ライフサイエンスコーパス: Tyr kinase

1 tify selective peptide inhibitors of protein Tyr kinases.

2 substrate sequence specificity of all human Tyr kinases.

3 ase, stk encodes a eukaryotic-like tyrosine (Tyr) kinase.

4 sion of the peptide inhibited ZAP-70 protein Tyr kinase activity by competing with protein substrates

5 tein kinase substrate in vitro This dual Thr-Tyr kinase activity is also observed for a eukaryotic du

6 The Ser/Thr/Tyr kinase activity of human biliverdin reductase (hBVR)

7 he Ser/Thr kinase activity of the MAP3K into Tyr kinase activity of the central dual specificity MAP2

8 rocessing through activation of its receptor Tyr kinase activity, and they suggest possible engagemen

9 ostin AG1478), a selective inhibitor of EGFR Tyr kinase activity, blocked EGFR and ERK activation by

10 Thr residues and to potentiate its intrinsic Tyr kinase activity.

11 ly transcribed RASSF1C isoform that promotes Tyr kinase activity.

12 Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase and intracellular scaffold/bridge/anchor, is

13 Data obtained with inhibitors of EGFR Tyr kinase and membrane metalloproteases support an inte

14 The simultaneous activation of all receptor Tyr kinases and nonreceptor Tyr kinases leads to complex

15 parison of the sequence specificities of the Tyr kinases and the SH2 phosphotyrosine (pTyr)-binding d

16 humans, suggesting that the fidelity between Tyr kinases and their protein substrate sequences has be

17 d reveal synchronous inhibition of KAT2A and Tyr-kinases as an effective therapeutic strategy.

18 s kinase 3 (Jak3) is a cytoplasmic tyrosine (Tyr) kinase associated with the interleukin-2 (IL-2) rec

19 results in the stimulation of intracellular Tyr kinase-based signaling cascades and cellular activat

20 a(1)-integrin inhibited Abeta stimulation of Tyr kinase-based signaling cascades in both THP-1 monocy

21 The kinase domain is unlike Ser/Thr/Tyr kinases but resembles two ATPases, Gyrase B and Hsp9

22 How a given Tyr kinase can phosphorylate a specific subset of protei

23 toring the effects of chemical inhibition of Tyr kinase CK2 or by mutating the phosphorylation site.

24 dentified an IL-2-JAK-independent SRC family Tyr-kinase-controlled signaling network that regulates a

25 Globally, the Tyr kinases demonstrate considerable diversity in optima

26 that Y155 is phosphorylated in vitro by the Tyr kinase domain of epidermal growth factor (EGF) recep

27 composed of a dual specificity (Ser/Thr and Tyr) kinase domain tethered to a calmodulin-like domain

28 Among the protein Tyr kinases expressed in neutrophils, only Fgr eluted ex

29 is mechanism is independent of Ror2 receptor Tyr kinase functions.

30 that the intrinsic substrate specificity of Tyr kinases has remained fundamentally unchanged from wo

31 ERBB and other receptor Tyr kinases have been identified as immediate early resp

32 ctase (hBVR) is a recently described Ser/Thr/Tyr kinase in the MAPK insulin/insulin-like growth facto

33 Genistein, a known Tyr kinase inhibitor, was found to inhibit the activitie

34 Human biliverdin reductase (hBVR), a Ser/Thr/Tyr kinase, inhibits apoptosis by reducing biliverdin-IX

35 ify specific inhibitors of ZAP-70, a protein Tyr kinase involved in T cell activation.

36 The related protein Tyr kinases, Lck and Syk, were not significantly inhibit

37 of all receptor Tyr kinases and nonreceptor Tyr kinases leads to complex cytoprotective responses in

38 d-binding domain, inhibition of the receptor Tyr kinase-mediating receptor activation, and overexpres

39 Cell lines dependent on the activation of Tyr kinase mitogen receptor targets of the resorcylic ac

40 tein that suppresses signaling from receptor Tyr kinases of the epidermal growth factor receptor/ErbB

41 mains, phosphorylated by protein Ser/Thr- or Tyr-kinases or mediate specific interactions with protei

42 alpha selectively mediates activation of the Tyr kinase Pyk2 and GTPase Rac1 to regulate barrier func

43 at acts as a positive transducer of receptor Tyr kinase (RTK) signaling, particularly the Ras-REK and

44 hBVR is a Ser/Thr/Tyr kinase/scaffold protein/transcription factor/intrace

45 pecificities of many families of Ser/Thr- or Tyr-kinases, SH2, SH3, PDZ, 14-3-3 and PTB domains, toge

46 specificities accurately identifies specific Tyr kinases that are dysregulated in cells after stimula

47 Using this information, Tyr kinases that are most compatible with phosphorylatin

48 typically have more than 50 distinct protein Tyr kinases that catalyse the phosphorylation of thousan

49 nent systems versus the 'eukaryotic' Ser/Thr/Tyr kinases) to carry out signal transduction.

50 Thr/Tyr kinase (TTK)/monopolar spindle 1 kinase (Mps-1) is a

51 as receptor (IRK) and nonreceptor (Src, Abl) Tyr kinases with greatly enhanced selectivity.