ライフサイエンスコーパス: Warburg

1 Warburg effect is a hallmark of cancer manifested by con

2 Warburg effect linked to cognitive-executive deficits in

3 Warburg effect or aerobic glycolysis provides selective

4 Warburg Micro syndrome and Martsolf syndrome are heterog

5 lic ATP/ADP, activation of glycolysis, and a Warburg metabolic phenotype in proliferating cells.

6 of increased aerobic glycolysis, known as a Warburg effect, including cytosolic PKM2 (pyruvate kinas

7 e role of UQCRH in cells that have entered a Warburg-like state through other mechanisms.

8 metabolism in MDA-MB-231 cells, which have a Warburg metabolic phenotype; these experiments indicated

9 Previously, our attempts to induce a Warburg-like state pharmaceutically via CPI-613 and PS48

10 e injury, which activates AMPK and induces a Warburg-like glycolysis in satellite cells.

11 y and modulates cell metabolism, promoting a Warburg-like metabolic phenotype.

12 AMPKalpha1(-/-) MuSCs showed a Warburg-like switch of their metabolism to higher glycol

13 ell types acquire a proteome that supports a Warburg phenotype with enhanced cell migration and proli

14 This metabolic reprogramming toward a Warburg phenotype occurred as a result of contact with p

15 ls by longwave UVA radiation, possibly via a Warburg-like effect, promotes melanoma invasiveness.

16 n particular, reovirus infection accentuated Warburg-like metabolic perturbations in cell lines relat

17 and lactate dehydrogenase A (LDHA) activity (Warburg effect).

18 Hence, cancer cells allocate Warburg metabolism to their corrupted CAFs, exploiting t

19 Although Warburg effect is considered a peculiarity critical for

20 ehyde-3-phosphate dehydrogenase activity and Warburg metabolism.

21 (ct)), double-layer capacitance (C(dl)), and Warburg impedance (W).

22 entifies MPI as a novel regulator of p53 and Warburg metabolism.

23 ulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial

24 ndicated that CO transiently induces an anti-Warburg effect by rapidly fueling cancer cell bioenerget

25 s while decreasing glycolysis, i.e. an 'anti-Warburg' effect.

26 metabolic requirement, a phenomenon known as Warburg effect.

27 were related to energy production as well as Warburg effect pathways, which may shed light on how ene

28 Aerobic glycolysis, originally identified by Warburg as a hallmark of cancer, has recently been impli

29 e beyond oxidative needs, a paradox noted by Warburg almost a century ago.

30 As noted by Warburg, many cancer cells depend on the consumption of

31 ain a growth advantage through the so-called Warburg effect by shifting glucose metabolism from oxida

32 arity to the glycolytic phenotype in cancer (Warburg effect).

33 Loss-of-function mutations in TBC1D20 cause Warburg Micro syndrome 4 (WARBM4), which is an autosomal

34 ostate tumors that did not exhibit a classic Warburg phenotype were equally sensitive.

35 The classic Warburg effect described in macrophages infected by Myco

36 ons in chRCC tumors, including the classical Warburg effect, the downregulation of gluconeogenesis an

37 CEFs (Ski-CEFs) do not display the classical Warburg effect.

38 Despite being known for decades (Warburg effect), the molecular mechanisms regulating thi

39 reasing HDO signal could be used to diagnose Warburg (cancer) metabolism.

40 uman neurological and developmental disorder Warburg Micro syndrome.

41 y an important mechanism by which Wnt-driven Warburg metabolism directs the use of glucose for cancer

42 duced HIF transcriptional activity and drove Warburg metabolic reprogramming, coupling AMPK-dependent

43 olism to a highly glycolytic phenotype, i.e. Warburg effect, is a common phenotype of cancer and acti

44 Its relationship to the established Warburg impedance model is validated theoretically and e

45 te kinase M2 (PKM2), a glycolytic enzyme for Warburg effect, is strongly upregulated in BC.

46 aerobic production of lactate from glucose (Warburg effect), extensive glutamine utilization and imp

47 ryos transiently exhibit aerobic glycolysis (Warburg effect), a metabolic adaptation also observed in

48 ated androgen signaling, aerobic glycolysis (Warburg effect), and aberrant activation of transcriptio

49 ng in Akt activation and aerobic glycolysis (Warburg effect), associated with ulceration.

50 both animal models and patients, glycolysis (Warburg effect) is also an early manifestation of CRPC t

51 metabolic genes associated with glycolysis (Warburg effect), fatty acid metabolism (lipogenesis, oxi

52 It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requir

53 n altered metabolism, including an increased Warburg effect and glutamine dependence, making the glut

54 HIF1alpha, but not HIF2alpha, induced Warburg-like metabolism characterized by increased glyco

55 llectively, these findings indicate that key Warburg effect enzymes play a central role in mediating

56 ) as a metabolic enzyme required to maintain Warburg metabolism in zebrafish embryos and in both prim

57 mor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis.

58 e for the pyruvate kinase M2 (PKM2)-mediated Warburg effect, namely aerobic glycolysis, in the regula

59 ts another hallmark of tumorigenesis, namely Warburg metabolism.

60 nce of a synaptic activity-mediated neuronal Warburg effect that may promote mitochondrial homeostasi

61 the other subpopulations, these hypoxic "non-Warburg" cells had highest oxygen consumption rates and

62 These respiring ("non-Warburg") cells were previously thought not to play a ke

63 The adoption of Warburg metabolism is critical for the activation of mac

64 The clinical features of Warburg Micro syndrome patients with RAB3GAP1 or RAB3GAP

65 ctivated T cells, which display hallmarks of Warburg metabolism, physiologically activated CD8(+) T c

66 r role in T-cell activation and induction of Warburg effect.

67 of the loss of cavin-3 include induction of Warburg metabolism (aerobic glycolysis), accelerated cel

68 bed energy metabolism hindering induction of Warburg phenotype.

69 ed glycolysis and visibly reduced markers of Warburg effect in ADPGK knock-out cells, finally leading

70 ation analysis revealed a uniform pattern of Warburg effect mutations influencing prognosis across al

71 However, targeting oncogenic regulators of Warburg effect has always been challenging owing to the

72 t in vitro proof of concept that reversal of Warburg effect might be a novel therapy for GBM.

73 Otto Warburg discovered that cancer cells exhibit a high rate

74 Otto Warburg's theory on the origins of cancer postulates tha

75 Decades ago, Otto Warburg observed that cancers ferment glucose in the pre

76 Although Otto Warburg first described aerobic glycolysis in cancer cel

77 Although Otto Warburg observed aerobic glycolysis nearly 90 years ago,

78 ature of solid tumours were reported by Otto Warburg almost a century ago.

79 itions, has been shown first in 1926 by Otto Warburg.

80 One of the major features of cancer is Otto Warburg's observation that many tumors have increased ex

81 t glycolysis even in the presence of oxygen (Warburg effect) and use of glutamine for increased biosy

82 ll of origin, thereby inhibiting a potential Warburg effect.

83 APOBEC3G promotes Warburg-like metabolic remodeling in HuT78 T cells under

84 wever, this treatment demonstrated a Reverse Warburg effect phenotype observed in cancer-associated s

85 amming in concert with disruption of several Warburg effect-related super-enhancers.

86 Since Warburg's observation that most cancers exhibit elevated

87 Since Warburg's observation, the importance of extracellular a

88 -dependent HIF activation and the subsequent Warburg metabolic transformation.

89 pers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict gluco

90 We demonstrated that "Warburg effect" is not modulated in the initial stage of

91 The Warburg effect contributes to cancer progression and is

92 The Warburg effect defines a pro-oncogenic metabolism switch

93 The Warburg effect describes an increase in aerobic glycolys

94 The Warburg effect is a chronic increase in glycolytic index

95 The Warburg effect is a tumor-related phenomenon that could

96 The Warburg effect is a tumorigenic metabolic adaptation pro

97 The Warburg effect is one of the metabolic hallmarks of canc

98 The Warburg effect, a common metabolic alteration of most tu

99 The Warburg effect, which originally described increased pro

100 n in the presence of abundant oxygen(4) (the Warburg effect).

101 suppressor in PCa that prevents EMT and the Warburg effect, and indicates that ABHD5 is a potential

102 ion, activation of the PI3K pathway, and the Warburg effect.

103 tures of tumor cells: glutaminolysis and the Warburg effect.

104 intellectual disability, apoptosis, and the Warburg effect.

105 factor-1alpha's downstream processes and the Warburg effect; induction of autophagy; augmentation of

106 and its focus expanded from glucose and the Warburg's effects on other nutrients, such as glutamine.

107 asis, immune escape, tumor angiogenesis, the Warburg effect and oncogene addiction and has been valid

108 A metabolic phenomenon known as the Warburg effect has been characterized in certain cancero

109 Known as the Warburg effect in the context of cancer growth, this phe

110 etabolic phenotype of cancer is known as the Warburg effect or aerobic glycolysis that consists of in

111 Drastic metabolic alterations, such as the Warburg effect, are found in most if not all types of ma

112 Reversing this phenomenon, known as the Warburg effect, may offer a generalized anticancer strat

113 eference of aerobic glycolysis, known as the Warburg effect, which facilitates cell proliferation.

114 he degree of aerobic glycolysis-known as the Warburg effect-is thus predicted to represent an adaptat

115 eir energy supply, a phenomenon known as the Warburg effect.

116 toward aerobic glycolysis, also known as the Warburg effect.

117 on to aerobic glycolysis, referred to as the Warburg effect.

118 presented by a glycolytic shift known as the Warburg effect.

119 gulate non-cell-cycle functions, such as the Warburg effect.

120 s the glycolytic adaptation described as the Warburg Effect.

121 utrients for biomass production known as the Warburg effect.

122 as an increased glycolytic rate known as the Warburg effect.

123 ase in aerobic glycolysis, also known as the Warburg effect.

124 onditions, a hallmark of cancer known as the Warburg effect.

125 f mitochondrial function and is known as the Warburg effect.

126 energy production, a phenomenon known as the Warburg effect.

127 tic state of aerobic glycolysis known as the Warburg effect.

128 n to generate ATP, a phenomenon known as the Warburg effect.

129 in cancer cells, commonly referred to as the Warburg effect.

130 ential use of glucose, which is known as the Warburg effect.

131 oA in the presence of oxygen is known as the Warburg effect.

132 ation in the cell, a phenomenon known as the Warburg effect.

133 is abundant, a phenomenon referred to as the Warburg effect.

134 e quiescent state, a phenomenon known as the Warburg effect.

135 lysis for ATP production, referred to as the Warburg effect.

136 lysis-driven metabolic program, known as the Warburg effect; however, few have been identified.

137 to the altered metabolic state known as the Warburg effect; one metabolic pathway, highly dependent

138 eased oxygen consumption, and attenuated the Warburg effect at the cellular level.

139 udy of tumor metabolism above and beyond the Warburg effect.

140 tralization of the acidosis generated by the Warburg glycolytic shift.

141 rease in glycolytic index, quantified by the Warburg index.

142 melanoma cells that are not described by the Warburg phenomenon.

143 ilability of oxygen, a phenomenon called the Warburg effect, is important for cancer cell growth.

144 imiting glycolytic enzyme known to cause the Warburg effect.

145 ated aerobic glycolysis in cancer cells (the Warburg effect) may be attributed to respiration injury

146 ism and is up-regulated in cancer cells (the Warburg Effect).

147 the ERK and JNK pathways in controlling the Warburg effect in cancer and discuss their implication i

148 tp53 GOF and a mechanism for controlling the Warburg effect.

149 tion in aerobic glycolysis counteracting the Warburg effect of cancer cells.

150 3 decreased proliferation and diminished the Warburg-like phenotype in SIRT3-deficient cell lines, an

151 GT1A_i2 proteins in HT115 cells enforced the Warburg effect, with a higher glycolytic rate at the exp

152 MicroRNA-31-5p enhances the Warburg effect via targeting FIH.

153 ic metabolism in an aerobic environment, the Warburg effect, but the explanation for this preference

154 regulating energy metabolism, especially the Warburg effect, and antioxidant defense, and thus the fu

155 All melanoma cells exhibited the Warburg phenomenon; they used more glucose and produced

156 Tumor cells exhibiting the Warburg effect rely on aerobic glycolysis for ATP produc

157 olic status of cancer cells experiencing the Warburg effect(2,3).

158 tions and therefore do not fully explain the Warburg effect.

159 her innate or acquired, helps to explain the Warburg phenomenon.

160 a lack of a quantitative explanation for the Warburg effect in cancer.

161 rkin deficiency is a novel mechanism for the Warburg effect in tumors.

162 ory axis is an important determinant for the Warburg effect in tumour cells and provide a mechanistic

163 IF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metab

164 ruvate kinase M2 (PKM2) is essential for the Warburg effect.

165 ignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogene

166 Aerobic glycolysis (the Warburg effect) is a metabolic hallmark of activated T c

167 r cells rely more on aerobic glycolysis (the Warburg effect) than mitochondrial oxidative phosphoryla

168 ost tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apo

169 Most tumor cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and promote t

170 It remains a matter of debate as to how the Warburg effect is regulated during tumor progression.

171 Here we explore how the Warburg effect might be linked to inflammation and infla

172 It is unclear how the Warburg effect that exemplifies enhanced glycolysis in t

173 ossible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (1

174 ion and underlying mechanism of UQCRH in the Warburg effect metabolism of ccRCC have not been charact

175 2, a fetal anabolic enzyme implicated in the Warburg effect, was activated by insulin in vivo and in

176 the lactate produced by cancer cells in the Warburg effect.

177 Larger increases in the Warburg elements and cell impedance are also found with

178 c alterations in cancer cells, including the Warburg effect that describes an increased glycolysis in

179 rofound metabolic alterations, including the Warburg effect wherein cancer cells oxidize a decreased

180 similar metabolic alterations, including the Warburg effect.

181 ing oxygen consumption, thereby inducing the Warburg effect.

182 ignaling pathway may be a way to inhibit the Warburg Effect to disrupt tumor growth.

183 er cells, SR9243 significantly inhibited the Warburg effect and lipogenesis by reducing glycolytic an

184 ngly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not

185 A new parameter measuring the Warburg effect (the ratio of lactate production flux to

186 thod has proven highly useful to monitor the Warburg effect in cancer, through MR detection of increa

187 ealing how CD44 could be a gatekeeper of the Warburg effect (aerobic glycolysis) in cancer cells and

188 We propose that KSHV induction of the Warburg effect adapts infected cells to tumor microenvir

189 ese results support an interpretation of the Warburg effect and glutamine addiction as features of a

190 duced kinase 1 (PINK1) is a regulator of the Warburg effect and negative regulator of glioblastoma gr

191 This results in the reversal of the Warburg effect and the inhibition of breast cancer cell

192 wild-type p53 prevents manifestation of the Warburg effect by controlling Pdk2.

193 cose to lactate conversion indicative of the Warburg effect can be imaged without hyper-polarization

194 ve recently emerged as key regulators of the Warburg effect during tumorigenesis and normal cellular

195 remutation, we evaluated the presence of the Warburg effect in peripheral blood mononuclear cells (PB

196 However, evidence for the occurrence of the Warburg effect in physiological processes has also been

197 tory axis is an important determinant of the Warburg effect in tumor cells, and provide a mechanistic

198 The discovery of the Warburg effect, the preference of cancer cells to genera

199 Imaging of the Warburg effect, which is the principal but not the sole

200 vide new insights into the regulation of the Warburg effect.

201 ropensity of AKT to modulate elements of the Warburg effect.

202 se M2 isoform (PKM2), a key regulator of the Warburg effect.

203 ess, enabling non-invasive monitoring of the Warburg effect.

204 it a glycolytic phenotype reminiscent of the Warburg effect.

205 that p53 status is a key determinant of the Warburg effect.

206 se M2 isoform (PKM2), a key regulator of the Warburg effect.

207 ma enabled quantitative visualization of the Warburg effect.

208 der aerobic conditions characteristic of the Warburg effect.

209 n and supporting a localized reversal of the Warburg shift toward aerobic glycolysis.

210 extracting the component that depends on the Warburg impedance from the total impedance.

211 Aerobic glycolysis or the Warburg effect (WE) is characterized by increased glucos

212 Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased me

213 Aerobic glycolysis or the Warburg effect links the high rate of glucose fermentati

214 olism of enhanced aerobic glycolysis (or the Warburg effect) is known as a hallmark of cancer.

215 gramming, known as aerobic glycolysis or the Warburg effect, allows tumor cells to sustain their fast

216 y a preference for aerobic glycolysis or the Warburg effect, and the cells resist matrix detachment-i

217 ed role of PKM2 in aerobic glycolysis or the Warburg effect, its non-metabolic functions remain elusi

218 inflammatory sites undergoing hypoxia or the Warburg effect.

219 even in the presence of abundant oxygen (the Warburg effect).

220 e of ATP to fuel cellular proliferation (the Warburg effect).

221 nhances LDH-A enzyme activity to promote the Warburg effect and tumor growth by regulating the NADH/N

222 osphorylation activates PDHK1 to promote the Warburg effect and tumor growth.

223 ert to regulate PDC activity and promote the Warburg effect.

224 ert to regulate PDC activity and promote the Warburg effect.

225 h cancer-specific splicing that promotes the Warburg effect and breast cancer progression.

226 is study reveals that miR-31-5p promotes the Warburg effect via direct targeting of FIH.

227 mediated PKM2 dephosphorylation promotes the Warburg effect, cell proliferation and brain tumorigenes

228 cogenic signaling pathways that regulate the Warburg effect in cancer cells has therefore become an a

229 decline of mitochondria thus reinforcing the Warburg effect.

230 ion, agents that scavenge ROS or reverse the Warburg effect prevent the transformation and malignant

231 mented that methylene blue (MB) reverses the Warburg effect evidenced by the increasing of oxygen con

232 estoration of Parkin expression reverses the Warburg effect in cells.

233 discovery has led researchers to revisit the Warburg hypothesis, first postulated in the 1950s, of ab

234 t mechanistically connects aberrant ROS, the Warburg effect, and carcinogenesis.

235 ecreased HIF-1alpha expression, shifting the Warburg phenotype to OXPHOS and inhibiting glioblastoma

236 43B osteosarcoma (OS) cell lines showing the Warburg effect in comparison with actively respiring Sao

237 that tumour-associated mutp53 stimulates the Warburg effect in cultured cells and mutp53 knockin mice

238 Mutp53 stimulates the Warburg effect through promoting GLUT1 translocation to

239 gely abolishes mutp53 GOF in stimulating the Warburg effect.

240 Finally, miR-644a expression suppresses the Warburg effect by direct targeting of c-Myc, Akt, IGF1R,

241 ize the potential benefit from targeting the Warburg effect.

242 tochondria (OXPHOS), a phenomenon termed the Warburg effect, which is a general feature of oncogenesi

243 aerobic glycolysis, a phenomenon termed the Warburg effect.

244 Here I show that the Warburg effect can be explained as a form of cooperation

245 ese findings support the hypothesis that the Warburg effect is a precisely regulated developmental me

246 This study reveals a mechanism that the Warburg effect is regulated by CHIP through its function

247 izing higher-grade tumors, we found that the Warburg effect is relatively more prominent at the expen

248 These results suggest that the Warburg effect, more specifically, diminished glucose ox

249 that regulate the PI3K pathway, and thus the Warburg effect, are elusive.

250 s miR-199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strat

251 the glycolytic pathway and contribute to the Warburg effect in cancer cells.

252 ase (PKM2), a key enzyme contributing to the Warburg effect in cancer, is significantly induced in DM

253 mitochondrial function, contributing to the Warburg effect in cancer.

254 erized by a glycolytic switch similar to the Warburg effect in cancer.

255 How ACAT1 is "hijacked" to contribute to the Warburg effect in human cancer remains unclear.

256 by DERL3 epigenetic loss contributes to the Warburg effect in the studied cells and pinpoints a subs

257 report that loss of PINK1 contributes to the Warburg effect through ROS-dependent stabilization of hy

258 Due to the Warburg effect, cancerous colonocytes rely on glucose as

259 This bioenergetic shift is similar to the Warburg effect, the metabolic signature of cancer cells.

260 rosine phosphorylation and gives rise to the Warburg effect.

261 er-enhancers in several genes related to the Warburg effect.

262 lar composition of PDC and contribute to the Warburg effect.

263 s a new molecular player contributing to the Warburg effect.

264 iferating cancer cells and contribute to the Warburg effect.

265 es mitochondrial respiration, leading to the Warburg effect.

266 Furthermore, contrary to the Warburg hypothesis, AML relies on oxidative phosphorylat

267 sition to aerobic glycolysis, similar to the Warburg metabolism displayed by cancer cells.

268 tabolism in HepG2 cells, contributing to the Warburg phenomenon.

269 tion of cancerous colonocytes undergoing the Warburg effect.

270 estigate molecular mechanisms underlying the Warburg effect, we first compared oxygen consumption amo

271 lonocytes and cancerous colonocytes when the Warburg effect was prevented from occurring, whereas it

272 the pathways classically associated with the Warburg effect.

273 ite matter (P < .001) in accordance with the Warburg theorem.

274 ycolysis was observed in accordance with the Warburg theorem.

275 The "Warburg effect" describes a peculiar metabolic feature o

276 Today this phenomenon is known as the "Warburg effect" and recognized as a hallmark of cancer.

277 er normoxic conditions, commonly called the "Warburg effect." Aerobic glycolysis often directly corre

278 gulation of glycolysis in cancer cells (the "Warburg effect") is common and has implications for prog

279 abolism, notably of aerobic glycolysis (the "Warburg effect"), the potential involvement of hypoxia-i

280 nas is dominated by aerobic glycolysis (the "Warburg Effect"), which allows only a small fraction of

281 profound effect on aerobic glycolysis (the 'Warburg effect').

282 metabolism (a cancer phenomenon termed the 'Warburg effect').

283 In contrast to Warburg's original hypothesis, accumulating evidence dem

284 that mutations in TBC1D20 may contribute to Warburg micro syndrome (WARBM); WARBM constitutes a spec

285 under normoxic conditions, with parallels to Warburg reprogramming.

286 mediator linking noncanonical Shh pathway to Warburg-like glycolysis in satellite cells, which is req

287 induced cancer cells, displaying the typical Warburg effect, to death or survival upon progressive gl

288 state hyperplasia revealed that CAFs undergo Warburg metabolism and mitochondrial oxidative stress.

289 Walker-Warburg syndrome (WWS) is clinically defined as congenit

290 nditions muscle-eye-brain disease and Walker-Warburg syndrome.

291 the congenital muscular dystrophies, Walker-Warburg syndrome, to mild forms of adult-onset limb-gird

292 ify genetic mutations responsible for Walker-Warburg syndrome (WWS), a genetically heterogeneous auto

293 rain and eye anomalies and range from Walker-Warburg syndrome to Fukuyama congenital muscular dystrop

294 clinical manifestations ranging from Walker-Warburg syndrome, the most severe form of dystroglycanop

295 nital muscular dystrophies, including Walker-Warburg syndrome, muscle-eye-brain disease, Fukuyama con

296 PD), are a relatively common cause of Walker-Warburg syndrome.

297 ominantly muscle phenotypes to severe Walker-Warburg syndrome and muscle-eye-brain disease with strik

298 can, which not only causes the severe Walker-Warburg syndrome but is also a common cause of the milde

299 tal muscular dystrophy 1C (MDC1C), to Walker-Warburg Syndrome and Muscle-Eye-Brain disease.

300 rom limb girdle muscular dystrophy to Walker-Warburg syndrome.