ライフサイエンスコーパス: aberrant

1 While the most of aberrant 3'-splice patterns were explained by SF3B1 muta

2 DIS3L2 loss, sustained 3'-end uridylation of aberrant 7SL RNA impacts ER-targeted translation and cau

3 Although B cell disorders and the aberrant Ab production are the leading extrahepatic mani

4 y-fueled disorders result, in part, from the aberrant accumulation of harmful lipid metabolites in ti

5 ved from patient fibroblasts accelerates the aberrant accumulation of this pathological hallmark shar

6 Thus, aberrant activation and dysregulation of CD8+ T cells oc

7 crobial infection and tissue damage, but its aberrant activation can lead to autoinflammatory disease

8 Finally, wediscuss how aberrant activation of antioxidant programs by the trans

9 We find aberrant activation of early B cell factor 1 (EBF1) to p

10 Aberrant activation of ER stress sensors and their downs

11 Here, we investigated the aberrant activation of HGF/MET and Wnt/beta-catenin casc

12 t upon loss of BMP signaling, tumors lead to aberrant activation of JNK/Mmp2 signaling, followed by i

13 Aberrant activation of phosphatidylinositide-3-kinase (P

14 essential for calcineurin inhibitor-induced aberrant activation of presynaptic and postsynaptic NMDA

15 in Acute Myeloid Leukemia (AML) leads to the aberrant activation of super enhancer (SE) landscapes th

16 n kinetics in knockout versus wild-type; (2) Aberrant activation of the glucose/lipid metabolism regu

17 Aberrant activation of the TAL1 is associated with up to

18 Aberrant activation of this signalling network is one of

19 Aberrant activation of TLRs by self-derived RNA and DNA

20 1) and G(i/o) pathways and shed light on how aberrant activation of TRPC4 may occur under pathologica

21 erentiation of LSCs via oxidative stress and aberrant activation of unfolded protein response (UPR) p

22 Aberrant activation of Wnt signaling also reveals freque

23 We explored whether managing this aberrant activity in adults could be a therapeutically b

24 ma-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer's disease

25 us erythematosus (lupus) is characterized by aberrant activity of the immune system, leading to varia

26 Protracted inflammation may result in aberrant adenosinergic signalling, which serves to susta

27 To function effectively proteins must avoid aberrant aggregation, and hence they are expected to be

28 integrin beta1 complex, which is critical to aberrant Akt activation, as SHIP1 diverts PI3K signaling

29 tor, into insoluble aggregates, resulting in aberrant alternative splicing.

30 ablished, rats transitioned abruptly between aberrant and baseline reach kinematics in a dopamine-dep

31 DD)J recombination is currently viewed as an aberrant and inconsequential variant of the canonical V(

32 ession of a significant fraction of both the aberrant and normal transcriptomes.

33 pmental switch resulting in the formation of aberrant and spectacular structures (clubs or galls).

34 s an infantile lung disease characterized by aberrant angiogenesis and impaired resolution of lung in

35 hoJ deficiency in ECs efficiently suppressed aberrant angiogenesis in ischemic retina.

36 Yet, resistance arises and aberrant AR signaling promotes disease.

37 epithelial repair response is cumulative and aberrant as, after multiple infections, the epithelium w

38 lly with aberrant cortico-thalamic iFC, i.e. aberrant associative striatum dopamine is associated wit

39 ing nanopore sequencing identified recurrent aberrant behavior characterized by low confidence, incor

40 edition and behavior was assessed using the Aberrant Behavior Checklist and Social Responsiveness Sc

41 al to clarify the balance between normal and aberrant behaviour of this protein.

42 predict the tendency of individuals to form aberrant beliefs from their bistable perception behavior

43 The aberrant beta-actin mRNA localization resulted in abnorm

44 Aberrant biomarker expression stratified the cohorts int

45 g of bone development, as well as normal and aberrant bone repair, has important therapeutic implicat

46 We find that SCF-FBXL17 disrupts aberrant BTB dimers that fail to stabilize an intermolec

47 cer potently blocks RIalpha LLPS and induces aberrant cAMP signaling.

48 Second, filgotinib suppresses HIV-1-driven aberrant cancer-related gene expression at the integrati

49 se master regulators have been implicated in aberrant cardiac remodeling, heart failure, and myocyte

50 as a danger signal, and consequently limits aberrant cell division and potential cellular transforma

51 6SS even when the disruption is generated by aberrant cell envelope biogenesis.

52 on to metabolic processes that contribute to aberrant cell proliferation and tumorigenesis.

53 ophosphatidic acid (LPA) have been linked to aberrant cell proliferation, oncogenesis, and metastasis

54 crease in Akt activity which may explain the aberrant cell survival, proliferation and invasion assoc

55 Analysis of aberrant cells within the cleft revealed expression of s

56 taneous hydrolysis, reactive oxygen species, aberrant cellular metabolism or other perturbations that

57 Aberrant cellular Myc (c-Myc) is a common feature in the

58 ling in depression, our results suggest that aberrant central glutaminergic signalling may underpin t

59 Aberrant changes in epigenetic modifications are closely

60 HSPCs in bone marrow after SCI is linked to aberrant chemotactic signaling that can be reversed by p

61 l alterations in NPC lysosomes and nature of aberrant cholesterol-mTORC1 signaling contribution to or

62 ted Drosophila embryos; (3) patient-specific aberrant chromatin conformation in a diffuse large B-cel

63 leads to cell cycle defects often linked to aberrant chromosomal condensation and segregation.

64 ncer genomes are extensively rearranged with aberrant chromosomal karyotypes.

65 in genome maintenance including DNA damage, aberrant chromosome condensation, and crossover defects

66 embly without DNA re-replication, leading to aberrant chromosome segregation.

67 Rho kinase signaling changes and downstream aberrant cofilin phosphorylation.

68 formatics tools to quantify the frequency of aberrant colony formations by the combined stressors of

69 ditive effect on increasing the frequency of aberrant colony formations.

70 Clinically-relevant radiotherapy induces aberrant complement activation, leading to brain injury.

71 cross the midline, which is indicative of an aberrant composition of the growth cone.

72 ves proteostasis by eliminating complexes of aberrant composition(2), but how it detects incorrect su

73 Furthermore, aberrant computational parameters of the Stroop task per

74 ntial biological roles under both normal and aberrant conditions.

75 striatal dopamine links topographically with aberrant cortico-thalamic iFC, i.e. aberrant associative

76 Aberrant CTCF binding was enriched for motifs for key my

77 exacerbates, the (G4C2)-RNA repeats-induced aberrant cytoplasmic accumulation of Ran.

78 o profound nuclear defects and GI generating aberrant cytoplasmic DNA, however simultaneous miR-181a

79 Aberrant DDR1 activity contributes to the progression of

80 Removal of NUP188 also resulted in aberrant dendrite tiling, suggesting a potential role of

81 that RNAi-mediated dElys depletion leads to aberrant development and, at the cellular level, to defe

82 ortical thickness in CNV carriers, implicate aberrant development of the cortical mantle in the patho

83 est that some individuals with CP exhibit an aberrant developmental trajectory of their somatosensory

84 ons act in a feed-forward fashion to promote aberrant DNA methylation in UC.

85 Aberrant dopamine function in the dorsal striatum and ab

86 Physiologically, this manifests as aberrant effective connectivity in intrinsic connections

87 ogenic controls in order to characterize the aberrant electrical activity in such a human context.

88 ) orm2 (-/-) seeds were nonviable, displayed aberrant embryo development, and had >80% reduced oil co

89 cause an irreversible loss of a structurally aberrant enzyme through proteolytic degradation.

90 Proteolytic degradation of a structurally aberrant enzyme would explain the superior potency of is

91 These aberrant epigenetic and transcriptional signatures illum

92 oids from mice, which was associated with an aberrant epithelial interferon signature.

93 upport a role of mucociliary dysfunction and aberrant epithelial pro-fibrotic response in the multifa

94 g disturbances (MLID), which may result from aberrant establishment of imprinted differentially methy

95 of miRNA-155 and miRNA-21 cancer biomarkers' aberrant expression and dynamic change in different cell

96 Our findings indicate that aberrant expression of a testis-specific transcription f

97 Here, we assessed aberrant expression of AR bearing different polyQ tracts

98 l system, we provide proof-of-principle that aberrant expression of fusogens in neurons results in ne

99 Thus, we propose that aberrant expression of fusogens in the nervous system di

100 We and others demonstrated aberrant expression of glycans in different cancer types

101 in a mouse-human mixture dataset and removes aberrant expression of marker genes in PBMC datasets.

102 iated relaxation of chromatin and consequent aberrant expression of multiple biotin-related genes, di

103 Aberrant expression of PDGFR-beta is associated with a n

104 This study provides in vivo evidence that aberrant expression of PLK1 triggers CIN and tumorigenes

105 articipants = 1184) the relationship between aberrant expression of prometastatic proteins S100A2 and

106 The aberrant expression of protein arginine methyltransferas

107 In breast cancer, aberrant expression of SIX1 has been demonstrated to sti

108 We asked whether this could be attributed to aberrant expression of small RNAs.

109 Aberrant expression of the cardiac gap junction protein

110 Aberrant expression of the transcription factor double h

111 us on the role of S1P in renal cells and how aberrant extracellular and intracellular S1P signaling c

112 Aberrant extracellular matrix (ECM) deposition and stiff

113 hat these effects were mostly independent of aberrant extracellular serotonin levels.

114 Aberrant ferroportin activity can lead to diseases of ir

115 hesis, altered lipid lamellae structure, and aberrant filaggrin (FLG) processing.

116 defective directionality of root growth, and aberrant flower and fruit morphology.

117 ur', that implies the transmissibility of an aberrant fold.

118 Proteinopathies result from aberrant folding and accumulation of specific proteins.

119 efrontal networks, and normalization of this aberrant function is thought to be critical for successf

120 lution into overt psychosis may stem from an aberrant functional reorganization of the brain during a

121 Although aberrant gene expression and DNA methylation profiles ar

122 Measuring aberrant gene expression has aided in identifying functi

123 rete molecular regulators, which control the aberrant gene expression programs that drive and maintai

124 D genome architecture are coordinated in the aberrant gene expression that drives prostate cancer dev

125 discomposed these interactions resulting in aberrant gene expression, mitochondrial dysfunctions, an

126 of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescen

127 A end-processing enzyme and promotes CSR and aberrant genomic rearrangements by suppressing the inser

128 that these differences are in part driven by aberrant glucocorticoid secretion during development, wi

129 Generating beta-cells to mitigate the aberrant glucose homeostasis manifested in the disease h

130 evated blood glucose, insulin resistance and aberrant glucose output in lean mice.

131 ession and metabolite signatures unveiled an aberrant glutamate metabolism and tricarboxylic acid (TC

132 Specifically, aberrant glycolysis, glutaminolysis, fatty acid and glyc

133 Anabolic metabolism mediated by aberrant growth factor signalling fuels tumour growth an

134 expression of hormone biosynthesis genes and aberrant growth patterns, including stunted bushy shoots

135 Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contribu

136 Individuals with aberrant gyrification in 68 cortical areas were identifi

137 The loss of KDM4A in oocytes causes aberrant H3K9me3 spreading over bdH3K4me3, resulting in

138 , have latent skin competence explaining why aberrant hair follicles or sebaceous glands are sometime

139 Co-occurrence of aberrant hepatocyte growth factor (HGF)/MET proto-oncoge

140 feration require Hedgehog (HH) signaling and aberrant HH signaling causes birth defects or cancers.

141 Moreover, aberrant high BMP signaling in the lesional epidermis is

142 Aberrant HOXA9 expression is a hallmark of most aggressi

143 y pubertal programming of the PVN results in aberrant HPA axis responsiveness when exposed to the hor

144 its, counteracting transcription leakage and aberrant hybrids at gene boundaries.

145 n of the lysine demethylase KDM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) a

146 1 as a posttranscriptional safeguard against aberrant hypoxic signaling and abnormal cell-cycle progr

147 Taken together, our findings indicate that aberrant IAV RNAs stimulate HLA presentation, which may

148 aberrant sensorimotor striatum dopamine with aberrant iFC between the auditory-sensorimotor network a

149 ciative striatum dopamine is associated with aberrant iFC between the salience network and thalamus,

150 -N-nitrosourea (ENU)-induced mutant mice for aberrant immune function, we identified mice with a synd

151 that most severe cases are characterized by aberrant immune responses and do not depend on viral bur

152 Aberrant immune responses including reactive phagocytes

153 ructure and function, demonstrating that the aberrant IMPG1 distribution is the main cause of the vis

154 d ACLF patients, but were significantly more aberrant in ACLF patients.

155 nction in Drosophila melanogaster through an aberrant increase in bulk neuronal protein synthesis.

156 However, some circumstances can result in an aberrant increase in centriole number-a phenotype that i

157 We conclude that AML displays an aberrant increase in CTCF occupancy that targets key gen

158 (GM), and if so, whether it is because of an aberrant increase in lipid synthesis.

159 isorders such as schizophrenia which involve aberrant increases in cortical broadband gamma activity.

160 These changes promote aberrant inflammation in response to known triggers of d

161 xist regulatory immune mechanisms to prevent aberrant inflammation.

162 nse to this disease is thought to lead to an aberrant inflammatory response or cytokine storm, which

163 Stroop task performance were associated with aberrant inhibitory connections.

164 I transcription elongation to suppression of aberrant initiation.

165 y, fatal outcome in AGMs was associated with aberrant innate immune signaling, complement dysregulati

166 reunion, adversity-experiencing pups showed aberrant interactions with mother and blunted cortical L

167 Aberrant internally deleted viral RNAs (vRNAs) known as

168 Chromothripsis accumulates, beginning with aberrant interphase replication of bridge DNA.

169 dopamine function in the dorsal striatum and aberrant intrinsic functional connectivity (iFC) between

170 Inactivation of Gish resulted in aberrant JNK pathway activation and excessive production

171 We also noted aberrant keratinocyte and fibroblast migration in the Rh

172 ator of defective chromosome congression and aberrant kinetochore-microtubule attachments which in tu

173 ting kinetochore components and so releasing aberrant kinetochore-microtubule interactions.

174 eed for effective treatment that attacks the aberrant kinome activation associated with resistance to

175 different developmental stages, mutants with aberrant leaf color and/or phenotype, and plants growing

176 PM girls (hyper/hypo: 2/5, 3 both) displayed aberrant LGI in 1-17 regions/person while 2 control boys

177 Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their surviva

178 t and adhesions between the vitreous and the aberrant macrovessel.

179 ocytosis is a hematological disease in which aberrant mast cells accumulate because of gain-of-functi

180 Energy disbalance and aberrant maturation likely hinder the integration of PV(

181 activated B cells favors the development of aberrant MBs prone to avoid plasmacytic differentiation

182 termine the cellular and molecular basis for aberrant megakaryopoiesis in myelofibrosis, we performed

183 y mutated in MCD/C5s and PENLs, suggest that aberrant memory B cells (MBs), and not plasmablasts, are

184 ypothesis, first postulated in the 1950s, of aberrant metabolism as an aetiological determinant of ca

185 Aberrant metabolism is a key factor in many neurological

186 tumor glioblastoma (GBM) is characterized by aberrant metabolism that fuels its malignant phenotype.

187 Aberrant methylated genes (DMGs) play an important role

188 o summarize, we have identified six feasible aberrant methylated-differentially expressed genes and p

189 However the triggers initiating aberrant methylation are unknown.

190 Extensive aberrant methylation of DNA is broadly documented in ear

191 that rcd4 mutants exhibit fewer centrioles, aberrant mitoses, and reduced basal bodies in sensory or

192 microtubule bundling in interphase cells and aberrant mitoses.

193 aracterized by a halt in the division cycle, aberrant morphology, and, in the case of IFN-gamma-induc

194 ultured Olfml3-deficient pericytes exhibited aberrant motility and altered pericyte association to en

195 ndrome is a spliceosomopathy associated with aberrant mRNA processing during development.

196 Translation of aberrant mRNAs can cause ribosomes to stall, leading to

197 erated in mitochondrial DNA (mtDNA) although aberrant mtDNA rNMP content has been identified in disea

198 Aberrant mTOR signaling occurs frequently in cancers, so

199 Human clinical traits and aberrant mutant phenotypes in laboratory organisms are n

200 ecific for microscopic underpinnings such as aberrant myelination or fiber density (FD).

201 Depletion of Lfc leads to aberrant myosin localization, thereby causing two effect

202 ge caused by A3B expression, we suggest that aberrant NEIL2 expression can explain certain instances

203 We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis

204 units to excitatory/inhibitory imbalance and aberrant network connectivity characteristic for these p

205 nces and impaired performance resulting from aberrant network excitability in psychiatric and neurolo

206 The way in which aberrant neural circuits contribute to epilepsy remains

207 rain developmental processes to the forms of aberrant neural connectivity that underlie common neurol

208 is higher activation may be an indication of aberrant neurodegenerative-related processes.

209 The current study tested the effects of aberrant neurogenesis in a mouse model of repeated mild

210 lammation to chronic outcomes, and show that aberrant neutrophil chemotaxis can move an otherwise hea

211 cues both the delay in wound closure and the aberrant neutrophil phenotype.

212 Aberrant NLRC5 signaling in macrophages can promote B-ce

213 on by antisense oligonucleotides circumvents aberrant NMD promoted by mutant SRSF2, restoring the exp

214 phenotype of Torsin manipulation represents aberrant NPC intermediates.

215 These variants result in aberrant NRROS proteins with impaired ability to anchor

216 form of the protein, named progerin, and an aberrant nuclear shape.

217 in the early steps of ICL repair to prevent aberrant nuclease resection, the role of BRCA2 in this p

218 class of antigens that have shown promise is aberrant O-glycoprotein epitopes.

219 thesis that reduced PABPN1 levels lead to an aberrant organization of the cytoskeleton.

220 in the absence of ERbeta was associated with aberrant overexpression of Tsc22d3 (GILZ), a glucocortic

221 Aberrant OX40 cosignaling has been implicated in autoimm

222 ent reversed these characteristics including aberrant p21(WAF1/CIP1) expression and subsequently redu

223 This aberrant pattern effectively blocks interneuron apoptosi

224 wever, dysregulated LLPS can also facilitate aberrant phase transitions and lead to protein aggregati

225 system, disease-associated mutant HTT causes aberrant phenotypes in myeloid-lineage innate immune sys

226 Aberrant photoreceptor function or morphogenesis leads t

227 t the role of NO and NOx under conditions of aberrant placental inflammation during pregnancy.

228 n TLE and expand on the notion of underlying aberrant plasticity.

229 howing pleiotropic developmental defects and aberrant pre-rRNA processing.

230 tions in tumor cells ultimately achieve this aberrant production is largely unknown.

231 neurodegenerative diseases characterized by aberrant protein misfolding and aggregation.

232 However, hallmarks of cancer such as aberrant protein phosphorylation and calcium-mediated ce

233 ability, increased swelling, potassium loss, aberrant protein phosphorylation, and dysregulated energ

234 We focus on how virus-induced aberrant proteostasis and protein aggregation resemble t

235 of Cic in the nodular zone accelerated both aberrant Purkinje neuron spiking and neurodegeneration.

236 In response to aberrant R loop accumulation, the ataxia telangiectasia

237 Aberrant Ras signaling drives 30% of cancers, and inhibi

238 others are expressed in only germ cells with aberrant reactivation in multiple cancers.

239 ere included if they have both exotropia and aberrant regeneration with a ptosis that improved on add

240 eal that commissural thinning results in the aberrant regulation of anxiety, providing a mechanistic

241 It mainly occurs due to aberrant regulation of the immune system leading to abno

242 These abnormalities were attributed to aberrant release of the microtubule organizing center (M

243 Aberrant remodeling of trabecular meshwork (TM) extracel

244 t, and others result from DNA replication or aberrant repair of breaks in sequence-specific contexts.

245 ile site damage is thought to arise from the aberrant repair of spontaneous replication stress, howev

246 Major depressive disorder is associated with aberrant resting-state functional connectivity across mu

247 ption factor 1 (RUNX1) acts as a mediator of aberrant retinal angiogenesis and has been implicated in

248 been identified as an important mediator of aberrant retinal angiogenesis in proliferative diabetic

249 ospho state, and Rgd3 overexpression rescues aberrant Rho3 localization and cell morphologies seen at

250 isms underlying DDX3X syndrome and highlight aberrant RNA metabolism in the pathogenesis of neurodeve

251 yltransferase leading to H4K16ac loss causes aberrant RNA Pol II recruitment, compromises the 3D orga

252 Here, we provide evidence that aberrant RNA products of influenza virus genome replicat

253 toxic gain-of-function involving direct and aberrant RNA-binding and strengthen the link between two

254 that UPF1/NMD suppresses the translation of aberrant RNAs.

255 Signals driving aberrant self-renewal in the heterogeneous leukemia stem

256 tween the salience network and thalamus, and aberrant sensorimotor striatum dopamine with aberrant iF

257 function of sensory neurons, suggesting that aberrant sensory function might be a common feature of A

258 Aberrant serum-induced ciliary resorption and cold-induc

259 Aberrant SHP2 activity leads to uncontrolled cell prolif

260 This aberrant signaling is associated with an increase in vas

261 Associated aberrant signaling is responsible for many forms of canc

262 ed by their unique cell surface proteins and aberrant signaling pathways.

263 n of the maladapted molecular mechanisms and aberrant signaling processes that underpin these conditi

264 Aberrant signaling through this cascade contributes to o

265 the TNFalpha trimer upon binding, leading to aberrant signaling when the trimer binds to TNF receptor

266 Aberrant splicing and transcript destabilization were as

267 mutation and show that it effectively blocks aberrant splicing in primary bronchial epithelial (hBE)

268 evidence suggesting that alternative and/or aberrant splicing may serve to influence the ability of

269 tic diseases caused by the overexpression or aberrant splicing of a specific protein.

270 entify that the SF3B1(R625H) mutation causes aberrant splicing of estrogen related receptor gamma (ES

271 lico analysis predicted the variant to cause aberrant splicing.

272 out altering evoked release, suggesting that aberrant spontaneous release is sufficient to cause dise

273 Data suggest that aberrant striatal dopamine and cortico-thalamic dysconne

274 We hypothesized that aberrant striatal dopamine links topographically with ab

275 by 14-3-3sigma in skin keratinocytes, shows aberrant subcellular partitioning and function in differ

276 entify DDR mutations, histone imbalances and aberrant subtelomeric chromatin as interconnected causes

277 get-derived neurotrophic factor NGF leads to aberrant subtype-restricted patterns of transcription fa

278 the involvement of multiple mechanisms, from aberrant synaptic development and ion channel deregulati

279 (FMRP) causes increased mRNA translation and aberrant synaptic development.

280 n of excitation/inhibition (E/I) balance and aberrant synaptic plasticity at the cortical level.

281 Importantly, aberrant systemic circulation of bile acids can greatly

282 by the restriction, albeit not complete, on aberrant T and B cell activation following anti-CD86 blo

283 It has been shown that aberrant Task3 expression correlates with neuronal dysfu

284 e in ATRX/DAXX(trunc) tumors, which carry an aberrant telomere variant repeat (TVR) distribution as a

285 To evaluate the potential contribution of aberrant thyroid hormone status to the epigenetic inheri

286 ting, and the generation and presentation of aberrant trans-frame peptides at the cell surface after

287 causal noncoding variants that may introduce aberrant transcription factor binding motifs or enhancer

288 This aberrant transcriptional program caused impairment in se

289 ctively interfere with its ability to modify aberrant translation products with C-terminal tails whic

290 ring the asexual reproduction and results in aberrant tubulin morphology suggesting protein aggregati

291 B1, a previously uncharacterized RBP, drives aberrant tumor expression and amplifies the effect of MY

292 ematosus (SLE), a condition characterized by aberrant type I IFN signaling, has not been determined.

293 ators are transposable elements (TEs), whose aberrant usage could contribute to oncogenic transcripti

294 l as for mechanisms that might contribute to aberrant V(D)J recombination and the development of lymp

295 Moreover, in these seeds, aberrant vacuolar phenotypes were observed that were dif

296 ericardial effusion, impaired blood flow and aberrant valvulogenesis.

297 Nek8445 depletion results in short flagella, aberrant ventral disk organization, loss of the funis, d

298 HLA upregulation in response to aberrant viral RNAs could be prevented by the Janus kina

299 Aberrant Wnt signaling drives a number of cancers throug

300 cular mechanism whereby nuclear MET promotes aberrant Wnt/beta-catenin signaling-mediated prostate tu