ライフサイエンスコーパス: Y-linked gene

1 ively recent, loss of at least one conserved Y-linked gene.

2 Y-linked gene, or to a deletion of a single Y-linked gene.

3 an adaptation to the decay of a homologous, Y-linked gene.

4 attern of X-linked genes < autosomal genes < Y-linked genes.

5 sition must be the main source of Drosophila Y-linked genes.

6 d re-probed with a range of different X- and Y-linked genes.

7 this species missed unexpressed, degenerate Y-linked genes.

8 ility is sensitive to the dosage of relevant Y-linked genes.

9 e of an intragenomic conflict between X- and Y-linked genes.

10 during spermatogenesis in the mouse of three Y-linked genes, 11 X-linked genes and 22 autosomal genes

11 f the early stages of the establishment of a Y-linked gene and demonstrates how the Drosophila Y has

12 somes has led to loss and differentiation of Y-linked genes and haplo-insufficiency for X-linked gene

13 Thus, if they invade Y-linked genes and selection against their insertion is

14 e latifolia, this largely involved losses of Y-linked genes, and not suppressed expression of Y-linke

15 e loss and pseudogenization, and most X- and Y-linked genes appear to have diverged in the period sub

16 Most Y-linked genes are expressed during spermatogenesis, and

17 sex-linked genes, and it is unclear whether Y-linked genes are losing full function.

18 About one-third of all neo-Y-linked genes are nonfunctional, containing either prem

19 This revealed that 45% of Y-linked genes are not expressed, and 23% are interrupte

20 runs counter to this hypothesis, most unique Y-linked genes are not situated in palindromes and have

21 ed the sex, or XY, body, within which X- and Y-linked genes are transcriptionally repressed.

22 e assessed mRNA expression in brain of eight Y-linked genes as well as their X-linked homologues, at

23 ducible across cohorts and identified X- and Y-linked genes, as well as those involved in dosage comp

24 g of genes precede and expedite the decay of Y-linked genes at the amino acid level?

25 from the rest of the genome, with only seven Y-linked genes being gained over the past 63 million yea

26 herians, which also possessed a very similar Y-linked gene; both characteristics were retained in mos

27 emonstrates a molecular mechanism by which a Y-linked gene can evolve male-beneficial effects.

28 This is the first study demonstrating that Y-linked genes can exclusively impact Valpha14i NK T dev

29 Because they lack recombination, Y-linked genes cannot be mapped genetically, leaving phy

30 Despite almost no overlap in Y-linked gene content in different species with independ

31 The Y-linked gene DDX3Y and its X-linked homolog DDX3X survi

32 lain why plants retain hundreds of expressed Y-linked genes despite millions of years of Y chromosome

33 of these validated hiPSC lines to test how X/Y-linked gene dosage impacts a widely used model for hum

34 The coupling of Y-linked gene duplication and gene conversion between pa

35 ted by the observation that, among primates, Y-linked genes evolved more rapidly than homologous X-li

36 repetitive DNA composition and discover new Y-linked gene families whose evolution is driven by both

37 nsistent with competition between the X- and Y-linked gene families.

38 t manner, consistent with previously defined Y-linked gene functions.

39 ([Formula: see text] = 0.926), while X- and Y-linked genes further contributed to the male V(A) and

40 n mammalian lineages where the corresponding Y-linked gene has been lost.

41 Selection on several Y-linked genes has contributed to the evolution of male

42 Most of the Y-linked genes have autosomal paralogs, so autosome-to-Y

43 ndently formed sex-chromosomes, we find that Y-linked genes have evolved convergent gene functions as

44 gence in both systems, we find evidence that Y-linked genes have started to undergo gene loss, causin

45 een in mammalian sex chromosomes, where most Y-linked genes have X-linked homologs, the Drosophila X

46 cific nucleotide variation associated with a Y-linked gene in five members of the Drosophila melanoga

47 htrog use a subtraction pipeline to identify Y-linked genes in 22 Diptera species, revealing patterns

48 uncover rapid and extensive degeneration of Y-linked genes in a plant species, Silene latifolia, tha

49 cally comparing the DNA sequences of unique, Y-linked genes in chimpanzee and human, which diverged a

50 R targeted at male spermatozoa, we show that Y-linked genes in female mosquitoes are exclusively foun

51 the male-specific X, expression of ancestral Y-linked genes in females, and X inactivation of the mal

52 ate that the rate of genetic degeneration of Y-linked genes in S. latifolia is as fast as in animals,

53 lar to what has been found for several other Y-linked genes in S. latifolia, and consistent with the

54 We also find rapid divergence among Y-linked genes, including copy number variation and rece

55 transcriptional inactivation of degenerating Y linked genes is an accidental by-product of mutation a

56 e longer-term estimate, the fate of most new Y-linked genes is defined by rapid degeneration and pseu

57 more, the rate of synonymous substitution in Y-linked genes is not significantly different from that

58 Loss of functional Y-linked genes is partly compensated for by gene-specifi

59 ty on the Y chromosome, and complete loss of Y-linked genes is possible if autosomal genes take over

60 dies have demonstrated that the diversity of Y-linked genes is substantially lower than that of their

61 Thus, Y-linked gene loss emerges as an additional driver of ge

62 Rescue of Y-linked gene loss through transposition to autosomes ha

63 miranda, which show the expected pattern of Y-linked genes < X-linked genes < autosomal genes; papay

64 anean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small

65 polymorphisms (SNPs), we identify three new Y-linked genes, one being duplicated on the Y chromosome

66 ure has been traced to a point mutation in a Y-linked gene, or to a deletion of a single Y-linked gen

67 is asynapsis triggers inactivation of X- and Y-linked genes, or meiotic sex chromosome inactivation (

68 nd divergence in a recently described X- and Y-linked gene pair (SLX-1 and SLY-1) of the plant Silene

69 Y-linked genes show faster accumulation of amino-acid re

70 ed dogma of mammalian sex determination, the Y-linked gene SRY initiates male development by inducing

71 mmalian sex determination, expression of the Y-linked gene Sry shifts the bipotential gonad toward a

72 For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli ce

73 mammalian gonad requires the expression of a Y-linked gene, Sry, during a brief window of time to ens

74 geted gene disruptions and insertions in two Y-linked genes--Sry and Uty.

75 2004 used Northern blotting to show that the Y-linked genes Ssty1 and Ssty2 have reduced expression i

76 Our results show that a Y-linked gene that does not differ among the tested stra

77 stages, we identified a small repertoire of Y-linked genes that lack X gametologs and are not Y-link

78 Amongst Y-linked genes that were downregulated due to LOY, KDM5D

79 Our results show that Y-linked gene traffic, and the molecular mechanisms gove

80 method provides a powerful means to identify Y-linked gene transfers and will help illuminate the evo

81 Despite all Y-linked gene transfers being evolutionarily recent (<1

82 In this species, many Y-linked genes were rescued by transposition to new geno

83 ound limited variation in the copy number of Y-linked genes, which raises the possibility of selectiv

84 Previous work showed that Y-linked genes Zfy1 and Zfy2 act as 'executioners' for t