ライフサイエンスコーパス: USP

1 USP <797> standards, radiation safety concerns, and work

2 USP and HD-OCT showed better agreement in CCT readings a

3 USP NaInS(2) films are used as a new photoanode material

4 USP thus establishes the precedent that invertebrate orp

5 ial of chronic pancreatitis patients, 90 000 USP U of pancreatin with meals decreased fat malabsorpti

6 eatment of fat malabsorption requires 90,000 USP U of lipase with meals.

7 that the DUB ubiquitin-specific protease 46 (USP-46) removes ubiquitin from the glutamate receptor GL

8 ating enzyme ubiquitin-specific protease-46 (USP-46) regulates the abundance of the glutamate recepto

9 0 and 6.0 in subjects treated with 55 IU (68 USP) and 75 IU (93 USP) of hyaluronidase respectively, v

10 We here study the role of the MHV-68 USP, encoded by ORF64.

11 ts treated with 55 IU (68 USP) and 75 IU (93 USP) of hyaluronidase respectively, versus 2.0 in saline

12 We have previously identified a USP in Mycobacterium smegmatis that is a product of the

13 the maturation of MC3T3 pre-osteoblasts in a USP-dependent and Arf6-independent manner.

14 stable cell lines overexpressing TRE17, in a USP-dependent manner.

15 al. provide a counterintuitive example of a USP residing in an E3 complex, and establish Usp37 as a

16 Through cell-based screening of a USP siRNA library, we discovered that knockdown of USP2a

17 The test utilized a USP-apparatus II with rotations of 50, 75 and 100rpm in

18 lity shift assays showed no binding of EcR-A/USP-1 to EcRE1.

19 squito Aedes aegypti receptor complex (AaEcR-USP), significantly enhancing DNA binding and transactiv

20 SP-encoding genes, but little is known about USP tissue distribution, pattern of expression, activity

21 a ligand that can transcriptionally activate USP would provide heuristic leads to the structure of po

22 ional proteomics approach to identify active USPs in normal, virus-infected, and tumor-derived human

23 catalysis and developing inhibitors against USPs.

24 loenzyme DUB families and highlight that all USPs tested display low linkage selectivity.

25 y ubiquitylation occurs more generally among USP-family enzymes.

26 jugates, suggesting that WDR-20, WDR-48, and USP-46 function together to deubiquitinate and stabilize

27 Two USP isoforms, USP-A and USP-B, with distinct N-termini, occur in the mosquito Ae

28 d the normal activation caused by EcR-B1 and USP-1 by 50%.

29 was expressed together with both EcR-B1 and USP-1, it reduced the normal activation caused by EcR-B1

30 EcR and USP are expressed, activated and autonomously required i

31 teins that co-immunoprecipitate with EcR and USP identified multiple Mediator subunits, including CDK

32 K8 protein positively correlate with EcR and USP levels, but inversely correlate with the activity of

33 heteromeric receptor composed of the EcR and USP nuclear receptor proteins.

34 ough a heterodimer consisting of the EcR and USP nuclear receptors.

35 s transduced by a heterodimer of the EcR and USP nuclear receptors.

36 heteromeric receptor composed of the EcR and USP proteins.

37 EcR and USP use similar surfaces, and rely on the deformed minor

38 iously increases the levels of CDK8, EcR and USP, yet down-regulates SREBP activity.

39 can Medical Association Drug Evaluations and USP-DI subsequently ceased publication, and the Medicare

40 RING domain ubiquitin ligases, of JAMM- and USP-domain-deubiquitinating enzymes, and of numerous ubi

41 lower than those obtained by both HD-OCT and USP at all follow-up visits.

42 The patients CCTs were measured with OCT and USP by three different examiners.

43 The differences between OCT and USP were not significant (t-test, p = 0.32).

44 The mean CCT measurements by the HD-OCT and USP were similar to baseline readings except for the thi

45 ing methods (such as sample-and-separate and USP apparatus 4).

46 Previous studies showed that EcR-B1/USP-1 bound only to EcRE1 and high levels of this comple

47 cR-A, however, reduced the binding of EcR-B1/USP-1 by about 50%.

48 mistry, the microdroplet reactors created by USP facilitate the formation of a wide range of nanocomp

49 urities were below the limits established by USP.

50 the proteasomal system or be reactivated by USP-33/20-mediated deubiquitination.

51 ubiquitin-like domain, whereas its catalytic USP domain is positioned variably.

52 Additionally, putative CF1/USP and Broad Complex Z2 transcription factor elements w

53 In contrast to other characterized USP deubiquitinases, our results indicate that USP28 has

54 a significant difference between compendial USP<71> and BacT/Alert testing (95.7% versus 89.0%; P =

55 s to evaluate three test systems (compendial USP<71>, Bactec FX, and BacT/Alert Dual-T) over seven di

56 an acceptable alternative to the compendial USP<71> method for product sterility testing.

57 ngal detection, respectively, the compendial USP<71> method significantly outperformed the Bactec FX

58 the United States Pharmacopeial Convention (USP) and international stakeholders collaborated to rede

59 AD in combination with Neoral (cyclosporine, USP MODIFIED) and corticosteroids.

60 l PUB domain, which binds the catalytic CYLD USP domain in a CYLD B-box-dependent manner.

61 e describe the crystal structure of the CYLD USP domain, revealing a distinctive architecture that pr

62 The results demonstrated that the developed USP 4 method was capable of detecting manufacturing proc

63 These results showed that the developed USP apparatus 4 method was capable of discriminating PLG

64 age of activation/differentiation, different USP activity profiles were revealed.

65 sophila melanogaster receptor complex (DmEcR-USP).

66 memory after extinction training by low-dose USP methylene blue (MB).

67 We found previously that the DUB USP-46 deubiquitinates the Caenorhabditis elegans glutam

68 in GST pull-down experiments, including EcR, USP, DHR3, SVP and betaFTZ-F1.

69 nockdown of the expression of Met, SRC, EcR, USP, BR-C (Broad-Complex), TOR (target of rapamycin), an

70 of the EcR subunit of the heterodimeric EcR-USP ecdysone receptor.

71 ement for a heterodimeric arrangement of EcR-USP subunits to bind to a symmetric DNA is unusual withi

72 ding interfaces to be the same as in the EcR-USP complex.

73 We describe the 2.24 A structure of the EcR-USP DNA-binding domain (DBD) heterodimer bound to an ide

74 We show that the EcR-USP ecdysone receptor is first activated in the extraemb

75 The EcR-USP heterodimer preferentially mediates transcription th

76 endly insecticides, the evolution of the EcR-USP heterodimer, and indeed Ashburner's classical bioche

77 CMI associates with TRR, as well as the EcR-USP receptor, and is required for hormone-dependent tran

78 Consistently, CDK8-CycC interacts with EcR-USP in vivo; in particular, CDK8 and Med14 can directly

79 Although EcR.USP-A recognizes the same ecdysteroid-responsive element

80 he same ecdysteroid-responsive elements, EcR.USP-B binds them with an affinity twofold higher than th

81 Likewise, EcR.USP-B transactivates a reporter gene in CV-1 cells twofo

82 an affinity twofold higher than that of EcR.USP-A.

83 in CV-1 cells twofold more strongly than EcR.USP-A.

84 yellow fever mosquito, Aedes aegypti, by EcR/USP and E74 in response to an elevation of 20E titers.

85 y demonstrates cell-autonomous roles for EcR/USP in controlling neuronal remodeling, potentially thro

86 other retinoid X receptor heterodimers, EcR/USP affects gene transcription in a ligand-modulated man

87 We found 502 significant regions of ECR/USP binding throughout the genome.

88 y, we found that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular d

89 Surprisingly, most identified primary EcR/USP targets are dispensable for MB neuronal remodeling.

90 controlled by the ecdysteroid receptor (EcR/USP) and products of ecdysteroid early responsive genes

91 at least three quarters of the remaining ECR/USP regions are near 20-HE-regulated genes in other tiss

92 We conclude that EcR/USP activation by the systemic ecdysteroid signal may be

93 We show that EcR/USP DNA binding activity requires activation by a chaper

94 ate third instar larvae, suggesting that EcR/USP loses its ability to function as an efficient activa

95 dicted for ecdysteroid activation of the EcR/USP heterodimer.

96 The ecdysone signal is transduced by the EcR/USP nuclear receptor heterodimer that binds to specific

97 that 20E mediates secretion through the EcR/USP receptor, and two early-gene products, the rbp(+) fu

98 ximal region containing binding sites to EcR/USP, GATA, C/EBP and HNF3/fkh is required for the correc

99 dimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormone receptor complex throughout the ent

100 st that in imaginal discs the unliganded EcR/USP complex acts as a ligand-sensitive ;gate' that can b

101 tion is also repressed by the unliganded EcR/USP complex but the block occurs after senseless express

102 l stage but suppressed by the unliganded EcR/USP complex.

103 suggest that silencing by the unliganded EcR/USP receptor and the subsequent release of silencing by

104 0-hydroxyecdysone (20E), consistent with EcR/USP acting as a 20E receptor.

105 Analysis of large gene families encoding USPs, nitroreductases, and DGATs demonstrates a mosaic d

106 constitutively bound endogenously expressed USPs 20 and 33 from the beta(2)AR immediately after agon

107 nfidence interval (CI): 0.98-0.996], and for USP, 0.97 (CI: 0.95-0.98).

108 adigms of USP action that do not include for USP a ligand-binding activity.

109 logic intervention, and future prospects for USP inhibitors to treat diverse cancers.

110 ated from one another in a liquid, while for USP it is hot droplets isolated from one another in a ga

111 Our results point to a novel function for USPs in the regulation and function of Polycomb complexe

112 show that the patterns of GAL4-EcR and GAL4-USP activation at the onset of metamorphosis reflect wha

113 In addition, both GAL4-EcR and GAL4-USP are activated in larval organs cultured with 20-hydr

114 -third instar imaginal discs results in GAL4-USP activation, but this response is not seen in imagina

115 We also show that GAL4-USP activation depends on EcR, suggesting that USP requi

116 es Pharmacopeia (USP) General Chapter <797> (USP <797>), "Pharmaceutical Compounding-Sterile Preparat

117 As reported here, USP activity is conserved in Marek's disease virus (MDV)

118 The herpesvirus USP thus appears to be required not only to maintain a f

119 ced activation, whereas the presence of high USP-2 prevented this increased activation.

120 de useful insights into the mechanism of how USP recognizes ubiquitin moieties in a chain structure,

121 cts residues that are conserved in the human USP family, and thus it is likely important for the inte

122 e expression ceases, AaSvp replaces AaEcR in USP heterodimers.

123 SPs featuring an N-terminal tandem domain in USP (DUSP) and ubiquitin-like (UBL) domain.

124 al cultures were more frequently negative in USP compared to NALC specimen aliquots (58% versus 43%;

125 vivo Inhibition of the proteasome increased USP-46 abundance, and this effect was nonadditive with i

126 in vitro to EcR and DHR38, both known insect USP partners.

127 Two USP isoforms, USP-A and USP-B, with distinct N-termini, occur in the m

128 s to tumor pathogenesis, and the role of its USP and TBC domains, are unknown.

129 MMP-9 and MMP-10, in a manner requiring its USP activity, but not its ability to bind Arf6.

130 alphaherpesvirus Marek's disease virus, its USP is involved in T-cell lymphoma formation.

131 Puf containing point mutations within its USP enzymatic domain failed to alter dMyc levels and dis

132 eight core gene groups (regulators, kinases, USPs, DGATs, nitroreductases, ferredoxins, heat shock pr

133 Like, USP, it activates transcription in Drosophila Schneider

134 M48(USP) adopts a papain-like fold, with the active-site cys

135 se domain of murine cytomegalovirus M48 (M48(USP)) in a complex with a ubiquitin (Ub)-based suicide s

136 ion with an exposed beta hairpin loop of M48(USP).

137 shown promise as alternatives to the manual USP<71> compendial method, but current published data ar

138 led each nuclear pharmacy laboratory to meet USP <797> requirements for facility design and environme

139 T-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications.

140 n IVRT method was developed using a modified USP 2 apparatus in conjunction with reverse-dialysis mem

141 ver, development of selective small-molecule USP inhibitors has been challenging, partly due to the h

142 Mean CCT values were 555.11 +/- 35.83 mum (USP), 535.82 +/- 41.10 mum (SP-2000P) and 552.57 +/- 36.

143 P-46 conjugates and increases the t (1/2) of USP-46.

144 c of Drosophila shows that in the absence of USP, early hormone responsive genes such as EcR, DHR3 an

145 In contrast, 20E inhibits activation of USP-A transcription.

146 bind and stimulate the catalytic activity of USP-46.

147 that repression involves the association of USP with DNA.

148 at EcR-A competes with EcR-B1 for binding of USP-1, leading to a decline in activity of the promoter.

149 ation here of these functional capacities of USP in a transcriptional activation pathway has signific

150 ffect is further enhanced by coexpression of USP-46.

151 rough a nuclear receptor complex composed of USP (ultraspiracle) and EcRB1 (ecdysone receptor B1) to

152 enting the ubiquitination and degradation of USP-46 in the proteasome.

153 X receptor (RXR) is the mammalian homolog of USP, we also solved the 2.60 A crystal structure of the

154 sence is required to sustain a high level of USP-B expression.

155 Ligand-binding pocket point mutants of USP that do not bind methyl epoxyfarnesoate act as domin

156 ficant implications for current paradigms of USP action that do not include for USP a ligand-binding

157 These newly revealed properties of USP might implicate similar properties for retinoid X re

158 in different cancers, the current status of USP inhibitor-mediated pharmacologic intervention, and f

159 in M. smegmatis biofilms along with that of USP(4207), suggesting that USP(4207) insulates KATms fro

160 anistic example for allosteric activation of USPs by their regulatory partners.

161 This family of USPs is conserved in all mycobacteria, and we suggest th

162 Given that a large number of USPs interact with WDR proteins, we propose that stabili

163 (USPs) USP15 and USP4 belong to a subset of USPs featuring an N-terminal tandem domain in USP (DUSP)

164 pulate transcriptional pathways dependent on USP or other orphan receptors.

165 Hs) from six different manufacturers and one USP standard sample.

166 t binding of ecdysteroids to either DHR38 or USP.

167 nd the ligand binding domain (LBD) of EcR or USP, combined with a GAL4-dependent lacZ reporter gene.

168 ement among the three observers using OCT or USP for pachymetry measurements was good.

169 d apo form of USP7, which differs from other USP deubiquitinases.

170 ty than ATP, an established ligand for other USPs.

171 tomography (HD-OCT), ultrasound pachymetry (USP), and dual Scheimpflug tomography.

172 both with the OCT and ultrasound pachymetry (USP), in patients suffering from glaucoma.

173 inherent precision of ultrasound pachymetry (USP), noncontact specular microscopy (SP-2000P) and the

174 hibitor of the ubiquitin specific peptidase (USP) 14/ubiquitin carboxyl-terminal hydrolase (UCH) L5 d

175 ymes, such as ubiquitin-specific peptidases (USPs).

176 U.S. Pharmacopeia (USP) chapter <797> calls for tryptic soy agar with polys

177 ) injection listed in the U.S. Pharmacopeia (USP); the draft Chemistry, Manufacturing, and Controls (

178 According to the United States Pharmacopeia (USP) General Chapter <797> (USP <797>), "Pharmaceutical

179 is the standard United States Pharmacopeia (USP) test for disintegration of immediate release tablet

180 randomly chosen side received 10% phenytoin USP and contralateral wounds received carrier alone.

181 The novel universal sample processing (USP) method has been reported to improve conventional di

182 rug Information for the Health Professional (USP-DI), and American Hospital Formulary Service Drug In

183 upts binding to USP-46 was unable to promote USP-46 abundance in vivo Finally, siRNA-mediated knockdo

184 pression of WDR-48, but not WDR-20, promotes USP-46 abundance in mammalian cells in culture and in C.

185 a ubiquitin (Ub)-specific cysteine protease (USP) domain embedded within the large tegument protein O

186 fy a human DUB, ubiquitin-specific protease (USP) 13, whose expression modulates the antiviral activi

187 rolase 6 [Ubp6; ubiquitin-specific protease (USP) 14 in mammals] is the most abundant proteasome-inte

188 Ubiquitin-specific protease (USP) 6 is a hominoid deubiquitinating enzyme previously

189 TRE17 encodes a ubiquitin-specific protease (USP) and a TBC (TRE2-Bub2-Cdc16) domain that promotes ac

190 s (DUBs) of the ubiquitin-specific protease (USP) class.

191 The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases.

192 binding to the ubiquitin-specific protease (USP) family of deubiquitinases.

193 The herpesvirus ubiquitin-specific protease (USP) family, whose founding member was discovered as a p

194 TRE17 encodes a ubiquitin-specific protease (USP), and a TBC domain that mediates binding to the Arf6

195 characterized a ubiquitin-specific protease (USP), Puffyeye (Puf), as a novel regulator of dMyc level

196 lso showed that ubiquitin-specific protease (USP)15 interacted with RORgammat, removed ubiquitin from

197 ated and stabilized by Ub-specific protease (USP)7 and USP10.

198 Ubiquitin-specific proteases (USP) are one class of DUBs that have drawn special atten

199 family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a varie

200 alled ubiquitin-specific cysteine proteases (USPs).

201 ating enzymes, ubiquitin-specific proteases (USPs) 20 and 33, thus, inhibiting lysosomal trafficking

202 tightly to particular Ub-specific proteases (USPs) and used phage display and saturation scanning mut

203 Ubiquitin specific proteases (USPs) are de-ubiquitinases (DUBs) that control protein u

204 Ubiquitin-specific proteases (USPs) constitute the largest family of deubiquitinating

205 ases (E3s) and ubiquitin-specific proteases (USPs) dynamically oppose each other during ubiquitinatio

206 Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all

207 ; however, the ubiquitin-specific proteases (USPs) that carry out deubiquitination of cellular substr

208 Ubiquitin-specific proteases (USPs) USP15 and USP4 belong to a subset of USPs featurin

209 identify specific universal stress proteins (USP) as abundantly expressed cAMP-binding proteins in sl

210 Universal stress proteins (USPs) are present in many bacteria, and their expression

211 v3130c), and many universal stress proteins (USPs).

212 The human genome contains many putative USP-encoding genes, but little is known about USP tissue

213 t synthesis with ultrasonic spray pyrolysis (USP) for the first time.

214 is the basis for ultrasonic spray pyrolysis (USP) with subsequent reactions occurring in the heated d

215 technique called ultrasonic spray pyrolysis (USP).

216 eptor, EcR, and the Drosophila RXR receptor, USP.

217 Isolated, recombinant USP from Drosophila melanogaster specifically binds meth

218 a model in which ubiquitin adducts regulate USP enzyme interactions and functions.

219 another mechanism by which WDR-48 regulates USP-46.

220 es of C. sapidus and other arthropod EcR/RXR/USP analyzed by in silico indicates a plausible, strong

221 The activity of specific USPs, including USP5, -7, -9, -13, -15, and -22, was up-

222 a model in which WDR-48 binds and stabilizes USP-46 protein levels by preventing the ubiquitination a

223 ans WDR-20 and WDR-48 can bind and stimulate USP-46 catalytic activity in vitro.

224 Moreover, one ICP0 ubiquitination target, USP-7, was also more stable after infection with these t

225 We found that USP-46 is ubiquitinated and that expression of WDR-48 re

226 Consistent with the notion that USP forms a heterodimer with the ecdysone receptor (EcR)

227 We observed that USP is able to activate as well as repress the Z1 isofor

228 We propose that USP(4207) sequesters KATms from diverse substrates whose

229 These results suggest that USP-B functions as a major heterodimerization partner fo

230 P activation depends on EcR, suggesting that USP requires its heterodimer partner to function as an a

231 long with that of USP(4207), suggesting that USP(4207) insulates KATms from its other substrates in t

232 The USP domain binds to Rpt1 in the immediate vicinity of th

233 e amino acid substitution that abolishes the USP activity of the MDV large tegument protein diminishe

234 domly numbered specimen was processed by the USP method and the other by the NALC method.

235 Overall, the mean CCT obtained by the USP was similar to that obtained by the HD-OCT throughou

236 phic skin tumor cylindromatosis, disrupt the USP domain, accounting for loss of CYLD catalytic activi

237 ore, we provide biochemical evidence for the USP domain of CYLD and the PUB domain of the SPATA2 comp

238 cularization, with an essential role for the USP domain.

239 cleared by day 7, indicating a role for the USP in the persistence of MHV-68 infection or efficient

240 and specificity of smear microscopy for the USP method were 52% and 86%, respectively, and were not

241 However, the USP activity in MHV-68 is unlikely to be involved in the

242 d cons of each of the QA tests stated in the USP, CMC, and EP and to propose a practical testing meth

243 ards and official monographs included in the USP.

244 the properties of EcR: one that involves the USP DNA-binding domain and one that can be achieved sole

245 dth was >/=0.6mm deemed critical to meet the USP criteria of immediate release products.

246 ents indicated that the EcR protein, not the USP protein, was responsible for ligand specificity.

247 79 mum, and 466.66 mum using the HD-OCT, the USP, and dual Scheimpflug tomography, respectively (P =

248 Here we show that many DUBs of the USP and UCH subfamilies can be reversibly inactivated up

249 uitin aldehyde stabilizes the binding of the USP domain in a position where it bridges the proteasome

250 We identify regions of the USP domain responsible for this specificity and demonstr

251 -is inserted within the globular core of the USP domain.

252 is study, we compared the performance of the USP method to that of the standard N-acetyl-L-cysteine-N

253 We determined the structure of the USP MSMEG_3811 bound to cAMP, and we confirmed through s

254 ompared with a "hockey stick" profile of the USP test.

255 Expression of the USP transcripts in MDV-transformed cell lines further su

256 ctive site of ORF64, we demonstrate that the USP activity of ORF64 is abolished.

257 These results suggest that the USP method did not provide any significant advantage ove

258 ties and disintegration time compared to the USP test method and most significantly, resulted in a li

259 These data establish a paradigm in which the USP ligand-binding pocket can productively bind ligand w

260 This review attempts to summarize the USPs implicated in different cancers, the current status

261 for binding of cAMP, and we show that these USPs bind cAMP with a higher affinity than ATP, an estab

262 tion, thus providing a defined role for this USP in mycobacterial physiology and stress responses.

263 Here, we explored the role of this USP (USP(4207)) in M. smegmatis and found that its gene

264 Up-regulation of this USP was a late event in the establishment of Epstein-Bar

265 Thus, USPs 20 and 33 serve as novel regulators that dictate bo

266 ated WDR-48 variant that disrupts binding to USP-46 was unable to promote USP-46 abundance in vivo Fi

267 Two USP isoforms, USP-A and USP-B, with distinct N-termini,

268 reporter promoter, and addition of wild-type USP rescues this activation.

269 on of WDR-48 reduces the levels of ubiquitin-USP-46 conjugates and increases the t (1/2) of USP-46.

270 Ultraspiracle (USP), the insect homologue of the vertebrate retinoid X

271 EcR-A, EcR-B1, or EcR-B2) and Ultraspiracle (USP) (reviewed in).

272 ) ecdysone receptor (EcR) and ultraspiracle (USP), USP being the insect orthologue of the vertebrate

273 e ecdysone receptor (EcR) and ultraspiracle (USP).

274 e ecdysone receptor (EcR) and ultraspiracle (USP).

275 : Ecdysone Receptor (EcR) and Ultraspiracle (USP)/Retinoid-X Receptor (RXR).

276 ndeed, the ability of the EcR-Ultraspiracle (USP) heterodimer to bind to polytene chromosomes and the

277 retinoid X receptor homologue Ultraspiracle (USP), the obligatory functional ecdysteroid receptor (Ec

278 retinoid X receptor homologue Ultraspiracle (USP).

279 zide requires the function of ultraspiracle (USP), a component of the canonical heterodimeric ecdyson

280 he ecdysone receptor (EcR) or Ultraspiracle (USP), the two components of the ecdysone receptor, cause

281 and its heterodimeric partner Ultraspiracle (USP).

282 eceptor (EcR) or its partner, ultraspiracle (USP) are required for expression of Vg genes.

283 nhancer to which the receptor ultraspiracle (USP) binds.

284 nvertebrate nuclear receptor, ultraspiracle (USP), an ortholog of the vertebrate RXR, is typically mo

285 g of the retinoid X receptor, ultraspiracle (USP), heterodimerizes with the ecdysone receptor (EcR) t

286 noxycarb as activators of the Ultraspiracle (USP) ligand-binding domain.

287 ucture, which is important for understanding USP catalysis and developing inhibitors against USPs.

288 Unlike USP porcine heparin, bovine intestinal heparin (BIH) has

289 This steroid hormone upregulates USP-B transcription and its presence is required to sust

290 f the naltrexone microspheres obtained using USP apparatus 4.

291 on the in vitro release data obtained using USP apparatus 4.

292 ypills were evaluated for drug release using USP dissolution testing.

293 Here, we explored the role of this USP (USP(4207)) in M. smegmatis and found that its gene is pr

294 sone receptor (EcR) and ultraspiracle (USP), USP being the insect orthologue of the vertebrate RXR.

295 results distinguish two mechanisms by which USP modulates the properties of EcR: one that involves t

296 These data support a model in which USP-46 promotes GLR-1 abundance at synapses by deubiquit

297 expressed EcR-A alone or in combination with USP-1 under the control of Autographa californica baculo

298 e that WDR-20 and WDR-48 form a complex with USP-46 and stimulate the DUB to deubiquitinate and stabi

299 DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ec

300 +/- 29 mum, and the average pachymetry with USP was 532 +/- 32 mum.

301 ing the activity of the subset of the UAF1 x USP complexes.