ライフサイエンスコーパス: X chromosome inactivation

1 sal of the mechanism for PRC2 recruitment in X chromosome inactivation.

2 , a protein that is central to Jpx's role in X chromosome inactivation.

3 of somatic cells, including the reversal of X chromosome inactivation.

4 osage relative to XY males, a process termed X chromosome inactivation.

5 gene expression that is critical to maintain X chromosome inactivation.

6 ompensation of X-linked genes is achieved by X chromosome inactivation.

7 nism to anchor Xist to the Xi and facilitate X chromosome inactivation.

8 pending on which X chromosome is silenced by X chromosome inactivation.

9 long been studied in genomic imprinting and X chromosome inactivation.

10 tion/repression, insulation, imprinting, and X chromosome inactivation.

11 into account the dosage effect due to female X chromosome inactivation.

12 chromosome but linger in regions that escape X chromosome inactivation.

13 DNA methylation associated with escape from X chromosome inactivation.

14 ed a novel function unique to the process of X chromosome inactivation.

15 having normal intelligence and highly skewed X chromosome inactivation.

16 cell proliferation, early embryogenesis and X chromosome inactivation.

17 chromatin remodeling, genomic imprinting and X chromosome inactivation.

18 ship between chromosomal characteristics and X chromosome inactivation.

19 ring in the choice and counting functions of X chromosome inactivation.

20 ng epigenetic control of gene imprinting and X chromosome inactivation.

21 chromosomes to determine whether to initiate X chromosome inactivation.

22 d in epigenetic regulation of imprinting and X chromosome inactivation.

23 n epigenetic gene-silencing events including X chromosome inactivation.

24 s a candidate for the regulator of imprinted X chromosome inactivation.

25 hromosome reveal that TCEAL7 is subjected to X chromosome inactivation.

26 erian characteristic of determinate paternal X chromosome inactivation.

27 and genes subject to genomic imprinting and X chromosome inactivation.

28 ) repeats may be mediators for the spread of X chromosome inactivation.

29 ormal RLIM mRNA levels and had highly skewed X chromosome inactivation.

30 f Polycomb target genes and silencing during X chromosome inactivation.

31 uring gastrulation, reminiscent of mammalian X Chromosome inactivation.

32 tion between the genders in a process called X chromosome inactivation.

33 role of the nuclear matrix in the process of X chromosome inactivation.

34 l for both the random and imprinted forms of X-chromosome inactivation.

35 ures in surviving animals, apparently due to X-chromosome inactivation.

36 mCH signature that identifies genes escaping X-chromosome inactivation.

37 or long-range epigenetic regulation such as X-chromosome inactivation.

38 late gene expression, genome imprinting, and X-chromosome inactivation.

39 rangements at the two alleles in response to X-chromosome inactivation.

40 hat has properties consistent with a role in X-chromosome inactivation.

41 ist that together regulate the initiation of X-chromosome inactivation.

42 ortant genetic elements or genes involved in X-chromosome inactivation.

43 egulation, heterochromatin organization, and X-chromosome inactivation.

44 nous X-X pairing and block the initiation of X-chromosome inactivation.

45 one X chromosome are silenced as a result of X-chromosome inactivation.

46 posed role as way stations in the process of X-chromosome inactivation.

47 ANCB, is localized at Xp22.31 and subject to X-chromosome inactivation.

48 ary and sufficient for Xist spreading during X-chromosome inactivation.

49 e 123 (DHR) oxidation data for percentage of X-chromosome inactivation.

50 r silencing by interrogating imprinted mouse X-chromosome inactivation.

51 its 5' end, to induce gene silencing during X-chromosome inactivation.

52 nd epigenetic changes such as imprinting and X-chromosome inactivation.

53 ransposon silencing, genomic imprinting, and X-chromosome inactivation.

54 lly observed through an increased skewing in X-chromosome inactivation [1].

55 including late implantation(1) and imprinted X chromosome inactivation(2), which is associated with e

56 The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromo

57 Recent studies have shown that, upon X-chromosome inactivation, active and inactive X chromos

58 Xist RNA, the master regulator of X chromosome inactivation, acts in cis to induce chromos

59 X chromosome inactivation analysis showed a discordant p

60 In addition, X chromosome inactivation analysis was done on the tumor

61 X-chromosome inactivation analysis indicated that this f

62 X-chromosome inactivation analysis may be useful for ide

63 ificant number of X-linked genes escape from X chromosome inactivation and are associated with a dist

64 sion that are seen during differentiation or X chromosome inactivation and are not dependent on dynam

65 future analyses into the genetic control of X chromosome inactivation and defines a 1.85-Mb interval

66 ression of Cbx7 inhibits differentiation and X chromosome inactivation and enhances ESC self-renewal.

67 X chromosome inactivation and genomic imprinting are cla

68 hoblast giant cell differentiation, paternal X chromosome inactivation and histone H3K27 tri-methylat

69 perties including differential regulation of X chromosome inactivation and of genes involved in oxida

70 ripotency, cell fate, cell cycle regulation, X chromosome inactivation and parental imprinting.

71 , such as cis-regulation of gene expression, X chromosome inactivation and random monoallelic express

72 lecular mechanism of chromosome silencing in X-chromosome inactivation and focus on topics where new

73 ntial allelic gene expression resulting from X-chromosome inactivation and genomic imprinting, a larg

74 stable transcriptional silencing, such as in X-chromosome inactivation and genomic imprinting.

75 s, Xlr3b, Xlr4b and Xlr4c, is independent of X-chromosome inactivation and has a dynamic and complex

76 best defined in epigenetic phenomena such as X-chromosome inactivation and imprinting, different clas

77 ion of Hox genes and animal body patterning, X-chromosome inactivation and possibly maintenance of em

78 , Rsx is silenced, linking Rsx expression to X-chromosome inactivation and reactivation.

79 ks ranging from heterochromatin formation to X-chromosome inactivation and transcriptional regulation

80 ubiquitin ligase important for initiation of X-chromosome inactivation and XIST transcription in ES c

81 therefore have a conserved role in imprinted X-chromosome inactivation and, ultimately, in sex chromo

82 ased on information gleaned from imprinting, X chromosome inactivation, and activation and silencing

83 ologic processes such as genomic imprinting, X chromosome inactivation, and silencing of repeat eleme

84 normal processes such as gene imprinting and X-chromosome inactivation, and aberrant CpG island hyper

85 trotransposon silencing, genomic imprinting, X-chromosome inactivation, and cancer.

86 of phenomena, including genomic imprinting, X-chromosome inactivation, and cis-regulatory evolution.

87 ent, tissue homeostasis, genomic imprinting, X-chromosome inactivation, and germ cell differentiation

88 including embryonic development, imprinting, X-chromosome inactivation, and stem cell differentiation

89 of Kdm5c, an X chromosome gene that escapes X chromosome inactivation, as a determinant of the X chr

90 ADs) to the regulation of imprinted loci and X chromosome inactivation, as well as rDNA contact maps

91 of hitherto unknown function, which escapes X-chromosome inactivation, as a candidate underlying the

92 Furthermore, using X-chromosome inactivation assays and tissue-specific del

93 ll beyond the initial findings of effects on X chromosome inactivation associated with lethality in f

94 n, which may explain why it does not trigger X chromosome inactivation at this stage.

95 Concordant genetic alterations and X chromosome inactivation between small-cell carcinoma a

96 We investigated whether genes escape X chromosome inactivation by positioning outside of the

97 Here we model the problem using X-chromosome inactivation by developing "BioRBP", an enz

98 chromosome to inactivate is normally random, X chromosome inactivation can be skewed in F1 hybrid mic

99 he Xce to candidate regions that overlap the X chromosome inactivation center (Xic), which includes t

100 ic elements located in a region known as the X chromosome inactivation center, and is regulated by a

101 ntifying Tsix regulatory elements within the X chromosome inactivation center.

102 alysis revealed distinct transcriptional and X chromosome inactivation changes associated with the ea

103 As a result of the process of X chromosome inactivation, chromatinon the mammalian ina

104 This bias was not attributable to X chromosome-inactivation defects, differential replicat

105 Clonality assays, based on X-chromosome inactivation, discriminate active from inac

106 long noncoding RNA (lncRNA) is essential for X-chromosome inactivation during female eutherian mammal

107 The reprogramming of X-chromosome inactivation during the acquisition of plur

108 e of potential phenotypic variability due to X chromosome inactivation effects.

109 X chromosome inactivation ensures equal dosage of X-link

110 X-chromosome inactivation equalizes the dosage of X-link

111 Whereas X chromosome inactivation evolved to solve the problem o

112 a long noncoding RNA (lncRNA) essential for X chromosome inactivation, folds into evolutionarily con

113 atus and controls heterochromatin formation, X-chromosome inactivation, genome imprinting, DNA repair

114 ocesses including heterochromatin formation, X-chromosome inactivation, genome imprinting, DNA repair

115 l pathways such as DNA methylation (DNMT3B), X chromosome inactivation (H2AFY), the DNA damage respon

116 Furthermore, skewed X chromosome inactivation has been found in the thyroid

117 stem for understanding epigenetic silencing, X chromosome inactivation has been previously linked to

118 the epigenetics associated with escape from X chromosome inactivation has potential for those suffer

119 nance, Polycomb-mediated gene silencing, and X chromosome inactivation have been elusive.

120 f how both the imprinted and random forms of X chromosome inactivation have come about.

121 Several studies suggest that highly skewed X chromosome inactivation (HSXI) is associated with recu

122 the hypothesis that-in organisms with early X chromosome inactivation-imprinted X chromosome inactiv

123 as previously shown to have diverse roles in X-chromosome inactivation, imprinting and double-strand

124 ng protein 1 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting, and DNA damage re

125 RNA-sequencing analysis of embryogenesis and X chromosome inactivation in a marsupial, the grey short

126 tin), the maintenance of DNA methylation and X chromosome inactivation in female cells (facultative h

127 enomenon occurs, in a random fashion, during X chromosome inactivation in female cells.

128 mammals, dosage compensation is achieved by X chromosome inactivation in female cells.

129 in imprinted gene expression and erosion of X chromosome inactivation in female hiPSCs and how under

130 nes, in the silencing of transposons, and in X chromosome inactivation in female mammals.

131 cript (Xist) gene is the master regulator of X chromosome inactivation in mammals.

132 locus is a cis-acting switch that regulates X chromosome inactivation in mammals.

133 the paternal X chromosome before and during X chromosome inactivation in preimplantation female embr

134 ve cases and concordant pattern of nonrandom X chromosome inactivation in the four remaining informat

135 sis showed a discordant pattern of nonrandom X chromosome inactivation in two of six informative case

136 circuitry that maintains XIST expression and X-chromosome inactivation in differentiated cells.

137 X-chromosome inactivation in eutherian mammals is mediat

138 However, unlike X-chromosome inactivation in female embryonic cells, whe

139 Our findings permit comparative studies of X-chromosome inactivation in mammals and pose questions

140 l loci or whole chromosomes, as in imprinted X-chromosome inactivation in mammals, is established and

141 omenon that occurs on a scale second only to X-chromosome inactivation in mammals.

142 r X-chromosome imprinting, however, concerns X-chromosome inactivation in specific circumstances and

143 made novel predictions of genes that escape X-chromosome inactivation in specific tissues.

144 patient for loss of heterozygosity (LOH) and X chromosome inactivation (in female patients).

145 Intriguingly, whereas some iPSCs maintained X chromosome inactivation, in others the X chromosome wa

146 X chromosome inactivation involves multiple levels of ch

147 X chromosome inactivation is an epigenetic dosage compen

148 Random X chromosome inactivation is mediated by Xist RNA expres

149 X chromosome inactivation is most commonly studied in th

150 male active X chromosome and, in response to X chromosome, inactivation is organized into euchromatin

151 X-chromosome inactivation is a mechanism of dosage compe

152 X-chromosome inactivation is a striking example of epige

153 pose questions about the mechanisms by which X-chromosome inactivation is achieved in eutherians.

154 X-chromosome inactivation is established during early de

155 found in metatherians (marsupials), and how X-chromosome inactivation is initiated in these mammals

156 Skewed X-chromosome inactivation is the likely cause of parkins

157 X-chromosome inactivation is then reversed in the inner

158 X-chromosome inactivation is widely believed to be rando

159 on-equivalence, rather than being limited to X-chromosome inactivation, is a fundamental property of

160 mechanism leading to genomic imprinting and X-chromosome inactivation, is widely reported at the non

161 men and variable in women because of skewed X-chromosome inactivation; its extensive/massive involve

162 s the "Barr body." Despite the importance of X chromosome inactivation, little is known about this 3D

163 se of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cel

164 lippines, the epigenetic factor of nonrandom X-chromosome inactivation may contribute to the skewing

165 These data are incompatible with simple X chromosome inactivation models.

166 s influence processes including development, X chromosome inactivation, obesity, schizophrenia, and d

167 ce), typically associated with initiation of X-chromosome inactivation, occurring in XX cells outside

168 r gene (HUMARA), we analyzed the patterns of X-chromosome inactivation of multiple distinct foci of w

169 eracting RNAs), position effect variegation, X-chromosome inactivation, parental imprinting, and para

170 ce is significantly correlated with a clonal X chromosome inactivation pattern (XCIP).

171 Furthermore, a severely skewed X chromosome inactivation pattern is found in women with

172 Clonality detection based on X-chromosome inactivation patterns (XCIP) requires discr

173 terogeneous with respect to natural history, X-chromosome inactivation patterns (XCIPs), and presence

174 Clonality analysis using X-chromosome inactivation patterns has revealed apparent

175 X-chromosome inactivation patterns were analyzed using l

176 th early X chromosome inactivation-imprinted X chromosome inactivation prevents biallelic X silencing

177 henotypic clonality methods are based on the X-chromosome inactivation principle.

178 nd hematopoietic precursor cells, before the X-chromosome inactivation process occurs.

179 d to recombinant males, we have measured the X chromosome inactivation ratio using allele-specific ex

180 X-chromosome inactivation ratios correlate with clinical

181 X-chromosome inactivation ratios were determined in geno

182 pVNTR alleles of MAOA did not correlate with X-chromosome inactivation ratios, determined at the X-li

183 ping with the possibility that the choice of X chromosome inactivation reflects stabilization of a hi

184 ncy and chromatin factors are illustrated by X chromosome inactivation, regulatory control by noncodi

185 X chromosome inactivation silences one of two X chromoso

186 dependent manner, is sufficient to determine X chromosome inactivation status.

187 ments, mitochondrial DNA (mtDNA) sequencing, X-chromosome inactivation study, global gene expression

188 MLS-affected females have severe skewing of X chromosome inactivation, suggesting that mutations in

189 Here, we introduce a new model of X chromosome inactivation that aims to account for the f

190 specific transcript (XIST), a key player in X-chromosome inactivation that encodes an RNA that coats

191 silenced in each female cell as a result of X chromosome inactivation, the mammalian dosage compensa

192 tination in Hox gene silencing as well as in X-chromosome inactivation, the enzyme(s) involved in H2A

193 male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptiona

194 ral processes such as genomic imprinting and X-chromosome inactivation, the functional significance o

195 Owing to extremely skewed (98%:2%) X-chromosome inactivation, the patient expressed almost

196 oles in diverse biological processes such as X chromosome inactivation, transposable element repressi

197 X chromosome inactivation triggered by Xist RNA can only

198 X-chromosome inactivation triggers fusion of A/B compart

199 es in the regulation of Hox gene expression, X-chromosome inactivation, tumorigenesis, and stem cell

200 Similarly, the same pattern of nonrandom X chromosome inactivation was present in both carcinoma

201 hnRNPK is essential for X chromosome inactivation, where it interacts with Xist

202 Smchd1 promotes X chromosome inactivation, whereas Chd7 regulates expres

203 netic changes, including DNA methylation and X chromosome inactivation, which create a robust epigene

204 ze silencing of X-linked genes in cis during X-chromosome inactivation, which equalizes X-linked gene

205 female XLP carrier showed completely skewed X chromosome inactivation within NKT cells, but not T or

206 urprisingly, in the protan carrier, in which X-chromosome inactivation would favor L- or M-cone clump

207 X chromosome inactivation (XCI) achieves dosage balance

208 In the early mammalian embryo, X chromosome inactivation (XCI) achieves dosage parity b

209 man ESCs (hESCs) invariably exhibit signs of X chromosome inactivation (XCI) and are considered devel

210 nscriptional aberrations in genes subject to X chromosome inactivation (XCI) and genomic imprinting,

211 embryonic stem cells (ESCs) with non-random X chromosome inactivation (XCI) and polymorphic X chromo

212 X chromosome inactivation (XCI) depends on a noncoding s

213 X chromosome inactivation (XCI) depends on the long nonc

214 X chromosome inactivation (XCI) equalizes gene expressio

215 stages, including 19 female tissues allowing X chromosome inactivation (XCI) escapers to also be dete

216 the Firre and Dxz4 loci are not required for X chromosome inactivation (XCI) in cell lines.

217 ng non-coding RNA essential for establishing X chromosome inactivation (XCI) in early embryos, is con

218 In early development, delayed and incomplete X chromosome inactivation (XCI) in some species causes v

219 X chromosome inactivation (XCI) is a global silencing me

220 X chromosome inactivation (XCI) is a key epigenetic gene

221 X chromosome inactivation (XCI) is an epigenetic mechani

222 X chromosome inactivation (XCI) is an essential mechanis

223 X chromosome inactivation (XCI) is controlled by a compl

224 In marsupials and in the early mouse embryo, X chromosome inactivation (XCI) is imprinted to occur se

225 In female marsupials, X chromosome inactivation (XCI) is imprinted, affecting

226 X chromosome inactivation (XCI) is initiated by expressi

227 In mice, X chromosome inactivation (XCI) is regulated by the anti

228 X chromosome inactivation (XCI) is the most dramatic exa

229 X chromosome inactivation (XCI) is the phenomenon throug

230 In mammals, X chromosome inactivation (XCI) is triggered by Xist RNA

231 We use the X chromosome inactivation (XCI) paradigm to explore the

232 ablished female XX hESC lines have undergone X chromosome inactivation (XCI) prior to differentiation

233 X chromosome inactivation (XCI) reduces the number of ac

234 X chromosome inactivation (XCI) silences transcription f

235 We compared the distribution of X chromosome inactivation (XCI) skewing percentages (ran

236 Random X chromosome inactivation (XCI) takes place in the ICM l

237 Female eutherian mammals use X chromosome inactivation (XCI) to epigenetically regula

238 Female mammals use X chromosome inactivation (XCI) to generate a transcript

239 n in the XIST promoter results in skewing of X chromosome inactivation (XCI) towards the inactive X c

240 In this study, a thorough analysis of X chromosome inactivation (XCI) was performed in both pr

241 landscape that predisposes it to erosion of X chromosome inactivation (XCI), a process that occurs s

242 CXCR3, an X-linked gene, is subject to X chromosome inactivation (XCI), but it is unclear wheth

243 Because of X chromosome inactivation (XCI), cells within RTT female

244 Evidence from epigenetic processes, such as X chromosome inactivation (XCI), indicates that CTCF ass

245 Xist, an essential lncRNA for X chromosome inactivation (XCI), interacts with 81 prote

246 Through the process of X chromosome inactivation (XCI), somatic cells of mammal

247 During X chromosome inactivation (XCI), the Polycomb Repressive

248 In X chromosome inactivation (XCI), unfavorable XCI ratios

249 ryos, somatic cells undergo a random form of X chromosome inactivation (XCI), whereas extraembryonic

250 ellular differentiation is tightly linked to X chromosome inactivation (XCI), whereas reprogramming t

251 thought to be dispensable after establishing X chromosome inactivation (XCI), Xist RNA is now known t

252 between XX and XY individuals occurs through X chromosome inactivation (XCI).

253 time in culture they undergo an "erosion" of X chromosome inactivation (XCI).

254 The Xist lncRNA mediates X chromosome inactivation (XCI).

255 extensive overlap with genes known to escape X chromosome inactivation (XCI).

256 he XIST RNA is a non-coding RNA that induces X chromosome inactivation (XCI).

257 resolution RNA allelotyping method, to study X chromosome inactivation (XCI).

258 Genomic imprinting and X-chromosome inactivation (XCI) are classic epigenetic p

259 We focus on X-chromosome inactivation (XCI) as a paradigm for fHC bu

260 Female somatic X-chromosome inactivation (XCI) balances the X-linked tr

261 X-chromosome inactivation (XCI) compensates for differen

262 active (Xi) X chromosomes because stochastic X-chromosome inactivation (XCI) confounds allele-specifi

263 In female mice, two forms of X-chromosome inactivation (XCI) ensure the selective sil

264 Two forms of X-chromosome inactivation (XCI) ensure the selective sil

265 X-chromosome inactivation (XCI) ensures the equality of

266 In mammals, X-chromosome inactivation (XCI) equalizes X-linked gene

267 How and why female somatic X-chromosome inactivation (XCI) evolved in mammals remai

268 chromosome in female cells is a hallmark of X-chromosome inactivation (XCI) in eutherians.

269 o achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals.

270 a few genes in diverse species suggests that X-chromosome inactivation (XCI) in marsupials is charact

271 ng transcription factors and participates in X-chromosome inactivation (XCI) in mice.

272 mammals, dosage compensation is achieved by X-chromosome inactivation (XCI) in the female.

273 is considered a prerequisite to reversal of X-chromosome inactivation (XCI) in the mouse inner cell

274 epigenetic reprogramming, as exemplified by X-chromosome inactivation (XCI) in which one female X ch

275 X-chromosome inactivation (XCI) is a classic epigenetic

276 X-chromosome inactivation (XCI) is initiated by expressi

277 X-chromosome inactivation (XCI) is initiated by the long

278 os that are mutated for the PcG protein Eed, X-chromosome inactivation (XCI) is not stably maintained

279 Extreme skewing of X-chromosome inactivation (XCI) is rare in the normal fe

280 X-chromosome inactivation (XCI) is the mammalian dosage

281 X-chromosome inactivation (XCI) is the process in which

282 In mammals, the silencing step of the X-chromosome inactivation (XCI) process is initiated by

283 genetic regulation, although how it mediates X-chromosome inactivation (XCI) remains largely unexplai

284 X-chromosome inactivation (XCI) silences one X chromosom

285 X-chromosome inactivation (XCI) silences transcription f

286 c analysis of chromatin modifications during X-chromosome inactivation (XCI) suggests that the silenc

287 The contribution of X-chromosome inactivation (XCI) to phenotypic variation

288 and binding diverse proteins(3-5) to achieve X-chromosome inactivation (XCI)(6,7).

289 ization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-me

290 Due to random X-chromosome inactivation (XCI), most RTT patients are f

291 ls with classic RTT have a random pattern of X-chromosome inactivation (XCI), nonbalanced patterns ha

292 To initiate X-Chromosome inactivation (XCI), the long noncoding RNA

293 long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which ma

294 X-chromosome inactivation (XCI), the random transcriptio

295 , we use tools of the epigenetic phenomenon, X-chromosome inactivation (XCI), to investigate their ep

296 reimplantation phases to establish imprinted X-chromosome inactivation (XCI).

297 Indeed, lncRNAs dominate control of random X-chromosome inactivation (XCI).

298 ge with XY males in a process referred to as X-chromosome inactivation (XCI).

299 n in female placental mammals is achieved by X-chromosome inactivation (XCI).

300 has been shown as an essential regulator in X-chromosome inactivation (XCI).