ライフサイエンスコーパス: abortus

1 ion should include both B. melitensis and B. abortus.

2 al inoculation of non-pregnant sheep with C. abortus.

3 cterial pathogens Brucella melitensis and B. abortus.

4 ansport has been found to attenuate Brucella abortus.

5 p40 than did mice infected with wild-type B. abortus.

6 teria Agrobacterium tumefaciens and Brucella abortus.

7 evasion of adaptive immune mechanisms by B. abortus.

8 tion rates in animals similar to those of B. abortus.

9 e processes, including virulence in Brucella abortus.

10 rotein, DNA repair, and SOS regulation in B. abortus.

11 factor for growth and virulence of Brucella abortus.

12 chronic infection of both S. meliloti and B. abortus.

13 umefaciens, and the animal pathogen Brucella abortus.

14 val of the global zoonotic pathogen Brucella abortus.

15 ols the cellular and infection biology of B. abortus.

16 induced by injection of heat-killed Brucella abortus.

17 analyzed Erfe-deficient mice injected with B abortus.

18 sis is a unique feature of GSR control in B. abortus.

19 A znuA knockout mutation in B. abortus 2308 (DeltaznuA) was constructed and found to be

20 tracellular trafficking of virulent Brucella abortus 2308 and attenuated hfq and bacA mutants was fol

21 s S19vjbR and B. abortus DeltavirB2 While B. abortus 2308 and S19 replicated inside mature osteoclast

22 roperoxide, but not hydrogen peroxide, in B. abortus 2308 and that OhrR represses the transcription o

23 retic analysis of cell lysates from Brucella abortus 2308 and the isogenic hfq mutant Hfq3 revealed t

24 llular replication, the numbers of acidic B. abortus 2308 BCP decreased while remaining cathepsin D(-

25 ve regulation of mntH expression in Brucella abortus 2308 but also identify the cis-acting elements u

26 nt, designated MEK2, was constructed from B. abortus 2308 by gene replacement, and the sodC mutant ex

27 tectable levels of Irr were found only in B. abortus 2308 cells by Western blot analysis following gr

28 ccine, since protection against wild-type B. abortus 2308 challenge was as effective as that obtained

29 BhuA exhibits maximum expression in Brucella abortus 2308 during growth under iron-deprived condition

30 eins represent important iron sources for B. abortus 2308 during its residence in the mammalian host

31 nated CAM220) derived from virulent Brucella abortus 2308 exhibited increased sensitivity to the alky

32 Ohr plays a prominent role in protecting B. abortus 2308 from organic hydroperoxide stress in in vit

33 1 gene product participates in protecting B. abortus 2308 from oxidative damage.

34 ntal findings indicate that SodC protects B. abortus 2308 from the respiratory burst of host macropha

35 es designated BAB2_0837-0840 in the Brucella abortus 2308 genome sequence are predicted to encode a C

36 d as BAB2_0350 and BAB2_0351 in the Brucella abortus 2308 genome sequence are predicted to encode Ohr

37 The gene annotated BAB2_1150 in the Brucella abortus 2308 genome sequence is predicted to encode a ho

38 he gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is predicted to encode the

39 s, we searched the Brucella suis 1330 and B. abortus 2308 genomes for genes with an upstream virB pro

40 The results of these studies suggest that B. abortus 2308 has at least one other heme oxygenase that

41 Interestingly, B. abortus 2308 impaired the growth of osteoclasts without

42 ired for the wild-type virulence of Brucella abortus 2308 in mice and indicated that the mntH gene is

43 nscription of the ftrA gene is induced in B. abortus 2308 in response to iron deprivation and exposur

44 on of isogenic mutants derived from Brucella abortus 2308 indicates that the AlcR homolog DhbR (2,3-d

45 Maximum expression of bhuA in B. abortus 2308 is observed during stationary phase when th

46 oduct, the expression of the mntH gene in B. abortus 2308 is repressed by Mn(2+), but not Fe(2+), and

47 ents a relevant environmental stress that B. abortus 2308 must deal with during its residence in the

48 rved in the spleens of mice infected with B. abortus 2308 or a virB mutant.

49 RNAs, indicating that the AbcR sRNAs from B. abortus 2308 perform redundant regulatory functions.

50 B. abortus 2308 persisted within these cathepsin D(-), LAMP

51 Mice infected with B. abortus 2308 produced an antibody response to the protei

52 macrophages or osteoclast precursors with B. abortus 2308 resulted in generation of smaller osteoclas

53 ponse to iron deprivation in the parental B. abortus 2308 strain, and a direct and specific interacti

54 sponsive two-component regulator in Brucella abortus 2308 that responds to decreasing levels of O(2)

55 tein plays a role in the ability of Brucella abortus 2308 to use heme as an iron source, an isogenic

56 s of an isogenic bhuA mutant derived from B. abortus 2308 verified that there is a link between BhuA

57 he transcriptional start site for mntH in B. abortus 2308 was determined by primer extension analysis

58 somal pathway and replication of virulent B. abortus 2308 within these vesicles corresponds with an i

59 e seen for control particles (heat-killed B. abortus 2308, live Escherichia coli HB101, or latex bead

60 In B. abortus 2308, MucR regulates a wide variety of genes who

61 ys an important role in the physiology of B. abortus 2308, particularly during its intracellular surv

62 In contrast to B. abortus 2308, the isogenic hfq and bacA mutants remained

63 into mature osteoclasts and infected with B. abortus 2308, the vaccine strain S19, and attenuated mut

64 Here we present the genome of B. abortus 2308, the virulent prototype biovar 1 strain, an

65 ir and resistance to oxidative killing in B. abortus 2308, XthA-1 is not required for wild-type virul

66 Early trafficking events of B. abortus 2308-containing phagosomes (BCP) were indistingu

67 D(+) BCP was significantly lower for live B. abortus 2308-infected cells than for either Brucella mut

68 isogenic ftrA mutant was constructed from B. abortus 2308.

69 AbcR1 and AbcR2) have been identified in B. abortus 2308.

70 to wild-type expression of virB in Brucella abortus 2308.

71 ith those of the virulent parental strain B. abortus 2308.

72 mentally infected with different doses of C. abortus (5x10(3), 5x10(5) and 5x10(7) inclusion forming

73 also show that DeltaybeY mutant of Brucella abortus, a mammalian pathogen, also accumulates a simila

74 m the anemia induced by heat-killed Brucella abortus, a model of inflammatory anemia.

75 Here, we demonstrate that Brucella abortus, a notorious reproductive pathogen, has the abil

76 ium meliloti, a legume symbiont and Brucella abortus, a phylogenetically related mammalian pathogen,

77 um meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian pathogen,

78 Two small RNAs in Brucella abortus, AbcR1 and AbcR2, are required for wild-type vir

79 Although B. abortus-activated T cells actively secreted the pro-oste

80 B. abortus ahpC and katE mutants exhibit wild-type virulenc

81 lence in C57BL/6 and BALB/c mice, but the B. abortus ahpC katE double mutant is extremely attenuated,

82 (astrocytes and microglia) infected with B. abortus also induced activation of HBMEC, but to a great

83 infection, we studied the persistence of B. abortus and an isogenic virB mutant deficient in the Vir

84 rtions supports previous indications that B. abortus and B. melitensis share a common ancestor that d

85 d S708 phages that are lytic for B. suis, B. abortus and B. neotomae.

86 In extravillous trophoblasts (EVTs), B. abortus and B. suis replicated within single-membrane ac

87 everal fragments were shared between only B. abortus and B. suis, B. abortus shared more fragments an

88 n OPS epitope equally common to all Brucella abortus and Brucella melitensis strains but unique to Br

89 s, manBA, virB2, and asp24, in both Brucella abortus and Brucella melitensis.

90 es that are predominantly lytic for Brucella abortus and Brucella neotomae; Group II included Bk, R/C

91 uced by an injection of heat-killed Brucella abortus and examined the contribution of hepcidin by com

92 -type strain of the ovine pathogen Chlamydia abortus and its nitrosoguanidine-induced, temperature-se

93 the role of DNA repair networks in Brucella abortus and its role in pathogenesis.

94 litensis 16 M would be similar to znuA in B. abortus and questioned whether it may also be an importa

95 m tumefaciens is a close relative of both B. abortus and S. meliloti, and this bacterium is the causa

96 stress survival and the interface between B. abortus and the host immune system.

97 To identify in vivo interactions between B. abortus and the host that lead to persistent infection,

98 ed bacteria Sinorhizobium meliloti, Brucella abortus, and Ochrobactrum anthropi.

99 ria mallei, Francisella tularensis, Brucella abortus, and ricin.

100 f 480 known bioactive compounds for novel B. abortus anti-infectives.

101 We demonstrate recognition of B. abortus antibodies through capture by fluorescent silica

102 All anti-C. abortus antibody isotypes increased in heifers following

103 such as Bacteroides fragilis and Salmonella abortus are observed for CD14(+/+), but not CD14(-/-), m

104 The lipid A molecules of S. meliloti and B. abortus are unusually modified with a very-long-chain fa

105 other chlamydial species, C. psittaci and C. abortus, are known zoonotic pathogens.

106 Here, we study the cell cycle of B. abortus at the single-cell level, in culture and during

107 s also dispensable for the persistence of B. abortus, B. melitensis, and B. suis in mice up to 4 week

108 neotomae is a rodent pathogen, and unlike B. abortus, B. melitensis, and B. suis, B. neotomae has not

109 d upon three pathogenic Brucella species: B. abortus, B. melitensis, and B. suis.

110 crodilution susceptibility tests of Brucella abortus, B. melitensis, and B. suis.

111 human and animal origin, including Brucella abortus, B. melitensis, B. ovis, B. neotomae, marine mam

112 ationships of five Brucella species-Brucella abortus, B. melitensis, B. suis, B. canis, and B. ovis-u

113 AI was induced with heat-killed Brucella abortus (BA).

114 The B. abortus bab1_1517 mutant strain was significantly attenu

115 nt BEA5, and, unlike the parental strain, B. abortus BEA5 cannot utilize heme as an iron source in vi

116 ison of the growth characteristics of the B. abortus bhuA mutant and 2308 in this medium suggested th

117 The B. abortus bhuA mutant HR1703 exhibits significant attenuat

118 n 2308, and unlike its parent strain, the B. abortus bhuA mutant is unable to maintain a chronic sple

119 Although the Brucella abortus bhuQ mutant DCO1 did not exhibit a defect in its

120 , and Pr phages that are lytic mainly for B. abortus, Brucella melitensis and Brucella suis; Group II

121 of the medically relevant pathogens Brucella abortus, Brucella melitensis, Bartonella henselae, and L

122 ium botulinum, Brucella melitensis, Brucella abortus, Brucella suis, and Brucella canis were extracte

123 , producing four clades as follows: Brucella abortus-Brucella melitensis, Brucella suis-Brucella cani

124 its transcription is strongly induced in B. abortus by various stressors encountered by the bacteria

125 The results reveal that B. abortus causes a chronic infection of lung tissue in BAL

126 Molecular components of the Brucella abortus cell envelope play a major role in its ability t

127 B. abortus cell-cycle progression is coordinated with intra

128 nate immunity of the CNS set in motion by B. abortus contributes to the activation of the blood-brain

129 Within this conserved Cp. abortus core genome we have identified the major regions

130 nce, primers were designed to construct a B. abortus deletion mutant.

131 n S19, and attenuated mutants S19vjbR and B. abortus DeltavirB2 While B. abortus 2308 and S19 replica

132 Introduction of a bhuQ mutation into the B. abortus dhbC mutant BHB2 (which cannot produce sideropho

133 al intracellular pathogens, such as Brucella abortus, display a biphasic infection process starting w

134 Livers from mice infected with B. abortus displayed a fibrogenic phenotype with patches of

135 ghlight that the control of DNA repair in B. abortus displays distinct features that are not present

136 Thus, proper control of B. abortus division site polarity is necessary for survival

137 Signaling pathways triggered by Brucella abortus DNA involves TLR9, AIM2, and stimulator of IFN g

138 r systems to show that the pathogen Brucella abortus does encounter alkylating stress during the firs

139 In dams, C. abortus dominated in milk and C. pecorum dominated in th

140 the x-ray crystal structures of the Brucella abortus DRL enzyme in its apo form and in complex with t

141 The intracellular bacterium Brucella abortus ensures its survival by forming the Brucella-con

142 r a conserved gene of unknown function in B. abortus envelope stress resistance and infection.

143 he prokaryotes Brucella melitensis, Brucella abortus, Erythrobacter litoralis, and Pseudomonas syring

144 e use a genomic approach to examine Brucella abortus evolution, cross-species transmission and spatia

145 ort the complete genome sequence of Brucella abortus field isolate 9-941 and compare it to those of B

146 human pathogenic Brucella species and to B. abortus field isolate 9-941.

147 melitensis for sheep and goats, and Brucella abortus for cattle).

148 nsis isolated from seven participants and B. abortus from one.

149 Compared with the parental strain, the B. abortus ftrA mutant displays a decreased capacity to use

150 The B. abortus ftrA mutant exhibits significant attenuation in

151 The Brucella abortus general stress response (GSR) system is required

152 suis or B. melitensis were present in the B. abortus genome.

153 y on day 70 of gestation with 2x10(6) IFU C. abortus (group 5).

154 a protein, which was detected in vitro in B. abortus grown to stationary phase.

155 A genome-scale analysis of the B. abortus GSR regulon identified stress response genes pre

156 of genes that closely overlaps the known B. abortus GSR regulon.

157 LovhK (bab2_0652), functions as a primary B. abortus GSR sensor.

158 The B. abortus GSR signaling pathway has multiple layers of pos

159 Thus, the B. abortus GSR system is dispensable for colonization but i

160 We conclude that the B. abortus GSR system regulates acute stress adaptation and

161 sent study the genes regulated by MucR in B. abortus have been elucidated using microarray analysis a

162 _0612 are highly over-produced in a Brucella abortus hfq mutant compared with the parental strain, an

163 ibute to the attenuation displayed by the B. abortus hfq mutant Hfq3 in the mouse model.

164 l DNA in the context of heat-killed Brucella abortus (HKBA) engages TLR9 in dendritic cells (DC), res

165 was crucial for increased replication of B. abortus in AAMs, and for chronic infection, as inactivat

166 Thus, opsonized B. abortus in human monocytes survives within phagosomes th

167 tion and further secretion of IL-1beta by B. abortus in macrophages.

168 and virB11 are essential for virulence of B. abortus in mice, while functions encoded by the virB1, v

169 nt for the T4SS to mediate persistence of B. abortus in the spleen.

170 Here, we show that a Brucella abortus in-frame mucR deletion strain exhibits a pronoun

171 iption of cell-cycle progression of Brucella abortus, including unipolar growth and the ordered initi

172 upernatant from macrophages infected with B. abortus induced bone marrow-derived monocytes (BMMs) to

173 Brucella abortus Infection of HBMEC with B. abortus induced the secretion of IL-6, IL-8, and MCP-1,

174 o and in vivo evidence showing that Brucella abortus-induced inflammatory response leads to the activ

175 Finally, these results suggest that B. abortus-induced UPR is triggered by bacterial cyclic dim

176 ate that the cross talk of LX-2 cells and B. abortus induces autophagy and fibrosis with concomitant

177 was dependent on IL-1beta because CS from B. abortus-infected astrocytes and microglia deficient in c

178 Although B. abortus-infected glial cells secreted IL-1beta and TNF-a

179 nisms of liver immune response induced by B. abortus-infected hepatic stellate cells.

180 In contrast, supernatants from B. abortus-infected hepatocytes and monocytes induce MMP-9

181 bortus, the capacity of supernatants from B. abortus-infected hepatocytes and monocytes to induce MMP

182 icate that activated T cells, elicited by B. abortus-infected macrophages and influenced by the infla

183 eterinarians with occupational exposure to C abortus-infected sheep revealed only sporadic immune res

184 ct antibodies to these surface antigens in C abortus-infected women who had undergone septic abortion

185 gs contribute to the persistence of Brucella abortus infection and that inactivation of Tregs with tu

186 However, with time, B. abortus infection induced Beclin-1 cleavage with concomi

187 The present study demonstrates that Brucella abortus infection induces the activation of the autophag

188 We demonstrated that B. abortus infection induces the expression of the UPR targ

189 We demonstrate that Brucella abortus infection inhibits matrix metalloproteinase-9 (M

190 BMEC) in response to infection with Brucella abortus Infection of HBMEC with B. abortus induced the s

191 -1 knockout mice were more susceptible to B. abortus infection than were wild-type animals, suggestin

192 nner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum stress senso

193 he TLR-initiated immune response to Brucella abortus infection.

194 tions of Igh6(-/-) mice in the context of B. abortus infection.

195 ssion of proinflammatory cytokines during B. abortus infection.

196 so important for the UPR induction during B. abortus infection.

197 dent transmembrane molecule STING, during B. abortus infection.

198 2, and AIM2 KO mice are less resistant to B. abortus infection.

199 ells (Tregs) in the pathogenesis of Brucella abortus infection.

200 fic antigen for the serodiagnosis of human C abortus infections was Pmp13G, which showed no cross-rea

201 e laboratory diagnosis of human and animal C abortus infections.

202 globulin M and complement-opsonized Brucella abortus infects and survives inside primary murine B cel

203 The models predict that the uterine C. abortus inoculum causing infertility is 8.5-fold higher

204 Signaling pathways triggered by B. abortus involves stimulator of IFN genes (STING), which

205 Chlamydophila abortus is a common cause of ruminant abortion.

206 Brucella abortus is a facultative intracellular bacterium that ca

207 Brucella abortus is a facultative, intracellular zoonotic pathoge

208 Brucella abortus is an intracellular bacterial pathogen and an et

209 Brucella abortus is an intracellular pathogen that persists withi

210 e obligate intracellular bacterium Chlamydia abortus is the causative agent of enzootic abortion of e

211 Significantly, Cp. abortus lacks any toxin genes, and also lacks genes invo

212 itors of intracellular replication reduce B. abortus metabolism in axenic culture and perturb feature

213 Twenty-six compounds inhibited B. abortus metabolism in axenic culture, thirteen of which

214 The B. abortus mntH mutant also exhibits extreme attenuation in

215 The B. abortus mntH mutant MWV15 exhibits increased susceptibil

216 o severe human anemia of inflammation, the B abortus model shows multifactorial pathogenesis of infla

217 A Brucella abortus mutant lacking TcpB fails to reduce levels of MA

218 Furthermore, B. melitensis but not B. abortus nor B. suis interfered with the invasive capacit

219 with B. abortus S2308 or pretreated with B. abortus O polysaccharide did not prevent rough CA180-ind

220 cit systemic infections with either Brucella abortus or B. melitensis at various doses.

221 immunosorbent assay with lysed Chlamydophila abortus or Chlamydophila pecorum elementary body antigen

222 hole limpet hemocyanin, heat-killed Brucella abortus, or infection with Nippostrongylus brasiliensis

223 S/SIGNIFICANCE: This study indicates that C. abortus Pmp18D is proteolytically processed at the cell

224 proteins into three distinct clades with C. abortus Pmp18D, being most similar to those originating

225 dings indicate that the 14-kDa protein of B. abortus possesses lectin-like properties and is essentia

226 The complete genomic sequence of B. abortus provides an important resource for further inves

227 This proteomic analysis of B. abortus provides novel insights into the mechanisms util

228 unctional analyses that demonstrated that B. abortus RadA complements a radA defect in E. coli but co

229 We considered the possibility that B. abortus RadA might be compensating for the loss of RecA

230 persensitive to UV damage, surprisingly a B. abortus recA null mutant conferred only modest sensitivi

231 E. coli but could not act in place of the B. abortus RecA.

232 y MHC II and allows host control of Brucella abortus replication in IL-4-treated DCs and in RUFY4-exp

233 icacy of these molecules as inhibitors of B. abortus replication in the intracellular niche suggests

234 ytotoxic compounds specifically inhibited B. abortus replication in the intracellular niche, which su

235 totoxic to human host cells and attenuate B. abortus replication in the intracellular niche.

236 racellular bacterial pathogens, including B. abortus Results from this study indicate that adverse re

237 -pregnant sheep with a low/medium dose of C. abortus results in a latent infection that leads in a su

238 ugated to type 1 T cell-independent Brucella abortus ring test Ag (BRT).

239 activity, while osteoclasts infected with B. abortus S19 and S19vjbR were significantly larger and ex

240 ils were observed in mice inoculated with B. abortus S19 but not in those inoculated with S19Deltavjb

241 1 x 10(4), 1 x 10(5), or 1 x 10(6) CFU of B. abortus S19 or the vaccine candidate B. abortus S19Delta

242 f B. abortus S19 or the vaccine candidate B. abortus S19DeltavjbR and monitored for the development o

243 In contrast, mice inoculated with B. abortus S19DeltavjbR did not show significant bone chang

244 Furthermore, macrophages preinfected with B. abortus S2308 or pretreated with B. abortus O polysaccha

245 rine macrophages were infected with Brucella abortus S2308-derived rough mutant CA180.

246 ared between only B. abortus and B. suis, B. abortus shared more fragments and had fewer nucleotide p

247 hen used to infect macrophages, DeltaznuA B. abortus showed minimal growth.

248 Further study with DeltaznuA B. abortus showed that its virulence in BALB/c mice was att

249 lling by cultured murine macrophages, the B. abortus sodC mutant also displayed significant attenuati

250 The attenuation displayed by the B. abortus sodC mutant in both resting and IFN-gamma-activa

251 The B. abortus sodC mutant was also found to be much more sensi

252 Brucella abortus SodC was monomeric and released by osmotic shock

253 e encoding the 14-kDa protein in virulent B. abortus strain 2308 induced a rough-like phenotype with

254 rotection against challenge with virulent B. abortus strain 2308 or B. suis strain 1330 but no protec

255 tracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of C

256 en genes, the genetic complements of both B. abortus strains are identical, whereas the three species

257 nserved signalling pathway that regulates B. abortus stress physiology and infection biology.

258 hyR and sigma(E1), are required for Brucella abortus stress survival in vitro and maintenance of chro

259 ition, priming cells with IFN-beta favors B. abortus survival in macrophages.

260 how that the intracellular pathogen Brucella abortus survives and replicates preferentially in altern

261 f the PmpD protein in the animal pathogen C. abortus (termed Pmp18D).

262 re higher in mice infected with wild-type B. abortus than in mice infected with the virB mutant, as s

263 response in mice infected with wild-type B. abortus than in mice infected with the virB mutant.

264 n spleens of mice infected with wild-type B. abortus than in virB mutant-infected mice.

265 sette in the intracellular pathogen Brucella abortus that consists of the toxin gene, brnT, and its a

266 teolysis is a novel regulatory feature in B. abortus that ensures proper control of GSR transcription

267 pestis, Francisella tularensis, and Brucella abortus), the last four of which are biothreat agents.

268 Brucella abortus, the bacteria responsible for bovine brucellosis

269 Yet, if LX-2 cells are infected with B. abortus, the capacity of supernatants from B. abortus-in

270 In the intracellular pathogen Brucella abortus, the general stress response (GSR) signalling sy

271 -excision repair pathways are required by B. abortus to face this stress in vitro and in a mouse infe

272 on of virB7 did not reduce the ability of B. abortus to persist in spleens of mice.

273 or virB11 markedly reduced the ability of B. abortus to persist in the spleens of mice at 8 weeks aft

274 virB locus markedly reduce the ability of B. abortus to survive in cultured macrophages or to persist

275 All mutations reduced the ability of B. abortus to survive in J774A.1 mouse macrophage-like cell

276 In B abortus-treated Hamp-KO compared with WT mice, anemia wa

277 B abortus-treated wild-type mice developed a moderate anem

278 B abortus-treated WT mice developed severe anemia with a h

279 odel was developed with heat-killed Brucella abortus treatment.

280 The Brucella abortus type IV secretion system (T4SS), encoded by the

281 The Brucella abortus type IV secretion system (T4SS), encoded by the

282 The bacterium Brucella abortus uses a type IV secretion system (VirB T4SS) to g

283 ich site is recognized by MucR from Brucella abortus using a similar mechanism involving contacts wit

284 The Brucella abortus virB locus contains 12 open reading frames, term

285 Mice infected with the B. abortus virB mutant elicited smaller increases in serum

286 In the mouse model, a B. abortus virB mutant was initially able to colonize the s

287 The Brucella abortus virB operon, consisting of 11 genes, virB1 to vi

288 e functions as a photoreceptor regulating B. abortus virulence.

289 In the mammalian pathogen Brucella abortus, VtlR is required for full virulence in a mouse

290 parenchyma upon intracranial injection of B. abortus was diminished in the absence of Nod-like recept

291 A 14-kDa protein of B. abortus was previously identified to be immunogenic in a

292 Infection of macrophages by B. abortus was stimulated by light in the wild type but was

293 Ovarian pieces from 24 weeks old abortuses were xenografted s.c. to severe combined immun

294 key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-p

295 duction triggered by infection with Brucella abortus, which induces ER stress by injecting the type I

296 spleen during a mixed infection with the B. abortus wild type.

297 S, we compared host responses elicited by B. abortus with those of an isogenic mutant in the virB ope

298 PPARgamma promotes chronic persistence of B. abortus within AAMs, and targeting this pathway may aid

299 The B. abortus xthA-1 mutant also displayed reduced resistance

300 Although the B. abortus xthA-1 mutant exhibited increased sensitivity to