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1 tions in a large portion of the p arm of the Y chromosome.
2 haplotypes and to resolve major parts of the Y chromosome.
3 cus on isolation and sequencing of the ovine Y chromosome.
4 basis of genetic interactions involving the Y chromosome.
5 the X chromosome and masculinization of the Y chromosome.
6 uman Y Chromosome, but not to the chimpanzee Y Chromosome.
7 res driving the evolution and biology of the Y chromosome.
8 nda, the species with the younger and larger Y chromosome.
9 d Y chromosomes leads to degeneration of the Y chromosome.
10 embly to generate a 15.87 Mb assembly of the Y chromosome.
11 impact can be attributed specifically to the Y chromosome.
12 quences as they are homologous to the bovine Y chromosome.
13 utation accumulation and degeneration of the Y chromosome.
14 fraction of leukocytes have lost the entire Y chromosome.
15 at now form the vast majority of non-African Y chromosomes.
16 anges in the overall genetic architecture of Y chromosomes.
17 equence alignments with human and chimpanzee Y Chromosomes.
18 he hominine (human, chimpanzee, and gorilla) Y Chromosomes.
19 trol strategies based on the manipulation of Y chromosomes.
20 recent or super-archaic origin of Neandertal Y chromosomes.
21 r, show that gene gain is prominent on young Y chromosomes.
22 No such genes were identified on the X and Y chromosomes.
23 ge lifespan is correlated with the number of Y chromosomes.
24 rize pseudoautosomal regions (PARs) of X and Y chromosomes.
25 of 222 Native American and relevant Eurasian Y chromosomes (24 new) from haplogroups Q and C [10], wi
27 nant force shaping gene-content evolution of Y-chromosomes across fly species.While X-chromosome gene
31 studies found an immune regulatory role for Y chromosome and a relationship between loss of Y chromo
32 ltaTsix) (X(DeltaTsix)O) ESCs, excluding the Y chromosome and instead implicating the X-chromosome do
33 is-specific protein Y-encoded (TSPY), on the Y chromosome and its X-homologue, TSPX, are cell cycle r
34 est that if there is common variation on the Y chromosome and mitochondrial DNA associated with behav
35 differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not
36 s study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexu
41 uggest these forces are not exclusive to the Y chromosome, and chromosomal degeneration may have occu
42 due to the presence of a large, repeat-rich Y chromosome, and male flies generally have a shorter av
44 to influence which alleles are linked to the Y chromosome, and some recent empirical evidence in supp
45 described in 2003 as carrying haplogroup DE* Y chromosomes, and analyzing them in the context of a ca
46 me effects estimated across five rare sex (X/Y) chromosome aneuploidy (SCA) syndromes, and (3) clarif
47 ightward inferior frontal asymmetries, while Y-chromosome aneuploidy reversed normative rightward med
50 lies relative to females, and repeats on the Y chromosome are disproportionally mis-expressed during
51 mic scan, we show that gene transfers to the Y chromosome are much more common than previously suspec
52 reviously reported in at least one mammalian Y Chromosome are represented either as active genes or p
55 to investigate this hypothesis, as the X and Y chromosomes are cytologically homomorphic and evolved
58 eir autosomal origins, but most genes on old Y-chromosomes are not simply remnants of genes originall
59 es without bound CENP-B, including the human Y chromosome, are shown to mis-segregate in cells at rat
60 nes often coamplify on recently formed X and Y chromosomes, are testis-expressed, and produce antisen
61 to approximately 50 kya, thus excluding the Y chromosome as providing evidence for recent gene flow
63 ics, except for differential expression of a Y-chromosome associated mRNA transcript, Eif2s3y, and th
67 e paternal X chromosome is shredded and only Y chromosome-bearing sperm are viable, resulting in a ma
68 wn, but it may reflect negative selection of Y chromosome-bearing sperm during spermatogenesis or mal
69 nappreciated epigenetic conflict on evolving Y chromosomes between transcription of essential genes a
70 sis of SCA reveals that supernumerary X- and Y-chromosomes both cause disproportionate reductions in
71 encing, assembly and annotation of the ovine Y chromosome, but also provide a validated approach to o
72 illa Y Chromosome to be similar to the human Y Chromosome, but not to the chimpanzee Y Chromosome.
73 ploid selection should oppose gene loss from Y chromosomes, but recent work on sex chromosomes of two
76 osome, and a first draft assembly of the pig Y Chromosome, by sequencing BAC and fosmid clones from D
78 Our study supports the hypothesis that the Y chromosome can contribute significantly to the evoluti
79 s lends support to the idea that the 'toxic' Y chromosome can create a mutational burden in males whe
81 d gross chromosomal aneuploidy and (2) X and Y chromosomes can exert focal, nonoverlapping and direct
82 The latter inference is in accordance with Y chromosome (chrY) distributions in present day populat
84 We find three evolutionary strata on the Y chromosome, consistent with the three inversions ident
85 hic, we estimate that about one-third of the Y chromosome, containing 568 transcripts and spanning 22
87 ins varied due to: (i) species origin of the Y chromosome (D. simulans or D. sechellia); (ii) locatio
90 Nevertheless, we found limited evidence for Y-chromosome degeneration in terms of gene loss and pseu
91 introduce a novel gene-drive strategy termed Y-CHromosome deletion using Orthogonal Programmable Endo
93 ic relationships of archaic and modern human Y chromosomes differ from the population relationships i
95 Despite their shared ancestry, mammalian Y chromosomes display enormous variation among species i
97 Females are XX, and two slightly different Y chromosomes distinguish males (XY) and hermaphrodites
100 cale survey of autosomal, mitochondrial, and Y chromosome diversity in 4,676 purebred dogs from 161 b
103 whether sexual risk factors and a biomarker (Y chromosome DNA) were associated with genital HPV partn
104 alyze approximately 120 kb of exome-captured Y-chromosome DNA from a Neandertal individual from El Si
105 on interchangeably, thus indicating that the Y chromosome does not harbor loci contributing to hybrid
106 blished the marked influence of both Yand X-/Y-chromosome dosage on total brain volume (TBV) and iden
107 quence can therefore lead to tissue-specific Y-Chromosome-driven sex biases in expression of critical
109 ubgroup largely confined to the inbred mouse Y chromosome.envvariations define three E-MLV subtypes,
110 Our results highlight the dynamic mode of Y chromosome evolution and open avenues for studies of m
113 romosome gene content tends to be conserved, Y-chromosome evolution is dynamic and difficult to recon
116 cated in four variable-sized clusters on the Y chromosome, expressed in male germ cells and possibly
117 This study describes previously unknown Y chromosome-expressed lncRNA regulators of radiation re
121 ional HP1D2 alleles that fail to prepare the Y chromosome for meiosis, thus providing evidence that t
122 e pig Y Chromosome, to compare the pig X and Y Chromosomes for homologous sequences, and thereby to r
123 reference of the male-specific region of the Y chromosome from Illumina short reads and then screened
124 distinguishing binary markers in 1,631 hg N Y chromosomes from a collection of 6,521 samples from 56
131 y the presence of a transgene containing the Y chromosome gene Sry This sex-reversal provided clear e
132 Mutations in Deleted in Azoospermia (DAZ), a Y chromosome gene, are an important cause of human male
133 Here, we analyzed quantitative profiles of Y-Chromosome gene expression across 36 human tissues fro
135 testis, we report many instances of elevated Y-Chromosome gene expression in a nonreproductive tissue
139 istence of functional redundancy between the Y chromosome genes and their homologs encoded on other c
140 in sexual differentiation and reproduction, Y chromosome genes are rarely described because they res
141 uito relative, suggesting rapid evolution of Y chromosome genes in this highly dynamic genus of malar
143 as from female XY mice selectively expressed Y chromosome genes, whereas genes known to escape X inac
145 One individual carried the deeply divergent Y chromosome haplogroup A00, which today is found almost
147 ondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longit
150 ether, our results suggest that the M. annua Y chromosome has at least two evolutionary strata: a sma
153 e find that the presence of a heterospecific Y chromosome has no significant effect on the expression
154 omplete sequence assemblies of heteromorphic Y chromosomes have only been generated across a handful
156 r histocompatibility antigens encoded on the Y chromosome (HY-Abs) develop after hematopoietic cell t
160 t the CRISPR/Cas12a system can eliminate the Y chromosome in embryonic stem cells with high efficienc
161 erous studies have implicated changes in the Y chromosome in male cancers, yet few have investigated
162 HP1D2 accumulates on the heterochromatic Y chromosome in male germ cells, strongly suggesting tha
165 y, the profound degradation of the ancestral Y chromosome in P. picta is counterbalanced by the evolu
166 asing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes
167 basis of the evolutionary divergence of the Y chromosome in the gambiae complex is complicated by co
168 sex-specific chromosomes [1, 2], such as the Y chromosomes in mammals [3] or W chromosomes in birds [
170 o re-investigate their divergence times from Y chromosomes in other continents, including a compariso
174 ferences between Neandertal and modern human Y chromosomes, including potentially damaging changes to
175 ertal lineage as an outgroup to modern human Y chromosomes-including A00, the highly divergent basal
177 have shown that genetic variation within the Y chromosome is associated with cholesterol levels, whic
179 tosomes, they are highly differentiated: the Y chromosome is dramatically smaller than the X and has
182 t spread of recombination suppression on the Y chromosome is fueled by the accumulation of sexually a
184 estor (TMRCA) of Neandertal and modern human Y chromosomes is approximately 588 thousand years ago (k
187 46.49%, indicating the success in the ovine Y chromosome isolation and the high quality of the Y chr
190 Suppression of recombination between X and Y chromosomes leads to degeneration of the Y chromosome.
192 ctions of changes, including testing whether Y chromosome-like regions are undergoing genetic degener
194 at have shaped the vast extent of this major Y chromosome lineage across numerous linguistically and
195 s of genome-wide SNP data [4]; and second, a Y chromosome lineage designated haplogroup C( *), presen
196 rse MSY and showed that various modern horse Y chromosome lineages split much later than the domestic
199 olleagues report a micropeptide encoded by a Y chromosome-linked lncRNA that may explain the higher i
202 gulation of male sexual differentiation by a Y chromosome-linked male determining factor (M-factor) i
205 sive genetic decay has resulted in the human Y chromosome losing 97% of its ancestral genes while gen
206 some cancer-related associations with mosaic Y chromosome loss.See related article by Wu et al., p.
207 lignancy, smoking behavior, telomere length, Y-chromosome loss, and other phenotypic characteristics.
208 hromosome and a relationship between loss of Y chromosome (LOY) in blood cells and a higher risk of c
210 at the Guanches carried common North African Y chromosome markers (E-M81, E-M78, and J-M267) and mito
212 mprising the complete mitochondrial genomes, Y-chromosome markers, and genotypes of a number of nucle
214 ined on both X chromosome heterozygosity and Y chromosome missingness, that consistently demonstrated
215 onducted a comprehensive genomic analysis of Y chromosome, mitochondrial DNA, and whole-genome sequen
222 the genes on the male-specific region of the Y chromosome (MSY) in these processes are uncertain.
223 sessing an identical X chromosome and CNV in Y chromosome multicopy genes exhibit sperm head abnormal
226 increased formation of endothelial cells and Y-chromosome(NEG) CPCs for 12 months and increased forma
228 es mitochondrial (mtDNA) and non-recombining Y chromosome (NRY) haplotypes to eliminate many pedigree
229 super-resolution sequencing, we explore the Y Chromosome of Bos taurus (bull) and find it to be domi
230 as the fertility is partially rescued by the Y chromosome of D. sechellia when it descends from a spe
233 content and structure of the nonrecombining Y chromosome of the primary African malaria mosquito, An
234 owever, we lack comprehensive studies of the Y chromosomes of Denisovans and Neanderthals because the
235 sovans and three Neanderthals shows that the Y chromosomes of Denisovans split around 700 thousand ye
237 sed the ability to differentiate between the Y chromosomes of father-son pairs, and imputed Y-STR gen
239 tegy for sequencing and assembling mammalian Y Chromosomes of sufficient quality for most comparative
240 despite their radically different structure, Y chromosomes of these two species of the gambiae comple
241 negative correlation between the loss of the Y chromosome or linc-SPRY3-2/3/4 and overall survival.
243 s race" (genomic conflict) between the X and Y chromosomes over the control of offspring sex ratio.
247 he unbiased comparison between the mtDNA and Y-chromosome population datasets emphasizes the sex-bias
249 ere phenotypically female; however, 58% were Y chromosome-positive, resembling the phenotype of human
250 romosomes evolved in parallel with mammalian Y chromosomes, preserving ancestral genes through select
252 ing for lactase persistence, blue eye color, Y chromosome R1b haplotypes, and the hemochromatosis C28
254 results indicated that 68.90% of reads were Y chromosome-related sequences as they are homologous to
255 theme that promises to broaden the reach of Y-chromosome research by shedding light on fundamental s
258 events, most likely inversions, reduced the Y chromosome's ability to recombine with the X chromosom
259 gins to emerge from recent insights into the Y chromosome's roles beyond the reproductive tract--a th
260 ects male genealogies, but the extremely low Y chromosome sequence diversity in horses has prevented
261 over, we have utilized the assembled gorilla Y Chromosome sequence to design genetic markers for stud
265 by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model
268 explored by testing the hypothesis that the Y chromosome serves as a carrier of the exposure impact
269 ce recombination is halted between the X and Y chromosomes, sex chromosomes begin to differentiate an
270 h demand for forensic pedigree searches with Y-chromosome short tandem repeat (Y-STR) profiling in la
271 fferential replication licensing or X versus Y chromosome size, but rather to 'maleness'-XX embryos c
273 ncing data to estimate the mutation rates of Y chromosome STRs (Y-STRs) with 2-6 bp repeat units that
274 he GUY1 protein is a primary signal from the Y chromosome that affects embryonic development in a sex
275 his hypothesis implies that a male who has a Y chromosome that is from a male that was exposed to an
277 teractions between the species origin of the Y chromosome, the identity of the D. mauritiana segment
278 programmable endonuclease that 'shreds' the Y chromosome, thereby converting XY males into fertile X
279 ly between species, revealing the Drosophila Y chromosome to be more dynamic than previously apprecia
281 genes limiting malaria transmission, driving-Y chromosomes to collapse a mosquito population, and gen
282 Here, we sequence 13 Aboriginal Australian Y chromosomes to re-investigate their divergence times f
283 address the contribution of 'heterospecific Y chromosomes' to fertility in hybrid males carrying a h
284 --both single copy and amplified--on the pig Y Chromosome, to compare the pig X and Y Chromosomes for
285 may also occur, both on the non-recombining Y chromosome, to shut down expression of maladapted gene
287 n the basis of 94 high-coverage re-sequenced Y chromosomes, we establish and date a detailed hg N phy
289 nic activation of RBMY (RNA-binding motif on Y chromosome), which is absent in normal hepatocytes but
290 variation of the P8 palindrome on the human Y chromosome, which contains two copies of the VCY (Vari
291 cytogenetic similarity to DFT1 and carries a Y chromosome, which contrasts with the female origin of
292 eespine stickleback (Gasterosteus aculeatus) Y chromosome, which is less than 26 million years old an
293 eage shared by Neanderthals and modern human Y chromosomes, which diverged from each other around 370
294 encing of sex-linked genes on both the X and Y chromosomes, which is a requirement of all current met
298 IV, and Crus I volumes with additional X- or Y-chromosomes; X-specific contraction of Crus II-lobule
299 ice harboring a Mus musculus domesticus-type Y chromosome (Y (POS) ), known as B6.Y (POS) mice, commo