ライフサイエンスコーパス: UDP-glucuronosyltransferase

1 chrome P450 or phase II conjugating enzymes (UDP-glucuronosyltransferase).

2 m deficiency of the hepatic enzyme bilirubin-UDP-glucuronosyltransferase.

3 otransferases, glutathione transferases, and UDP-glucuronosyltransferases.

4 ucuronic acid in the liver via the action of UDP-glucuronosyltransferases.

5 The human UDP-glucuronosyltransferase 1 (UGT1) locus spans nearly

6 A polymorphism in the promoter of the UDP-glucuronosyltransferase 1 (UGT1A1) gene has been sho

7 P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiat

8 In humanized UDP glucuronosyltransferase-1 (hUGT1) mice that express

9 nits (pfu) intravenously) in adult bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rat

10 olerance to adenoviral antigens in bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient Gunn rat

11 via gastroduodenostomy tubes into bilirubin-UDP-glucuronosyltransferase-1 (BUGT1)-deficient jaundice

12 tyltransferase (pSV2-CAT) or human bilirubin-UDP-glucuronosyltransferase-1 (pSVK3-hBUGT1) genes were

13 iplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at le

14 us result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inabili

15 UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the g

16 valuated the impact of oral iAs treatment on UDP-glucuronosyltransferase 1A1 (UGT1A1) expression and

17 e evaluated the impact of lactational TCS on UDP-glucuronosyltransferase 1A1 (UGT1A1) expression and

18 To study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and s

19 UDP-glucuronosyltransferase 1A1 (UGT1A1) is a vital meta

20 In mammals, UDP-glucuronosyltransferase 1A1 (UGT1A1) is the sole enz

21 UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an import

22 lpha), CAR, cytochrome P-450 2b10 (Cyp2b10), UDP-glucuronosyltransferase 1a1 (Ugt1a1), sulfotransfera

23 hich in turn is detoxified primarily through UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed glucu

24 ing cytochrome P450 [Cyp] 2b10, Cyp2c55, and UDP-glucuronosyltransferase 1a1 [Ugt1a1]).

25 tributed isozymes encoded at the UGT1 locus, UDP-glucuronosyltransferase 1A10 (UGT1A10) metabolizes a

26 nstitutive or ligand-induced CYP1A1; CYP1A2; UDP glucuronosyltransferase 1A2; NAD(P)H dehydrogenase,

27 UDP-glucuronosyltransferase 1A7 (UGT1A7) is a major UGT

28 The UDP-glucuronosyltransferase 2 family, polypeptide B15 (U

29 Members of the human UDP-glucuronosyltransferase 2B family are located in a c

30 feration and stemness by inducing the enzyme UDP-glucuronosyltransferase 2B15 (UGT2B15), which promot

31 UDP-glucuronosyltransferase 2B17 (UGT2B17) is a key enzy

32 EPI is primarily inactivated by UDP-glucuronosyltransferase 2B7 (UGT2B7) in the liver.

33 Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in

34 obably due to interindividual differences in UDP-glucuronosyltransferase activity and/or excretion pa

35 This paralleled the hepatic bilirubin-UDP-glucuronosyltransferase activity, which was above 50

36 ecombinant adenovirus (Ad), adenovirus human UDP-glucuronosyltransferase (Ad-hBUGT1) carrying the hBU

37 Polymorphisms in UDP-glucuronosyltransferases and sulfotransferases may c

38 450s, glutathione S-transferases, esterases, UDP-glucuronosyltransferases, and ABC transporters.

39 ss heme oxygenase, biliverdin reductase, and UDP-glucuronosyltransferases, and there was concordance

40 adenoviral antigens, we immunized bilirubin-UDP-glucuronosyltransferase (BUGT)-deficient jaundiced G

41 NA was injected intravenously into bilirubin-UDP-glucuronosyltransferase-deficient Gunn rats.

42 rlying developmental effects of a microsomal UDP-glucuronosyltransferase-encoding gene from pea (Pisu

43 Heterogeneity in uridine 5'-diphosphate (UDP) glucuronosyltransferase expression across the human

44 ion resulted in a reduced level of bilirubin UDP-glucuronosyltransferase expression in the liver.

45 genetic inhibition of hepatic conjugation by UDP glucuronosyltransferase family 1 member A1 (UGT1A1),

46 observed across a 200 kb region spanning the UDP-glucuronosyltransferase family, including UGT1A1, an

47 While pretreatment with UDP-glucuronosyltransferase inhibitor, nilotinib, reduce

48 ved hydrophobic region in the bilirubin-type UDP-glucuronosyltransferase isozyme was first uncovered

49 Consistent with the UDP-glucuronosyltransferase requirement for regulated ph

50 l as related detoxification enzymes, notably UDP-glucuronosyltransferases, suggesting a network of as

51 was attributed to metabolic deactivation by UDP-glucuronosyltransferases that were expressed in RASW

52 The human major bilirubin UDP glucuronosyltransferase (transferase), HUG-Brl, and

53 erone as substrate, we showed that LNCaP had UDP-glucuronosyltransferase (UDPGT) activity.

54 en is associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1 activity that can

55 Microsomal uridine diphosphate (UDP)-glucuronosyltransferase (UGT) protein expression an

56 The human UDP-glucuronosyltransferase (UGT) 1A (UGT1A) locus is re

57 al recessive inherited deficiency of hepatic UDP-glucuronosyltransferase (UGT) 1A1 activity.

58 e of constitutional genetic variation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast ca

59 etabolized solely through glucuronidation by UDP-glucuronosyltransferase (UGT) 1A1, it is now known t

60 ts induce the bilirubin-metabolizing enzyme--UDP-glucuronosyltransferase (UGT) 1A1--to prevent the on

61 of the rabbit liver dexamethasone-inducible UDP-glucuronosyltransferase (UGT) 2B13 RNA is related in

62 Because human prostate-distributed UDP-glucuronosyltransferase (UGT) 2B15 metabolizes 5alph

63 nvestigate the inhibitory effects of TKIs on UDP-glucuronosyltransferase (UGT) activities, and to qua

64 o indinavir-mediated impairment of bilirubin UDP-glucuronosyltransferase (UGT) activity and would be

65 drogen glucuronidation, catalyzed by the two UDP-glucuronosyltransferase (UGT) enzymes UGT2B15 and UG

66 ts of the UGT1A gene, encoding half of human UDP-glucuronosyltransferase (UGT) enzymes, undergo alter

67 The UDP-glucuronosyltransferase (UGT) family of enzymes is i

68 and endoxifen, is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

69 AHA metabolism is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes.

70 protein-protein interactions between several UDP-glucuronosyltransferase (UGT) isoforms and cytochrom

71 The UDP-glucuronosyltransferase (UGT) isozyme system is crit

72 UDP-glucuronosyltransferase (UGT) isozymes catalyze deto

73 UDP-glucuronosyltransferase (UGT) isozymes detoxify meta

74 e 1 (NQO1), glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and phenol sulfotrans

75 and hepatic glutathione S-transferase (GST), UDP-glucuronosyltransferase (UGT), and sulfotransferase

76 UDP-glucuronosyltransferase (UGT)-mediated glucuronidati

77 explained at least partly by upregulation of UDP-glucuronosyltransferase (UGT).

78 ent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play ma

79 Human UDP-glucuronosyltransferases (UGT) are the dominant phas

80 UDP-glucuronosyltransferases (UGT) catalyze the conjugat

81 Particularly, interaction with UDP-glucuronosyltransferases (UGT) enzymes is an importa

82 T), gamma-glutamylcysteine synthetase (GCS), UDP-glucuronosyltransferases (UGT),epoxide hydrolase, as

83 ence similarity to the rat CGT enzyme and to UDP-glucuronosyltransferases (UGT).

84 variable exons arrayed in tandem, including UDP glucuronosyltransferase (UGT1), plectin, neuronal ni

85 The human UDP-glucuronosyltransferase UGT1A locus encodes up to 12

86 r glioma-associated protein 1 (GLI1) and the UDP glucuronosyltransferase (UGT1A) family of enzymes ar

87 Crigler-Najjar syndrome model animal lacking UDP-glucuronosyltransferase (UGT1A1), was used as recipi

88 The UDP-glucuronosyltransferase, UGT1A1, is the critical enz

89 required for hepatic bilirubin elimination, UDP-glucuronosyltransferase, UGT1A1.

90 UDP-glucuronosyltransferase UGT1A7 catalyzes the glucuro

91 on of two androgen-inactivating enzymes, the UDP-glucuronosyltransferases UGT2B15 and UGT2B17, was as

92 The UDP-glucuronosyltransferase UGT2B7 is an important human

93 Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded

94 e efficient in drug conjugation catalyzed by UDP-glucuronosyltransferases (UGTs) and now report on th

95 UDP-glucuronosyltransferases (UGTs) are critical to the

96 UDP-glucuronosyltransferases (UGTs) are highly expressed

97 UDP-glucuronosyltransferases (UGTs) are important enzyme

98 UDP-glucuronosyltransferases (UGTs) are membrane-bound p

99 Among the 19 functional UDP-glucuronosyltransferases (UGTs) in humans, UGT2B7 is

100 ffinity label [beta-32P]5-azido-UDP-GlcUA to UDP-glucuronosyltransferases (UGTs) in intact, but not i

101 g rapid, reversible down-regulation of human UDP-glucuronosyltransferases (UGTs) in LS180 cells follo

102 eta-D-glucopyranosides (glucuronides) by the UDP-glucuronosyltransferases (UGTs) is a significant met

103 ferator-activated receptor alpha (PPARalpha)-UDP-glucuronosyltransferases (UGTs) signalling is an imp

104 human liver microsomes and human recombinant UDP-glucuronosyltransferases (UGTs) was characterized an

105 The UGT1A cluster encodes a family of UDP-glucuronosyltransferases (UGTs), which facilitate ce

106 sion and catalytic activity of human hepatic UDP-glucuronosyltransferases (UGTs).

107 nduction of cytoprotective genes such as the UDP-glucuronosyltransferases (UGTs).

108 probe to identify the phenol binding site of UDP-glucuronosyltransferases (UGTs).

109 ulatory patterns of the phase II superfamily UDP-glucuronosyltransferases (UGTs).

110 m is carried out by the Super gene family of UDP-glucuronosyltransferases (UGTs).

111 PsUGT1, which encodes a microsomal UDP-glucuronosyltransferase, was cloned from root tips o

112 tipraz both induce an unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a