ライフサイエンスコーパス: a highly conserved

1 Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phospho

2 sphate isomerase (TIM) barrel structure with a highly conserved active site.

3 Therefore, a highly conserved activity of lentiviral Nef proteins h

4 itry initiated by the IL1B regulator induces a highly conserved acute phase response in each organ as

5 Fear, which represents a highly conserved adaptive response to threatening envi

6 We identified a highly conserved ADAR dimerization interface and valid

7 Expression of a highly conserved, alkaline-regulated, sodium ATPase wa

8 actamase (MBL) superfamily of enzymes harbor a highly conserved alphabetabetaalpha MBL-fold domain an

9 The missense mutation affects a highly conserved amino acid and is predicted to severe

10 The Thr518Met mutation altered a highly conserved amino acid in the MYRF protein and th

11 a damaging mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of t

12 The identified mutation affects a highly conserved amino acid residue in the zinc finger

13 d with the disease in the pedigree, affected a highly conserved amino acid residue, and was predicted

14 We identified 66Y (N1 numbering), a highly conserved amino acid that was critical for the

15 We identify a highly conserved amino acid, Gly449, that is necessary

16 The mutation is situated in a highly conserved and critically important region of WI

17 Sleep is a highly conserved and essential behaviour in many speci

18 TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding pr

19 Arginine finger is a highly conserved and essential residue in many GTPase

20 Epithelial-mesenchymal transition (EMT) is a highly conserved and fundamental process in developmen

21 CK2 is a highly conserved and pleiotropic serine/threonine kina

22 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway

23 ere we describe a molecular switch involving a highly conserved anion binding site in CK1.

24 Membrane Protein Palmitoylated 5 (MPP5) is a highly conserved apical complex protein essential for

25 action between Par-3's second PDZ domain and a highly conserved aPKC PDZ-binding motif (PBM) that is

26 The Src homology 2 (SH2) domain has a highly conserved architecture that recognizes linear p

27 Here, we show that a highly conserved arginine residue in the C-terminal do

28 Here, we report that a highly conserved aromatic triad of three amino acids,

29 mammals and fungi because it capitalizes on a highly conserved Asp-Ser-Leu-Asp amino acid sequence i

30 ltransferase that mediates the conversion of a highly conserved aspartate residue in a cyclic substra

31 s NRRL B-3009 catalyzes the rearrangement of a highly conserved aspartate residue to a beta-amino aci

32 binding site had been ablated by deletion of a highly conserved aspartic acid at position 385, which,

33 pproaches identified Asp93, which is part of a highly conserved AspGlu dyad found in all dual domain

34 One Tn7 integration pathways recognizes a highly conserved attachment (att) site in the chromoso

35 YbeY is a highly conserved bacterial RNase that has been implica

36 The FtsZ protein is a highly conserved bacterial tubulin homolog.

37 a rare heterozygous missense variant within a highly conserved beta-integrin-binding domain of TLN1

38 We have identified a highly conserved binding site of miR-124 in the 3'-unt

39 Epibatidine shares a highly conserved binding site with acetylcholine, maki

40 while the A-type PfEMP1 bind ICAM-1 through a highly conserved binding surface, the BC-type PfEMP1 u

41 tions of the lateral hypothalamic area (LHA)-a highly conserved brain region that orchestrates feedin

42 n present in mitochondrial Cbp3 homologs and a highly conserved C-terminal domain comprising a ubiqui

43 d intrinsically disordered linker (IDL), and a highly conserved C-terminal peptide (CTP) motif that m

44 are present only in angiosperms and possess a highly conserved C-terminal region containing linear m

45 We identify a highly conserved C-terminal TBP-interaction domain (CT

46 the alphaB and betaB structural elements and a highly conserved carboxylate-binding loop.

47 s of penicillin are a family of enzymes with a highly conserved catalytic activity involved in the fi

48 RNase E consists of a highly conserved catalytic domain and a variable non-c

49 imal functional region of HBx and identified a highly conserved CCCH motif in HBx that is likely resp

50 is scenario describes the activation of ERK, a highly conserved cell-signaling enzyme.

51 ying Treg function through the modulation of a highly conserved, cell-intrinsic metabolic pathway.

52 t a post-attachment step by interacting with a highly conserved central alpha helix-rich domain.

53 cells in the colitis response and shows how a highly conserved chromatin remodeling factor has a dis

54 DEK is a highly conserved chromatin-bound protein whose upregul

55 Acyl carrier protein (ACP) is a highly conserved cofactor protein that is required by

56 Mre11-Rad50-Xrs2 (MRX) is a highly conserved complex with key roles in various asp

57 of commensal fungi are mediated by mannans, a highly conserved component of fungal cell walls, since

58 The N-end rule pathway is a highly conserved constituent of the ubiquitin proteaso

59 re, we provide evidence for the existence of a highly conserved, continuous, PC-specific epitope sequ

60 ovel missense mutation Cys694Arg that alters a highly conserved cysteine in the RING domain.

61 The p.Cys1691Ser substitution affects a highly conserved cysteine residue and is predicted by

62 infections.IMPORTANCE Arenavirus NPs contain a highly conserved DEDDh ExoN motif, through which LASV

63 Autophagy is a highly conserved degradation process that is involved

64 We have identified a highly conserved DNA methyltransferase, which we term

65 FANCM is a highly conserved DNA remodeling enzyme that promotes t

66 sual case in which an equivalent mutation in a highly conserved domain of yeast and mammalian Erks ca

67 efining feature of EAG (Kv10-12) channels is a highly conserved domain on the N terminus, known as th

68 ork mapped the immunosuppressive activity to a highly conserved domain, termed the immunosuppressive

69 MDA-9/Syntenin, a highly conserved double-PDZ domain-containing scaffold

70 Lissencephaly-1 (LIS1) is a highly conserved dynein-regulatory factor that binds d

71 CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1) is a highly conserved E3 ubiquitin ligase from plants to an

72 pressed hemicentin-1 (hmcn-1), which encodes a highly conserved ECM glycoprotein, results in ectopic

73 We further show that a highly conserved eight-base-pair segment of SL3 is not

74 ating C1C2-specific MAb showed that it bound a highly conserved Env gp120 epitope.

75 Poly (ADP-ribose) polymerase-1 (PARP1) is a highly conserved enzyme focused on the self-repair of

76 It binds to a highly conserved epitope in antigenic site IV of the R

77 Monoclonal antibody (mAb) 10E8 recognizes a highly conserved epitope on HIV and is capable of neut

78 COVA1-16 binds a highly conserved epitope on the SARS-CoV-2 RBD, mainly

79 We use an mAb to protect a highly conserved epitope on the stem domain of HA.

80 CR3022 targets a highly conserved epitope, distal from the receptor bin

81 g and transgenic approaches demonstrate that a highly conserved ERG-bound enhancer located upstream o

82 The bacterial cell wall is a highly conserved essential component of most bacterial

83 losis (Mtb) fumarate hydratase (fumarase) is a highly conserved essential protein that shares an acti

84 nesis, we show that three amino acids within a highly conserved esterase domain in putative PMR5 orth

85 on proteins Hop2 and Mnd1, which are part of a highly conserved eukaryotic protein complex that parti

86 Arenavirus nucleoproteins (NPs) contain a highly conserved exoribonuclease (ExoN) motif, through

87 d from isoforms LRRC8C and LRRC8E to uncover a highly conserved extracellular region preceding the se

88 clamp loader clade, RarA protein is part of a highly conserved family of DNA metabolism proteins.

89 We and others identified a highly conserved family of sterol transport proteins (

90 division and sporulation (SEDS) proteins are a highly conserved family of transmembrane glycosyltrans

91 The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how

92 A highly conserved FLV motif was identified in the C-ter

93 tRNA 2-thiolation is a highly conserved form of tRNA modification among livin

94 me gnathostomes, all three lamprey Pax6 have a highly conserved full-length paired domain.

95 Corollary discharge is a highly conserved function of motor systems throughout

96 CD4 downregulation on infected cells is a highly conserved function of primate lentiviruses.

97 ss multiple papillomavirus types, indicating a highly conserved function within the L2 protein and th

98 ther, our results demonstrate that IFT88 has a highly conserved function within the primary cilia of

99 olymerases (PARPs) promote ADP-ribosylation, a highly conserved, fundamental posttranslational modifi

100 Trace amine-associated receptor 1 (TAAR1) is a highly conserved G-protein-coupled receptor bound by e

101 KCNQ5 is a highly conserved gene encoding an important channel fo

102 -related oncogene; also known as DCUN1D1) is a highly conserved gene that functions as an E3 in neddy

103 We have now identified a highly conserved glutamate residue in the transmembran

104 bstitutions (p.Glu117Val and p.Glu117Gly) at a highly conserved glutamic acid residue located in the

105 llular form of the prion protein (PrP(C)) is a highly conserved glycoprotein mostly expressed in the

106 DNA ligases are a highly conserved group of nucleic acid enzymes that pl

107 rming growth factor beta (TGFbeta) family is a highly conserved group of proteins with roles in cellu

108 RAS GTPase is a highly conserved GTP-binding protein with crucial func

109 PEP87 corresponds to a highly conserved helical region of the HA2 subunit of

110 ria, repair of DNA double-strand breaks uses a highly conserved helicase-nuclease complex to unwind D

111 The mutant protein lacks a highly conserved helix consisting of the C-terminal fo

112 the conformation of the heme and changes in a highly conserved helix I motif that is associated with

113 yzed to date, serine palmitoyltransferase is a highly conserved heterodimeric enzyme complex.

114 r Anopheles mosquitoes, which is detected by a highly conserved heteromeric receptor consisting of th

115 or the periplasm of bacteria is mediated by a highly conserved heterotrimeric membrane protein compl

116 ay mechanism postulates proton transfer from a highly conserved histidine centrally positioned in the

117 nally, all types of neurons are specified in a highly conserved histogenic order, although its signif

118 Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the

119 H2A.Z is a highly conserved histone variant of the canonical hist

120 esidues adjacent to Asn-110 and Asn-137 form a highly conserved hydrophobic cleft interacting with th

121 Our data reveal that splicing has a highly conserved impact on the availability of sodium

122 rt that overexpression of an operon encoding a highly conserved inorganic phosphate importer, PstSCAB

123 Notch signaling is a highly conserved intercellular pathway with tightly re

124 This variant lies within a highly conserved interface required for protein homodi

125 Autophagy is a highly conserved intracellular clearance pathway in wh

126 may be functionally redundant, as they share a highly conserved kinase domain.

127 s of mechanistic target of rapamycin (mTOR), a highly conserved kinase within a nutrient-sensing path

128 Our analysis revealed that a highly conserved layer of threonine residues in the po

129 n interaction of the leucine in helix 8 with a highly conserved leucine in helix 1 that stabilizes th

130 Vps13 is a highly conserved lipid transfer protein found at multi

131 Autophagy is a highly conserved lysosomal degradation pathway, which

132 nonstructural protein 3 (nsP3) that contains a highly conserved MacroD-type macrodomain at the N term

133 AMPK is a highly conserved master regulator of metabolism, which

134 Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct

135 factor (SRF)-mediated gene transcription is a highly conserved mechanism that connects dynamic reorg

136 SRC3, a highly conserved member of the steroid receptor coacti

137 UNC-45A is a highly conserved member of the UNC-45/CRO1/She4p famil

138 ut small RNA sequencing to identify miR-204, a highly conserved microRNA dramatically enriched in lym

139 nuclear receptor and major drug target, has a highly conserved minor splice variant, GRgamma, which

140 Hsp70 is a highly conserved molecular chaperone critical for the

141 Hsp90 is a highly conserved molecular chaperone important for the

142 Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone involved in ATP-d

143 In this study, we found that HSP90, a highly conserved molecular chaperone, is overexpressed

144 we found that the N-terminal 24RRR26 of Cap, a highly conserved motif among circovirus species, was r

145 Here, we identified a highly conserved motif near the C-terminal region of t

146 ccurs through crossed surround inhibition is a highly conserved motif of transcallosal interactions i

147 The retromer is a highly conserved multimeric protein complex present in

148 The target of rapamycin complex 1 (TORC1) is a highly conserved multiprotein complex that functions i

149 Molybdenum cofactor (Moco) biosynthesis is a highly conserved multistep pathway.

150 d by removal of the GPI-modification signal, a highly conserved N-glycan or the deletion of predicted

151 A highly conserved N-linked glycan within the IgG-Fc tai

152 Phylogenetic analysis suggests a highly conserved nature of the INH2 gene.

153 The proteostasis network is a highly conserved network of cellular stress responses

154 PAR proteins constitute a highly conserved network of scaffolding proteins, adap

155 mediated by the hypothalamic-pituitary axis, a highly conserved neurohormonal cascade that culminates

156 rates thyrotropin-releasing hormone (TRH) is a highly conserved neuropeptide that exerts the hormonal

157 Interestingly, this regulation required a highly conserved NF-kappaB-binding site but not a pred

158 In this study, we show that a highly conserved NFAT binding site within the distal n

159 Heterochromatin protein 1 (HP1), a highly conserved non-histone chromosomal protein in eu

160 DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility

161 MHC-E is a highly conserved nonclassical MHC class Ib molecule th

162 ajor histocompatibility complex E (MHC-E) is a highly conserved nonclassical MHC-Ib molecule that tig

163 f-function mutations in NR2F1, which encodes a highly conserved nuclear receptor that serves as a tra

164 WDR5 is a highly-conserved nuclear protein that performs multipl

165 Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible vi

166 The primary cilium is a highly conserved organelle housing specialized molecul

167 Gpr27 is a highly conserved, orphan G protein coupled receptor (G

168 Mammalian Ecdysoneless (ECD) is a highly conserved ortholog of the DrosophilaEcd gene pr

169 eport the identity of swip-13, which encodes a highly conserved ortholog of the human atypical MAP ki

170 hey show that the Galpha C-terminus binds to a highly-conserved patch on the concave surface of the R

171 Notch signaling is a highly conserved pathway pivotal to T-cell differentia

172 Nucleotide excision repair (NER) is a highly conserved pathway that removes helix-distorting

173 e shared across diverse cell types including a highly conserved peak at the Csf-1 gene promoter.

174 This uORF encodes a highly conserved peptide (CPuORF) that is present in v

175 independent of GTP hydrolysis and located in a highly conserved peptide of 18 amino acids (termed D-o

176 We found a highly conserved peptide sequence motif for HLA-C*05:0

177 acterized by low cell-surface expression and a highly conserved peptide-binding cleft.

178 Using a proteomic screen, we identified a highly conserved phospho-acceptor site on the HPV-16 a

179 Intriguingly, a highly conserved phosphomimetic RxEP motif in NS3 was

180 Dorso-ventral (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates.

181 Each of these proteins has a highly conserved primary activity; however, numerous a

182 ur Zn(2+) binding sites within each subunit: a highly conserved primary site in transmembrane domain

183 iruses interface with the autophagy pathway, a highly conserved process for recycling cellular compon

184 We found that a highly conserved proline in the CMGC insert of the DYR

185 segregated with the disease and substitutes a highly conserved proline residue with leucine (p.P72L)

186 n, and that the terminal web in turn retains a highly conserved protein (EXC-9/CRIP1) that regulates

187 cinate dehydrogenase complex (complex II) is a highly conserved protein complex composed of the SDH1

188 The exocyst is a highly conserved protein complex found in most eukaryo

189 SMC5/6 is a highly conserved protein complex related to cohesin an

190 In elongation factor G (EF-G), a highly conserved protein composed of 5 domains, the 2

191 This design is a demonstration that a highly conserved protein fold is not uniquely necessar

192 ationally controlled tumor protein (TCTP) is a highly conserved protein functioning in multiple cellu

193 conclusion, we have demonstrated that CAPG, a highly conserved protein in eutherian mammals, elicits

194 s an ABCB1 auxin transporter and Dw1 encodes a highly conserved protein involved in the regulation of

195 Rad52 is a highly conserved protein involved in the repair of DNA

196 XPhi uses an infection strategy that targets a highly conserved protein of Gram-negative bacteria ess

197 Scribble is a highly conserved protein regulator of cell polarity th

198 NS1 is a highly conserved protein secreted at high concentratio

199 id of secretome phage display, we identified a highly conserved protein that specifically binds and i

200 PHB1 is a highly conserved protein with diverse functions that d

201 P47Rec is a highly conserved protein with submicrovillar localizat

202 MIM), or Metastasis Suppressor 1 (MTSS1), is a highly conserved protein, which links the plasma membr

203 Here, we identify a highly conserved protein-interaction surface in MDC1 t

204 tasis-associated stroma was characterized by a highly conserved proteomic signature, prominently incl

205 pocampus.Finally, we confirm that Lhx2 binds a highly conserved putative enhancer of Dmrt5, suggestin

206 of Haemophilus influenzae LpoA (HiLpoA) has a highly conserved, putative substrate-binding cleft bet

207 lyzed by O-acetylserine sulfydrylase (OASS), a highly conserved pyridoxal 5'-phosphate (PLP)-dependen

208 Autophagy is a highly conserved recycling pathway that promotes cell

209 associated (CA) HIV-1 DNA and RNA, targeting a highly conserved region in HIV-1pol, with sensitivitie

210 In this study, a highly conserved region in the N terminus of FMDV caps

211 ipitation, we demonstrate that SOX3 binds to a highly conserved region in the Ngn3 promoter region in

212 n residues M10-I17, which is included within a highly conserved region near the N-terminal.

213 inkage at multiple sites near the D1 domain, a highly conserved region of bacterial flagellins that i

214 icroRNA, miR-30, with three binding sites in a highly conserved region of its 3' UTR, operates as rep

215 tional CD4-restricted T-cell epitopes within a highly conserved region of membrane protein, which ind

216 phorylation of a single tyrosine (p*Y504) in a highly conserved region of the fibronectin type III (F

217 A RNA interference construct, designed to a highly conserved region of these genes, was used to tr

218 virtually unstudied despite being located in a highly conserved region proximal to the proteolytic si

219 The antibody binds to RSV G at a highly conserved region stabilized by two disulfide bo

220 ant, which carries two amino acid changes to a highly conserved region, yields a dominant-negative ph

221 gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lip

222 Gle1 is a highly conserved regulator of RNA-dependent DEAD-box A

223 gnal sequence of the bacterial protein MgrB, a highly conserved regulator of virulence and antibiotic

224 nalysis and cell culture studies to identify a highly conserved regulatory mechanism linking anxiety

225 ar, the p.Thr270Ala missense variant affects a highly conserved residue in the DBL homology domain, w

226 C479 is a highly conserved residue in the extracellular domain o

227 I109 is a highly conserved residue in the forkhead box (Fox) dom

228 A missense mutation in a highly conserved residue in the RacGEF domain results

229 persistent PKD1 phosphorylation at Ser(203), a highly conserved residue located within the PKD1 N-ter

230 dentified a single novel missense variant in a highly conserved residue of FLNC (filamin C; p.V2297M)

231 mouse model with an RNase H2 AGS mutation in a highly conserved residue of the catalytic subunit, Rna

232 ression, while the missense variant affected a highly conserved residue of the homeobox domain, was c

233 robe to establish that Cys306 of yeast Gpd1, a highly conserved residue within the active site, is th

234 The mutation is at a highly conserved residue within the DNA binding domain

235 we found that Lin28 (also known as Lin28A), a highly conserved RNA-binding protein, is associated wi

236 rkably simple genome of ~3 kb, encoding only a highly conserved RNA-dependent RNA polymerase (RdRp).

237 cribe the identification of translin (trsn), a highly conserved RNA/DNA binding protein, as essential

238 One of these subclades plays a highly conserved role in cell division, while the dist

239 tion in zebrafish cloche mutants, indicating a highly conserved role in vertebrate vasculogenesis and

240 The superior colliculus (SC) plays a highly conserved role in visual processing and mediate

241 tural accessions of this species, indicating a highly conserved role of this protein in controlling o

242 o CENP-A assembly-by binding to CENP-C using a highly conserved SANTA domain.

243 tor kinase LegK7 which phosphorylates MOB1A, a highly conserved scaffold protein of the Hippo pathway

244 Autophagy is a highly conserved self-degradative process that has a k

245 at a single amino acid change (Arg135Gly) in a highly conserved sensor kinase (LiaS) of a poorly defi

246 The hybrid histidine kinase 3 (HHK3) is a highly conserved sensor kinase in fungi that regulates

247 sp/Glu-rich hypervariable region followed by a highly conserved sequence comprising two potential HXH

248 A cross-species analysis identifies a highly conserved sequence element in LINC-PINT that is

249 A highly conserved sequence motif on helix I contributes

250 Phosphorylation of a highly conserved serine cluster in the intracellular d

251 A highly conserved serine located at position 375 in gro

252 ng identified a germline mutation (S631G) at a highly conserved serine residue in the uncharacterized

253 Mechanistic target of rapamycin (MTOR) is a highly conserved serine/threonine kinase that critical

254 A highly conserved set of approximately 1,000 proteins i

255 Eukaryotes use a highly conserved set of drug efflux transporters that

256 Granzyme B cleaves a highly conserved set of proteins in all three bacteria

257 The Hedgehog (Hh) pathway is a highly conserved signaling cascade crucial for cell fa

258 l-related kinase 1 and 2 (ERK1/2) pathway is a highly conserved signaling cascade with numerous essen

259 Small GTP-binding proteins represent a highly conserved signaling module in eukaryotes that r

260 ble for substrate association, by binding to a highly conserved site at the interface between the two

261 1, one of the five core COPII components, is a highly conserved small GTPase, which, upon GTP binding

262 ious GAS M-Prts have shown that they contain a highly conserved sortase A-dependent cell wall-anchore

263 A highly conserved Sox2/Pax6 bound site near the Sprouty

264 A highly conserved SOX9-binding enhancer located in intr

265 Maresin 1 (MaR1) is a highly conserved specialized proresolving mediator (SP

266 Exogenous administration of MaR1, a highly conserved SPM, propagated inflammatory resoluti

267 amine and N-acetylmuramic acid appended with a highly conserved stem peptide.

268 ent at the equator of the mitotic spindle is a highly conserved step during cell division; however, i

269 opeptide Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in

270 we exchanged selected amino acid residues in a highly conserved stretch within the regulatory region

271 ractions networks (PPINs) are known to share a highly conserved structure across all organisms.

272 This is a highly conserved structure and the target of numerous

273 The synaptonemal complex (SC), a highly conserved structure built between homologous me

274 possess a distinct architecture and comprise a highly conserved subfamily among fungal species.

275 e fine specificity is strongly influenced by a highly conserved substitution that regulates receptor

276 The mammalian Csf1r locus contains a highly conserved super-enhancer, the fms-intronic regu

277 The RSV F protein is a highly conserved surface glycoprotein and is the main

278 hat the RVC20 binding determinants reside in a highly conserved surface of G, rationalizing its broad

279 n PHF5A demonstrating that Y36 is located on a highly conserved surface.

280 A highly conserved threonine near the C terminus of gp12

281 We previously showed that the exocyst, a highly conserved trafficking complex, is necessary for

282 a subunit of the THO complex that is part of a highly conserved transcription and export complex know

283 Dmrt1 is a highly conserved transcription factor, which is critic

284 Capicua (CIC) is a highly conserved transcriptional repressor that is dif

285 h results from cis/trans isomerization about a highly conserved Trp-Pro imide bond in a region of the

286 disrupting the putative interaction between a highly conserved Trp/Glu residue pair in the lower por

287 of an N-terminal signal sequence containing a highly conserved twin-arginine motif.

288 200 eukaryotic-like proteins is paired with a highly conserved type IV secretion system (T4SS).

289 we identify Abl-mediated phosphorylation of a highly conserved Tyr residue in the P + 1 loop of prot

290 0 is markedly enhanced by phosphorylation of a highly conserved tyrosine (Y313 in Hsp90alpha) in the

291 l potential phosphorylation sites, including a highly conserved tyrosine residue (Y382), into alanine

292 COP1 is a highly conserved ubiquitin ligase that regulates diver

293 Autophagy-related protein 8 (ATG8) is a highly conserved ubiquitin-like protein that modulates

294 Calreticulin is a highly conserved, ubiquitous Ca(2+)-buffering protein

295 gellar-associated polypeptide (FAP)57/WDR65, a highly conserved WD repeat, coiled coil domain protein

296 WDR92 is a highly conserved WD-repeat protein that has been propo

297 ceptor class A domain-containing 3 (LDLRAD3)-a highly conserved yet poorly characterized member of th

298 ndently many times within the genus and that a highly conserved yet versatile T4SS secretes an except

299 A highly conserved zinc finger transcription factor, Mot

300 y of the Vpx- or Vpr-CRL4 E3 ligase requires a highly conserved zinc-binding motif.