retinoic acid

113 erapies because of their ability to activate Toll-like receptor 7 (TLR7) and/or TLR8 on innate immune

114 We established Toll-like receptor 7 (TLR7) as a cell-surface RNA (csRNA

115 ex differences in demyelination and identify Toll-like receptor 7 (TLR7) as a potential target to ame

116 we present evidence showing that a ligand of Toll-like receptor 7 (TLR7) can induce anti-HCV immunity

117 Toll-like receptor 7 (TLR7) detects viral RNA, but can b

118 Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased mo

119 Toll-like receptor 7 (Tlr7) has been linked to systemic

120 ole of extracellular miRNAs and their sensor Toll-like receptor 7 (TLR7) in brain inflammation and ne

121 Toll-like receptor 7 (TLR7) is an established therapeuti

122 Our previous study demonstrated that Toll-like receptor 7 (TLR7) is essential in the inductio

123 Toll-like receptor 7 (TLR7) is expressed on multiple typ

124 Toll-like receptor 7 (TLR7) is known for eliciting immun

125 Toll-like receptor 7 (TLR7) is required for promoting ge

126 shown that a moderate increase of the innate Toll-like receptor 7 (TLR7) is sufficient for the develo

127 pha (IFN-alpha) in response to HIV-1-encoded Toll-like receptor 7 (TLR7) ligands than pDCs derived fr

128 Toll-like receptor 7 (TLR7) mediates autoantigen and vir

129 e cell-autonomous and rescued by ablation of Toll-like receptor 7 (TLR7) or MyD88.

130 s to viruses that are recognized through the Toll-like receptor 7 (TLR7) or TLR9 signaling pathway.

131 ne innate inflammatory responses mediated by Toll-like receptor 7 (TLR7) remain to be fully elucidate

132 Here we demonstrate that Toll-like receptor 7 (TLR7) sensing and type I interfero

133 Toll-like receptor 7 (TLR7) signaling predominantly regu

134 e the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling.

135 gh circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of

136 Toll-like receptor 7 (TLR7) signals to B cells are criti

137 Toll-like receptor 7 (TLR7) stimulation in the airways m

138 differentiation-associated gene 5 (MDA5) and Toll-like receptor 7 (TLR7) to induce transcription of t

139 m dying cells acted on neighbouring tumoural Toll-like receptor 7 (TLR7) to non-canonically activate

140 Toll-like receptor 7 (TLR7) triggers antiviral immune re

141 Imiquimod (IQ) is an agonist of Toll-like receptor 7 (TLR7) used to treat various infect

142 We found that functional Toll-like receptor 7 (TLR7) was expressed in C-fiber pri

143 endosomal uptake, and probably signaling via Toll-like receptor 7 (TLR7) were critical for sensing of

144 ic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), and IFNgamma receptors on B

145 The X-linked gene, Toll-like receptor 7 (Tlr7), regulated sex-specific IFN

146 In mice deficient for Toll-like receptor 7 (TLR7), transcribed ERV loci can re

147 ess pattern recognition receptors, including Toll-like receptor 7 (TLR7), which recognizes guanosine-

148 nity-purified anti-Ro60 antibody induces the Toll-like receptor 7 (TLR7)-dependent generation of supe

149 Using Toll-like receptor 7 (TLR7)-dependent mouse models of sy

150 The induction of toll-like receptor 7 (TLR7)-dependent type I interferons

151 interferon (IFN-alpha/beta) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent

152 We investigated the hypothesis that reduced Toll-like receptor 7 (TLR7)-derived signaling drove the

153 that internalize red blood cells develop in Toll-like receptor 7 (TLR7)-driven inflammation.

154 In mice with toll-like receptor 7 (TLR7)-driven lupus, ZEB2 is essent

155 antibody production was largely dependent on Toll-like receptor 7 (TLR7).

156 port that several guanosine analogs activate Toll-like receptor 7 (TLR7).

157 ation-domain-containing protein 2 (NOD2) and Toll-like receptor 7 (TLR7).

158 cognition of intracellular Y. pestis by host Toll-like receptor 7 (TLR7).

159 and this response is attributed to platelet Toll-like receptor 7 (TLR7).

160 tion induced by compound CL097, a ligand for Toll-like receptor 7 (TLR7).

161 a new systemic immunostimulatory agent, the Toll-like receptor-7 (TLR7) agonist R848, to augment rad

162 r rapid excitation of nociceptor neurons via toll-like receptor-7 (TLR7) and its coupling to TRPA1 io

163 Imiquimod is a small-molecule ligand of Toll-like receptor-7 (TLR7) that is licensed for the tre

164 Toll-like receptors 7 (TLR7) and 8 (TLR8) each sense sin

165 LR2 (Toll-like receptor 2)-engaged and TLR7 (Toll-like receptor 7)/TLR8 (Toll-like receptor 8)-engage

166 nterferon, whereas in macrophages, lysosomal Toll-like receptor 7 was activated.

167 A candidate gene on the X chromosome, toll-like receptor 7, was then examined.