ライフサイエンスコーパス: Xenopus embryo

1 same Wnt target genes as beta-catenin in the Xenopus embryo ().

2 ion of a subset of mesodermal markers in the Xenopus embryo.

3 resence of an analogous network in the early Xenopus embryo.

4 ent to induce ectopic Flk1 expression in the Xenopus embryo.

5 the correct establishment of the axes of the Xenopus embryo.

6 e expression in the animal hemisphere of the Xenopus embryo.

7 to the formation of the DMZ of the stage 10 Xenopus embryo.

8 of the nervous system for the 32-cell stage Xenopus embryo.

9 efited from the study of gastrulation in the Xenopus embryo.

10 rm as well as the complete elongation of the Xenopus embryo.

11 both endoderm and mesoderm formation by the Xenopus embryo.

12 e rundown and termination of swimming in the Xenopus embryo.

13 ion of gene regulatory networks in the early Xenopus embryo.

14 appropriate neural tube morphogenesis in the Xenopus embryo.

15 gh during the rapid cell cycles of the early Xenopus embryo.

16 e to modulation of Hedgehog signaling in the Xenopus embryo.

17 al ectoderm to their proper locations in the Xenopus embryo.

18 tegrity of the epidermal layer in developing Xenopus embryos.

19 ts TGF-beta signaling in mammalian cells and Xenopus embryos.

20 stricted accumulation of the xCR1 protein in Xenopus embryos.

21 igrating cranial neural crest (CNC) cells in Xenopus embryos.

22 e in regulating cell and tissue movements in Xenopus embryos.

23 by overexpression of Kaiso in cell lines and Xenopus embryos.

24 MOC-1 (XSMOC-1) and explored its function in Xenopus embryos.

25 e kinases are important for Wnt signaling in Xenopus embryos.

26 when expressed as an independent protein in Xenopus embryos.

27 ll imaging of large-scale ZGA in whole-mount Xenopus embryos.

28 -catenin-induced secondary axis formation in Xenopus embryos.

29 s for the successful integration of DNA into Xenopus embryos.

30 ed enzymatic activities and abnormal CNSs in Xenopus embryos.

31 , induction of endogenous gene expression in Xenopus embryos.

32 ve neural-restricted transgene expression in Xenopus embryos.

33 gs", which are required for wound healing in Xenopus embryos.

34 of Sall1 to repress Gbx2 in cell culture and Xenopus embryos.

35 Drosophila and mammalian cells as well as in Xenopus embryos.

36 s sufficient to induce insulin expression in Xenopus embryos.

37 Hex target in embryonic stem (ES) cells and Xenopus embryos.

38 timing and intensity of Nodal signalling in Xenopus embryos.

39 movements, and eye and brain development in Xenopus embryos.

40 e co-expressed during midline development in Xenopus embryos.

41 velled and JNK is enriched in the nucleus of Xenopus embryos.

42 t, kermit 2/XGIPC has a distinct function in Xenopus embryos.

43 response to hyperactivated FGF signaling in Xenopus embryos.

44 Smad2/3 in vitro, in mammalian cells and in Xenopus embryos.

45 metric gene expression and of the viscera in Xenopus embryos.

46 dorsal axis is activated extracellularly in Xenopus embryos.

47 , and ciliated epidermal cells of developing Xenopus embryos.

48 cific reporter gene expression in transgenic Xenopus embryos.

49 expression during gastrulation in transgenic Xenopus embryos.

50 ralateral sides of the spinal cord of living Xenopus embryos.

51 ogenous BMP signaling activity in transgenic Xenopus embryos.

52 catenin-mediated secondary axis induction in Xenopus embryos.

53 nd severely expanded posterior structures in Xenopus embryos.

54 al crest is involved in heart development in Xenopus embryos.

55 e and extent of injury caused to the skin of Xenopus embryos.

56 tor were ectopically expressed in developing Xenopus embryos.

57 or (ARF) that binds to the Mix.2 promoter in Xenopus embryos.

58 tudied in insect and mammalian cells, and in Xenopus embryos.

59 vely inhibits nodal but not activin in early Xenopus embryos.

60 of the events of gastrulation in developing Xenopus embryos.

61 lls and characterize the vasculature of live Xenopus embryos.

62 d4, and transcription in mammalian cells and Xenopus embryos.

63 of neural crest induction by the mesoderm in Xenopus embryos.

64 signaling is blocked during gastrulation of Xenopus embryos.

65 ivate signaling and induce secondary axes in Xenopus embryos.

66 or blood and endothelial cells in developing Xenopus embryos.

67 that reported for a p2y receptor cloned from Xenopus embryos.

68 xpression pattern to lambda-olt 2-1 in early Xenopus embryos.

69 le in the early stages of eye development in Xenopus embryos.

70 tes in the development of sensory neurons in Xenopus embryos.

71 ional signaling via the ERK pathway in early Xenopus embryos.

72 cancer cells and in the Spemann organizer of Xenopus embryos.

73 l progenitor pool during axial elongation in Xenopus embryos.

74 terphase extract isolated from post-gastrula Xenopus embryos.

75 ally enhanced neuronal induction activity in Xenopus embryos.

76 n transcription and induce secondary axis in Xenopus embryos.

77 ding partner, WBP11, in early development of Xenopus embryos.

78 erior neural development and gastrulation in Xenopus embryos.

79 tory pathway by Ctx was not only observed in Xenopus embryos.

80 to recapitulate spindle scaling observed in Xenopus embryos.

81 on and block differentiation in both ESC and Xenopus embryos.

82 4l) has robust neuronal-inducing activity in Xenopus embryos.

83 h showed differential expression patterns in Xenopus embryos.

84 1 in morphogenesis during the development of Xenopus embryos.

85 was essential for pronephric development in Xenopus embryos.

86 eta-catenin activation in cultured cells and Xenopus embryos.

87 lent Noonan syndrome and JMML mutations into Xenopus embryos.

88 nction of Arg disrupted axial development in Xenopus embryos.

89 e Wnt11-like proteins in NC specification in Xenopus embryos.

90 and migrating cranial neural crest cells of Xenopus embryos.

91 s greatly synergized in the dorsalization of Xenopus embryos.

92 collective cell movement and ciliogenesis in Xenopus embryos.

93 ng the patterning of left-right asymmetry in Xenopus embryos.

94 these proteins were tested by expression in Xenopus embryos.

95 for proper tight junction function in early Xenopus embryos.

96 feedback inhibitor in ventral regions of the Xenopus embryo; (2) CV2 complexes with Twisted gastrulat

97 In Xenopus embryos, a dorsal-ventral patterning gradient is

98 We performed several in vivo assays in Xenopus embryos, a functional model of canonical Wnt sig

99 amba et al. reveal, through their studies of Xenopus embryos, a novel mechanism for regulating fibron

100 In Xenopus embryos, Amer2 is expressed mainly in the dorsal

101 8b are expressed in pluripotent cells of the Xenopus embryo and are enriched in cells that respond to

102 - and FGF4-induced mesoderm formation in the Xenopus embryo and FGF-dependent angiogenesis in the chi

103 wn that Smicl is expressed maternally in the Xenopus embryo and is later required for transcription o

104 Wnt signal transduction specificity in both Xenopus embryos and 293T cells.

105 tl4 is expressed in the Spemann organizer of Xenopus embryos and acts as a Wnt antagonist to promote

106 y, we improved immunolocalization methods in Xenopus embryos and analyzed the distribution of endogen

107 In Xenopus embryos and animal caps as well as DLD-1 cells,

108 he embryonic axis upon ventral injections in Xenopus embryos and appears to regulate cell proliferati

109 we examine the function of Oct4 homologs in Xenopus embryos and compare this to the role of Oct4 in

110 Neil-deficiency in Xenopus embryos and differentiating mouse embryonic stem

111 ntisense oligos causes hyperdorsalization of Xenopus embryos and ectopic expression of the Wnt/beta-c

112 n of mRNA coding for GFP-tagged Shh in early Xenopus embryos and find that Sulf1 restricts ligand dif

113 In murine embryonic stem cells, Xenopus embryos and human urothelial cells, cyclin E is

114 ecifically blocks BMP-dependent signaling in Xenopus embryos and in a mammalian model of bone formati

115 f expression profiling of Oct4/POUV-depleted Xenopus embryos and in silico analysis of existing mamma

116 Studies with Xenopus embryos and individuals with the congenital resp

117 ic demethylase 4d removes H3K9me3 marks from Xenopus embryos and inhibits the repression of lambda-ol

118 oreover, KLF4 inhibits the axis formation of Xenopus embryos and inhibits xenograft tumor growth in a

119 here that SOST antagonizes Wnt signaling in Xenopus embryos and mammalian cells by binding to the ex

120 imulate TCF3 phosphorylation in gastrulating Xenopus embryos and mammalian cells.

121 that altering lamin levels in vivo, both in Xenopus embryos and mammalian tissue culture cells, also

122 nd gain- and loss-of-function experiments in Xenopus embryos and mouse P19 cells demonstrated that Ge

123 Cleaving Xenopus embryos and parthenogenetically activated eggs t

124 LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal

125 esses required for normal eye development in Xenopus embryos and specifically requires an Src homolog

126 ability of GSK-3 to block eye development in Xenopus embryos and suggest that GSK-3 regulates eye dev

127 55 reduced XWnt8-induced axis duplication in Xenopus embryos and tamoxifen-induced polyposis formatio

128 of a set of innate immune response genes in Xenopus embryos and that splicing-blocking morpholinos l

129 of GATA4, 5 and 6 in presumptive endoderm in Xenopus embryos and their induction of endodermal marker

130 n cultured and explanted neurons and in live Xenopus embryos and zebrafish larvae.

131 more, both Shn and hShn1 activate the BRE in Xenopus embryos, and both repress brk and rescue embryon

132 t gene programs in human in vitro models and Xenopus embryos, and cause craniofacial defects.

133 uces ectopic expression of vascular genes in Xenopus embryos, and that combinatorial knockdown of the

134 orrect pattern of cortical actin assembly in Xenopus embryos, and that lysophosphatidic acid (LPA) an

135 eins regulated similar genes in ES cells and Xenopus embryos, and that PouV proteins capable of suppo

136 th the dorsal and ventral sides of the early Xenopus embryo are involved in creating the body plan.

137 Early Xenopus embryos are large, and during the egg to gastrul

138 oggin1 is able to induce a secondary axis in Xenopus embryos argues that N. vectensis could possess a

139 w here, using the developing ectoderm of the Xenopus embryo as a model, that F-actin assembly is a pr

140 Here, we present the ciliated epidermis of Xenopus embryos as a facile model system for in vivo mol

141 pression of a target gene, engrailed-2, in a Xenopus embryo assay.

142 e expressed in the vegetal hemisphere of the Xenopus embryo at the early gastrula stage.

143 ltraviolet cross-linking assays performed on Xenopus embryos at different stages of neural developmen

144 ulated by Lef1 in the involuting mesoderm of Xenopus embryos at gastrula stages.

145 In Xenopus embryos, Bicc1 binds and represses specific mate

146 In contrast, cell division failure in early Xenopus embryo blastomeres has been attributed to a role

147 but not embryos, and injection of dmos into Xenopus embryos blocks mitosis and elevates active MAPK

148 In Xenopus embryos, body patterning and cell specification

149 RNA is symmetrically expressed in the 1-cell Xenopus embryo but becomes localized during the first tw

150 umulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed e

151 Cv-2 can weakly antagonise BMP4 activity in Xenopus embryos, but that in other in vitro assays Cv-2

152 Inhibition of MASTR function in the Xenopus embryo by using dominant-negative constructions

153 We have studied this process in Xenopus embryos by analyzing the expression of the bHLH

154 We addressed these issues in Xenopus embryos by manipulating the timing and location

155 ray screen for genes that are upregulated in Xenopus embryos by the transcriptional activator protein

156 tudy, geminin was eliminated from developing Xenopus embryos by using antisense techniques.

157 jection of Plx1NA but not Plx1NAWF mRNA into Xenopus embryos caused cleavage arrest and formation of

158 Similarly, depletion of CCDC11 in Xenopus embryos causes defective assembly and motility o

159 Here, we have analyzed when and how Xenopus embryo cells perceive and interpret a BMP signal

160 When injected into Xenopus embryos, CHL2 RNA induced a secondary axis.

161 CRISPR/Cas9-mediated TBX4 deletion in Xenopus embryos confirmed its restricted role during leg

162 we show that addition of recombinant CDC6 to Xenopus embryo cycling extract delays the M-phase entry

163 and dorsal injection of active Jnk mRNA into Xenopus embryos decreases the dorsal marker gene express

164 Xenopus embryos depleted of Lim1 lack anterior head stru

165 In Xenopus embryos, depletion of IQGAP1 reduced Wnt-induced

166 the anterior component of embryonic blood in Xenopus embryos derive from populations of progenitors t

167 o complement TMTC3 rescue of gastrulation in Xenopus embryo development.

168 lication and leads to mild ventralization in Xenopus embryo development.

169 esis in human fetuses, and sox4 knockdown in Xenopus embryos diminishes brain and whole-body size.

170 In Xenopus embryos, disruption of PDGFRalpha signaling caus

171 y morpholino injection) or overexpression in Xenopus embryos disrupts convergent extension, a hallmar

172 In the Xenopus embryo, DRAGON both reduces the threshold of the

173 Here, we show that wounding of one cell in Xenopus embryos elicits Rho GTPase activation around the

174 quadruple knockdown of ADMP and BMP2/4/7 in Xenopus embryos eliminates self-regulation, causing ubiq

175 In Xenopus embryos, ephrinB1 plays a role in retinal progen

176 ressing a non-Geminin-binding Cdt1 mutant in Xenopus embryos exactly reproduces the phenotype of gemi

177 ween the cytoplasm and nucleus both in early Xenopus embryo explants and in living zebrafish embryos,

178 The early Xenopus embryo expresses three maternally inherited Tcf/

179 is similar to phenotypic effects observed in Xenopus embryos expressing activated FGFR1.

180 e bundles from the spinal cord of transgenic Xenopus embryos expressing green fluorescent protein in

181 ity of Sall1 to repress Gbx2 was impaired in Xenopus embryos expressing mutant forms of Sall1 that ar

182 and its ability to cause cardiac defects in Xenopus; embryos expressing Noonan SHP-2 mutations exhib

183 Experiments in Xenopus embryo extracts reveal that changes in cellular

184 In the absence of CASZ1, Xenopus embryos fail to develop a branched and lumenized

185 ally, we analyze mRNA expression patterns in Xenopus embryos for each TACC protein and observe neural

186 nscription factor VegT, is required in early Xenopus embryos for the formation of both the mesoderm a

187 In Xenopus embryos, for example, transcription is believed

188 Xenopus embryos form two distinct kinds of muscle cells

189 in the developing pancreas of both mouse and Xenopus embryos from early specification onward showing

190 ive domain and other related constructs into Xenopus embryos gave identical phenotypes.

191 In Xenopus embryos, Gdf3 misexpression results in secondary

192 The Xenopus embryo has provided key insights into fate speci

193 neurons in the swimming rhythm generator of Xenopus embryos has been studied using pharmacological b

194 ng dissociated nerve and muscle derived from Xenopus embryos have indicated that the properties of tr

195 deo-rate 4D microscopic imaging of a beating Xenopus embryo heart at a rate of 30 volumes/s.

196 BMP activity is upregulated or inhibited in Xenopus embryos hematopoietic precursors are specified p

197 In Xenopus embryos, Hes6 is co-expressed with MyoD in early

198 Similarly, depletion of miR-427 in Xenopus embryos hinders the organizer formation and lead

199 and to visualize long-range signaling in the Xenopus embryo in real time.

200 we have studied neuronal development in the Xenopus embryo in the absence of n1-src, while preservin

201 PCD takes place within the neuroectoderm of Xenopus embryos in a reproducible stereotypic pattern, s

202 ansiently inhibits neural crest migration in Xenopus embryos in a Snail1-dependent manner, indicating

203 an important role for ARF1 and ARF2 in early Xenopus embryos in controlling the convergent extension

204 olarity signaling regulates morphogenesis in Xenopus embryos in part through the assembly of the fibr

205 the regulation of different TCF proteins in Xenopus embryos in vivo.

206 a transcriptomic analysis on gastrula stage Xenopus embryos in which MyoD has been knocked-down.

207 cate that long-range signalling in the early Xenopus embryo, in contrast to some other developmental

208 Cardiogenesis assays in Xenopus embryos indicate that CycD2 enhances the cardiog

209 signaling in cultured mammalian cells and in Xenopus embryos, indicating evolutionary conservation of

210 Microinjection of synthetic xBtg-x mRNA into Xenopus embryos induced axis duplication and completely

211 Expression of LRRFIP2 in Xenopus embryos induced double axis formation and Wnt ta

212 pe but not mutant NEUROG3 messenger RNA into xenopus embryos induced NEUROD1 expression.

213 Finally, CKIepsilon(MM2) expression in Xenopus embryos induces both axis duplication and additi

214 In ectodermal explants from Xenopus embryos, inhibition of BMP signaling is sufficie

215 Xenopus embryos injected with Mat89Bb morpholinos arrest

216 subset of cleavage stage blastomeres in the Xenopus embryo is competent to contribute cells to the r

217 The ectoderm of the Xenopus embryo is permeated by a network of channels tha

218 o and that the phenotype of Geminin-depleted Xenopus embryos is caused by abnormal Cdt1 regulation.

219 Dorsal axis formation in Xenopus embryos is dependent upon asymmetrical localizat

220 we show that early notochord development in Xenopus embryos is regulated by apoptosis.

221 In Xenopus embryos, it was found that Wnts induce epidermis

222 In Xenopus embryos, knockdown of Chd7 or overexpression of

223 In Xenopus embryos, knockdown of Rusc1 or overexpression of

224 While Xenopus embryos lacking endoderm contain aggregates of a

225 teral and ventral mesoderm in gastrula stage Xenopus embryos, leading us to investigate whether it ha

226 pression of a dominant-negative AP-2alpha in Xenopus embryos led to reduced Fmr1 levels.

227 of sustained maternal JNK activity in early Xenopus embryos may provide a timing mechanism for contr

228 When Foxn4 activity is inhibited in Xenopus embryos, MCCs show transient ciliogenesis defect

229 A recent study of myosin-X function in early Xenopus embryo mitosis now reports that this unconventio

230 Furthermore, when expressed in Xenopus embryos, MTG family members inhibited axis forma

231 in the axonal shaft by expressing GFP-EB1 in Xenopus embryo neurons in culture.

232 In Xenopus embryos, Ngd is found in both neural tube and ne

233 In antiSOX3c-injected Xenopus embryos, normal animal-vegetal patterning of mes

234 ating that long-range signaling in the early Xenopus embryo occurs by diffusion rather than by these

235 Knockdown of Balpha in Xenopus embryos or mammalian tissue culture cells suppre

236 In Xenopus embryos, overexpression of sortilin leads to a d

237 In Xenopus embryos, overexpression of the protein causes fa

238 In Xenopus embryos, PACSIN2 is ubiquitously expressed, sugg

239 ltaNp63 by morpholino injection in the early Xenopus embryo potentiates mesoderm formation whereas ec

240 In the Xenopus embryo, Ptk7 functionally interacts with Ror2 to

241 xpression, we demonstrate that in developing Xenopus embryos, RASSF10 shows a very striking pattern i

242 ble to exert long-range effects in the early Xenopus embryo, reinforcing the view that it functions a

243 ulatory wild-type beta-subunit XKCNE1 in the Xenopus embryo resulted in a striking alteration of the

244 isense morpholino mediated PouV knockdown in Xenopus embryos resulted in severe posterior truncations

245 Inhibition of KLF2 function in the Xenopus embryo results in a dramatic reduction in Flk1 t

246 Ablation of the premigratory neural crest in Xenopus embryos results in abnormal formation of the hea

247 Microinjection of Hes6 RNA in vivo in Xenopus embryos results in an expansion of the myotome,

248 Furthermore, Shox2 overexpression in Xenopus embryos results in extensive repression of Nkx2-

249 mal cell fate, whereas knockdown of USP12 in Xenopus embryos results in reduction of a subset of meso

250 Studies in Xenopus embryos revealed that Wise either enhances or in

251 Recent work in Xenopus embryos reveals an unexpected developmental role

252 In Xenopus embryos, Ripk4 synergized with coexpressed Xwnt8

253 In Xenopus embryos, SCP2/Os4 and human SCP1, 2, and 3 cause

254 Examination of global H2Bub1 level in Xenopus embryos shows that H2Bub1 is developmentally reg

255 In Xenopus embryos, Smad4 shows stereotyped, uncorrelated b

256 operties and targets of p2y purinoceptors in Xenopus embryo spinal neurons.

257 re experiments, promoted axis duplication in Xenopus embryos, stimulated low-density lipoprotein rece

258 hat BMP-3 is a dorso-anteriorizing factor in Xenopus embryos that interferes with both activin and BM

259 In Xenopus embryos that lack Shroom2 function, we observed

260 We demonstrate, using Xenopus embryos, that CTGF also regulates signalling thr

261 We conclude that in Xenopus embryos, the BMP pathway is a major physiologica

262 In Xenopus embryos, the cell cycle is driven by an autonomo

263 In Xenopus embryos, the dorso-ventral and antero-posterior

264 In Xenopus embryos, the expression of Pitx2 gene in the lef

265 g dorso-ventral patterning of Drosophila and Xenopus embryos, the formation of the fly wing, and mous

266 Moreover, when injected into Xenopus embryos, the nanocrystal-micelles were stable, n

267 In early Xenopus embryos, the prototypical XFast-1/Smad2/Smad4 co

268 In Xenopus embryos, the three TBP family factors are all es

269 mbryos and in the organizer of Lim1-depleted Xenopus embryos; the latter can be rescued to a consider

270 When applied to Xenopus embryos, this system enables blue light-dependen

271 ) regulate convergent extension movements in Xenopus embryos through the noncanonical Wnt/planar cell

272 /BMP complexes; (6) CV2 depletion causes the Xenopus embryo to become hypersensitive to the anti-BMP

273 Exposure of Xenopus embryos to AChE-inhibiting chemicals results in

274 We developed an assay in Xenopus embryos to analyze regulatory sequences of the z

275 Here we use Xenopus embryos to demonstrate in vivo that Xtsulf1 play

276 hase cyclins and cyclin-dependent kinases in Xenopus embryos to determine their effect on early devel

277 ient for perturbing ciliogenesis, sensitized Xenopus embryos to Hh signaling, leading to phenotypes t

278 Inhibition of myocardin activity in Xenopus embryos using morpholino knockdown methods resul

279 A T-box transcription factor identified in Xenopus embryos, VegT, appears to function near the top

280 In Xenopus embryos, ventral injection of BMPER mRNA results

281 lity of CKI to induce secondary body axes in Xenopus embryos was reduced by the B56 regulatory subuni

282 Using gain-of-function approaches in the Xenopus embryo, we show that myocardin is sufficient to

283 l-defined expression pattern in the brain of Xenopus embryos, we analyzed the methylation status of t

284 isense morpholino based knockdown studies in Xenopus embryos, we demonstrate that endogenous XtSulf1

285 By overexpression assays in Xenopus embryos, we found that both RA and FGF receptor

286 In Xenopus embryos, we have shown that ATP, and its antagon

287 phenotypes were further confirmed in MCCs of Xenopus embryos when CAMSAP3 expression was knocked down

288 t to produce gross phenotypic alterations in Xenopus embryos when overexpressed by mRNA injection.

289 has not demonstrated biological activity in Xenopus embryos when overexpressed by mRNA injection.

290 We took advantage of the Xenopus embryo, which exhibits remarkable capacities to

291 to drive segmental expression in transgenic Xenopus embryos while those from the Xenopus laevis mesp

292 ectopic axes and inhibits head formation in Xenopus embryos, while ectopic HNF3beta inhibits mesoder

293 glutamatergic neurons for the 32-cell stage Xenopus embryo with the goal of determining whether earl

294 the onset of zygotic gene expression in the Xenopus embryo with the translocation of Smicl from cyto

295 Inhibition of endogenous Dlx activity in Xenopus embryos with an EnR-Dlx homeodomain fusion prote

296 Similarly, Xenopus embryos with endogenous TFII-I expression downre

297 show that in gastrula and early-somite stage Xenopus embryos, Wnt/beta-catenin activity must be repre

298 Here we report that in mammalian cells and Xenopus embryos, Wnt/Fz signaling coactivates Rho and Ra

299 In the Xenopus embryo, XProfilin2 is temporally expressed throu

300 Suppressing its expression in Xenopus embryos yields terminally specified neurons with