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1  that one allele of the MGMT promoter has an aberrant methylation.
2 suggesting that the CDX1 gene is a target of aberrant methylation.
3 recursor of endometrial carcinoma) for hMLH1 aberrant methylation.
4  distinct signaling pathways responsible for aberrant methylation.
5 cteristics of methyltransferase that lead to aberrant methylation.
6  to the protection from or susceptibility to aberrant methylation.
7  the RNA and/or protein level and subsequent aberrant methylation activity.
8                                              Aberrant methylation also contributes to later stages of
9 are involved in suppressing MS4A3, including aberrant methylation and a MECOM-C/EBPepsilon axis.
10 xtensive epigenetic abnormalities, including aberrant methylation and abnormal imprinted gene express
11 urther evidence for a potential link between aberrant methylation and diseases of aging.
12 d from 5-azacytidine-treated patients lacked aberrant methylation and DNMTi treatment of primary MDS
13 ning and gene expression profiling, we found aberrant methylation and epigenetic silencing of a small
14         Offspring of F0(DSS) males exhibited aberrant methylation and expression patterns of multiple
15 enome-wide epigenetic studies to investigate aberrant methylation and histone code patterns, the two
16     To provide a baseline estimate of global aberrant methylation and identify target sequences for a
17                                              Aberrant methylation and silencing of TMS1 was accompani
18  differ in their intrinsic susceptibility to aberrant methylation and that this susceptibility can be
19 denocarcinomas; (b) the frequency of RASSF1A aberrant methylation and the value of the methylation in
20 however, the mechanisms responsible for this aberrant methylation are poorly understood.
21              However the triggers initiating aberrant methylation are unknown.
22 , head and neck, and endometrium to identify aberrant methylation associated with RNA and protein abu
23                                We identified aberrant methylation at 928 cytosines affecting 326 ALP
24                               High levels of aberrant methylation at CIMP-related markers in MSH2-met
25 r (ER) alpha-negative breast tumors displays aberrant methylation at one site within the ER gene CpG
26 nts occurring at fertilization, resulting in aberrant methylation at some promoters and repetitive el
27 ific effects play a strong role in recurrent aberrant methylation at specific CpG sites across differ
28 2), indicating that PatMAn predicts not only aberrant methylation, but also PRC2 binding.
29 CXXC domain allows TET1 to protect CGIs from aberrant methylation, but it also limits its ability to
30 nance of T-cell lymphomas and contributes to aberrant methylation by both de novo and maintenance met
31 NA methyltransferases are needed, given that aberrant methylation by these enzymes is associated with
32                                          The aberrant methylation can begin very early in tumor progr
33                  These results indicate that aberrant methylation can cooperate with chromosome delet
34                                              Aberrant methylation changes are associated with changes
35  biological investigations, such as checking aberrant methylation changes during tumorigenesis, monit
36                                              Aberrant methylation changes, often present in a minor a
37  Methylight) to boost detection of low-level aberrant methylation-changes.
38                                              Aberrant methylation, consisting of DNA hypomethylation
39                                              Aberrant methylation contributes to the pathogenesis of
40                   Our results show that most aberrant methylation events are focal and independent of
41                             Sixty percent of aberrant methylation found in tumors is also present in
42 r study shows that DNMT1 mutations cause the aberrant methylation implicated in complex pathogenesis.
43 quent in breast and renal carcinoma, showing aberrant methylation in 30 and 20% of the cases, respect
44 hese results provide evidence for widespread aberrant methylation in AML, with identification of nove
45 dditional cellular factors exist that govern aberrant methylation in breast cancer cells.
46 pe from apoptosis, supporting a new role for aberrant methylation in breast tumorigenesis.
47 amine the major uses of RLGS in the study of aberrant methylation in cancer and discuss the significa
48      This is consistent with the notion that aberrant methylation in cancer may be attributable to ta
49 slands remain unmethylated, a subset accrues aberrant methylation in cancer via unknown mechanisms.
50 To study the potential mechanisms underlying aberrant methylation in cancer, we have determined the m
51 t CDH13 expression is frequently silenced by aberrant methylation in colorectal cancers and adenomas
52 f CDH13 by luciferase assay and examined its aberrant methylation in colorectal cancers, cell lines,
53 evalence of genes known to be deregulated by aberrant methylation in HCC (e.g., Ras association [RalG
54 some 12q23.1 that was affected frequently by aberrant methylation in human astrocytomas and oligodend
55 ave been previously described as targets for aberrant methylation in human cancer.
56 a non-genetic biological mechanism underlies aberrant methylation in iPSCs and that it is likely base
57 ibility that MSH2 is a target susceptible to aberrant methylation in Lynch syndrome.
58                                              Aberrant methylation in MDS and secondary AML tended to
59  demonstrate a relationship between SV40 and aberrant methylation in MMs.
60                       Finally, we identified aberrant methylation in multiple genes also targeted by
61 omplex 2 (PRC2) complex and silenced through aberrant methylation in non-small-cell lung cancer cell
62  suggest that SPARC is a frequent target for aberrant methylation in pancreatic cancer and that SPARC
63            To identify potential targets for aberrant methylation in pancreatic cancer, we analyzed g
64  approach, we identified 7 novel targets for aberrant methylation in pancreatic cancer.
65 many of them may represent novel targets for aberrant methylation in pancreatic carcinoma.
66                                              Aberrant methylation in PCBM was associated with mutatio
67 ntiation program were significant targets of aberrant methylation in prostate cancer.
68  the relevance of defective MGMT function by aberrant methylation in relation to the presence of K-ra
69  the relevance of defective MGMT function by aberrant methylation in relation to the presence of p53
70 nzymes and methylation-specific PCR, we find aberrant methylation in the AR expression-negative cell
71 ach to be a powerful method to uncover novel aberrant methylation in the cancer epigenome.
72                                We identified aberrant methylation in the CpG island of SOCS-1 that co
73                       The active role of the aberrant methylation in transcriptional silencing of gen
74 ors, most of which have never been linked to aberrant methylation in tumors.
75                       RLGS was used to study aberrant methylation in two mouse models that overexpres
76                                              Aberrant methylation in urine and serum DNA generally wa
77  are crucial for eukaryotic development, and aberrant methylation-induced silencing of tumour suppres
78 ate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in huma
79 f certain cytosines with a methyl group, and aberrant methylation is a hallmark of human diseases inc
80                                              Aberrant methylation is a major mech-anism for loss of f
81 t epigenetic inactivation of RASSF1A through aberrant methylation is an early step in thyroid tumorig
82                                              Aberrant methylation is associated with disease progress
83 ation profiling allowed us to determine that aberrant methylation is commonly present in normal aging
84                                         This aberrant methylation is evident in 83% of papillary thyr
85 inogenesis hinges on the question of whether aberrant methylation is sufficient to drive gene silenci
86 erestingly, LOI status did not correspond to aberrant methylation levels of the imprinted DMRs or wit
87                                         This aberrant methylation may be due to increased expression
88                        Nevertheless, certain aberrant methylation modifications can have lethal conse
89                                              Aberrant methylation of 5' CpG islands is thought to pla
90                                              Aberrant methylation of 5'CpG islands is a key epigeneti
91  expression of TMS1 that was associated with aberrant methylation of a CpG island in the promoter of
92  active maternal allele of the H19 gene, and aberrant methylation of a differentially methylated regi
93 pecific loss of transcription may arise from aberrant methylation of a nonmutated promoter region, id
94 had hMLH1 promoter hypermethylation, whereas aberrant methylation of any of the other mismatch repair
95  remission ones: in 82 of those with initial aberrant methylation of at least one gene, 59 (72%) had
96                       Using MSP, we detected aberrant methylation of at least one locus in 60% of car
97                                              Aberrant methylation of at least one of these genes was
98                                              Aberrant methylation of at least one of these genes was
99 analysis in a larger panel of specimens, and aberrant methylation of at least one of these three gene
100                                              Aberrant methylation of CACNA1G was also examined in var
101                                              Aberrant methylation of candidates was further confirmed
102             Our results demonstrate frequent aberrant methylation of CDH13 in breast and lung cancers
103                                              Aberrant methylation of CDH13 was present in 7 of 13 (54
104 ion of a particular DNA methyltransferase to aberrant methylation of Cosmc in these cells.
105                                              Aberrant methylation of COX2 was also detected in 12 of
106                                              Aberrant methylation of CpG island DNA blocked Pol II re
107                                              Aberrant methylation of CpG islands acquired in tumor ce
108                                              Aberrant methylation of CpG islands and genomic deletion
109                                              Aberrant methylation of CpG islands and silencing of the
110                                              Aberrant methylation of CpG islands in gene promoters of
111                                              Aberrant methylation of CpG islands in human tumors has
112                                              Aberrant methylation of CpG islands in promoter regions
113                                              Aberrant methylation of CpG islands in promoter regions
114 TGF-beta during carcinogenesis could involve aberrant methylation of CpG islands in the 5' region of
115 ning (RLGS) is useful for global analysis of aberrant methylation of CpG islands, but has not been am
116                                              Aberrant methylation of CpG-dense islands in the promote
117 werful approach for studying the dynamics of aberrant methylation of critical tumor suppressor genes
118 WTs with normal imprinting of IGF2 also show aberrant methylation of CTCF binding sites, indicating t
119                                    Extensive aberrant methylation of DNA is broadly documented in ear
120     Epigenetic editing of gene expression by aberrant methylation of DNA may help tumor cells escape
121                            We speculate that aberrant methylation of DNMT3B target sites could contri
122                     Cancers often exhibit an aberrant methylation of gene promoter regions that is as
123 we show that one category of DNA alteration, aberrant methylation of gene promoter regions, can enorm
124                     Our results suggest that aberrant methylation of GSTP1 may contribute to the carc
125 human tumors originating in other organs for aberrant methylation of GSTP1 using methylation-specific
126 type-phenotype relationship in BWS, in which aberrant methylation of H19 and LIT1 and UPD are strongl
127                          We thus demonstrate aberrant methylation of human TSHR as a likely molecular
128 pontaneous abortion mouse model reveals that aberrant methylation of Ido1 is linked to pregnancy loss
129 ha) gene expression has been associated with aberrant methylation of its CpG island in a significant
130 16 cells determined that these cells possess aberrant methylation of multiple CpG dinucleotides withi
131                                              Aberrant methylation of multiple CpG islands has been de
132 umor and the matched urine and serum DNA for aberrant methylation of nine gene promoters (CDH1, APC,
133                                 Furthermore, aberrant methylation of NORE1A and SOCS3 promoters was o
134                                              Aberrant methylation of normally unmethylated CpG island
135 geal, and endometrial neoplasms and gliomas, aberrant methylation of p14ARF was a relatively common e
136                                              Aberrant methylation of p15 (>10%) was found in 27% of p
137                                              Aberrant methylation of p15INK4B is associated with tran
138 thermore, methylation analyses revealed that aberrant methylation of pinin CpG islands was correlated
139                     These data indicate that aberrant methylation of ppENK and its transcriptional re
140                                      Because aberrant methylation of ppENK or p16 was more often dete
141 cing of Hsp47 in NB cells is associated with aberrant methylation of promoter CpG islands and that Hs
142                                              Aberrant methylation of promoter CpG islands in cancer i
143 or genes in human cancers is associated with aberrant methylation of promoter region CpG islands and
144               Gene silencing associated with aberrant methylation of promoter region CpG islands is a
145                                              Aberrant methylation of promoter region CpG islands is a
146               Gene silencing associated with aberrant methylation of promoter region CpG islands is o
147         Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is o
148           Epigenetic silencing involving the aberrant methylation of promoter region CpG islands is w
149                                              Aberrant methylation of promoter sequences is observed a
150          SV40-infected HM showed progressive aberrant methylation of seven genes (RASSF1A, HPP1, DcR1
151                                      Lastly, aberrant methylation of several genomic loci was confirm
152                                              Aberrant methylation of TFPI-2 was also detected in 73%
153                                              Aberrant methylation of TFPI2 was detected in almost all
154 tidine (5-aza-dC) treatment, suggesting that aberrant methylation of the ABCG2 gene was associated wi
155 ndance, as measured by real-time RT-PCR, and aberrant methylation of the ATM gene promoter.
156                                              Aberrant methylation of the ATM promoter was independent
157 reast tumors (stage II or greater) displayed aberrant methylation of the ATM proximal promoter region
158         We investigated the possibility that aberrant methylation of the CpG island flanking the 5' t
159                  These results indicate that aberrant methylation of the CpG island in the CDX1 promo
160 n of p16/CDKN2 in gliomas may be mediated by aberrant methylation of the CpG island, which is in the
161 eyed 111 ductal carcinomas of the breast for aberrant methylation of the estrogen receptor-alpha and
162                              To test whether aberrant methylation of the FHIT gene may play a role in
163  whether SV40 infection of normal HM induces aberrant methylation of the genes previously studied in
164    Most of the cell lines were shown to have aberrant methylation of the GPC3 promoter region.
165 lated DNA sequences, we now demonstrate that aberrant methylation of the p16 and/or O6-methyl-guanine
166                                              Aberrant methylation of the p16 gene was found in 12% of
167 he first time that an epigenetic alteration, aberrant methylation of the p16 gene, can be an early ev
168 cell cycle regulation and Rb-/- cells showed aberrant methylation of the paternally expressed gene 3
169 ined bisulfite restriction analysis revealed aberrant methylation of the POU2F3 promoter in 18 of 46
170                                              Aberrant methylation of the ppENK gene was found in 7.7%
171                                              Aberrant methylation of the promoter region has emerged
172  with chromosome deletion at the FZD9 locus, aberrant methylation of the remaining allele was associa
173 ction of human mesothelial cells (HM) causes aberrant methylation of the tumor suppressor gene (TSG)
174  are pivotal in maintaining and perpetuating aberrant methylation of the VHL CpG island.
175                Here we studied the nature of aberrant methylation of the von Hippel-Lindau (VHL) dise
176                                          The aberrant methylation of these genes represents a new ave
177  by mutations in mismatch repair genes or by aberrant methylation of these genes stabilizing their do
178                         In contrast, no such aberrant methylation of these genes was observed in norm
179 analysis of primary patient samples revealed aberrant methylation of TIMP-2 in 33/90 (36.7%) cases of
180                                              Aberrant methylation of TIMP-3 occurred in primary cance
181                        Tumors that exhibited aberrant methylation of TMS1 generally expressed reduced
182 11 of 27) of primary breast tumors exhibited aberrant methylation of TMS1.
183                                              Aberrant methylation of tumor suppressor genes can lead
184 ility, epigenetic instability results in the aberrant methylation of tumor suppressor genes.
185 hylation also represents the first report of aberrant methylation on an X-linked gene associated with
186 rostate cancer cells due at least in part to aberrant methylation or gene amplification.
187 thylated CpG island in normal cells and that aberrant methylation overcomes these boundaries to direc
188                                 Detection of aberrant methylation pattern could serve as an excellent
189                           Here, we report an aberrant methylation pattern that may be responsible for
190 required for normal development of mice, and aberrant methylation patterns are associated with certai
191 -chromosome inactivation, and imprinting yet aberrant methylation patterns are one of the most common
192                                              Aberrant methylation patterns have long been known to ex
193 rks from the somatic cell type of origin and aberrant methylation patterns in hiPSCs.
194 plain this suppressive effect but identified aberrant methylation patterns in MYD88 wild-type patient
195 in luminal differentiation contribute to the aberrant methylation patterns in prostate cancer.
196 alternative mechanism for the genesis of the aberrant methylation patterns observed in tumor cells.
197                                              Aberrant methylation patterns occur in several inherited
198 cal to CpG island promoters, suggesting that aberrant methylation patterns of non-CpG island promoter
199                                           As aberrant methylation patterns often accompany disease st
200  mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer.
201 ool for the investigation of both normal and aberrant methylation patterns.
202                          The hypothesis that aberrant methylation plays a direct causal role in carci
203 ctors (clone and passage), and we found that aberrant methylation preferentially occurs at CpGs assoc
204 y-5-azacytidine treatment of cell lines with aberrant methylation restored gene expression.
205                      To examine whether this aberrant methylation results from genetic variation or n
206 ethylation levels, but specifically prevents aberrant methylation spreading into CGIs in differentiat
207 ation of methylation across the CGRs reveals aberrant methylation status in carriers across a rearran
208  (6/20) of breast cancer cell lines, and the aberrant methylation status was strongly associated with
209                             The incidence of aberrant methylation was 65% in the 26 human primary HCC
210                                              Aberrant methylation was also detected in four of eight
211 ted genes CD37, HDAC1, NOTCH1, and CDK5 when aberrant methylation was associated with inverse changes
212                      Inactivation of MGMT by aberrant methylation was associated with the appearance
213        In gliomas and colorectal carcinomas, aberrant methylation was detected in 40% of the tumors,
214                                              Aberrant methylation was found in several breast cancer
215                                 In addition, aberrant methylation was found in three CpG islands (MIN
216                                       p14ARF aberrant methylation was not related to the presence of
217                                              Aberrant methylation was seen in every sample, on averag
218                 Finally, the significance of aberrant methylation was shown by sensitivity of MPN-der
219  promoter of the RASSF1 gene, frequencies of aberrant methylation were significantly lower in MMs tha
220 in tumor cells as well as the association of aberrant methylation with long-range silencing of neighb

 
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