ライフサイエンスコーパス: abortive

1 quence, CCPs without cargo are almost always abortive.

2 the fate of infection, either productive or abortive.

3 found significant subpopulations that remain abortive.

4 eotide incision repair (NIR) product with an abortive 3'-terminal dC close to the scissile position i

5 Consequently, the abortive 66S pre-rRNPs are prematurely released from the

6 heral and mesenteric lymph nodes, leading to abortive activation and deletion of tyrosinase-specific

7 ndirect pathway CD4(+) T cells, resulting in abortive activation and deletion without detrimental eff

8 at appears to favor tumor survival and drive abortive activation of immune cells.

9 dendritic cell maturation, resulting in the abortive activation of naive CD8(+) T cells, and is depe

10 r transgenic CD8 cells are shown to be in an abortive activation state prior to their deletion, showi

11 tion by liver antigens likely contributes to abortive activation, exhaustion, and early death of CD8(

12 The abortive activity of topoisomerases can result in clasto

13 Abortive adenylylation was suppressed at low ATP concent

14 e, and the blocked T-cell progenitors become abortive and die by apoptosis.

15 s of CCP dynamics, including the turnover of abortive and productive CCP species and their relative c

16 inding and infection, and the infections are abortive and productive in ex vivo and activated B cells

17 ts into the mechanism that controls both the abortive and productive RNA synthesis.

18 -initiation complexes in vitro and represses abortive and productive transcription initiation, as wel

19 omplex, enhances DNA melting, and stimulates abortive and productive transcription.

20 Consistent with the characteristics of both abortive and promoter-proximal sigma(70)-dependent pause

21 as well as helped to clarify a mechanism for abortive and prophylactic drugs.

22 rejoined by TOP2 but on occasion can become abortive and remain unsealed.

23 of the antiprogestin mifepristone (RU486, an abortive) are unknown.

24 pe of replication, therefore, can be termed "abortive," as RSV is capable of entering the cells in th

25 ence of costimulatory signals can lead to an abortive attempt at activation and subsequent anergy.

26 n plating efficiency was observed, with many abortive attempts at cell division apparent in the doubl

27 oposed to be a vinylogous amide derived from abortive beta-deprotonation of the ketimine intermediate

28 r trauma, regeneration of adult CNS axons is abortive, causing devastating neurologic deficits.

29 ideas, cargo often escapes from a pit before abortive CCP termination or endocytic vesicle production

30 tion to an increase in CCP size, turnover of abortive CCPs increases, and the rate of CCP maturation

31 In contrast, other CCPs (abortive CCPs) are relatively short-lived and disassembl

32 tion to the cytoplasm leads to death through abortive cell cycle induction.

33 To characterize these abortive cells, we recovered cell populations that survi

34 ranslocation: productive passage of cargo or abortive channel occlusion by cargo.

35 ranslocation: productive passage of cargo or abortive channel occlusion by cargo.

36 ncovered an excellent candidate for the wild abortive-CMS-encoding gene; like most of the CMS-associa

37 is normal, while the other carries the wild abortive-CMS.

38 limited because unambiguously distinguishing abortive coats (ACs) from bona fide clathrin-coated pits

39 etic mutants cause an increased incidence of abortive cohesin deposition events that result in compro

40 Both the open complex and an abortive complex containing a short RNA primer extending

41 With BFA, the association rate of the abortive complex is drastically reduced by a factor of 4

42 on bubble expands at its leading edge in the abortive complex, results that confirm and extend the pr

43 allosteric effect combine to stabilize such abortive complex.

44 gle in the open complex as well as in the +3 abortive complex: a bend of 49 degrees +/- 7 degrees was

45 eparate sessions: preventive (preceding) and abortive (concurrent) verum acupuncture (VAp and VAa), c

46 plex containing a DNA bubble and enters into abortive cycles of RNA synthesis before escaping the pro

47 ically from the downstream end exhibits less abortive cycling and little perturbation of the final tr

48 Most abortive cycling occurs in the slower phase (>10 s), whe

49 alysis of a transcription cycle analogous to abortive cycling that underlies the sigma(70)-dependent

50 polymerase, which shows dramatically reduced abortive cycling, also transitions to elongation later,

51 likely the primary energetic contributor to abortive cycling.

52 ationship with cleavage furrow formation and abortive cytokinesis.

53 ptic cup formation, and lens development was abortive despite normal Pax6 expression in the lens epit

54 , (3) meiotic plants with autonomous (though abortive) development and (4) meiotic plants lacking aut

55 ctor that prevents infection by inducing the abortive disassembly of capsid cores recognized by its C

56 hibits retroviral infection by promoting the abortive disassembly of incoming retroviral capsid cores

57 echanisms by which TRIM5alpha can induce the abortive disassembly of retroviral capsids have remained

58 tive control and WT rhTRIM5alpha induced the abortive disassembly of viral cores, indicating a role f

59 uring N deprivation and by the occurrence of abortive divisions during N refeeding.

60 (Aptx), a DNA-binding protein that resolves abortive DNA ligation intermediates.

61 ates at DNA nicks or breaks that result from abortive DNA ligation reactions.

62 When loop B of the TBD is altered, abortive DNA products are observed during leading strand

63 ng model in which end associations represent abortive DNA repair intermediates when the number of tel

64 opo II) poisons such as etoposide can induce abortive DNA strand breaks in which Topo II remains cova

65 g exposure, resulting in long-term memory or abortive effector responses, correlating with T cell-DCs

66 In contrast, RO3306 induced abortive endoreduplication and apoptosis in embryonic st

67 to recruit p300 during either phase leads to abortive enhancer formation and a lack of target gene ex

68 in a hyperinfection phenotype consisting of abortive epidermal infection events uncoupled from nodul

69 nce system could improve the surveillance of abortive events in French cattle.

70 either CME initiation rates or frequency of abortive events, our data instead identify maturation th

71 programs (i.e., between active, latent, and abortive fates).

72 studies with an inducible L2 mutant revealed abortive formation of the crescent membrane.

73 HD1 restriction factor, potentially reducing abortive forms of infection.

74 Abortive Foxp3 expression was caused by production of in

75 Thus, PE prevents the accumulation of abortive genotoxic DNA intermediates arising from strand

76 replication in macrophages is productive or abortive has been a topic of debate.

77 it was proposed that prestin manages only an abortive hemicycle that results in the trapped anion act

78 ion, mostly involving pyroptosis elicited by abortive HIV infection of CD4 T cells in lymphoid tissue

79 rm of programmed cell death triggered during abortive HIV infection, is associated with the release o

80 sensor required for CD4 T cell death due to abortive HIV infection.

81 he death of these "bystander" cells involves abortive HIV infection.

82 clude A3G and A3F from virions, resulting in abortive HIV replication in nonpermissive human T cells.

83 We conclude that abortive HSV-1 infection is a common feature during infe

84 esidues may prevent undesirable reactions or abortive hydrolysis of the covalently bound enzyme-subst

85 on of primary macrophages lacking emerin was abortive in that viral cDNA localized to the nucleus but

86 ication systems (R-M) (Tock & Dryden, 2005), abortive infection (Abi) (Chopin et al, 2005), Argonaute

87 Bacterial abortive infection (Abi) systems are 'altruistic' cell d

88 ding restriction-modification systems (R-M), abortive infection (Abi), Argonaute-based interference,

89 A commonly used phage resistance strategy is abortive infection (Abi), in which the infected cell com

90 fection likely stems from factors other than abortive infection and caspase-1-dependent pyroptosis in

91 arge fraction of infected cells dies through abortive infection and has a half-life of approximately

92 HIV-1-induced abortive infection and pyroptotic cell death were also n

93 HIV-2 Vpx gene product, thereby diminishing abortive infection and pyroptotic cell death within byst

94 ative estimates of parameters characterizing abortive infection and support the notion that abortive

95 pression to establish quiescence and prevent abortive infection and that the virus usurps a Daxx-medi

96 vidual cell and supports growing evidence of abortive infection by some types of CRISPR-Cas systems.

97 These cells undergo abortive infection characterized by the cytosolic accumu

98 of RabA2 resulted in an increased number of abortive infection events, including bursting of ITs and

99 To investigate the role of abortive infection in driving CD4(+) T cell loss in vivo

100 This confirms the importance of abortive infection in driving T cell depletion.

101 at does not express NS2 and NS4 underwent an abortive infection in HAE-ALI.

102 ubules near masses of dense viroplasm during abortive infection in the absence of the A17 or A14 prot

103 cells, indicating that SAMHD1 contributes to abortive infection in these cells.

104 nity against bacteriophage lambda through an abortive infection mechanism.

105 ellular viral replication centers results in abortive infection of DCs with both VV and MVA.

106 we analyzed the role of both proteins in the abortive infection of human HeLa cells with the poxvirus

107 by replication in hepatocytes and not by the abortive infection of Kupffer cells and the following cy

108 Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4

109 levels, and that SAMHD1 expression promotes abortive infection of this important memory cell subset.

110 ves the infected cell but rather enforces an abortive infection pathway leading to infected cell deat

111 ortive infection and support the notion that abortive infection represents an important mechanism und

112 Immunity results in an abortive infection response, where infected cells do not

113 ing CRISPR-Cas, restriction-modification and abortive infection systems (1-4) .

114 However, the contribution of abortive infection to T cell loss and how quickly aborti

115 rabbit cells tested, vMyxM062-KO conducts an abortive infection, although it initiates viral DNA repl

116 e tissue die through pyroptosis triggered by abortive infection, i.e., infection of resting T cells i

117 In its abortive infection, the gamma(1)34.5 null mutant induces

118 e adsorption inhibition, injection blocking, abortive infection, toxin-antitoxin, and CRISPR-Cas syst

119 s the demise of bystander CD4 T cells due to abortive infection, viral DNA sensing, inflammasome asse

120 rity of CD4(+) T cells in tissue die through abortive infection, where the accumulation of incomplete

121 as reverse transcription (RT), resulting in abortive infection.

122 s induces substantial cell death, leading to abortive infection.

123 on were evident in infected pDCs, indicating abortive infection.

124 ystems that operate via immunity rather than abortive infection.

125 DNA injection, restriction/modification, and abortive infection.

126 oci and resistance to bacteriophages through abortive infection.

127 inefficiently completed, which results in an abortive infection.

128 ounts, suggesting that many cells go through abortive infection.

129 ectors to mediate bacteriophage immunity via abortive infection.

130 immunity against bacteriophages by inducing abortive infection.

131 susceptible and permissive cell populations, abortive infections can be detected in subpopulations of

132 We have previously identified abortive infections in HeLa cells infected with herpes s

133 defense strategy: that both restriction and abortive infections operate during coevolution with phag

134 ing cells have been reported only to exhibit abortive infections with vaccinia virus (VACV).

135 ial sites of infection, potentially limiting abortive infections.

136 identified three transmembrane proteins with abortive infectivity (ABI) domains, elements first descr

137 btained evidence for RNA backtracking during abortive initial transcription and for additional pausin

138 transcription reactions to better understand abortive initiation and promoter escape in vivo.

139 ex at the point where steric clash initiates abortive initiation and sigma(A) dissociation.

140 Abortive initiation assays confirm that ExsA enhances th

141 a transcript is extended to +2 and +3 in an abortive initiation complex.

142 acteristics of in vitro abortive initiation: Abortive initiation increases upon stabilizing interacti

143 -molecule DNA nanomanipulation, we show that abortive initiation involves DNA "scrunching"--in which

144 Abortive initiation may be viewed as promoter proofreadi

145 It has not been known whether abortive initiation occurs in vivo.

146 deletion had no effect on promoter binding, abortive initiation or promoter escape, TFIIS-stimulated

147 purification away from excess nucleotide and abortive initiation products so that the purified comple

148 anscribed sequence (ITS) of N25 lengthen the abortive initiation program, resulting in the release of

149 a'omegasigma(70)), we compare productive and abortive initiation rates, short RNA distributions, and

150 In addition, we show that in vivo abortive initiation shows characteristics of in vitro ab

151 emplates, consistent with models attributing abortive initiation to the accumulation of strain in the

152 Polymerase structure is permissive for abortive initiation, thereby setting a lower limit on po

153 karyotic RNA polymerase (RNAP) can engage in abortive initiation-the synthesis and release of short (

154 racking and arrest in a process analogous to abortive initiation.

155 relates with a markedly reduced frequency of abortive initiation.

156 initiation shows characteristics of in vitro abortive initiation: Abortive initiation increases upon

157 e of C-terminal positive charges, results in abortive insertion of this transmembrane domain by the S

158 nontemplate strands is a major force driving abortive instability (although collapse from the downstr

159 l enzyme) results in substantially increased abortive instability and is likely the primary energetic

160 The results suggest that abortive instability is a by-product of the mechanistic

161 in RNA polymerases that dramatically reduce abortive instability.

162 mb site-2 (NNI2) lead to the accumulation of abortive intermediates three-five nucleotides in length.

163 B2-null merozoites with RBCs leads to either abortive invasion with rapid RBC lysis, or successful en

164 d; they subsequently tend to become entirely abortive, irrespective of their lipid content.

165 lication in most mammalian cells but have an abortive-late phenotype, in that the block to replicatio

166 ttenuated the propensity of rats to display "abortive lever pressing," a species-typical risk assessm

167 taxin (APTX), which suppresses mutagenic and abortive ligation at sites of oxidative DNA damage.

168 e that repairs A5'pp5'DNA ends formed during abortive ligation by classic 3'-OH/5'-PO4 ligases, is al

169 d in repair of A5'pp5'DNA ends formed during abortive ligation by classic ligases, is highly effectiv

170 Abortive ligation during base excision repair (BER) lead

171 removes 5'-AMP groups from DNA, a product of abortive ligation during DNA repair and replication.

172 onsequence of ligase failure by removing the abortive ligation product, i.e. the 5'-adenylate (5'-AMP

173 in the removal of adenylates that arise from abortive ligation reactions that take place at incised a

174 This could explain why LIG3 is less prone to abortive ligation than LIG1.

175 enerate and/or exacerbate DNA damage through abortive ligation that produces chemically adducted, tox

176 tion of full-size transcripts by suppressing abortive loss of short RNAs.

177 s production, and, importantly, prevents the abortive lytic cycle.

178 these data suggest a possible role of K8 in abortive lytic DNA replication occurring in early stages

179 express late viral proteins and thus had an abortive lytic form of EBV infection.

180 onsequence of a latent infection rather than abortive lytic infection.

181 results show that the SL mutant induces an "abortive" lytic infection in humanized mice that is comp

182 s, exhibits characteristics indicative of an abortive meiosis, including slight enlargement of sperma

183 en shown to produce haploid sperm through an abortive meiosis.

184 centrioles that are produced from the first abortive meiotic division, which occurs in the honeybee.

185 be considered for future pediatric trials of abortive migraine therapeutics.

186 Aberrant and abortive mitotic events result in the formation of micro

187 analyze and compare polyadenylated RNAs from abortive MOCV infections of several cell lines and a hum

188 e expression level of chitinase 1 and caused abortive molting in the insects.

189 Our results indicate that the abortive nature of initial synthesis is caused, at least

190 verting double-strand break repair away from abortive NHEJ and toward homologous recombination.

191 Additionally, POLRMT+TFB2M makes 2-mer abortives on LSP, but longer RNAs are observed only with

192 does not necessarily derive from the use of abortive or newborn animals with ultrathin hides, but co

193 placebo interventions (preventive, PAp, and abortive, PAa, placebo acupuncture; placebo cetirizine p

194 ism of brefeldin A (BFA) that conducts to an abortive pentameric Arf1-Mg(2+)-GDP-BFA-Sec7 complex.

195 patible crosses showed even distributions of abortive phenotypes over time, suggesting that host agei

196 The lifetime distribution of abortive pits calculated from our model agrees well with

197 In contrast, we could not detect auxilins in abortive pits or at any time during coated pit assembly.

198 /=12 years of age with labor and delivery or abortive pregnancy outcome between 2005 and 2013.

199 some traffic jams that block initiation, and abortive (premature) termination of stalled ribosomes.

200 ver, there is no evidence of an uncoupled or abortive process in the deamination reaction, as indicat

201 bing complexes, with a resulting decrease in abortive product release.

202 the scrunched open complex exhibits reduced abortive product synthesis, suggesting that scrunching a

203 characteristically unstable, yielding short abortive products on the path to elongation.

204 In vitro, CTL-expressed Ag induced an abortive proliferative response in specific B lymphocyte

205 beta7 on naive B cells, which resulted in an abortive proliferative response.

206 tumor Ag in the lymph node and underwent an abortive proliferative response.

207 DNA containing epsilonC lesions, forming an abortive protein-DNA complex; such binding not only shie

208 It provokes abortive recombination and compromises DNA repair in a m

209 ure of injured peripheral axons mimicked the abortive regeneration typically seen after CNS injury.

210 may lead to hyper forward translocation and abortive release at VLAT positions.

211 To determine the impact of abortive replication at different stages of the viral li

212 ellular and viral membranes under normal and abortive replication conditions.

213 a subset of human cell lines and found that abortive replication of H1N1 viruses in HeLa cells can b

214 re cellular factors in HeLa cells results in abortive replication of H1N1, H3N2, and LPAI viruses, wh

215 viruses, is not likely to be responsible for abortive replication of RSV during reinfection.

216 our knowledge, this is the first evidence of abortive replication of RSV in vivo.

217 Here, we showed that the abortive replication of several OPXV species in a Chines

218 release in the lung, but it does not prevent abortive replication of the virus.

219 Their repression results in abortive replication with the accumulation of dense mass

220 RF3 or TV-norovirus chimeric RNA resulted in abortive replication without the production of infectiou

221 l gene expression program with some lytic or abortive replication.

222 ctions along the RNA, risking collisions and abortive replication.

223 dually and collectively in productive versus abortive responses, new potential therapeutic targets ca

224 riad of potential signaling pathways linking abortive ribosome synthesis to cell-cycle regulators may

225 These observations and the lack of abortive RNA in initiation from short-lived ribosomal pr

226 se inhibition leading to the accumulation of abortive RNA products correlated with the amplification

227 rtive synthesis and increases full-length to abortive RNA ratio relative to full-length (FL) Rpo41.

228 tional changes provide a basis to understand abortive RNA synthesis during early stages of initiation

229 uring productive RNA synthesis as opposed to abortive RNA synthesis.

230 f promoter binding, bending and melting, and abortive RNA synthesis.

231 ly unstable, leading to the release of short abortive RNA transcripts.

232 evels in the presence of GreB, which rescues abortive RNAs (</=15 nucleotides) associated with backtr

233 The different length-distributions of abortive RNAs released from OCs with different lifetimes

234 ed nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatch

235 negative breast cancer cell lines undergo an abortive S phase and apoptotic cell death due to loss of

236 k3 can bypass the arrest and proceed into an abortive S phase followed by apoptosis.

237 s and achieve bipolar attachment, leading to abortive segregation and fragmentation of incompletely r

238 initiation, early elongation, elongation and abortive states-under seven experimental conditions of C

239 eletion of 1-270 amino acids (DN270) reduces abortive synthesis and increases full-length to abortive

240 The mechanisms of abortive synthesis and promoter escape during initiation

241 ntify a sequence element that modulates both abortive synthesis and the formation of arrested elongat

242 and growing RNA:DNA with the C-tail explain abortive synthesis and transition into elongation.

243 Mtf1 C-tail with short RNA-DNA hybrids cause abortive synthesis but clashes with longer RNA-DNA trigg

244 melting, template alignment, DNA scrunching, abortive synthesis, and transition into elongation.

245 ts after i.v. AML induction, consistent with abortive T cell activation and peripheral tolerance.

246 part by the activity of regulatory T cells, abortive T-cell activation and T-cell anergy.

247 s to a propagation of errors that results in abortive termination of protein synthesis.

248 when ribosome collisions at stalls stimulate abortive termination of the leading ribosome or cause en

249 ch collision with a trailing ribosome causes abortive termination of the stalled ribosome.

250 s, ribosome collisions selectively stimulate abortive termination without fine-tuning of kinetic rate

251 an S-adenosylmethionine (AdoMet)-binary and abortive ternary complex containing 8-hydroxyquinoline,

252 2 s(-1) for the dissociation of ADP from the abortive ternary complex, ERK2.Ets.ADP.

253 Thus, we define a pathway of abortive Th1 cell development that results in the specia

254 ells and helper-deficient CD8(+) T cells are abortive, these cells can differentiate into effectors a

255 is not exclusively due to a futile cycle of abortive TLS followed by exonucleolytic reversal.

256 Furthermore, the transition from abortive to productive elongation is kinetically limitin

257 ote the transition of RNA polymerase II from abortive to productive elongation.

258 of 6 and 7 nucleotides and a lower ratio of abortive to productive initiation events was observed fo

259 and in mouse post-mitotic neurons following abortive TOP2 activity.

260 engaging the diverse DNA damage triggers of abortive Top2 reactions.

261 phosphodiesterase-2, an enzyme that repairs 'abortive' TOP2-induced DSBs, in individuals with intelle

262 ydrolyzes 5'-tyrosine-DNA adducts that mimic abortive Top2cc.

263 Despite this essential role, abortive topoisomerase activity generates aberrant prote

264 DNA phosphodiesterase-1 protects cells from abortive topoisomerase I (Top1) activity by hydrolyzing

265 DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potentia

266 hydrolyzing 5'-tyrosyl DNA adducts formed by abortive topoisomerase II (Top2) cleavage complexes to a

267 ence of topoisomerase poisons, can result in abortive topoisomerase-induced DNA strand breaks.

268 Atoh1 in hair cells is likely caused by the abortive trans-differentiation of supporting cells into

269 re than 5-fold without affecting the rate of abortive transcript stimulation.

270 pe RNAP in promoter-dependent transcription, abortive transcript synthesis, transcript elongation or

271 ncrease in the ability of TFIIB to stimulate abortive transcription ('superstimulation').

272 al to maintain genomic integrity and prevent abortive transcription and translation initiation.

273 The detailed characterizations include abortive transcription assays, RNAP/promoter complex sta

274 y RNA in real time without interference from abortive transcription byproducts.

275 unpolyadenylated transcripts, probably from abortive transcription elongation.

276 nclude that oocyte maturation signals induce abortive transcription events in which FCP-1 may recycle

277 nerated as byproducts of RNA degradation and abortive transcription initiation.

278 ts in the TFIIB 'linker domain' to stimulate abortive transcription was systematically quantitated us

279 Abortive transcription, the premature release of short t

280 ogram, resulting in the release of very long abortive transcripts (VLATs) 16-19 nucleotides long.

281 ed nucleic acid probes, we directly detected abortive transcripts in bacteria.

282 Abortive transcripts may have functional roles in regula

283 The trailing complex can bind and make abortive transcripts when the leading complex is between

284 or mapping single ends cannot, such as short abortive transcripts, bicistronic messages and overlappi

285 ant in preventing the premature synthesis of abortive transcripts, suggesting its involvement in a ge

286 AP promoter association or the production of abortive transcripts.

287 te the production of very short (< or =5 nt) abortive transcripts.

288 ne and five Ds derivatives generated through abortive transposition events.

289 dministration may have potential as an acute abortive treatment for convulsive seizures in emergency

290 harmacokinetics trial data of drugs used for abortive treatment of migraine submitted to the FDA from

291 l challenge in pediatric trials of drugs for abortive treatment of migraine.

292 d migraine, and the symptom is responsive to abortive triptan treatments.

293 vels of incorrectly processed viral ends and abortive two-long-terminal-repeat circles.

294 y caspase-1-mediated pyroptosis triggered by abortive viral infection.

295 The round cells were characteristic of an abortive viral infection.

296 Abortive viral infections are usually studied in populat

297 In summary, following an abortive VZV infection, RMs developed an adaptive immune

298 hesus macaques (RMs) with VZV resulted in an abortive VZV infection.

299 e-production state increases, short-lived or abortive waves due to ROS-induced ROS release coexist wi

300 VACV infection in ex vivo B cells was abortive, which occurred at the stage of late viral gene