ライフサイエンスコーパス: VGLUT

1 VGLUT expression argues that dysplastic neurons may be g

2 VGLUT(2) -immunoreactive (IR) neurons in the MPG were ra

3 characterized antibodies against VGLUT(1) , VGLUT(2) , and calcitonin gene-related peptide (CGRP) we

4 lar glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).

5 Here we studied VGLUTs type 1 and 2 (VGLUT(1) and VGLUT(2) , respectively) in neurons innerva

6 he vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VG

7 essed for vesicular glutamate transporter-2 (VGLUT-2), tryptophan-hydroxylase (TrOH), glial fibrillar

8 ral cord interneurons was increased in eat-4 VGLUT mutants compared with wild-type controls.

9 sed ventral cord abundance of GLR-1 in eat-4 VGLUT mutants.

10 The effects of eat-4 VGLUT mutations on GLR-1 abundance in the ventral cord w

11 thrin adaptin protein unc-11 AP180 and eat-4 VGLUT.

12 onical vesicular glutamate transporter EAT-4/VGLUT and another vesicular transporter, VST-1.

13 euron classes to initiate and maintain eat-4/VGLUT expression.

14 regulatory modules drive expression of eat-4/VGLUT in distinct glutamatergic neuron classes.

15 ng the vesicular glutamate transporter eat-4/VGLUT, induction of neuropeptide expression, changes in

16 s, the vesicular glutamate transporter EAT-4/VGLUT, is expressed in 38 of the 118 anatomically define

17 To understand how a VGLUT isoform might influence transmitter release, we ha

18 Abundant VGLUT(2) -IR nerves were detected in all layers of the c

19 Previously characterized antibodies against VGLUT(1) , VGLUT(2) , and calcitonin gene-related peptid

20 in situ hybridization, using probes against VGLUT(1) and VGLUT(2) , was also performed.

21 have ipsilateral descending axons, were also VGLUT-positive, as were the ventrally located VeMe inter

22 we studied VGLUTs type 1 and 2 (VGLUT(1) and VGLUT(2) , respectively) in neurons innervating the mous

23 idization, using probes against VGLUT(1) and VGLUT(2) , was also performed.

24 ires GABA(A)Rs and NMDARs in PNs, as well as VGLUT and cAMP signaling in the multiglomerular inhibito

25 porter that have recently been identified as VGLUTs 1 and 2.

26 However, the demonstration of astrocytic VGLUT expression is largely based on immunostaining, and

27 l-projecting octaval populations lacked both VGLUT and glutamate.

28 d by vesicular glutamate transporters called VGLUTs.

29 re detected in all layers of the colorectum; VGLUT(1) -IR nerves were sparse.

30 Cs represent the first synthetically derived VGLUT inhibitors and are promising templates for the dev

31 Because the different VGLUT isoforms generally have a non-redundant pattern of

32 on of ArcN neurons immunoreactive for either VGLUT-2 (74 +/- 21 versus 342 +/- 84 cells/section, P <

33 While elevated VGLUT expression increases quantal size, the minimum num

34 1) that most colorectal DRG neurons express VGLUT(2) , and to a lesser extent, VGLUT(1) ; 2) abundan

35 A smaller percentage of neurons expressed VGLUT(1) .

36 Most colorectal DRG neurons expressed VGLUT(2) and often colocalized with CGRP.

37 ation of myenteric plexus neurons expressing VGLUT(2).

38 ( approximately 6%) but not those expressing VGLUT type 1.

39 s express VGLUT(2) , and to a lesser extent, VGLUT(1) ; 2) abundance of VGLUT2-IR fibers innervating

40 Neurons positive for VGLUT include the commissural CoPA, MCoD, UCoD, and some

41 study reports a previously unknown role for VGLUT as an acid-extruding protein when deposited in the

42 A dual role for VGLUT serves to integrate neuronal activity and pH regul

43 Altogether, our data suggests a role for VGLUT(2) in colorectal glutamatergic neurotransmission,

44 To investigate how VGLUT expression can regulate synaptic strength in vivo,

45 Thus, we examined concurrent changes in VGLUT levels and somatosensory projections in the CN usi

46 ransmission via a mechanism that may involve VGLUT inhibition rather than activation of mGlu2/3 recep

47 fferents may be regulated by a distinct, non-VGLUT, mechanism.

48 synaptic vesicles via functional coupling of VGLUT and VST-1.

49 and current knowledge on the distribution of VGLUT isoforms in highly visual mammals, we examined the

50 These results indicate a diversity of VGLUT isoform combinations expressed in different spinal

51 wn that glucose stimulates the expression of VGLUT isoform 2 (VGLUT2) in beta cells via transcription

52 The pathway-specific expression of VGLUT isoforms in the CN may be associated with the intr

53 led to more potent competitive inhibitors of VGLUT.

54 d into vesicles, and the specific paralog of VGLUT expressed affects the release probability.

55 nocytochemistry showed a punctate pattern of VGLUT immunoreactivity throughout the entire cell body a

56 hese results demonstrate how the activity of VGLUTs can be coordinated with large shifts in proton an

57 esses, whereas pharmacological inhibition of VGLUTs abolished mechanically and agonist-evoked Ca2+-de

58 hether there is a link between the number of VGLUTs on vesicles and release probability.

59 data will be key in interpreting the role of VGLUTs in human pathologies.

60 nd associated with 5-HT cells than the other VGLUT types.

61 A particular VGLUT isoform, VGLUT3, exhibits an overlapping, but uniq

62 s were also found to receive dual-phenotype (VGLUT + VGAT) inputs; these varied with season in a mann

63 t hydrolysis, were investigated as potential VGLUT inhibitors in synaptic vesicles.

64 ns of neurons, and VGLUT1 is the predominant VGLUT in the neocortex, hippocampus, and cerebellar cort

65 ns of neurons, and VGLUT1 is the predominant VGLUT in the neocortex, hippocampus, and cerebellar cort

66 te transporter 2 (VGLUT2) is the predominant VGLUT isoform expressed in the basal forebrain and brain

67 Vesicular glutamate receptor (VGLUT) 3 machinery orchestrates glutamate release, and i

68 found that vesicles with drastically reduced VGLUT expression were released with a lower probability.

69 In addition, kismet mutants exhibit reduced VGLUT, a synaptic vesicle marker, at stimulated but not

70 at the plasma membrane, thereby restricting VGLUT activity to synaptic vesicles.

71 Here we studied VGLUTs type 1 and 2 (VGLUT(1) and VGLUT(2) , respectivel

72 At mammalian synapses, VGLUT expression level determines the amount of glutamat

73 mate accumulation in model vesicles and that VGLUT Cl(-) channel function increases the transport eff

74 Taken together, these data indicate that VGLUTs play a functional role in exocytotic glutamate re

75 In the DG, the VGLUT inhibitors Congo Red and Rose Bengal, and the mGlu

76 substituted QDCs tested as inhibitors of the VGLUT system, the 6-PhCH=CH-QDC (K(i) = 167 microM), 6-P

77 f the key elements needed for binding to the VGLUT protein based on the structure-activity relationsh

78 cultured mouse hippocampal neurons where the VGLUT expression level has been severely altered.

79 Preobraschenski et al. (2014) show that the VGLUTs, in addition to transporting glutamate, also prov

80 les with glutamate and mammals express three VGLUT isoforms (VGLUT1-3) with distinct spatiotemporal e

81 favor of the expression of any of the three VGLUTs by gray matter protoplasmic astrocytes of the pri

82 e, is a known vesicular glutamate transport (VGLUT) inhibitor and has also been proposed as an mGlu2/

83 The vesicular glutamate transport (VGLUT) system selectively mediates the uptake of L-gluta

84 sponsible for vesicular glutamate transport (VGLUTs) that show no sequence similarity to the other tw

85 napses, the vesicular glutamate transporter (VGLUT) fills vesicles with glutamate.

86 cluding the vesicular glutamate transporter (VGLUT) genes for glutamatergic neurons, the neuronal gly

87 cluding the vesicular glutamate transporter (VGLUT) genes for glutamatergic neurons, the neuronal gly

88 Vesicular glutamate transporter (VGLUT) has been reported to be involved in glucose-induc

89 isoforms of vesicular glutamate transporter (VGLUT) in the cat retina.

90 The vesicular glutamate transporter (VGLUT) plays an essential role in synaptic transmission

91 Vesicular glutamate transporter (VGLUT) proteins regulate the storage and release of glut

92 the lamprey vesicular glutamate transporter (VGLUT) provides an anatomical basis for the general dist

93 ressing the vesicular glutamate transporter (VGLUT) type 2 ( approximately 6%) but not those expressi

94 les via the vesicular glutamate transporter (VGLUT), a mechanism conserved across phyla, and this stu

95 ypes of the vesicular glutamate transporter (VGLUT).

96 ated by the vesicular glutamate transporter (VGLUT).

97 unc-2) or a vesicular glutamate transporter (VGLUT; eat-4), the abundance of GLR-1 in the ventral ner

98 the three vesicular glutamate transporters (VGLUT 1-3) in the locus coeruleus (LC) and the dorsal ra

99 Vesicular Glutamate Transporters (VGLUT) accumulate glutamate into synaptic vesicles (SV)

100 ression of vesicular glutamate transporters (VGLUTs) 1 and 2 accounts for the release of glutamate by

101 Vesicular glutamate transporters (VGLUTs) 1 and 2 show a mutually exclusive distribution i

102 ion of the vesicular glutamate transporters (VGLUTs) 1, 2, and 3.

103 Vesicular glutamate transporters (VGLUTs) are essential for filling synaptic vesicles with

104 The three vesicular glutamate transporters (VGLUTs) are expressed in distinct populations of neurons

105 The three vesicular glutamate transporters (VGLUTs) are found in different populations of neurons, a

106 synapses, vesicular glutamate transporters (VGLUTs) are responsible for filling synaptic vesicles wi

107 The vesicular glutamate transporters (VGLUTs) concentrate the principal excitatory neurotransm

108 Vesicular glutamate transporters (VGLUTs) have been extensively studied in various neurona

109 The vesicular glutamate transporters (VGLUTs) package glutamate into synaptic vesicles, and th

110 of several vesicular glutamate transporters (VGLUTs) similarly revealed an unexpected molecular diver

111 functional vesicular glutamate transporters (VGLUTs) that are critical for vesicle refilling.

112 Vesicular glutamate transporters (VGLUTs) that load glutamate into synaptic vesicles are n

113 ed through vesicular glutamate transporters (VGLUTs) that ultimately dictate glutamatergic output.

114 s requires vesicular glutamate transporters (VGLUTs) to concentrate cytosolic glutamate in synaptic v

115 n requires vesicular glutamate transporters (VGLUTs) to sequester glutamate into synaptic vesicles.

116 ed whether vesicular glutamate transporters (VGLUTs) were differentially distributed among the two di

117 d with the vesicular glutamate transporters (VGLUTs), we characterize a chloride conductance that is

118 Vesicular glutamate transporters (VGLUTs), which selectively package glutamate into synapt

119 cular sorting will be critical to understand VGLUT's involvement in normal and pathological condition

120 the C. elegans central nervous system, using VGLUT-pHluorin to monitor synaptic vesicle exocytosis an

121 e differences in the sorting of VMATs versus VGLUTs to SVs at the synapse.

122 at conjugation of these gold nanoprobes with VGLUT-2 antibodies and polyethyleneimine (PEI) facilitat