ライフサイエンスコーパス: UPS

1 UPS characterization of the same FA-PVSK thin films prov

2 UPS function and relative activity was analyzed using a

3 UPS impacts transcriptional regulation by controlling th

4 UPS-indel identifies 15% redundant indels in dbSNP, 29%

5 UPS-indel is theoretically proven to find all equivalent

6 ionally, by Universal Proteomics Standard 1 (UPS-1) spiking we obtained a comprehensive coverage of 7

7 degradation of GL3 and EGL3 proteins is 26S UPS-dependent.

8 epeat expression triggered accumulation of a UPS reporter in a length-dependent fashion.

9 mouse model of tauopathy and in a cross to a UPS reporter mouse (line Ub-G76V-GFP).

10 n and relative activity was analyzed using a UPS reporter protein consisting of a short degron, CL1,

11 Accordingly, UPS substrates accumulate in prion-infected mouse brains

12 Oylation partially stabilizes TOC159 against UPS-dependent degradation under stress conditions.

13 the synapse by dephosphorylation-induced and UPS-mediated degradation provides a mode to regulate pro

14 that loss of both Rb and p53 renders MFS and UPS dependent on Skp2, which can be therapeutically expl

15 iferation in RB1- and TP53-deficient MFS and UPS depends on SKP2; inhibiting SKP2 with the neddylatio

16 It has been noted that MFS and UPS frequently lose function of the tumor suppressor gen

17 MFS and UPS have recently been shown to commonly harbor copy num

18 irmed that a significant fraction of MFS and UPS patient samples (n = 94) harbor chromosomal deletion

19 omising novel systemic therapies for MFS and UPS.

20 ndings reveal expression deficits in MT- and UPS-related genes specific to layer 3 and/or layer 5 pyr

21 ptic density-95 mRNA, required both PP2A and UPS.

22 e patient group (P-values for MT-related and UPS-related pathways were <10(-7) and <10(-5), respectiv

23 OsNRPD1a and mediates its ubiquitination and UPS-dependent degradation in vitro and in vivo.

24 and RGSV infection induce ubiquitination and UPS-dependent degradation of rice NUCLEAR RNA POLYMERASE

25 o-ubiquitination, reduced ubiquitination and UPS-mediated degradation of myosin heavy chain 6, cardia

26 However, mixed-meal consumption attenuated UPS-mediated proteolysis, independent of energy status o

27 ile prevention of RAN translation attenuated UPS impairment in cells and suppressed the genetic inter

28 alth through mediating the interplay between UPS and autophagy/lysosome system and its alteration pro

29 udies, suggest that the relationship between UPS activity and memory retrieval depends on training pa

30 protein in cells, we observed that blocking UPS resulted in accumulation of GFP-HNF1alpha in cytopla

31 Simultaneously activating both UPS and autophagy might provide a powerful strategy for

32 USP14 may provide a strategy to promote both UPS and autophagy for developing novel therapeutics targ

33 ion of electronic structure determination by UPS with length- and work function-dependent transport m

34 nt, but it was dose-dependently increased by UPS inhibitors bortezomib and MG132.

35 did not tolerate structural perturbation by UPS when tested, indicating that structural integrity of

36 Moreover, comparing UPS-indel to state-of-the-art approaches for indel call

37 y, knockdown of UBC9 significantly decreased UPS function in the model and resulted in increased aggr

38 While a non-degradable UPS polymer induces granulomatous inflammation that pers

39 This paper describes UPS-indel, a utility tool that creates a universal posit

40 sis, but pharmacological agents that enhance UPS activity have been challenging to establish.

41 Overexpression of UBC9 enhanced UPS function in cardiomyocytes, whereas knockdown of UBC

42 cription of Atrogin-1 and MuRF1 and enhances UPS-mediated protein degradation in heart.

43 Here, we examined UPS activity after an extended-access cocaine self-admin

44 y plant pathogens target host RNA Pol IV for UPS-dependent degradation to induce disease symptoms.

45 , which targets the RdDM compotent NRPD1 for UPS-mediated degradation in rice.

46 ety of applications, including screening for UPS activating molecules and selecting for mammalian cel

47 In schizophrenia, studies have found UPS transcript abnormalities in both blood and brain, an

48 proteasome system positive inclusions (FTLD-UPS) that stained negatively for tau, TDP-43, and FUS.

49 a tumor suppressor protein and that the Gank-UPS-mediated reduction of CUGBP1 is a key event in the d

50 al contact, the correspondence of epsilon(h)(UPS) and epsilon(h)(trans) also indicates that the top c

51 ificantly, direct measurements of epsilon(h)(UPS) by ultraviolet photoelectron spectroscopy (UPS) for

52 s of the HOMO-Fermi level offset (epsilon(h)(UPS)) by ultraviolet photoelectron spectroscopy (UPS) fo

53 terial effectors exploit or require the host UPS for their action, as currently best studied in Pseud

54 It has been suggested that the host UPS mediates this uncoating process, but there is no evi

55 es that pathogenic bacteria subvert the host UPS to facilitate infection.

56 acterial pathogens are known to use the host UPS, the first prokaryotic F-box protein, an essential c

57 Further, it is unclear whether impaired UPS regulation of Sub2 in the absence of Mdm30 alters mR

58 These results show a novel role for BDNF in UPS regulation at the synapse, which is likely to act to

59 in MPNST; and gemcitabine plus docetaxel in UPS.

60 This rapid increase in UPS-mediated proteolysis continued for many hours and re

61 ese findings suggest that CGG repeats induce UPS impairment at least in part through activation of RA

62 eubiquitination by USP14 is known to inhibit UPS.

63 uce cancer cell apoptosis through inhibiting UPS function.

64 evidence that a signaling axis involving key UPS components contributes to oligodendrocyte developmen

65 By linking UPS activity to a simple and tunable fluorescence output

66 R into a fluorescent signal, thereby linking UPS activity to an easily detectable output, which can b

67 drives proliferation of patient-derived MFS/UPS cell lines deficient in both Rb and p53 by degrading

68 and potential as a therapeutic target in MFS/UPS.

69 Whereas loss of Cuz1 alone causes only minor UPS degradation defects, its combination with mutations

70 t long-lived) cell proteins generally, model UPS substrates having different degrons, and aggregation

71 med to generate a mouse model for monitoring UPS function using a green fluorescent protein (GFP)-bas

72 e various spectroscopic methods (UV-vis-NIR, UPS, pulse EPR), electrochemistry and spectroelectrochem

73 e new insight into the spectrum of action of UPS in cilia biology and may provide novel opportunities

74 e present study investigated the activity of UPS during in vitro capacitation of fresh boar spermatoz

75 g diseases, and discuss the exciting area of UPS-targeting drug development for pulmonary disease.

76 In the assessment of UPS responses to varied protein intakes, ED, and feeding

77 In this article, we discuss the biology of UPS-targeting drugs, their use as therapy for neoplasia,

78 own induction of responses characteristic of UPS inhibition, and experiments using cellular reporter

79 ctionally with Cdc48/p97/VCP, a component of UPS required for degradation of RNAPII.

80 tic F-box protein, an essential component of UPS, was identified in Agrobacterium.

81 expression of FMRpolyG enhanced induction of UPS impairment in cell models, while prevention of RAN t

82 ion of markers associated with inhibition of UPS and ERAD functions, which induces irresolvable prote

83 cogenic mutant p53 by targeted inhibition of UPS components, particularly key deubiquitinases (DUBs)

84 one leads to changes in expression levels of UPS-related proteins which has a knock-on effect on over

85 that this circuit responds to modulation of UPS activity in cell culture arising from the inhibitor

86 Comparing the performance of UPS-indel with existing variant normalization tools vt n

87 ED resulted in the up-regulation of UPS-associated gene expression, as mRNA expression of th

88 e novel results support the proposed role of UPS in sperm capacitation and open several new lines of

89 riants, expanding the phenotypic spectrum of UPS-dependent disorders.

90 ing models posit that Cdc48 acts upstream of UPS receptors.

91 Subsequently, the effects of UBC9 on UPS function were tested in a proteotoxic model of desmi

92 Manipulating K6a phosphorylation or UPS activity may provide opportunities to harness the in

93 onal design of inhibitors for DUBs and other UPS proteins.

94 adation by the ubiquitin-proteasome pathway (UPS) are determined by their rates of ubiquitination, we

95 Between May 2011 and May 2016, 287 patients (UPS: n = 97 [33.8%]; HG-MLPS: n = 65 [22.6%]; SS: n = 70

96 provide support for the idea that the plant UPS uncoats synthetic T-complexes via the Skp1/Cullin/F-

97 Ubiquitin/26S proteasome (UPS)-dependent proteolysis of a variety of cellular prot

98 51 in pH cooperativity for a representative UPS block copolymer, by far the largest reported in the

99 S) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes.

100 S) and undifferentiated pleomorphic sarcoma (UPS) are highly genetically complex soft tissue sarcomas

101 ma and undifferentiated pleomorphic sarcoma (UPS) lack specific molecular underpinnings, show high ra

102 hibits undifferentiated pleomorphic sarcoma (UPS) tumour growth.

103 ), and undifferentiated pleomorphic sarcoma (UPS).

104 ed unstructured peptide-insertion screening (UPS) with electrophysiological and fluorescence recordin

105 -assembly of a series of ultra-pH sensitive (UPS) block copolymers.

106 orted the development of ultra-pH-sensitive (UPS) nanoprobes with sharp pH response using fluorophore

107 In the future, specific UPS proteins may serve as new biomarkers or therapeutic

108 The expression of specific UPS proteins in podocytes differentiated children with m

109 ay for future studies that focus on specific UPS enzymes or ubiquitinated substrates.

110 ) by ultraviolet photoelectron spectroscopy (UPS) for CnT and CnDT SAMs agree remarkably well with th

111 ) by ultraviolet photoelectron spectroscopy (UPS) for OPT n and OPD n SAMs on Ag, Au, and Pt agree re

112 ibit ultraviolet-photoelectron spectroscopy (UPS) signatures expected of metallic solids.

113 opy, ultraviolet photoelectron spectroscopy (UPS), cyclic voltammetry, and DFT computation.

114 with ultraviolet photoelectron spectroscopy (UPS).

115 XS); ultraviolet photoelectron spectroscopy (UPS); Fourier transform-infrared (FT-IR) spectroscopy; t

116 sing ultraviolet photoemission spectroscopy (UPS), we show here that exposure of BLFO surfaces to UV

117 e effects of unpredictable postnatal stress (UPS), a mouse model of complex ELS, using high resolutio

118 The most clinically successful UPS-active agents (bortezomib and lenalidomide) are limi

119 discuss the experimental data which suggest UPS dysfunction is a common feature of cardiomyopathies,

120 ubiquitin-26S proteasome degradation system (UPS) in plants is involved in the signal transduction of

121 ulation of the ubiquitin-proteasomal system (UPS) enables pathogenic accumulation of disease-driving

122 proteins by the ubiquitin-proteasome system (UPS) accompanies the maternal-to-zygotic transition.

123 The ubiquitin-proteasome system (UPS) also plays an important role in protein homeostasis

124 The ubiquitin-proteasome system (UPS) and autophagy are two major intracellular degradati

125 onse (UPR), the ubiquitin-proteasome system (UPS) and autophagy, appear indispensable for longevity i

126 ively block the ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway, we show that HNF1a

127 mediated by the ubiquitin/proteasome system (UPS) and autophagy/lysosome system and is fundamental fo

128 tive arm of the ubiquitin proteasome system (UPS) and is required for mouse embryonic development, in

129 ic systems, the ubiquitin proteasome system (UPS) and the autophagosomal/lysosomal system, in persist

130 degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors,

131 elicited by the ubiquitin proteasome system (UPS) but that it is orchestrated by the F-Box protein, F

132 d expression of ubiquitin proteasome system (UPS) components have implicated protein degradation.

133 The ubiquitin proteasome system (UPS) controls many cellular processes, including the ini

134 The ubiquitin proteasome system (UPS) degrades misfolded proteins including those implica

135 The ubiquitin proteasome system (UPS) directs programmed destruction of key cellular regu

136 The ubiquitin-proteasome system (UPS) for protein degradation has been under intensive st

137 ondrial (MT) or ubiquitin-proteasome system (UPS) functions were markedly downregulated in the patien

138 The ubiquitin-proteasome system (UPS) has been implicated in the retrieval-induced destab

139 gulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clea

140 Ubiquitin-26S proteasome system (UPS) has been shown to play central roles in light and h

141 The ubiquitin proteasome system (UPS) has emerged as a drug target for diverse diseases c

142 The ubiquitin-proteasome system (UPS) has emerged as a therapeutic focus and target for t

143 In Drosophila, ubiquitin proteasome system (UPS) impairment led to enhancement of CGG-repeat-induced

144 egulated by the ubiquitin-proteasome system (UPS) in a process controlled by the envelope-localized u

145 e (PHD) and the ubiquitin proteasome system (UPS) in primary rat astrocytes.

146 ral role of the ubiquitin-proteasome system (UPS) in the degradation of cellular proteins, proteasome

147 ole of the host ubiquitin/proteasome system (UPS) in the infection process.

148 the role of the ubiquitin-proteasome system (UPS) in the regulation of fertilization, including sperm

149 olvement of the ubiquitin proteasome system (UPS) in their pathogenesis.

150 The ubiquitin-proteasome system (UPS) influences gene transcription in multiple ways.

151 The ubiquitin proteasome system (UPS) is a major regulator of protein processing, traffic

152 proteins by the ubiquitin-proteasome system (UPS) is an essential biological process in the developme

153 The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular p

154 The ubiquitin-proteasome system (UPS) is an important post-translational regulatory mecha

155 mediated by the ubiquitin-proteasome system (UPS) is critical to eukaryotic protein homeostasis.

156 ulation via the ubiquitin proteasome system (UPS) is crucial for normal HSC function; the loss of whi

157 The ubiquitin-proteasome system (UPS) is involved in most cellular processes.

158 The ubiquitin proteasome system (UPS) is known to regulate expression of many synaptic pr

159 The ubiquitin proteasome system (UPS) is primarily responsible for cellular protein degra

160 The ubiquitin-proteasome system (UPS) is responsible for the bulk of protein degradation

161 otic cells, the ubiquitin-proteasome system (UPS) is responsible for the regulated degradation of int

162 The ubiquitin proteasome system (UPS) maintains the integrity of the proteome by selectiv

163 asis, including ubiquitin-proteasome system (UPS) mediated protein degradation, endoplasmic reticulum

164 erations in the ubiquitin-proteasome system (UPS) or the autophagy-lysosomal pathway (ALP).

165 The ubiquitin-proteasome system (UPS) plays a central role in processing cellular protein

166 The ubiquitin-proteasome system (UPS) plays a critical role in removing unwanted intracel

167 The ubiquitin proteasome system (UPS) presents many opportunities for pharmacological int

168 ase MDM2 by the ubiquitin-proteasome system (UPS) promotes carcinogenesis and malignant transformatio

169 The ubiquitin-proteasome system (UPS) regulates diverse cellular pathways by the timely r

170 The ubiquitin proteasome system (UPS) regulates many biological pathways by post-translat

171 The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation

172 wn whether such ubiquitin-proteasome system (UPS) regulation of Sub2 occurs cotranscriptionally via i

173 bstrates to the ubiquitin-proteasome system (UPS) remains unclear.

174 haracterize the ubiquitin proteasome system (UPS) response to varied dietary protein intake, energy d

175 ocesses such as ubiquitin-proteasome system (UPS) to avoid a build-up of misfolded protein aggregates

176 y with the ubiquitylation-proteasome system (UPS) to facilitate the degradation of misfolded proteins

177 s, inhibits the ubiquitin-proteasome system (UPS) via targeting both 19S proteasome-specific DUBs and

178 ins through the ubiquitin-proteasome system (UPS) via the activities of E3 ubiquitin ligases regulate

179 tivation of the ubiquitin-proteasome system (UPS) was detected which resulted in a decreased expressi

180 found that the ubiquitin-proteasome system (UPS) was essential in RMC.

181 on pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons.

182 omeostasis, the ubiquitin proteasome system (UPS), as it relates to lung disease.

183 -depends on the ubiquitin-proteasome system (UPS), but the specific processes regulated by the UPS du

184 egulator of the ubiquitin proteasome system (UPS), controls ciliogenesis, cilia elongation and Hh sig

185 omponent of the ubiquitin proteasome system (UPS), have an integral role in maintaining this balance.

186 argeting of the ubiquitin-proteasome system (UPS), known to be essential for the viability of tumor c

187 Targeting the ubiquitin-proteasome system (UPS), therefore, is an attractive avenue to combat drug

188 teolysis by the ubiquitin proteasome system (UPS), which catalyzes most protein degradation in mammal

189 estrated by the ubiquitin proteasome system (UPS), which constitutes a cascade of enzymes that transf

190 trated that the ubiquitin-proteasome system (UPS), which is known to influence synaptic strength, dyn

191 quitination and ubiquitin proteasome system (UPS)-mediated degradation of FMRP in dendrites upon DHPG

192 and the rate of ubiquitin-proteasome system (UPS)-mediated proteolysis following heat stress.

193 n-regulation of ubiquitin proteasome system (UPS)-related genes, in particular, components of multime

194 ound within the ubiquitin-proteasome system (UPS).

195 erformed by the Ubiquitin-Proteasome System (UPS).

196 degraded by the ubiquitin-proteasome system (UPS).

197 I, Rpb1, by the ubiquitin proteasome system (UPS).

198 degraded by the ubiquitin-proteasome system (UPS).

199 the POI by the ubiquitin-proteasome system (UPS).

200 ded through the ubiquitin proteasome system (UPS).

201 tivities of the ubiquitin-proteasome system (UPS).

202 radation by the ubiquitin-proteasome system (UPS).

203 ion through the Ubiquitin-Proteasome System (UPS).

204 tination by the ubiquitin-proteasome system (UPS).

205 aratus, and the ubiquitin-proteasome system (UPS).

206 truction by the ubiquitin-proteasome system (UPS).

207 mediated by the ubiquitin-proteasome system (UPS).

208 mponents of the ubiquitin-proteasome system (UPS).

209 (KAMPs) by the ubiquitin-proteasome system (UPS).

210 tophagy and the ubiquitin proteasome system (UPS).

211 egulated by the ubiquitin proteasome system (UPS).

212 is requires the ubiquitin-proteasome system (UPS).

213 We show that UPS induces several neuroanatomical alterations that wer

214 Here we show that UPS-dependent proteolysis of two of these TFs, GLABROUS

215 and GATK LeftAlignAndTrimVariants shows that UPS-indel is able to identify 456,352 more redundant ind

216 The UPS also functions in protein quality control, rapidly i

217 The UPS catalyzes the destruction of many critical protein s

218 The UPS comprises a sequential series of enzymatic processes

219 The UPS effects selective degradation of ubiquitinated targe

220 The UPS library provides a useful toolkit to study pH regula

221 The UPS may function to suppress FDH mediated stress respons

222 , mTOR inhibition coordinately activates the UPS and autophagy, which provide essential amino acids a

223 Because the UPS is a crucial regulator of the cell cycle, and abnorm

224 Because the UPS measurements involve SAMs bonded to only one metal c

225 re is a compensatory interaction between the UPS and autophagy in HIF2alpha degradation.

226 ophagy, and reveal a causal link between the UPS and autophagy, the major pathways for degradation of

227 Therefore, a balance between the UPS and the chaperones tightly controls neuronal differe

228 Both the UPS and autophagy/lysosome system exhibit reduced effici

229 f mRNA from the nucleus-is influenced by the UPS and that all major arms of the system--from the firs

230 cyte-specific protein alpha-actinin-4 by the UPS depended on oxidative modification in membranous nep

231 but the specific processes regulated by the UPS during pruning have been largely elusive.

232 idative stress, cyclin C is destroyed by the UPS following nitrogen starvation.

233 o unfold and be rapidly ubiquitinated by the UPS for degradation at the proteasome.

234 t protein kinase (PKA) on proteolysis by the UPS in several mammalian cell lines.

235 The degradation of proteins by the UPS occurs independently of the autophagy pathway, and i

236 intracellular proteins to degradation by the UPS, we developed an unbiased method for large-scale ide

237 g of polyubiquitinated pQC substrates by the UPS.

238 and native channels to downregulation by the UPS.

239 sic mechanisms of protein degradation by the UPS.

240 In this study, we expand the UPS design to a library of nanoprobes with operator-pred

241 One of the challenges facing the UPS field is to delineate the complete cohort of substra

242 and selectivity efficiency inferred from the UPS data.

243 However, whether and how the UPS contributes to oligodendrocyte dysfunction and repai

244 understanding the emerging field of how the UPS regulates HSC activity may lead to novel targets for

245 These findings directly implicate the UPS and actin cytoskeleton in regulating prions via a st

246 Key players in the UPS are E3 ubiquitin ligases, responsible for conjugatio

247 Specific targets in the UPS may be more efficacious and less toxic.

248 candidates for therapeutic modulation in the UPS.

249 ow that Cuz1 modulates Cdc48 function in the UPS.

250 ithione complex (NiPT) potently inhibits the UPS via targeting the 19S proteasome-associated DUBs (UC

251 ization neuron dendrite pruning and link the UPS to the control of mRNA metabolism.

252 Notably, the UPS was overwhelmed in podocytes during experimental glo

253 ls, the targeting of other components of the UPS (e.g., the E3 ubiquitin ligases) can lead to an incr

254 activity confirmed similar activation of the UPS after retrieval of saline and cocaine memories.

255 Unsurprisingly, components of the UPS also play crucial roles during various stress respon

256 itself or specific proximal pathways of the UPS are in development as antiproliferatives or immunomo

257 This global characterization of the UPS as a key regulator of stem cell pluripotency opens t

258 Inhibition of the UPS caused a G2/M arrest due to constitutive accumulatio

259 ht a proteolysis-independent function of the UPS during class IV dendritic arborization neuron dendri

260 d proteins, small-molecule modulators of the UPS have the potential to significantly expand the drugg

261 Here, the role of the UPS in plant defense and its exploitation by effectors a

262 and promising approach in regulation of the UPS involves targeting deubiquitinases (DUB).

263 Conversely, the versatility and scope of the UPS provides opportunities for therapeutic intervention.

264 which can be stimulated by components of the UPS that also trigger their destruction.

265 review article focuses on components of the UPS that have been demonstrated to be deregulated by a v

266 of a general and reversible inhibitor of the UPS, bortezomib, in treating mantle cell lymphoma and mu

267 de an overall review of the mechanics of the UPS, describe aberrancies leading to cancer, and give an

268 vity that are perturbed by disruption of the UPS.

269 refore, they are essential regulators of the UPS.

270 cate that H727 cells remain dependent on the UPS for cell survival and growth despite harboring intri

271 However, whether BDNF acts on the UPS to mediate the effects on long-term synaptic potenti

272 MARCB1-deficient cancers and reliance on the UPS which provides the foundation for a mechanism-inform

273 g the levels of key regulatory proteins, the UPS contributes to nearly every aspect of cellular funct

274 myeloma has demonstrated that targeting the UPS has therapeutic potential.

275 ent drug therapies selectively targeting the UPS.

276 In addition, we provide evidence that the UPS and ALP might be functionally connected such that im

277 In summary, our results indicate that the UPS is likely to participate in tuning synaptic efficacy

278 We demonstrate that the UPS is the main degradation pathway for alpha-synuclein

279 We also noted that the UPS regulates both Tomo-1 expression and functional outp

280 in regulating protein breakdown through the UPS in the heart is not known.

281 t pathobiological mechanisms relating to the UPS and lung disease have been the focus of research, wi

282 uality control machinery and targeted to the UPS for degradation in mammalian cells.

283 hannel ubiquitination and sensitivity to the UPS, suggesting a role in pain processing.

284 ent density and increased sensitivity to the UPS.

285 Thus manipulation of DISC1 levels via the UPS may provide a novel method to explore DISC1 function

286 One way in which the UPS affects transcription centers on transcriptional act

287 ectrical resistance agrees strongly with the UPS data suggesting the creation of a thin conductive la

288 lead to oncogenesis, aberrancies within the UPS pathway can result in a malignant cellular phenotype

289 uitin E3 ligase for HSF1 degradation through UPS.

290 In contrast to UPS-mediated, ER-associated degradation, few components

291 In contrast, exposure to UPS induced fronto-limbic hyper-connectivity in males, b

292 iquitin and ubiquitylated proteins is key to UPS function, the mechanisms that regulate ubiquitin hom

293 TOC159, TOC159K1370R was destabilized under UPS-inducing stress conditions.

294 rbing switch from stable protein to unstable UPS substrate unlike other methods currently used to int

295 Moreover, using UPS-targeted RNAi screens, we identify additional regula

296 rominent in layer 3 pyramidal cells, whereas UPS-related gene alterations were more prominent in laye

297 However, it is not clear whether UPS and autophagy can be controlled by a common regulato

298 x7 null genotype ERMS incidence drops, while UPS becomes the most frequent subtype.

299 and suppressed the genetic interaction with UPS manipulation in Drosophila.

300 By employing XPS, UPS and UV-Vis diffuse reflectance spectroscopy for furt