ライフサイエンスコーパス: V(D)J recombination

1 sity (D), and joining (J) subgenic elements (V(D)J recombination).

2 which is required for rejoining DSBs during VDJ recombination.

3 atic hypermutation levels and in features of V(D)J recombination.

4 re, we aimed to study the role of XLF during V(D)J recombination.

5 igating how these dynamic mechanisms control V(D)J recombination.

6 double-strand breaks (DSBs) generated during V(D)J recombination.

7 teins participate in the DNA repair phase of V(D)J recombination.

8 tions, play a fundamental role in regulating V(D)J recombination.

9 rucial to quantitatively capture kinetics in V(D)J recombination.

10 te asymmetry important for the 12/23 rule of V(D)J recombination.

11 ucial for DNA double-strand break repair and V(D)J recombination.

12 A rearrangements in lymphoid cells, known as V(D)J recombination.

13 defect in DNA double-strand break repair and V(D)J recombination.

14 omplex that reflects the known 12/23 rule of V(D)J recombination.

15 ional levels to facilitate their assembly by V(D)J recombination.

16 epair of DNA double-strand breaks (DSBs) and V(D)J recombination.

17 g an unexpected role for RAG proteins beyond V(D)J recombination.

18 AG1) and RAG2 result in loss or reduction of V(D)J recombination.

19 y chain (IgH) gene locus prior to and during V(D)J recombination.

20 ect consequences of BCL11A/RAG modulation on V(D)J recombination.

21 lation of antigen receptor gene assembly via V(D)J recombination.

22 en receptor variable region gene segments by V(D)J recombination.

23 ased on lymphocyte Ag receptors generated by V(D)J recombination.

24 and breaks created by ionizing radiation and V(D)J recombination.

25 ted activation of germline transcription and V(D)J recombination.

26 cleavage activity, is required for efficient V(D)J recombination.

27 y impaired DNA damage responses or defective V(D)J recombination.

28 hich plays essential roles in DNA repair and V(D)J recombination.

29 napse and end-joining at modest level during V(D)J recombination.

30 rotein(s) to limit error-prone repair during V(D)J recombination.

31 ne lymphocytes show no measurable defects in V(D)J recombination.

32 g lymphocyte Ag receptor loci cleaved during V(D)J recombination.

33 2+) are present, unlike a single nick during V(D)J recombination.

34 re defects in end joining during chromosomal V(D)J recombination.

35 sites is dispensable for the joining step of V(D)J recombination.

36 sequences may have a role in long-range IgH V(D)J recombination.

37 ring proper repair of DNA breaks made during V(D)J recombination.

38 transcriptional accessibility helps control V(D)J recombination.

39 lopment and their lymphocytes support normal V(D)J recombination.

40 both hairpin opening and end-ligation during V(D)J recombination.

41 ding the stage at which this locus undergoes V(D)J recombination.

42 rticipates in a specialized version of NHEJ, V(D)J recombination.

43 and inconsequential variant of the canonical V(D)J recombination.

44 ding of the Igkappa locus in preparation for V(D)J recombination.

45 y and caused by defects in lymphoid-specific V(D)J recombination.

46 ect consequences of BCL11A/RAG modulation on V(D)J recombination.

47 ther to facilitate or to impose a barrier to V(D)J recombination.

48 rk that regulates B cell fate by controlling V(D)J recombination.

49 pening step, which is crucial and unique for V(D)J recombination.

50 T-cell development and T-cell receptor (TCR) V(D)J recombination.

51 hairpin intermediates that are formed during V(D)J recombination.

52 rated during Variable, Diverse, and Joining [V(D)J] recombination.

53 inetics of variable, diversity, and joining [V(D)J] recombination.

54 that are assembled in developing B cells by V(D)J recombination(1).

55 requires the participation of all V genes in V(D)J recombination(16), which depends on contraction of

56 RAG1 and RAG2 mediate VDJ recombination, a process necessary for the maturatio

57 DSBs) induced by the RAG endonuclease during V(D)J recombination activate the Ataxia Telangiectasia m

58 partial immune defects caused by suboptimal V(D)J recombination activity, a DNA repair defect, or bo

59 a significant role in governing the level of V(D)J recombination activity.

60 RAG1 with a nucleolar marker, and increased V(D)J recombination activity.

61 utation that impairs, but does not abrogate, V(D)J recombination activity.

62 fferential activation of component parts for V(D)J recombination, allelic exclusion, and receptor edi

63 B cell antigen receptor (BCR) repertoire by V(D)J recombination also generates autoreactive B cells.

64 ting Genes, RAG1 and RAG2, are essential for V(D)J recombination and adaptive immunity.

65 in B-cell progenitors, promoting DSB repair, V(D)J recombination and cell survival.

66 gnals creates an ectopic hub of RAG-mediated V(D)J recombination and chromosomal translocations.

67 rmal kinase activity and underwent efficient V(D)J recombination and class switch recombination, indi

68 tion and associated molecular events such as V(D)J recombination and class switch recombination.

69 decrease in the fitness of cells undergoing V(D)J recombination and CSR.

70 atients with primary immunodeficiencies with V(D)J recombination and DNA repair deficiencies.

71 ng' process, which can also lead to Iglambda V(D)J recombination and expression, provides a mechanism

72 responsible for opening DNA hairpins during V(D)J recombination and for processing a subset of patho

73 ion within the Ig heavy chain locus precedes V(D)J recombination and has been proposed to be associat

74 clease that opens coding hairpin ends during V(D)J recombination and has critical roles in postirradi

75 f RAG1 is a negative regulatory mechanism in V(D)J recombination and identify regions of the RAG1 N-t

76 ) mediates double-stranded DNA break repair, V(D)J recombination and immunoglobulin class switch reco

77 ATM is important for V(D)J recombination and immunoglobulin class-switch reco

78 TEMIS C terminus is dispensable for cellular V(D)J recombination and in vitro nuclease assays with C-

79 Degradation of RAD21 eliminated all V(D)J recombination and interactions associated with RAG

80 Although NHEJ is required for V(D)J recombination and lymphocyte development, XLF-defi

81 C)) exhibit lymphopenia, reflecting impaired V(D)J recombination and lymphocyte development.

82 intains genome stability and is required for V(D)J recombination and lymphocyte development.

83 However, ATM deficiency causes only modest V(D)J recombination and lymphocyte developmental defects

84 d transposition, illuminate the evolution of V(D)J recombination and provide insight into the princip

85 ted pro-B lines abrogates DSB joining during V(D)J recombination and sensitizes the cells to ionizing

86 We find that APE2 is not required for V(D)J recombination and that the turnover rate of APE2-d

87 mechanisms that might contribute to aberrant V(D)J recombination and the development of lymphoid tumo

88 y different recombination reactions, such as V(D)J recombination and transposition.

89 harbour intermediates indicative of ongoing V(D)J recombination and which contain cells with pro-B,

90 mmed mechanistic feature of CSR as it is for V(D)J recombination and, if so, how this is achieved is

91 mphopenia associated with a severe defect in V(D)J recombination and, in the absence of p53, increase

92 uman IGHV1-2( *)02 segment to undergo normal V(D)J recombination and, thereby, leads to the generatio

93 Variable, diversity and joining (V(D)J) recombination and immunoglobulin class switch rec

94 data provide a window into the mechanisms of VDJ recombination and diversity creation and allow us to

95 Mutations impairing VDJ recombination and DNA repair were the most common un

96 This mechanism promotes VDJ recombination and effective selection of cells expre

97 ficant correlation between biases induced by VDJ recombination and our inferred selection factors tog

98 B ligation, resulting in failure to complete VDJ recombination and subsequent block of B-lymphocyte m

99 Recent advances in modelling VDJ recombination and subsequent selection of T- and B-c

100 nteraction with Ligase IV or DNA-PKcs reduce V(D)J recombination, and Artemis mutations that affect i

101 Shark Ag receptors are generated through V(D)J recombination, and because it is a mechanism known

102 ns involving the Tcralpha/delta locus during V(D)J recombination, and instead harbor alterations at t

103 In mice, C-NHEJ, V(D)J recombination, and lymphocyte development are, at

104 deficiency in mice severely impairs C-NHEJ, V(D)J recombination, and lymphocyte development while al

105 e to state in a hidden Markov model (HMM) of VDJ recombination, and assumed that mutations occur via

106 ort frequency estimation, learn the rules of VDJ recombination, and generalize well to unseen sequenc

107 chastic steps: random receptor generation by VDJ recombination, and selection based on the recognitio

108 a process called variable-diversity-joining (VDJ) recombination] and, upon successful rearrangement,

109 hain that, owing to junctional biases during V(D)J recombination, appear much more frequently than pr

110 RAG2, a late evolutionary addition in V(D)J recombination, appears to enforce the sharp kinks

111 combinatorial splicing of coding segments by V(D)J recombination are hallmarks of vertebrate immunity

112 Ig gene locus contraction and looping during V(D)J-recombination are essential for creating a diverse

113 ntroduced by somatic mutation or heavy chain VDJ recombination are necessary and sufficient for Dsg3

114 Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimen

115 for understanding retroviral integration and V(D)J recombination as well as many other DNA transposit

116 nd in increased ARTEMIS activity in cellular V(D)J recombination assays.

117 V(D)J recombination assembles Ag receptor genes during l

118 V(D)J recombination assembles and diversifies Ig and T c

119 V(D)J recombination assembles immunoglobulin and T cell

120 We propose that dicentrics formed by joining V(D)J recombination-associated IgH DSBs to DSBs downstre

121 iversity (D), and joining (J) gene segments [V(D)J recombination] asynchronously in nuclei of develop

122 by the CCCTC binding factor (CTCF) regulates V(D)J recombination at Ag receptor loci.

123 The RAG1/RAG2 endonuclease initiates V(D)J recombination at antigen receptor loci but also bi

124 Enhancers at AR loci are known to control V(D)J recombination at associated alleles, in part by in

125 tify the genomic instability associated with V(D)J recombination at the TCRdelta locus as the molecul

126 uggest that the nuclear periphery suppresses V(D)J recombination, at least in part, by segregating Tc

127 During V(D)J recombination, ATM and DNA-PKcs have unique functi

128 The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombi

129 her with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome sta

130 ic DNA insertions by transposition and trans-V(D)J recombination, but only few such putative events h

131 G2 recombinase (RAG) cleaves DNA to initiate V(D)J recombination, but RAG also belongs to the RNH-typ

132 ation-activating gene endonuclease initiates V(D)J recombination by cleaving a pair of gene segments

133 pe long-range interactions and contribute to V(D)J recombination by facilitating lineage- and develop

134 ation activating gene endonuclease initiates V(D)J recombination by generating DSBs between two V(D)J

135 ropose that recombination centers coordinate V(D)J recombination by providing discrete sites within w

136 Conversely, we report low levels of V(D)J recombination by RAG1 in the absence of RAG2.

137 We conclude that CTCF can regulate V(D)J recombination by segregating RSSs into distinct lo

138 Our results suggest that V(D)J recombination can be regulated by AMPK activation,

139 ferences in CDR H3 junctional regions during VDJ recombination can alter reactivity and evolutionary

140 Null mutations in genes involved in V(D)J recombination cause a block in B- and T-cell devel

141 the lack of variable, diversity and joining [V(D)J] recombination completely abolishes the Tcralpha/d

142 orting that E2A, PAX5, and the RAGs are in a VDJ recombination complex bound to key sequences on the

143 We show that pre-BCR activation releases the VDJ recombination complex through calmodulin binding to

144 Our studies elucidate a long-sought Igh V(D)J recombination control region and indicate a new ro

145 Initiation of V(D)J recombination critically relies on the formation o

146 includes overexpression of genes involved in VDJ recombination, CXCR4 pathway signaling, and BCL2 fam

147 CD8(+) thymocytes, but led to no discernible V(D)J recombination defect in G1 phase cells beyond that

148 evealed specific signatures in patients with V(D)J recombination-defective primary immunodeficiencies

149 vation in XLF-deficient pro-B lines leads to V(D)J recombination defects associated with marked degra

150 icient patients in the absence of measurable V(D)J recombination defects.

151 on of a CBE-based IgH locus element disrupts V(D)J recombination domains and, correspondingly, alters

152 an inability to process and join chromosomal V(D)J recombination DSB intermediates.

153 o find that PAXX deficiency has no impact on V(D)J recombination DSB joining in ATM-deficient pro-B l

154 report that PAXX is dispensable for joining V(D)J recombination DSBs in G1-arrested mouse pro-B-cell

155 As V(D)J recombination DSBs occur in developing progenitor

156 ent for NHEJ to resolve DSBs associated with V(D)J recombination, DSBs associated with CSR can be res

157 Restricted V(D)J recombination during fetal development was postula

158 ating gene products, RAG1 and RAG2, initiate V(D)J recombination during lymphocyte development by cle

159 V(D)J recombination ensures the diversity of the adaptiv

160 ned XLF and H2AX deficiency severely impairs V(D)J recombination, even though H2AX deficiency alone h

161 Regulation of V(D)J recombination events at immunoglobulin (Ig) and T-

162 region exons are assembled by RAG-initiated V(D)J recombination events in developing gammadelta thym

163 nerally believed to result from illegitimate V(D)J recombination events.

164 ssion levels of several transcripts encoding V(D)J recombination factors were decreased in adults as

165 over, since the classical 12/23 rule for the V(D)J recombination fails to explain the V(DD)J recombin

166 n initial random DNA editing process, called VDJ recombination, followed by functional selection of c

167 SJ defects, indicating that the overlapping V(D)J recombination functions of ATM and DNA-PKcs are me

168 thy humans suggests an important role of the V(D)J recombination-generated junctional and allele-spec

169 damage-induced cell death, however, because V(D)J recombination generates double-strand breaks and m

170 eptor (TCR) and immunoglobulin (Ig) genes by V(D)J recombination generates the antigen receptor (AgR)

171 es showed greatly enhanced expression of the VDJ recombination genes DNTT, RAG1, and RAG2, but not AI

172 role for the C-terminal region of Artemis in V(D)J recombination has not been defined, despite the pr

173 -established functions in the DNA repair and V(D)J recombination, hence loss of DNA-PK leads to sever

174 development, XLF-deficient mice have normal V(D)J recombination, highlighting the need for an altern

175 V(D)J recombination in B and T cells is required for the

176 h or without V/J restriction, as a result of V(D)J recombination in B or T cells.

177 ates RAG-mediated cleavage and repair during V(D)J recombination in CD4(+) CD8(+) DP thymocytes.

178 netic locus (Tcra/Tcrd locus) that undergoes V(D)J recombination in CD4(-)CD8(-) double-negative (DN)

179 shows that XLF has an important role during V(D)J recombination in creating diversity of the reperto

180 and resolves the DSBs generated during both V(D)J recombination in developing lymphocytes and class

181 RAG initiates antibody V(D)J recombination in developing lymphocytes by generat

182 r and Ig gene segments that are required for V(D)J recombination in developing lymphocytes.

183 ntial role in adaptive immunity by mediating V(D)J recombination in developing lymphocytes.

184 ination by RAG1 alone differs from canonical V(D)J recombination in having lost the requirement for a

185 tigen receptors, which are generated through V(D)J recombination in lymphoid precursors.

186 ctor (XLF) C-NHEJ protein is dispensable for V(D)J recombination in normal cells, but because of func

187 equired for efficient class switch (CSR) and V(D)J recombination in part because they protect DNA end

188 The RAG endonuclease initiates Igh locus V(D)J recombination in progenitor (pro)-B cells(1).

189 he V(H)-to-D intergenic region regulates Igh V(D)J recombination in the contexts of developmental ord

190 V(D)J recombination in the vertebrate immune system gene

191 ence that HMGB1 plays a critical role during V(D)J recombination in vivo.

192 icient lymphocytes, despite moderate role in V(D)J recombination in WT cells.

193 ubstrate histone H2AX are both essential for V(D)J recombination in XLF-deficient lymphocytes, despit

194 and differences exist between brain SGR and VDJ recombination in the immune system, the first identi

195 signaling in B-cell development, we studied VDJ recombination in the pro-B cells of FLT3/ITD mice an

196 nt translocations and amplifications involve V(D)J recombination-initiated breaks in the Tcrd locus,

197 mutant mice harbor translocations that fuse V(D)J recombination-initiated IgH double-strand breaks (

198 tions during lymphocyte development, joining V(D)J recombination intermediates during antigen recepto

199 mosome alterations that result from aberrant V(D)J recombination involve breaks at single recombinati

200 ase with zebrafish maturity, suggesting that VDJ recombination involves a level of deterministic prog

201 V(D)J recombination is essential to generate antigen rec

202 V(D)J recombination is initiated by RAG1 and RAG2, which

203 V(D)J recombination is initiated by the binding of the R

204 V(D)J recombination is initiated by the RAG endonuclease

205 V(D)J recombination is initiated by the recombination-ac

206 V(D)J recombination is initiated by the recombination-ac

207 At most AgR loci, V(D)J recombination is regulated so that only one allele

208 Within the 2.7-megabase mouse Igh locus, V(D)J recombination is regulated to ensure specific and

209 To understand better the mechanism by which V(D)J recombination is suppressed at the nuclear periphe

210 ously in double-negative thymocytes and that V(D)J recombination is suppressed on peripheral as compa

211 V(D)J recombination is the distinguishing feature of ada

212 The first step in V(D)J recombination is the formation of specific DNA dou

213 Here, we show that V(D)J recombination is unaffected by the complete absenc

214 This process, known as "VDJ recombination", is implemented via a series of stoch

215 CTCF-mediated looping was shown to influence V(D)J recombination, it was not possible to fully resolv

216 domain and, correspondingly, shifts the Tcrd V(D)J recombination landscape by leading to predominant

217 combined DNA-PKcs and ATM deficiency during V(D)J recombination leads to accumulation of unjoined SE

218 Despite the central role of the PC in V(D)J recombination, little is understood about its stru

219 her, these data suggest a mechanism by which V(D)J recombination may feed back to regulate local Dbet

220 years that the variable (diversity) joining [V(D)J] recombination-mediated assembly of diverse B and

221 dels are defined in terms of a probabilistic V(D)J recombination model which is sometimes combined wi

222 ll development, RAG-dependent DNA breaks and V(D)J recombination occur at three T-cell receptor (TCR)

223 V(D)J recombination occurs during the antigen-independen

224 precisely at differentiation stages in which V(D)J recombination occurs.

225 versity through N-nucleotide addition during V(D)J recombination of IG/TCR genes, here we propose tha

226 c repeat (CRISPR) loci in prokaryotes and by V(D)J recombination of immunoglobulin genes in vertebrat

227 to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any sp

228 V(D)J recombination of TCR loci is regulated by chromati

229 Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain ge

230 e discuss CTCF function in the regulation of V(D)J recombination on the basis of established knowledg

231 lele, with subsequent feedback inhibition of V(D)J recombination on the other allele.

232 nome instability, has only modest effects on V(D)J recombination or lymphocyte development.

233 In addition to its role in VDJ recombination, our study points out that the full-le

234 We found that, despite defective V(D)J recombination, P1(-/-)/D(-/-) lymphomas lacked clo

235 F protein is not required for the process of V(D)J recombination per se, CTCF turned out to be essent

236 ly resolve the relative contributions to the V(D)J recombination phenotype of changes in accessibilit

237 the impact of heritable factors on both the V(D)J recombination process and on thymic selection.

238 d participates in hairpin opening during the V(D)J recombination process and repair of a subset of DN

239 tes are assembled from gene fragments by the V(D)J recombination process.

240 velopment of T and B cells by initiating the VDJ recombination process that leads to generation of a

241 fferent ages, we quantify the changes in the VDJ recombination process that occur from embryo to youn

242 nts can induce specific abnormalities of the VDJ recombination process.

243 cal impact of selection on the output of the VDJ recombination process.

244 During V(D)J recombination, RAG targeting to correct sites vers

245 transposition pathway resembles that of the V(D)J recombination reaction and the mechanism of hAT an

246 g DSB intermediates of the G1 phase-specific V(D)J recombination reaction in progenitor lymphocytes.

247 e RAG1/RAG2 endonuclease (RAG) initiates the V(D)J recombination reaction that assembles immunoglobul

248 This process is executed by the V(D)J recombination reaction, which can be divided into

249 al lamina propria (LP), where the associated V(D)J recombination/receptor editing processes modulate

250 During V(D)J recombination, recombination activating gene (RAG)

251 During V(D)J recombination, recombination activating gene prote

252 Here we report in mice a key Igh V(D)J recombination regulatory region, termed intergenic

253 Immunoglobulin heavy-chain locus V(D)J recombination requires a 3D chromatin organization

254 Antigen receptor locus V(D)J recombination requires interactions between widely

255 ciency in Artemis is associated with lack of V(D)J recombination, sensitivity to radiation and radiom

256 ructural constraints form the basis to shape VDJ recombination sequences into MHC-restricted repertoi

257 rd, including sequential rearrangements from V(D)J recombination signal sequence fusions.

258 terminal inverted repeats (TIRs) resembling V(D)J recombination signal sequences.

259 versification of the immunoglobulin genes by V(D)J recombination, somatic hypermutation, and class sw

260 V(D)J recombination takes place during lymphocyte develo

261 ay distinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and sha

262 developed approach for studying chromosomal V(D)J recombination that has been modified to allow for

263 This process called V(D)J recombination that involves the RAG recombinase bi

264 immature B cells, allowing continued Igkappa V(D)J recombination that replaces the initial VkappaJkap

265 ginates in a stochastic DNA editing process (VDJ recombination) that acts on the surface receptor gen

266 of the germline TCR locus, a process termed V(D)J recombination, that has the potential to generate

267 ing gene 1 (RAG1) and RAG2 proteins initiate V(D)J recombination, the process that assembles the B- a

268 is essential in vertebrates because, during V(D)J recombination, the RAG complex generates hairpins

269 During V(D)J recombination, the RAG1/2 recombinase is thought t

270 Produced through V(D)J recombination, this loop is quite diverse, with di

271 the C-terminal region of Artemis influences V(D)J recombination through its interaction with both Li

272 Developing B lymphocytes undergo V(D)J recombination to assemble germ-line V, D, and J ge

273 sistent with the requirement for NHEJ during V(D)J recombination to ensure diversity of the adaptive

274 The ability of V(D)J recombination to generate vast primary B-cell repe

275 RAG-2 enzyme upon entry to S phase restricts V(D)J recombination to the G0-G1 phase of the cell cycle

276 discriminate against MHC binding, suggesting VDJ recombination together with Valpha/Vbeta pairing det

277 ned to function in cells that have undergone VDJ recombination using any combination of variable (V),

278 in (Ig)-superfamily of genes; and instead of V(D)J recombination VLR are somatically assembled by a g

279 d RAG2 for antigen receptor gene assembly by V(D)J recombination was a crucial event in the evolution

280 Defective V(D)J recombination was complemented by wild-type ARTEMI

281 V(D)J recombination was preserved in NIR-deficient DN3 d

282 alian RAG1-RAG2 recombinase, which initiates V(D)J recombination, we find that the active site is rec

283 ms by which CTCF-mediated looping can impact V(D)J recombination, we introduced an ectopic CTCF bindi

284 To clarify the role of the RR in V(D)J recombination, we totally deleted it in the mouse

285 To identify mechanisms that regulate V(D)J recombination, we used proximity-dependent biotin

286 RAG1-like, have a latent ability to initiate V(D)J recombination when coexpressed with RAG2 and that

287 The first occurs during VDJ recombination, when inverted DH genes are usually av

288 upstream of Cmu, have important roles during V(D)J recombination, whereas there is no clue about a ro

289 ch developing lymphocyte by a process called V(D)J recombination, which assembles specific, independe

290 In contrast to V(D)J recombination, which is almost exclusively depende

291 gene assembly occurs through the process of V(D)J recombination, which is initiated when the RAG end

292 ing the lymphoid-specific DNA rearrangement, V(D)J recombination, which is required for lymphocyte de

293 that catalyzes specific DNA cleavage during V(D)J recombination, which is required for the assembly

294 oping lymphocytes, DSBs are generated during V(D)J recombination, which is required to assemble the s

295 Immunoglobulin genes are formed through V(D)J recombination, which joins the variable (V), diver

296 tor repertoire is sculpted by the process of V(D)J recombination, which must strike a balance between

297 rise to the RAG1-RAG2 recombinase (RAG) and V(D)J recombination, which produces the diverse repertoi

298 the core-enhancer Emu element mainly affects VDJ recombination with minor effects on class switch rec

299 Despite a severe defect in VDJ recombination with partial blockade at the pro-B cel

300 n genetic and molecular features of NHEJ and V(D)J recombination within cells.