ライフサイエンスコーパス: VH

1 VH and RBD shared a positive covariance with metabolism

2 VH replacement represents a RAG-mediated secondary rearr

3 EA-treated goats exhibited lower (P < 0.01) VH as compared with Sham-A or VH group.

4 m-A, VH or EA group showed higher (P < 0.01) VH at days 7-22 than the Control-goats.

5 lower for Yorkshire, with 0.07 (VW) to 0.11 (VH).

6 ere moderate in Landrace, ranging from 0.30 (VH) to 0.61 (VA), and lower for Yorkshire, with 0.07 (VW

7 A total of 4429 VH intravascular ultrasound frames from 53 patients were

8 gene is rearranged to a D gene followed by a VH gene rearranging to the DJH rearrangement.

9 he engrafted B-1 cell population expressed a VH-DH-JH composition similar to cord blood B-1 cells, in

10 We observe similar behavior for a VH domain grafted with a large hydrophobic peptide from

11 with high probability, DHJH elements reach a VH element within minutes.

12 Patients with a VH from a single-center hernia clinic were prospectively

13 Goats of Sham-A, VH or EA group showed higher (P < 0.01) VH at days 7-22

14 Moreover, Abeta VH domains with negatively charged CDR3 mutations show s

15 d with cases where the findings were absent (VH: OR 5.57 [95% CI 3.48-8.93], DFE: OR 4.65[95% CI 2.91

16 ghest level of discrimination of both acinar VH (measured by using phase 3 slope analysis of multiple

17 eletion (core or full length) did not affect VH gene usage.

18 somatic mutations in the VH CDR and altered VH CDR3 physicochemical properties.

19 roscopically low-grade ileitis on day 22 and VH at days 7-22.

20 but less (P < 0.01) than those in Sham-A and VH groups on day 22.

21 ount simultaneous CDR loops conformation and VH/VL orientation optimisation upon antibody sequence ch

22 ntogeny into two types: CDR H3-dominated and VH-gene-restricted.

23 ts caused intestinal barrier dysfunction and VH, which were blocked by the LPS antagonist LPS-RS or b

24 ues for VH gene mutation, H-CDR3-length, and VH/JH usage, comparing these different characteristics w

25 ntextual information through the VH-mPFC and VH-amygdala pathways.

26 RC1 activation, but posttreatment MTORC1 and VH were correlated (rho = 0.51; P = 0.001), and change i

27 Time to progression of PDR and VH were calculated with Cox regression after stratifying

28 s) from large phage-displayed Fab, scFv, and VH libraries by panning against the receptor binding dom

29 model, despite an unexpected CDRH3 tilt and VH/VL interface deviation, which indicates that the mode

30 A single domain antibody VH-9.7 showed selectivity for five distinct patient-deri

31 ion-based technology for sequencing antibody VH-VL repertoires from >2 x 10(6) B cells per experiment

32 induced VH and confirm whether EA attenuates VH through spinal PAR-2 activation and CGRP release, goa

33 However, direct comparisons between VH-IVUS and OCT are lacking and it remains unknown wheth

34 urther demonstrate that the distance between VH, D, and JH gene segments influence their ability to r

35 nd to reside in a deep pocket formed between VH and VL domains of the Fab fragments.

36 Selective and biased VH:VL pairing was particularly evident among expanded cl

37 e immunogen but nonetheless exhibited biased VH use, V(D)J mutation, and clonal expansion comparable

38 to constitutively express the LEDGF-binding VH and these cells showed interference with HIV viral re

39 Both VH-IVUS and OCT can reliably identify TCFA, although OCT

40 d distinct gene segment usage biases in both VH and VL sequences within the naive and memory compartm

41 5/11.91 required affinity maturation of both VH and VL for efficient binding to cit-H2B.

42 CDR H3 ontogenies and the other achieved by VH-gene-restricted ontogenies.

43 ctions at the population level; (ii) certain VH:VL gene pairs were significantly enriched or depleted

44 W33T of the associated variable heavy chain (VH) allele were identified and confirmed by gene sequenc

45 Variable heavy chain (VH) family frameworks (FWRs) have been reported to affec

46 nature and human immunoglobulin heavy chain (VH) repertoire that was relatively uncoupled from other

47 eas variable gene segment of the H Ig chain (VH) gene usage in asthma reflected germline distribution

48 e sequencing of both immune receptor chains (VH+VL or TCRbeta/delta+TCRalpha/gamma) at the single-cel

49 s to understand the determinants of clinical VH indices commonly reported by using IOS and MBW.

50 VH and VL reverted into GL), hybrid clones (VH/VL region reverted into GL), and N-glycosylation muta

51 Combined VH-IVUS/OCT imaging markedly improved TCFA identificatio

52 Combining VH-defined fibroatheroma and fibrous cap thickness </=85

53 Common VH gene usage indicates common humoral immune responses,

54 formational specificity of the corresponding VH domains.

55 0.0001) and higher cumulative hospital cost (VH: RR 1.97[95% CI 1.64-2.37], P < 0.0001, DFE: RR 1.8[9

56 5.60, and 7.29 times more likely to develop VH, respectively.

57 es (4Q DBH) had 3.84 higher HR of developing VH (95% CI 1.39-10.62, P = .0095).

58 ed study that included 34 eyes with diabetic VH.

59 over 100 candidates encoded by 11 different VH genes.

60 unctional diversity rather than differential VH gene use.

61 ted intergenic repeat elements and 5' distal VH genes were compromised by the Setd1a-cKO.

62 ents and a corresponding reduction in distal VH gene segment use.

63 Bcl2 expression overcomes defects in distal VH-DJH and secondary Vkappa-Jkappa rearrangement associa

64 Here, we have marked the distal VH and DH-JH-Emu regions with Tet-operator binding sites

65 determining regions (CDRs) of single-domain (VH) antibodies.

66 pecifically label VHHs [the variable domain (VH) of a camelid heavy-chain only antibody] with (18)F o

67 elative orientation of the variable domains, VH and VL.

68 influences on the distribution of expressed VH and VL genes and by influencing the amino acid compos

69 l response composed of most of the expressed VH gene segments, illustrating the considerable genetic

70 hen egg white lysozyme revealed an extended VH binding interface, with complementarity-determining r

71 chometrically validated the AHQ as the first VH-specific, stakeholder-informed PROM.

72 breeds, with the lowest of 0.67 +/- 0.29 for VH and VW for Landrace.

73 entification was 63.6%, 78.1%, and 76.5% for VH-IVUS and 72.7%, 79.8%, and 79.0% for OCT.

74 gh abundance of IGVH2 and IGVH5 families for VH and IGVLK12 and IGVLK22 for VLK.

75 Management patterns for VH are heterogeneous, often with little supporting evide

76 All OTP intakes are screened for VH and HIV and evaluated for rescreening annually.

77 Surgery for VH and ERM generally results in favorable outcomes, but

78 uences from different subsets or tissues for VH gene mutation, H-CDR3-length, and VH/JH usage, compar

79 increased the positive predictive value for VH intravascular ultrasound to identify clinical present

80 Two prototype bnAbs were derived from VH-germlines that were 99% identical and used a common g

81 apture; subsequent emulsion RT-PCR generated VH-VL amplicons for next-generation sequencing.

82 s in transgenic mice expressing the germline VH of the VRC01 antibody but diverse mouse light chains.

83 ted to overlap-PCR to generate germline (GL; VH and VL reverted into GL), hybrid clones (VH/VL region

84 57 (74.8%) patients showed viable HCC (Group VH).

85 NVH (0%) and in 25 (15.9%) patients in Group VH (P=0.003).

86 l injection, or sorafenib, whereas, in Group VH, 110 of the 157 (70.1%) patients received bridging th

87 ypermutation (SHM) within the Ig variable H (VH) and variable L (VL) chains and Fab-N-linked glycosyl

88 cingulate metabolism; visual hallucinations (VH) with bilateral dorsolateral-frontal cortex, posterio

89 logical mechanisms of visual hallucinations (VHs) in patients with Parkinson disease (PD) by analyzin

90 ts with >=2-step reduction in vitreous haze (VH) on the Miami scale or with a reduction of systemic c

91 change in visual acuity (VA), vitreous haze (VH), and central macular thickness (CMT) at month 6.

92 mates of VS traits, vulva area (VA), height (VH), and width (VW) measurements, were moderately to hig

93 n effect of micronutrients on villus height (VH).

94 use in patients with a vitreous hemorrhage (VH) secondary to proliferative diabetic retinopathy (PDR

95 vitrectomy (PPV): 6 for vitreous hemorrhage (VH), 1 for epiretinal membrane (ERM), and an additional

96 c retinopathy (PDR) and vitreous hemorrhage (VH).

97 n cases of nonresorbing vitreous hemorrhage (VH).

98 vitrectomy for diabetic vitreous hemorrhage (VH).

99 rograms (OTPs) do not offer viral hepatitis (VH) or human immunodeficiency virus (HIV) testing despit

100 inal Hernia-Q (AHQ), a novel ventral hernia (VH) patient-reported outcomes measure (PROM).

101 ctices in the management of ventral hernias (VH).

102 Nonoperative management of ventral hernias (VHs) is often recommended for patients at increased risk

103 characterized by ventilation heterogeneity (VH).

104 duced Fos expression in ventral hippocampal (VH) neurons projecting to the prelimbic cortex (PL) and

105 ptogenetic silencing of ventral hippocampal (VH) terminals in the PL of adult male Long-Evans rats se

106 ed synaptic strength of ventral hippocampus (VH) excitatory synapses onto D1 medium spiny neurons (D1

107 ronal population in the ventral hippocampus (VH) projects to both the mPFC and amygdala and is recrui

108 lculated in vivo based on virtual histology (VH) intravascular ultrasound and whether PSS varied acco

109 of 4 intraoperative findings [visible hole (VH), diffuse fibrinopurulent exudate (DFE) extending out

110 Importantly, however, VH neurons projecting to both PL and BA were more likely

111 Human VH single domains represent a promising class of antibod

112 er, our results demonstrate that fully human VH domains can be constructed that are not only stable a

113 r HIV-1 Env V2 recognition resulted in human VH pairing with mouse lambda L chains instead of allowin

114 Unfortunately, isolated human VH domains also generally display poor biophysical prope

115 Notably, nonproductive human VH rearrangements in the transgenic mice expressed short

116 ast, previously reported structures of human VH single domains had failed to recapitulate this proper

117 2 Abs were isolated that used the same human VH gene segment as an RV144 V2 Ab but paired with a mous

118 n of phage display libraries of stable human VH domains and the selection of binders against a divers

119 the dominance of Vlambda pairing with human VH for HIV-1 Env V2 recognition resulted in human VH pai

120 nition and quantification of vitreous humor (VH) cystine as well as provide the portability for on sp

121 ure (EA) relieves visceral hypersensitivity (VH) with underlying inflammatory bowel diseases.

122 dysfunction, and visceral hypersensitivity (VH).

123 ng linear combinations of the I(VV)(t) and I(VH)(t) decays or acquiring the I(VV)(t) and I(VH)(t) dec

124 H)(t) decays or acquiring the I(VV)(t) and I(VH)(t) decays with static polarizers before fitting them

125 ctly from the analysis of the I(VV)(t) and I(VH)(t) fluorescence decays acquired with a standard time

126 ts were conducted whereby the I(VV)(t) and I(VH)(t) fluorescence decays of a series of oligoquinoline

127 global analysis of simulated I(VV)(t) and I(VH)(t) fluorescence decays which were found to match per

128 nd vertically (I(VV)(t)) and horizontally (I(VH)(t)) polarized emission for time-resolved fluorescenc

129 donors led to a number of key findings: (i) VH and VL gene sequences pair in a combinatorial fashion

130 d, including a small number of dominating Ig-VH clusters that might represent the most active clonall

131 ntified a large number of closely related Ig-VH clusters that were common to both CSF and peripheral

132 We identified clusters of related Ig-VH transcripts in the CSF of both patients.

133 -checked against appropriate trastuzumab IgE VH variants.

134 ormatics clustering of related IgM-VH or IgG-VH transcripts was used to determine whether active B-ce

135 Bioinformatics clustering of related IgM-VH or IgG-VH transcripts was used to determine whether a

136 somatic hypermutation in the immunoglobulin VH locus.

137 Fewer mutations within immunoglobulin VH rearrangements of CD19(-) BMPC may indicate their dif

138 c PCs had lower numbers of mutations both in VH and VL genes than in non-TG2-specific PCs.

139 ange in MTORC1 was correlated with change in VH in the placebo group (rho = 0.63; P = 0.03).

140 we observed selective amino acid changes in VH and VL and striking CDR3 length and J segment selecti

141 Primary outcomes were changes in VH, in vivo small intestinal barrier dysfunction assesse

142 pplementation protected against a decline in VH over the supplementation period, and improved barrier

143 o had the potential for a 2-step decrease in VH demonstrated a 2-step decrease (40% in Group 1 and 46

144 measuring, quantifying and tracking PROMs in VH patients.

145 ware tool was used to model recombination in VH regions which allowed for the quantification of some

146 ilumab or placebo with >=2-step reduction in VH or corticosteroid dose <10 mg/day was 46.1% vs. 30.0%

147 resulted in ex novo N-glycosylation sites in VH and/or VL regions.

148 ive study comparing management strategies in VH patients with comorbidities.

149 wk AA, but not MM, supplementation increased VH by 16% (34.5 mum) compared with placebo (P = 0.04).

150 assess the effects of EA on ileitis-induced VH and confirm whether EA attenuates VH through spinal P

151 mechanism by which EA treats ileitis-induced VH is not clearly known.

152 from HS or LFM-treated IBS patients, induced VH in rats, which was ameliorated by LPS-RS.

153 he full-length Emu region does not influence VH segment usage but ensures efficient Igmu-chain expres

154 rough cyclin D3 (Ccnd3), which also inhibits VH transcription.

155 TNBS-injected goats were allocated into VH, Sham acupuncture (Sham-A) and EA groups, while goats

156 ent and the conventional RSS of the invading VH gene, leaving behind a footprint of up to five base p

157 ind gp120 at different angles via juxtaposed VH and VL contact surfaces.

158 The crystal structure of the LEDGF-VH complex reveals that the single domain antibody mimic

159 Massive VH-VL repertoire analyses of three human donors provided

160 eyes with VH grade >=2 at baseline, the mean VH reduction from baseline to week 16 was significantly

161 ase is a major driver of clinically measured VH in adults with asthma.

162 contextual retrieval of emotional memories, VH neurons with collaterals to both areas may be particu

163 uzumab moiety paired with affinity-modulated VH and VL regions of the anti-EGFR GA201 mAb were tested

164 een January 2008 and January 2015 with a new VH secondary to PDR and treated with IVB were included.

165 , mean luminal area </=4 mm(2), noncalcified VH-defined thin-cap fibroatheroma).

166 93 [6.16-9.46]; P=0.02), and in noncalcified VH-defined thin-cap fibroatheroma (9.23 [7.33-11.44] ver

167 PSS was higher in noncalcified VH-defined thin-cap fibroatheroma compared with thick-ca

168 rehabilitation of patients with nonclearing VH after TS.

169 eyes that presented with a fundus-obscuring VH, defined as vision of 20/400 or worse and requiring a

170 Analysis of VH and VL germline back-mutants reveals binding to H3 an

171 ased on central reading center assessment of VH and 64.0% vs. 35.0% (P = 0.0372) based on investigato

172 0.0372) based on investigator assessment of VH, respectively.

173 measures were mean duration of clearance of VH and rate of recurrent hemorrhage with any additional

174 >= 0.05), the mean duration of clearance of VH was 7.8 +/- 1.8 weeks, 5 days for group I and II resp

175 ve states are prevented by depotentiation of VH to NAcmSh synapses, restoring Kir2.1 function in D1R-

176 We sought to investigate the effects of VH families on IgE interaction with FcepsilonRIalpha, an

177 Investigator evaluation of VH was a prespecified, planned secondary analysis.

178 distribution and, notably, the frequency of VH with low somatic hypermutation (SHM) was strikingly h

179 es to colorectal distension, an indicator of VH, were recorded by electromyography.

180 st that the pathophysiological mechanisms of VH in PD may include a global loss of network efficiency

181 However, the topographical mechanisms of VH in the lung remain poorly understood.

182 ibodies are derived from a limited number of VH/VL genes and can bind to and neutralize diverse HIV-1

183 ntral brain regions, whereas the presence of VH is associated with a more global loss of connectivity

184 sequencing analysis of the V(D)J regions of VH and VLK genes, demonstrating the high abundance of IG

185 risk of PDR whereas 4Q DBH increases risk of VH.

186 is mouse model, we characterized the role of VH replacement in the diversification of the primary Ig

187 al PL firing during optogenetic silencing of VH-PL suggest that the VH continuously updates the PL wi

188 gains in the identification and treatment of VH in this high prevalence setting.

189 21 clonal families and employed a variety of VH genes.

190 On VH-IVUS, plaque (10.91+/-4.82 versus 8.42+/-4.57 mm(2);

191 Primary end point was based on VH evaluation by a central reading center.

192 ific antibody composed of 2 heavy-chain-only VH (VHH) binding domains against both TcdA and TcdB (des

193 and evaluation of a camelid heavy-chain-only VH domain (VHH)-based neutralizing agent (VNA) targeting

194 wer (P < 0.01) VH as compared with Sham-A or VH group.

195 curs between the cryptic RSS of the original VH element and the conventional RSS of the invading VH g

196 up to five base pairs (bps) of the original VH gene that is often further obscured by exonuclease ac

197 matic hypermutations compared with all other VHs, a characteristic of secondary Ab repertoire diversi

198 We initiated an opt-out VH and HIV testing and linkage-to-care program within ou

199 Altogether, we analyzed paired VH and VL sequences of 1482 TG2-specific and 1421 non-TG

200 native antibody variable heavy-light pairs (VH-VL pairs) remains a major challenge, and no technolog

201 ethods For this retrospective study, 15 PD + VH patients, 40 PD - VH patients, and 15 control partici

202 ents with VH (hereafter, referred to as PD + VH patients) and without VH (hereafter, referred to as P

203 racentral and occipital regions in both PD + VH and PD - VH patients (mean whole-brain functional con

204 In PD + VH patients, nine additional frontal, temporal, occipita

205 whole-brain functional connectivity in PD + VH vs PD - VH, 0.12 +/- 0.01 [standard deviation] vs 0.1

206 icipants (mean of these nine regions in PD + VH, PD - VH, and control 0.12 +/- 0.02, 0.14 +/- 0.03, a

207 spective study, 15 PD + VH patients, 40 PD - VH patients, and 15 control participants from a prospect

208 d occipital regions in both PD + VH and PD - VH patients (mean whole-brain functional connectivity in

209 d without VH (hereafter, referred to as PD - VH patients) and control participants.

210 (mean of these nine regions in PD + VH, PD - VH, and control 0.12 +/- 0.02, 0.14 +/- 0.03, and 0.16 +

211 n functional connectivity in PD + VH vs PD - VH, 0.12 +/- 0.01 [standard deviation] vs 0.14 +/- 0.03,

212 interacted with spA, none of our pertuzumab VH variants, including VH3, associated with spA.

213 etween IgE and omalizumab for the pertuzumab VH variants.

214 Preferred VH rearrangements among antigen-binding, naive B cells w

215 cific autoantibody repertoire with preferred VH:VL usage and pairings, limited mutations, clonal domi

216 skewing toward the incorporation of proximal VH gene segments and a corresponding reduction in distal

217 ntitative villous height: crypt depth ratio (VH: CrD) measurements revealed significant duodenal muco

218 non-resolving VH in group I. late recurrent VH occurred in two eyes (11.8%) in group II, IVA was giv

219 g) is effective in improving VA and reducing VH and CMT in eyes with noninfectious intermediate uveit

220 by interrogation of paired H chain V region (VH) and L chain V region (VL) sequences of individual an

221 red heavy- and light-chain variable regions (VH and VL, respectively) from large populations of singl

222 oglobulin (Ig) heavy chain variable regions (VH) from CSF and subsorted peripheral blood B-cell popul

223 CDR residue in heavy chain variable regions (VH), is important for humanization of mouse antibodies.

224 eyes (17.6%) due to recurrent non-resolving VH in group I. late recurrent VH occurred in two eyes (1

225 pha significantly longer than the respective VH family variants within each model antibody.

226 There is restricted VH and VL combination and usage among the antibodies.

227 s by EA attenuates the ileitis and resultant VH.

228 ], P = 0.001), and higher rates of revisits (VH: OR 2.02 [95% CI 1.34-3.04], P = 0.001, DFE: OR 1.59[

229 relative to Abeta monomers, whereas the same VH domains with other polar CDR3 mutations recognize bot

230 natorial phage display, we screened selected VH genes paired with their corresponding VL library for

231 etermine what Igs ABCs express, we sequenced VH and Vkappa rearranged genes from unimmunized 22-mo-ol

232 ibody Capture technology to isolate a single VH antibody domain that binds to LEDGF.

233 co-expressing an anti-RAS heavy chain single VH domain, that binds to mutant RAS several thousand tim

234 e its function, we created a panel of single-VH domain antibodies (VHHs) that recognize distinct epit

235 Although expression of some VH genes was similar in mouse and human (IGHV3-23, IGHV3

236 alyzed the transglutaminase 2 (TG2)-specific VH:VL autoantibody repertoire of celiac disease (CD) pat

237 pe-specific antibody responses with specific VH alleles, and it highlights the importance of germline

238 including longer cumulative length of stay (VH: Rate ratio [RR] 3.15[95% CI 2.86-3.46], DFE: RR 3.06

239 A number of studies have demonstrated that VH markers derived by using impulse oscillometry (IOS) o

240 We have previously demonstrated that VH replacement can efficiently rescue the development of

241 We find that VH expression and solubility are strongly enhanced by in

242 Given that VH family biases have been previously reported in IgE of

243 Our results indicate that VH replacement occurs before Ig light chain rearrangemen

244 We show that VH gene repertoires and somatic hypermutation rates of a

245 The VH-CH1-hinge domains of mAb2 are fused through a peptidi

246 , suggesting that they can also activate the VH-mPFC-amygdala pathway.

247 removing clashes between both the VL and the VH, and between the VL and CXCL13.

248 recisely positioned at the elbow between the VH and CH1 domains.

249 vealed that direct communication between the VH and PL during training is necessary for contextual fe

250 The linker between the VH and VL domains exhibits the dominant dynamical respon

251 at there is a linear correlation between the VH cystine concentration and TSD as the concentration of

252 ying allosteric communications caused by the VH family FWRs to the FcepsilonRIalpha-, Her2-, and spA-

253 y, in one donor the genomic DNA encoding the VH and CH1 domains was deleted, leading to the productio

254 We further examined the VH repertoire of Ag-specific memory B cells induced by i

255 ty of selected RA-rmAbs was abrogated in the VH and VL GL counterpart.

256 sitive selection of somatic mutations in the VH CDR and altered VH CDR3 physicochemical properties.

257 any effects, stabilizing any CDR loop in the VH domain triggers a destabilizing response in all CDR l

258 are likely to stabilize all CDR loops in the VH domain, and, when these residues are not buried, the

259 ibodies from immunized animals by mining the VH:VL paired antibody repertoire encoded by highly expan

260 dependent polypeptides, each composed of the VH of 1 antibody in tandem with the VL of the other anti

261 e show that the optogenetic silencing of the VH prevented the recall of contextual fear memory in mic

262 mutations and maintain the structure of the VH/VL interface.

263 rine protease that is able to cleave off the VH domain of IgG.

264 hat the Igh locus superanchor sequesters the VH and DHJH regions into a spatial confined geometric en

265 ogenetic silencing of VH-PL suggest that the VH continuously updates the PL with the current contextu

266 changes in QSFR quantities indicate that the VH domain is typically rigidified, whereas the VL domain

267 Third, the VH repertoire of Lin28b-induced BM B1a B cells differs f

268 ld convey contextual information through the VH-mPFC and VH-amygdala pathways.

269 the Igh locus superanchor interacts with the VH region repertoire across vast genomic distances.

270 ferent time points after immunization, their VH and VL genes were sequenced, and the corresponding an

271 e adult donors, we performed high-throughput VH sequencing of human B cell subsets defined by IgD and

272 Similarly, 5-year progression to VH varied by baseline DR: no DR (1.1%), mild (2.9%), mod

273 port is provided for linkage or relinkage to VH or HIV care.

274 Virtual-histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT) can asse

275 Lastly, patients undergoing VH repair were prospectively administered the pre- and p

276 cts to generate approximately 518,000 unique VH and VL sequences from sorted naive and memory B cell

277 viduals with previously diagnosed, untreated VH or HIV.

278 secondary rearrangement in which an upstream VH element recombines with a rearranged VHDHJH joint to

279 Cells whose antibodies use VH genes that encode a more flexible elbow are more like

280 opment, immunoglobulin heavy-chain variable (VH), diversity (DH), and joining (JH) segments assemble

281 g antibody region: the heavy-chain variable (VH)-encoded "elbow" between variable and constant domain

282 pacts the 2-Mb region that encodes variable (VH) gene segments.

283 s of mutations acquired by a human variable (VH) domain that was evolved using strong selections for

284 generally positioned over each IgH variable (VH) coding segment, directly adjacent to the recombinati

285 o the mechanism of interactions with various VH FWRs.

286 sed V-to-DJ rearrangements and altered Vbeta/VH repertoire.

287 Inefficient Vbeta/VH recombination signal sequences (RSSs) have been hypot

288 Because Vbetas/VHs only recombine to DJ complexes, the Rag1(C/C) phenot

289 ology and compared with coregistered ex vivo VH-IVUS and OCT.

290 s, (ii) docking methodology to refine the VL-VH relative orientation and (iii) de novo prediction of

291 Herein, we use UV-vis, CD, XAS, EPR, VT/VH-MCD, and resonance Raman spectroscopies, augmented wi

292 uently than JH locus distal D genes, whereas VH locus proximal D genes were observed more frequently

293 Experts agreed that complications with VH repair (VHR) increase in obese patients (grade A), cu

294 ed by AA supplementation and correlated with VH.

295 In the subgroup of eyes with VH grade >=2 at baseline, the mean VH reduction from bas

296 All 7 eyes with VH or ERM had improved vision postoperatively.

297 functional connectivity in PD patients with VH (hereafter, referred to as PD + VH patients) and with

298 ions have in the management of patients with VH secondary to PDR.

299 and function are better among patients with VHs managed operatively.

300 referred to as PD + VH patients) and without VH (hereafter, referred to as PD - VH patients) and cont