ライフサイエンスコーパス: Tr1 cell

1 rgy with c-Maf to promote the development of Tr1 cells.

2 7-induced differentiation of IL-10-producing Tr1 cells.

3 ICOS further promotes IL-27-driven Tr1 cells.

4 cluding differentiation into IL-10-secreting Tr1 cells.

5 xpansion and/or maintenance of IL-27-induced Tr1 cells.

6 ta promote the generation of IL-10-producing Tr1 cells.

7 ls induced the generation of IL-10-producing Tr1 cells.

8 tic activity in HNSCC abrogated outgrowth of Tr1 cells.

9 e function of differentiated IL-10-producing Tr1 cells.

10 ing P. falciparum infection, particularly in Tr1 cells.

11 in vivo persistence of alloantigen-specific Tr1 cells.

12 re transcriptional factors characteristic of Tr1 cells.

13 Finally, we confirmed these data using human TR1 cells.

14 ay is required for functional development of Tr1 cells.

15 27 activates Egr-2 to induce IL-10 producing Tr1 cells.

16 -10, and promoting development of regulatory Tr1 cells.

17 dicinal product containing an average of 10% Tr1 cells.

18 controls the early metabolic reprograming of Tr1 cells.

19 a significant change in the frequency of TH1/TR1 cells.

20 une disease-suppressing T regulatory type 1 (TR1) cells.

21 N-gamma/IL-10-secreting T regulatory type 1 (Tr1) cells.

22 istent with the phenotype of T regulatory-1 (Tr1) cells.

23 xp3(+) Tregs and Foxp3(-) type 1 regulatory (Tr1) cells.

24 differentiation of type 1 regulatory T cell (Tr1) cells.

25 gamma-coproducing CD4+ T (type I regulatory [Tr1]) cells.

26 Tr1 cells also had a distinct transcriptome, including h

27 develop methods to isolate and expand human Tr1 cells and define their functions.

28 he first evidence for a differential role of Tr1 cells and Foxp3(+) Tregs in regulating innate immune

29 Tr1 cells and FOXP3-positive Treg cells suppressed proli

30 n human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a

31 licular helper (TFH) cells are precursors of TR1 cells and that the TFH-to-TR1 cell transdifferentiat

32 omoters, which resulted in the generation of Tr1 cells and the amelioration of experimental autoimmun

33 gered the formation and expansion of cognate TR1 cells and their recruitment to the CNS-draining lymp

34 CD4+Foxp3(-) IL-10-producing (Tr1) cells and CD4+Foxp3+ regulatory (Treg) cells were a

35 rcinomas (HNSCC) induce type 1 regulatory T (Tr1) cells and contribute to carcinogenesis by creating

36 estinal IL-10-producing type 1 regulatory T (Tr1) cells and decrease diabetes incidence.

37 pressing regulatory T cells, IL-10-secreting Tr1 cells) and Th17 cells in rodents have been defined,

38 s in the differentiation of FoxP3(+) T(reg), Tr1 cells, and IL-17-producing T cells (Th17).

39 y responses, expansion of type 1 regulatory (Tr1) cells, and restriction of humoral immunity during m

40 9b(+) lymphocyte-activation gene 3 (LAG3)(+) TR1 cells, antigen-specific proliferative responses, and

41 y, we show that granzyme B-expressing CD4(+) Tr1 cells are capable of killing target cells in a perfo

42 Tr1 cells are CD4+ T lymphocytes that are defined by the

43 Th2 cells revealed that only the regulatory Tr1 cells are characterized by both LIF and IL10 release

44 Tr1 cells are currently used in several immune-mediated

45 e that CD4(+) T cells with the properties of Tr1 cells are present in the intestinal lamina propria a

46 The human PSA-induced Tr1 cells are profoundly anergic and exhibit nonspecific

47 atory (Treg) cells, and T regulatory type 1 (Tr1) cells are essential for ensuring peripheral immune

48 Type 1 regulatory T (Tr1) cells are inducible, interleukin (IL)-10(+)FOXP3(-)

49 Regulatory T type 1 (TR1) cells are potent suppressors of immune responses an

50 Type 1 regulatory T cells (Tr1 cells) are induced by interleukin-27 (IL-27) and hav

51 CD90.1+Foxp3-IL-10+ Tr1 cells arise from memory cells and rejoin the tissue-

52 effectors including highly proliferative Th1/Tr1 cells, as well as GC Tfh and Tfh-like cells lacking

53 This loss of Tr1 cell-associated IL-10 secretion was specific to CD46

54 eneration of CD4(+) T cells that express the Tr1-cell-associated molecules IL-10, inducible T-Cell co

55 stered these ubiquitous or even CNS-specific TR1 cells away from the CNS, abrogating their antienceph

56 hus, our study provides proof of concept for Tr1 cell-based therapies in experimental GN.

57 These data suggest that to optimize TR1 cell-based therapy, IL-10 receptor expression has to

58 These results further characterize Tr1 cell biology and provide essential knowledge for the

59 eriodic syndrome patients, was suppressed by Tr1 cells but not Foxp3(+) Tregs.

60 Surprisingly, Tr1 cells, but not Foxp3(+) Tregs, inhibited the transcr

61 Tr1 cells, but not FOXP3-positive Treg cells, isolated f

62 f is essential for the induction of IL-10 by Tr1 cells, but the molecular mechanisms that lead to the

63 a amplified the generation of induced IL-10+ Tr1 cells by IL-27.

64 nd differentiation of IL-10-producing murine Tr1 cells by inducing three key elements: the transcript

65 Leukemic cells induce Tr1 cells by phenocopying hematopoietic stem cells, whic

66 sought to determine whether peanut-specific TR1 cells can be generated in vitro from peripheral bloo

67 Peanut-specific TR1 cells can be induced from HC subjects and patients w

68 10-producing Th1 (induced type I regulatory [Tr1]) cells can also promote parasite persistence or imp

69 We also describe heterogeneity of Tr1 cell coinhibitory receptor expression that has impli

70 (Treg cells) and type 1 regulatory T cells (Tr1 cells), concomitant with a reduction in central nerv

71 tes in NOD mice required IL-10 signaling, as Tr1 cells could not suppress CD4(+) T cells with a domin

72 Tr1 cell culture supernatants promoted differentiation o

73 Finally, we used human TR1 cells, currently employed for cell therapy, to confi

74 Accordingly, Tr1 cells derived from MT-deficient mice showed an incre

75 ortant mediator of type I IFN production and Tr1 cell development and activation during malaria.

76 Tr1 cell development and suppressive function of Itk def

77 e critical role for type I IFN signaling for Tr1 cell development was confirmed in vivo using a precl

78 metallothioneins (MTs) that in turn prevent Tr1 cell development.

79 Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging

80 Conversely, CD39 promotes Tr1 cell differentiation by depleting eATP.

81 vely active HRas rescues IRF4 expression and Tr1 cell differentiation in Itk(-/-) cells.

82 molecular pathways for negatively regulating Tr1 cell differentiation remain elusive.

83 een STATs and MTs in regulating IL-10 during Tr1 cell differentiation.

84 e factors serve a pioneering function during Tr1 cell differentiation.

85 ase activity is required for mouse and human Tr1 cell differentiation.

86 r AHR inactivation by HIF1-alpha and inhibit Tr1 cell differentiation.

87 ligands responsible for T regulatory type 1 (Tr1) cell differentiation remain undefined.

88 er these data suggest that naturally-arising Tr1 cells do not necessarily give rise to more Tr1 upon

89 However, whether Tr1 cells emerge in renal inflammation and, moreover, wh

90 model, we found a direct correlation between Tr1 cell engraftment and protection from weight loss in

91 sting the ability to generate donor-specific Tr1 cell-enriched lymphocytes from patients on dialysis

92 The Tr1 cell-enriched lymphocytes were generated by cocultur

93 The Tr1 cell-enriched medicinal products can be efficiently

94 The Tr1 cell-enriched medicinal products generated from PBMC

95 The ability to generate clinical-grade Tr1 cell-enriched products was defined by testing the re

96 gulatory network, involving antigen-specific Tr1 cells exhibiting a distinct transcriptome and indire

97 rized T cell subsets including Th1, Th2, and Tr1 cells express functional Bonzo, suggesting expressio

98 We found that murine TR1 cells expressed functional IL-10Ralpha.

99 esponses and promotes the differentiation of Tr1 cells expressing interferon-gamma and IL-10 and lack

100 DVax identified them as type 1 regulatory T (Tr1) cells expressing IL-10, granzyme B, perforin, CCL5

101 This mechanism effectively redirects Tr1 cells from a role in preventing cancer to maladaptiv

102 expression distinguishes CD90.1+Foxp3-IL-10+ Tr1 cells from CD90.1+Foxp3-IL-10- 'former' Tr1.

103 inhibited the generation of IL-10-producing Tr1 cells from naive and memory CD4(+) T cells induced b

104 -producing cells of several types, including Tr1 cells, from naturally tolerant patients suggests an

105 ity and expression of the genes required for Tr1 cell function.

106 , Th17, T follicular helper (Tfh), Treg, and Tr1 cells has helped to define unique surface molecules,

107 However, how IL-27 induces the expansion of Tr1 cells has not been elucidated.

108 rance, active suppression by T-regulatory 1 (Tr1) cells has emerged as an essential factor in the con

109 ressive properties, and IL-10-producing CD4+ Tr1 cells have been characterized as regulators of Th1-m

110 vely regulate the generation and function of Tr1 cells have been elusive.

111 These intestinal antigen-specific Tr1 cells have the ability to migrate to the periphery v

112 ratio is discussed as a possible cause of PA TR1 cell impairment.

113 Th2/Tc2, Th9/Tc9, Th17/Tc17, Th22/Tc22, and Tr1 cells in 26 filariae-infected individuals stimulated

114 characterized the spatiotemporal dynamics of Tr1 cells in a house dust mite model of allergic airway

115 signaling were used to test the activity of TR1 cells in a murine inflammatory bowel disease model,

116 e investigated the intra-hepatic presence of Tr1 cells in biopsies from a genotype 1b infected patien

117 roinflammation with an emphasis on Tregs and Tr1 cells in MS.

118 ICOShigh Treg induced Tr1 cells in nonactivated RC and Th2 cells in preactivat

119 Here, we examined the role of Tr1 cells in patients with multiple sclerosis (MS) by st

120 evaluated survival of adoptively transferred Tr1 cells in patients.

121 hat distinguished IL-10-Th1 cells from IL-10+Tr1 cells in Plasmodium falciparum-infected people who p

122 ther, our data show a key role of intestinal Tr1 cells in the control of effector T cells and develop

123 Finally, we could also identify Tr1 cells in the kidneys of patients with antineutrophil

124 HNSCC plays a major role in the induction of Tr1 cells in the tumor microenvironment.

125 d MHCII molecules, which in turn induces the Tr1 cells in upper small intestine.

126 required for the TCR-induced development of Tr1 cells in various organs, and in the mucosal system d

127 ired for the differentiation and function of Tr1 cells in vitro and in vivo.

128 igated the role of IL-10 signaling in mature TR1 cells in vivo.

129 in 10 (IL-10)-producing T-regulatory type 1 (TR1) cells in vivo.

130 of a regulatory subset of CD4(+) cells, the Tr1 cells, in an IL-27-dependent manner in vitro and in

131 We showed that Tr1 cells, in contrast to the non-Tr1 population, displa

132 Several cytokines derived from Th3 and Tr1 cells, including IL-10, are believed to regulate ora

133 on factors that promote IL-10 secretion from Tr1 cells induced by IL-27.

134 inhibited the generation of IL-10-producing Tr1 cells induced by two physiologic stimuli, the induci

135 are functional compared with peanut-specific TR1 cells induced from healthy control (HC) subjects.

136 thymically derived CD4(+)CD25+ TR cells and Tr1 cells induced in the periphery through exposure to a

137 /CD28 or CD3/CD46 (to generate T regulatory [Tr1] cells), induced substantial expression of granzyme

138 mmunotherapy (OIT) leads to antigen-specific TR1 cell induction has not been established.

139 ream of ITK, Ras activity is responsible for Tr1 cell induction, as expression of constitutively acti

140 er, neither transfer nor depletion of former Tr1 cells influences either Tr1 numbers or the inflammat

141 Bir Tr1 cells inhibited proliferation and IFN-gamma producti

142 Transfer of Bir Tr1 cells into SCID mice did not result in colitis, and

143 Phenotypes of Tr1 cells isolated from control individuals vs patients

144 ting gut-associated lymphoid tissue to boost Tr1 cells may be important in type 1 diabetes management

145 r capacity to produce high amounts of IL-10, Tr1 cells may have unique therapeutic effects in disease

146 Consistent with the role for IL-10 in Tr1 cell-mediated suppression, inhibition of inflammasom

147 T regulatory type 1 (Tr1) cell-mediated induction of tolerance in preclinical

148 HIF1-alpha degradation and takes control of Tr1 cell metabolism.

149 IL10 is an anti-inflammatory cytokine, so Tr1 cells might be used in the treatment of inflammatory

150 We also identified a conserved Tr1 cell molecular signature shared between patients wit

151 cy of malaria-specific adaptive regulatory T/Tr1 cells (p = 0.024), and the addition of neutralizing

152 e target cell proliferation, suggesting that Tr1 cells play an important role.

153 IL-10-producing CD4(+) type 1 regulatory T (Tr1) cells play a critical role in the maintenance of pe

154 Type 1 regulatory T (Tr1) cells play a pivotal role in restraining human T-ce

155 characterize the CD3(+)CD4(+) Th, Treg, and Tr1 cell populations simultaneously across 23 memory T c

156 e already defined CD3(+)CD4(+) Th, Treg, and Tr1 cell populations, for a total of 11 Th cell, 4 Treg,

157 ells from unmanipulated mice are enriched in Tr1 cell precursors, enabling differentiation of cells t

158 CD4(+) T regulatory type 1 (TR1) cells produce large amounts of this cytokine and ar

159 Bir Tr1 cells proliferated poorly, but their proliferation w

160 IL-10-producing Tr1 cells promote tolerance but their contributions to t

161 In conclusion, TR1 cell regulatory activity is dependent on IL-10 recep

162 er, factors and molecular signals sustaining TR1 cell regulatory activity still need to be identified

163 y roles in Tr1-suppressive function and that Tr1 cells represent the active component of the T-allo10

164 mmercial CD19-targeted CAR T cells, Eomes(+) Tr1 cells represented a stable population comprising 40%

165 TR1 cells required IL-10 receptor signaling to activate

166 ivity, but not the retention of autoreactive TR1 cells, requires local autoantigen expression.

167 Mechanistically, HDVax-induced Tr1 cells selectively killed MHC-II tumour antigen-prese

168 In line with this, Tr1 cells showed a strong suppressive activity ex vivo a

169 chromatin accessibility, and upregulation of TR1 cell-specific genes linked to chromatin regions that

170 olerance, but the diversity of Th, Treg, and Tr1 cell subsets has not been fully characterized.

171 ns, for a total of 11 Th cell, 4 Treg, and 1 Tr1 cell subsets.

172 Human Tr1 cells suppress proliferation of effector T cells (ad

173 IL-27-induced type 1 regulatory T (Tr1) cells suppress autoimmunity by producing IL-10.

174 e mice, only the ubiquitous antigen-specific TR1 cells suppressed liver autoimmunity.

175 proliferation of effector T cells, but only Tr1 cells suppressed secretion of IL1B and tumor necrosi

176 Tumour-specific Tr1 cells suppressed tumour rejection induced by anti-PD

177 l network, which generates suppressive human Tr1 cells that may be harnessed for the control of aller

178 wever, distinct induced T regulatory type 1 (Tr1) cells that lack Foxp3 expression also regulate T ce

179 Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are inst

180 tic cells are implicated in the induction of Tr1 cells, the signals that negatively regulate the gene

181 Tr1 cells then inhibit cytotoxic CD8+ T cells, preventin

182 The ability of Tr1 cells to cure diabetes in NOD mice required IL-10 si

183 The ability of Foxp3(+) Tregs and Tr1 cells to suppress adaptive immune responses is well

184 precursors of TR1 cells and that the TFH-to-TR1 cell transdifferentiation process is characterized b

185 At the single-cell level, the TFH-to-TR1 cell transition is accompanied by both, downregulati

186 We compared the ability of Tr1 cells versus Foxp3(+) Tregs to suppress IL-1beta pro

187 ells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-1

188 f IL-27 in cDC and through the generation of Tr1 cells, we propose that the PGE2-induced inhibition o

189 Furthermore, T-allo10-derived Tr1 cells were detectable in the peripheral blood of HSC

190 Human Tr1 cells were generated from peripheral blood mononucle

191 CD49b(+)LAG3(+) TR1 cells were induced in pea-T10 cells at comparable pe

192 lated with anti-CD3 and anti-CD28 beads, and Tr1 cells were purified by using an IL10 cytokine-captur

193 Collectively, these data show that cytotoxic Tr1 cells, which maintain peripheral tolerance, also inh

194 T regulatory type 1 (Tr1) cells, which are defined by their regulatory functi

195 vels of effector cytokines, and type 1 Treg (Tr1) cells, which are FOXP3-negative and secrete interle

196 motes the differentiation of IL-10-secreting Tr1 cells while inhibiting Th17 generation and molecules

197 re were striking defects in the induction of Tr1 cells with CD46 costimulation as measured by IL-10 b

198 TR1 cells with impaired IL-10 receptor signaling lost th

199 SCC or exogenous PGE(2) induced outgrowth of Tr1 cells with the CD3(+)CD4(+)CD25(-)IL2Rbeta(+)IL2Rgam