ライフサイエンスコーパス: Trypanosoma brucei

1 cal disease caused by the protozoan parasite Trypanosoma brucei .

2 nzamides (CNBs) against bloodstream forms of Trypanosoma brucei .

3 tozoa (Leishmania spp., Plasmodium spp., and Trypanosoma brucei).

4 in tRNAs from Bacillus subtilis, plants and Trypanosoma brucei.

5 orthologue, PNT1, in the parasitic protozoon Trypanosoma brucei.

6 by RNA polymerase I (Pol I) in the parasite Trypanosoma brucei.

7 diting in kinetoplastid protists typified by Trypanosoma brucei.

8 ents in the large ribosomal subunit (60S) of Trypanosoma brucei.

9 e boundaries of previously annotated CDSs in Trypanosoma brucei.

10 As and is unique for kinetoplastids, such as Trypanosoma brucei.

11 generates functional mitochondrial mRNAs in Trypanosoma brucei.

12 telomeric ESs and VSG antigenic switching in Trypanosoma brucei.

13 characterize the non-snRNP PRP19 complex of Trypanosoma brucei.

14 P2 in either the cytosol or mitochondrion of Trypanosoma brucei.

15 and the early diverging parasitic protozoan, Trypanosoma brucei.

16 lar activity against the bloodstream form of Trypanosoma brucei.

17 all lysine residues for all core histones of Trypanosoma brucei.

18 ut not CD8(+), T cells in mice infected with Trypanosoma brucei.

19 . Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei.

20 ganisation of transcription in the genome of Trypanosoma brucei.

21 ith either of two subspecies of the parasite Trypanosoma brucei.

22 essential for retrograde cargo transport in Trypanosoma brucei.

23 ,3-d]pyrimidines are inhibitors of PTR1 from Trypanosoma brucei.

24 tion of 19 kinetochore proteins (KKT1-19) in Trypanosoma brucei.

25 cycle, and development in the model parasite Trypanosoma brucei.

26 glycoprotein (VSG) expression sites (ESs) of Trypanosoma brucei.

27 somiasis is caused by the eukaryotic microbe Trypanosoma brucei.

28 cytokinesis in the early-branching eukaryote Trypanosoma brucei.

29 were found to be essential for the growth of Trypanosoma brucei.

30 aused by a single-celled protozoan parasite, Trypanosoma brucei.

31 ammalian cells, CL synthesis is essential in Trypanosoma brucei.

32 ndidates, Xpo-t and Xpo-5 for tRNA export in Trypanosoma brucei.

33 ke and the modulation of drug sensitivity in Trypanosoma brucei.

34 Trypanosoma brucei, a causative agent of African Sleepin

35 ng their function in the protozoan parasite, Trypanosoma brucei, a causative agent of African trypano

36 We examined BBSome functions in Trypanosoma brucei, a flagellated protozoan parasite tha

37 Differentiation of Trypanosoma brucei, a flagellated protozoan parasite, be

38 Trypanosoma brucei, a hemoflagellated parasitic protozoa

39 rganisms belonging to the phylum euglenozoa: Trypanosoma brucei, a lethal human parasite, and Euglena

40 Trypanosoma brucei, a lethal parasite living in the huma

41 and condition-specific metabolic network of Trypanosoma brucei, a parasitic protozoan responsible fo

42 mography structures of the 96-nm repeat from Trypanosoma brucei, a protozoan parasite in the Excavate

43 Trypanosoma brucei, a protozoan parasite that causes hum

44 Trypanosoma brucei, a unicellular parasite, contains sev

45 Bloodstream-form Trypanosoma brucei acquire iron by receptor-mediated end

46 sites such as the sleeping sickness pathogen Trypanosoma brucei adapt to different host environments,

47 A Trypanosoma brucei adenosine transporter is well known f

48 rominent defence of the unicellular parasite Trypanosoma brucei against the host immune system is a d

49 Structural studies performed in Trypanosoma brucei already highlighted the numerous pecu

50 The flagellated eukaryote Trypanosoma brucei alternates between the insect vector

51 The Trypanosoma brucei aminopurine transporter P2/TbAT1 has

52 In Trypanosoma brucei, an ancient unicellular eukaryote, on

53 e biosynthesis pathway of the human parasite Trypanosoma brucei, an early branching eukaryote that la

54 Trypanosoma brucei, an early divergent microbial eukaryo

55 The compounds were assessed for Trypanosoma brucei and Leishmania major PTR1 inhibition

56 ct life cycle stages of two human parasites; Trypanosoma brucei and Leishmania mexicana.

57 el can be applied to the characterization of Trypanosoma brucei and Leishmania spp. ribosomes as well

58 in two well-studied kinetoplastid parasites, Trypanosoma brucei and Leishmania, focusing on recent wo

59 wledge largely stems from the human pathogen Trypanosoma brucei and mouse experimental models.

60 In Trypanosoma brucei and related kinetoplastids, gene expr

61 zation of this channel to acidocalcisomes of Trypanosoma brucei and suggest that caution should be ex

62 The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for sign

63 roducts exhibit significant activity against Trypanosoma brucei and T. cruzi, featuring favorable dru

64 interference (RNAi) has been investigated in Trypanosoma brucei and to a lesser extent in Leishmania

65 ickness, is caused by the protozoan parasite Trypanosoma brucei and transmitted through the bite of i

66 We also compare Trypanosoma brucei and Trypanosoma congolense, parasites

67 o be essential for survival and virulence of Trypanosoma brucei and, in Trypanosoma cruzi, PDEC2 was

68 Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with re

69 Mitochondrial ribosomes of Trypanosoma brucei are composed of 9S and 12S rRNAs, eub

70 an trypanosomiasis, caused by infection with Trypanosoma brucei are needed.

71 ological process for the bloodstream form of Trypanosoma brucei as the parasite would otherwise accum

72 y a pivotal role in life-cycle regulation of Trypanosoma brucei, as the translocation of a protein ph

73 Trypanosoma brucei belongs to a group of protists that s

74 Trypanosoma brucei BILBO1 (TbBILBO1) is an essential com

75 cells but were effective in cell cultures of Trypanosoma brucei brucei (EC(50) = 1-15 muM) and elimin

76 h a single-digit micromolar activity against Trypanosoma brucei brucei (EC50 = 2.97 muM), thus being

77 on by several protozoan parasites, including Trypanosoma brucei brucei Endocytosis and acidification

78 ine transport activities in bloodstream form Trypanosoma brucei brucei found that these cells express

79 een of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promisi

80 eening of a focused protease library against Trypanosoma brucei brucei in culture.

81 ate immunity against the veterinary pathogen Trypanosoma brucei brucei is conferred by trypanosome ly

82 d low micromolar levels of inhibition of the Trypanosoma brucei brucei parasite grown in culture.

83 ts: I172V, I172A, L232A, and P168A (TIM from Trypanosoma brucei brucei); a 208-TGAG for 208-YGGS loop

84 everal African trypanosome species including Trypanosoma brucei brucei, but not the human-infective p

85 een of approximately 87000 compounds against Trypanosoma brucei brucei, we recently identified eight

86 e glycerol kinase and alternative oxidase of Trypanosoma brucei brucei.

87 RNase H1 loss is tolerated by the parasite Trypanosoma brucei but no work has examined the function

88 rotozoan parasites Plasmodium falciparum and Trypanosoma brucei by microscopy imaging, proving that t

89 Trypanosoma brucei causes African sleeping sickness for

90 Trypanosoma brucei causes African trypanosomiasis and co

91 Trypanosoma brucei causes fatal human African trypanosom

92 Trypanosoma brucei causes human African trypanosomiasis

93 The protist parasite Trypanosoma brucei causes Human African trypanosomiasis

94 Trypanosoma brucei causes human African trypanosomiasis

95 Trypanosoma brucei causes human African trypanosomiasis

96 Trypanosoma brucei causes human African trypanosomiasis

97 The protozoan parasite Trypanosoma brucei causes the fatal illness human Africa

98 A defining feature of Trypanosoma brucei cell shape is the lateral attachment

99 red the transcriptomes of cultured procyclic Trypanosoma brucei cells in early and late logarithmic p

100 kinase system of the kinetoplastid parasite Trypanosoma brucei, consisting of three highly similar a

101 The mitochondrial 45 S SSU* complex in Trypanosoma brucei contains the 9 S SSU ribosomal RNA, a

102 Trypanosoma brucei CRK9 is an essential cyclin-dependent

103 also showed high inhibitory potency against Trypanosoma brucei cultures.

104 Trypanosoma brucei cyclic nucleotide phosphodiesterase B

105 n addition, the binding mode of 14t with the Trypanosoma brucei CYP51 (TbCYP51) orthologue has been c

106 The Trypanosoma brucei cysteine protease cathepsin B (TbCatB

107 e tsetse fly-transmitted African trypanosome Trypanosoma brucei depends on maintenance and expression

108 ly assembled flagellum in the human parasite Trypanosoma brucei depends on the faithful duplication a

109 Survival of Trypanosoma brucei depends upon switches in its protecti

110 ishmania displays striking conservation with Trypanosoma brucei, despite the latter parasite replicat

111 al metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle because the inse

112 However, in Trypanosoma brucei, disorganized arrays of microtubules

113 The human parasite Trypanosoma brucei does not synthesize heme de novo and

114 generates functional mitochondrial mRNAs in Trypanosoma brucei Editing is catalyzed by three distinc

115 ential for growth of the parasitic protozoan Trypanosoma brucei, enabling the study of its function i

116 Trypanosoma brucei encodes three paralogue single-protei

117 Trypanosoma brucei encodes two deoxyhypusine synthase pa

118 ere, we report that TbVtc4 (Vtc4 ortholog of Trypanosoma brucei) encodes, in contrast, a short chain

119 Unlike other type II TKs, the Trypanosoma brucei enzyme (TbTK) is a tandem protein wit

120 Trypanosoma brucei evades the host immune system through

121 ad of important trypanosome variants such as Trypanosoma brucei evansi that exploit mechanical transm

122 clusion ensures that the African trypanosome Trypanosoma brucei exclusively expresses only 1 of thous

123 screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexa

124 Trypanosoma brucei expresses a diverse repertoire of N-g

125 Trypanosoma brucei expresses a large number of cyclins a

126 However, Trypanosoma brucei expresses an unusual CPC consisting o

127 The bloodstream form of the human pathogen Trypanosoma brucei expresses oligomannose, paucimannose,

128 Trypanosoma brucei faces relentless immune attack in the

129 We sought to develop inhibitors of Trypanosoma brucei FolD (TbFolD) as potential antiparasi

130 segmented gene conversion, is fundamental in Trypanosoma brucei for both VSG gene switching and for g

131 ine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification.

132 tivity against either human FPPS (HsFPPS) or Trypanosoma brucei FPPS (TbFPPS), the most active being

133 amides have been identified as inhibitors of Trypanosoma brucei from screening of a focused protease

134 st Trypanosoma, including the human pathogen Trypanosoma brucei gambiense and Trypanosoma cruzi paras

135 uman African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense can be diagnosed in the ear

136 NECT as first-line treatment in second-stage Trypanosoma brucei gambiense HAT.

137 The World Health Organization targeted Trypanosoma brucei gambiense human African trypanosomias

138 Infection rates of Trypanosoma brucei gambiense in tsetse are extremely low

139 to replace the current treatment regimen for Trypanosoma brucei gambiense infections, following a pos

140 Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a parasitic infection th

141 e of Human African Trypanosomiasis caused by Trypanosoma brucei gambiense.

142 this effect in an important human pathogen, Trypanosoma brucei gambiense.

143 on of both alleles of JGT from the genome of Trypanosoma brucei generates a cell line that completely

144 In Trypanosoma brucei, genes are arranged in Polycistronic

145 The Trypanosoma brucei genome contains more than 1,000 VSG g

146 However, the Trypanosoma brucei genome encodes only the last two step

147 number of constitutive origins mapped in the Trypanosoma brucei genome is less than the minimum requi

148 l evaluation of aminopyrazole derivatives as Trypanosoma brucei GSK3 short inhibitors.

149 In contrast to most other eukaryotes Trypanosoma brucei has a single mitochondrion whose sing

150 microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a defined size, shape, and form

151 th sleeping sickness, caused by the parasite Trypanosoma brucei, have disruptions in both sleep timin

152 l for growth and infectivity of the parasite Trypanosoma brucei However, the mechanism by which TbIP(

153 context of the VSG layer, the dimensions of Trypanosoma brucei HpHbR and VSG have been determined by

154 In this study, we report the structure of Trypanosoma brucei HpHbR in complex with human haptoglob

155 ausative agent of African sleeping sickness, Trypanosoma brucei In mitochondria of this pathogen, mos

156 insect salivary glands for all subspecies of Trypanosoma brucei, including the human pathogens.

157 ed to TbKHC1, an orphan kinesin H chain from Trypanosoma brucei, inhibited T. musculi excreted/secret

158 ositol pyrophosphate biosynthetic pathway in Trypanosoma brucei: inositol polyphosphate multikinase (

159 The life cycle of Trypanosoma brucei involves developmental transitions th

160 eptor (TfR) of the bloodstream form (BSF) of Trypanosoma brucei is a heterodimer comprising glycosylp

161 Trypanosoma brucei is a kinetoplastid parasite that caus

162 Trypanosoma brucei is a parasitic protozoan that undergo

163 Trypanosoma brucei is a protist parasite causing sleepin

164 Trypanosoma brucei is a protozoan parasite that evades i

165 The African trypanosome Trypanosoma brucei is a single-celled eukaryote with a s

166 Trypanosoma brucei is a vector borne, lethal protistan p

167 Trypanosoma brucei is an extracellular parasite that cau

168 The basal body in the human parasite Trypanosoma brucei is structurally equivalent to the cen

169 The parasite Trypanosoma brucei is the causative agent of African sle

170 Trypanosoma brucei is the causative agent of African sle

171 The eukaryotic protozoan parasite Trypanosoma brucei is the causative agent of human Afric

172 The unicellular parasite Trypanosoma brucei is transmitted between mammals by tse

173 The African trypanosome, Trypanosoma brucei, is a parasitic protozoan that achiev

174 receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in

175 OM protein of the early diverging protozoan Trypanosoma brucei, is signal-anchored.

176 g sickness, caused by the protozoan parasite Trypanosoma brucei, is universally fatal if untreated, a

177 The mitochondrion of the parasitic protozoan Trypanosoma brucei lacks tRNA genes and therefore import

178 The mitochondrion of the parasitic protozoan Trypanosoma brucei lacks tRNA genes, and thus imports al

179 tive agent of human African trypanosomiasis, Trypanosoma brucei, lacks de novo purine biosynthesis an

180 screen with 176 individual bloodstream form Trypanosoma brucei lines identified PKs required for pro

181 Here we present evidence that the Trypanosoma brucei mitochondrial calcium uniporter (TbMC

182 In Trypanosoma brucei, mitochondrial pre-mRNAs undergo 3'-5

183 In Trypanosoma brucei, most mitochondrial mRNAs undergo edi

184 In Trypanosoma brucei, most mitochondrial mRNAs undergo int

185 Trypanosoma brucei N-myristoyltransferase (TbNMT) is an

186 es, putative stem-loops from L. donovani and Trypanosoma brucei nucleobase transporter mRNAs were not

187 the causative agent, the protozoan parasite Trypanosoma brucei, occurs through receptor-mediated end

188 e effects of the sleeping sickness parasite, Trypanosoma brucei, on sleep patterns in mice, under bot

189 Trypanosoma brucei parasites successfully evade the host

190 rican trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited treatment opti

191 allelic exclusion and antigenic variation in Trypanosoma brucei parasites.

192 In Trypanosoma brucei, PE synthesis has been shown to occur

193 The Polo-like kinase (PLK) in Trypanosoma brucei plays multiple roles in basal body se

194 Trypanosoma brucei possesses a highly complex RNA editin

195 To identify new chemotypes against Trypanosoma brucei, previously we identified 797 potent

196 Trypanosoma brucei PRMT7 (TbPRMT7) is a protein arginine

197 ation of the proliferative cell cycle of the Trypanosoma brucei procyclic life cycle stage, three sub

198 volutionarily early divergent human parasite Trypanosoma brucei proliferates through binary cell fiss

199 The major Trypanosoma brucei protein arginine methyltransferase, T

200 Cardiolipin depletion-induced changes in the Trypanosoma brucei proteome.

201 Trypanosoma brucei, protozoan parasites that cause human

202 on of the potentials of the redox centers in Trypanosoma brucei QSOX provides a context for understan

203 t that CRK1, a G1 cyclin-dependent kinase in Trypanosoma brucei, regulates anterograde protein traffi

204 The infectious metacyclic forms of Trypanosoma brucei result from a complex development in

205 ains of TR from the basal eukaryotic species Trypanosoma brucei, revealing the ancestry of TR compris

206 roove binders was evaluated in vitro against Trypanosoma brucei rhodesiense (8 compounds) and Plasmod

207 iprotozoal assays, ten of the oils inhibited Trypanosoma brucei rhodesiense (IC(50) 15.9-64.5 mug/mL)

208 ition of the cysteine proteases rhodesain of Trypanosoma brucei rhodesiense and falcipain-2 of Plasmo

209 .045 muM against the human pathogenic strain Trypanosoma brucei rhodesiense and is more than 4000 tim

210 logues possess micromolar activities against Trypanosoma brucei rhodesiense and Leishmania donovani a

211 tent inhibitory effect against the parasites Trypanosoma brucei rhodesiense and Leishmania donovani w

212 ent manner and demonstrated activity against Trypanosoma brucei rhodesiense bloodstream forms, which

213 r proteins that contribute to virulence, and Trypanosoma brucei rhodesiense EVs contain the serum res

214 stance to most African trypanosomes, but not Trypanosoma brucei rhodesiense or T.b. gambiense, which

215 layed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with selectivity

216 ural product displayed high activity against Trypanosoma brucei rhodesiense, a recalcitrant parasite

217 gnized as a strong inhibitor of rhodesain of Trypanosoma brucei rhodesiense, endowed with a k(second)

218 ch as Plasmodium falciparum, Lassa Virus and Trypanosoma brucei rhodesiense, has resulted in elevated

219 ave additional trypanolytic activity against Trypanosoma brucei rhodesiense, the cause of acute Afric

220 orrelation with the human infective parasite Trypanosoma brucei rhodesiense, the most potent compound

221 st important human trypanosomatid pathogens (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, and L

222 c markers in CSF from patients infected with Trypanosoma brucei rhodesiense, using 1H nuclear magneti

223 ite concentrations in patients infected with Trypanosoma brucei rhodesiense, using liquid chromatogra

224 We report X-ray structures of Trypanosoma brucei S-adenosylmethionine decarboxylase al

225 ved following RNAi-mediated silencing of the Trypanosoma brucei SODA ortholog suggests that SODA is e

226 Trypanosoma brucei spp. cause African human and animal t

227 The protozoan parasites Trypanosoma brucei spp. cause important human and livest

228 sites Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp., respectively.

229 Trypanosoma brucei stumpy forms are the only stage that

230 Humans are susceptible to two Trypanosoma brucei subspecies but protected from other t

231 The disease has two forms, Trypanosoma brucei (T b) rhodesiense and T b gambiense;

232 Trypanosoma brucei (T. brucei) is responsible for the fa

233 ng drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the causative agent for

234 Here, we exploited Trypanosoma brucei (Tb), an early diverging eukaryote wh

235 tal disease caused by the protozoan parasite Trypanosoma brucei (Tb).

236 e atomic structure of its close homolog from Trypanosoma brucei (TbASNA) at 2.2 A.

237 Nonetheless, the GMPR of Trypanosoma brucei (TbGMPR) includes a unique structure

238 e SAS-4 homolog in the flagellated protozoan Trypanosoma brucei, TbSAS-4, plays an unusual role in co

239 Trypanosoma brucei TFIIH harbours all core complex compo

240 the procyclic and bloodstream form stages of Trypanosoma brucei that yields viable and proliferative

241 Here, we show that in the PAM of Trypanosoma brucei the function of Pam18 has been replac

242 ing the cell cycle of the protozoan parasite Trypanosoma brucei The source of components required to

243 axoneme formation in the flagellate protist Trypanosoma brucei, the causal agent of African sleeping

244 Trypanosoma brucei, the causative agent of African sleep

245 Lipid metabolism in Trypanosoma brucei, the causative agent of African sleep

246 13b ortholog in the evolutionarily divergent Trypanosoma brucei, the causative agent of African sleep

247 ruzi, the causative agent of Chagas disease; Trypanosoma brucei, the causative agent of African sleep

248 Here, we report that Trypanosoma brucei, the causative agent of African trypa

249 the trypanocidal activity of nicotinamide on Trypanosoma brucei, the causative agent of African trypa

250 es (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African

251 Trypanosoma brucei, the causative agent of human African

252 mpound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African

253 of polyamine metabolism in bloodstream-form Trypanosoma brucei, the causative agent of human African

254 point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African

255 , which had been identified as a hit against Trypanosoma brucei, the causative agent of human African

256 Here, we show that Trypanosoma brucei, the causative agent of human sleepin

257 The parasite Trypanosoma brucei, the causative agent of sleeping sick

258 Trypanosoma brucei, the causative agent of sleeping sick

259 In Trypanosoma brucei, the composition of the gamma-tubulin

260 Trypanosoma brucei, the etiologic agent of African Sleep

261 In the case of Trypanosoma brucei, the etiological agent of African try

262 A recent genome-wide analysis of Trypanosoma brucei, the etiological agent of sleeping si

263 In the sleeping sickness parasite Trypanosoma brucei, the kinetoplast is a chain mail-like

264 tron microscopy structure of the ribosome of Trypanosoma brucei, the parasite that is transmitted by

265 In Trypanosoma brucei, the proteins that make up the kineto

266 In the parasite Trypanosoma brucei, the single PLK homologue TbPLK is ne

267 In Trypanosoma brucei, the small noncoding TBsRNA-10 was fi

268 In Trypanosoma brucei, the vast majority of gRNAs are trans

269 In Trypanosoma brucei, three of the five centrins associate

270 Unusually for a eukaryote, Trypanosoma brucei transcribes its variant surface glyco

271 rin uptake, we determined the structure of a Trypanosoma brucei transferrin receptor in complex with

272 ow that cytosine 32 in the anticodon loop of Trypanosoma brucei tRNA(Thr) is methylated to 3-methylcy

273 resistant strains of the protozoal pathogens Trypanosoma brucei, Trypanosoma congolense and Leishmani

274 nt parasites and include the human pathogens Trypanosoma brucei, Trypanosoma cruzi, and Leishmania sp

275 e diseases caused by the protozoan parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania sp

276 The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania sp

277 nd biogenesis of the array, with emphasis on Trypanosoma brucei, Trypanosoma cruzi, and Leishmania, w

278 wth, and infectivity of the trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, and Leishmania.

279 pathway and its enzymes have been studied in Trypanosoma brucei, Trypanosoma cruzi, and various Leish

280 In the protist Trypanosoma brucei, two distinct genes encode fairly dif

281 Mitochondrial mRNAs in Trypanosoma brucei undergo extensive insertion and delet

282 ghly motile and versatile protozoan pathogen Trypanosoma brucei undergoes a complex life cycle in the

283 Trypanosoma brucei undergoes cytokinesis uni-directional

284 Trypanosoma brucei uses multiple mechanisms to evade det

285 The sleeping sickness parasite, Trypanosoma brucei, uses quorum sensing (QS) to balance

286 nhibited J synthesis in Leishmania major and Trypanosoma brucei using DMOG.

287 its application to the pathogenic protozoan, Trypanosoma brucei, using hyperpolarized (13)C1 pyruvate

288 ve-site residues of PRMT7 from the protozoan Trypanosoma brucei We have designed 26 single and double

289 bitor of proliferation for the HAT pathogen (Trypanosoma brucei), we have now tested this class of an

290 ulation of glycosomes in live procyclic form Trypanosoma brucei When added to cells, this fluorescent

291 Compound 64 cured mice infected with Trypanosoma brucei when dosed orally down to 2.5 mg/kg.

292 component of approximately 20S editosomes in Trypanosoma brucei which contains a degenerate, noncatal

293 In the unicellular parasite Trypanosoma brucei, which causes African sleeping sickne

294 The protozoan parasite Trypanosoma brucei, which causes devastating diseases in

295 An example is Trypanosoma brucei, which causes human African trypanoso

296 Tsetse flies transmit Trypanosoma brucei, which is the parasite that causes hu

297 idal activity against the protozoan parasite Trypanosoma brucei with IC50 < 5 muM, being each of thos

298 more potent than nifurtimox against in vitro Trypanosoma brucei with very low cytotoxicity against hu

299 in the causative agent of sleeping sickness, Trypanosoma brucei, with that of human erythrocytes, and

300 Here, we identify the Trypanosoma brucei ZC3H39/40 RNA-binding proteins as reg