ライフサイエンスコーパス: VDJ recombination

1 which is required for rejoining DSBs during VDJ recombination.

2 ements is essential for locus activation and VDJ recombination.

3 action with factors implicated in regulating VDJ recombination.

4 ighest potential CDR3 diversity generated by VDJ recombination.

5 strand breaks including those induced during VDJ recombination.

6 ensitive, but having only a modest defect in VDJ recombination.

7 H3 acetylation status was tightly linked to VDJ recombination.

8 pling enhancer activity to accessibility for VDJ recombination.

9 for example by ionizing radiation or during VDJ recombination.

10 or near a JH segment, suggesting an error in VDJ recombination.

11 actions with the 3'CBE, but does not restore VDJ recombination.

12 etic, there is also nongenetic modulation of VDJ recombination.

13 RAG1 and RAG2 mediate VDJ recombination, a process necessary for the maturatio

14 ter immunization and assessed peripheral IgH VDJ recombination activities in C57BL/6 (B6) mice congen

15 data provide a window into the mechanisms of VDJ recombination and diversity creation and allow us to

16 Mutations impairing VDJ recombination and DNA repair were the most common un

17 This mechanism promotes VDJ recombination and effective selection of cells expre

18 ficant correlation between biases induced by VDJ recombination and our inferred selection factors tog

19 B ligation, resulting in failure to complete VDJ recombination and subsequent block of B-lymphocyte m

20 Recent advances in modelling VDJ recombination and subsequent selection of T- and B-c

21 e to state in a hidden Markov model (HMM) of VDJ recombination, and assumed that mutations occur via

22 ort frequency estimation, learn the rules of VDJ recombination, and generalize well to unseen sequenc

23 chastic steps: random receptor generation by VDJ recombination, and selection based on the recognitio

24 ed DNA damage in pro-B cells, independent of VDJ recombination, and these cells had evidence of slowe

25 a process called variable-diversity-joining (VDJ) recombination] and, upon successful rearrangement,

26 ntroduced by somatic mutation or heavy chain VDJ recombination are necessary and sufficient for Dsg3

27 n of the TCR alpha joining gene segments for VDJ recombination at an early stage of T cell developmen

28 hat c-Myb plays a crucial role in activating VDJ recombination at the endogenous TCR-delta locus.

29 hancer, the inserted Vbeta segment underwent VDJ recombination at the same frequency as the natural c

30 Developmental activation of VDJ recombination at the T cell receptor (TCR) delta loc

31 elements in the developmental regulation of VDJ recombination at the TCR alpha/delta locus was exami

32 DN stage as observed in RAG-/- mice, DJ and VDJ recombination at the TCR beta locus was functional,

33 ), a specialized DNA polymerase intrinsic to VDJ recombination, broadly expressed within CD34(+) prog

34 role in the ability of E(delta) to activate VDJ recombination by analyzing VDJ recombination in mice

35 ary, is not sufficient for the activation of VDJ recombination by E(delta).

36 ferences in CDR H3 junctional regions during VDJ recombination can alter reactivity and evolutionary

37 onstrate that population-wide individualized VDJ recombination can result in orders of magnitude of d

38 lineage commitment and T cell receptor beta VDJ recombination, Cd3 expression and beta-selection hav

39 been implicated in IgH locus transcription, VDJ recombination, class switch recombination, and somat

40 orting that E2A, PAX5, and the RAGs are in a VDJ recombination complex bound to key sequences on the

41 We show that pre-BCR activation releases the VDJ recombination complex through calmodulin binding to

42 includes overexpression of genes involved in VDJ recombination, CXCR4 pathway signaling, and BCL2 fam

43 expression vector significantly restores the VDJ recombination deficits in DNA-PKcs-deficient cells,

44 Random VDJ recombination early in T and B cell development enab

45 Although increased numbers of illegitimate VDJ recombination events do not directly portend leukemi

46 mline DH segment was expressed in functional VDJ recombination events involving different JH segments

47 n initial random DNA editing process, called VDJ recombination, followed by functional selection of c

48 VDJ recombination follows probabilistic rules that can b

49 es showed greatly enhanced expression of the VDJ recombination genes DNTT, RAG1, and RAG2, but not AI

50 ) to activate VDJ recombination by analyzing VDJ recombination in mice carrying a minilocus in which

51 and differences exist between brain SGR and VDJ recombination in the immune system, the first identi

52 signaling in B-cell development, we studied VDJ recombination in the pro-B cells of FLT3/ITD mice an

53 of TCR-delta gene rearrangement, we compared VDJ recombination in transgenic mice carrying two versio

54 agment of E(delta) is sufficient to activate VDJ recombination in vivo.

55 r (E(delta)) efficiently activates minilocus VDJ recombination in vivo.

56 ase with zebrafish maturity, suggesting that VDJ recombination involves a level of deterministic prog

57 Ordered assembly of Ag receptor genes by VDJ recombination is a key determinant of successful lym

58 VDJ recombination is developmentally regulated in vivo b

59 This process, known as "VDJ recombination", is implemented via a series of stoch

60 that enables inter-individual comparison of VDJ recombination models.

61 VDJ recombination of T cell receptor and immunoglobulin

62 In addition to its role in VDJ recombination, our study points out that the full-le

63 velopment of T and B cells by initiating the VDJ recombination process that leads to generation of a

64 fferent ages, we quantify the changes in the VDJ recombination process that occur from embryo to youn

65 cal impact of selection on the output of the VDJ recombination process.

66 nts can induce specific abnormalities of the VDJ recombination process.

67 DNA interstrand cross-links, involvement in VDJ recombination, repair of DNA double-strand breaks, a

68 was measured along versions of a transgenic VDJ recombination reporter and the endogenous T cell rec

69 So far, it remains unknown whether VDJ recombination rules differ between individuals.

70 ructural constraints form the basis to shape VDJ recombination sequences into MHC-restricted repertoi

71 lopmental and maturational changes involving VDJ recombination, somatic hypermutation and class switc

72 enic mice containing variants of a minilocus VDJ recombination substrate.

73 ginates in a stochastic DNA editing process (VDJ recombination) that acts on the surface receptor gen

74 discriminate against MHC binding, suggesting VDJ recombination together with Valpha/Vbeta pairing det

75 ned to function in cells that have undergone VDJ recombination using any combination of variable (V),

76 The first occurs during VDJ recombination, when inverted DH genes are usually av

77 the core-enhancer Emu element mainly affects VDJ recombination with minor effects on class switch rec

78 Despite a severe defect in VDJ recombination with partial blockade at the pro-B cel