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1 on change from cubic to tetragonal phase is about 9%.

2 hemotherapy has a 5-year overall survival of about 10%.

3 rresponds to a theoretical drag reduction of about 27%.

4 ne-resistant bacteria in their offspring, by about 50%.

5 % and that proteinuria increases the risk by about 70%.

6 er the optimized experimental conditions was about 80%.

7 norganic N, which was reduced by a factor of about 2.

8 t with a relatively low activation energy of about 1.0 electronvolt, a value close to that previously

9 Pakistan will need to invest about 9.0% of its yearly health expenditure to enable su

10 ximately 100 million patient encounters with about 155 000 physicians from 417 health systems.

11 Here we show how the morphology of about 11,000 coastal deltas worldwide, ranging from smal

12 nd human modification to the landscape until about 1,000 to 1,500 y ago.

13 We also find an extreme bottleneck until about 1,000 y ago, which is followed by distinct expansi

14 of the AIS during the Last Glacial Maximum (about 26,000 to 20,000 years ago), triggers an earlier r

15 water regimes; 73,573 eQTLs are detected for about 30,000 expressing genes with high-density genome-w

16 About 400,000 years ago, during the interglacial period

17 emission from gas SCVF is estimated to reach about 75,000 t/y based on the existing inventory calcula

18 y a prominent infraorbital nerve, containing about 80,000 axons.

19 trol of the global theta with a precision of about 0.1 degrees has been demonstrated(1-7), little inf

20 in the nearby communities were increased by about 0.1 mug m(-3) due to the aviation emission, equiva

21 f the integration and deletion reactions was about 0.1% and 20%, respectively.

22 average power conversion efficiency (PCE) of about 0.1%, which is among the highest reported for a 1D

23 ta on pneumonia mortality, we estimated that about 1.1 million in-hospital deaths (UR, 0.9-1.4 in-hos

24 Thymine dimers were found at a potential of about 1.1 V in ammonium acetate (pH 7.0) and 1.25 V in a

25 The ratio of ClaST to WMNsST was about 4:1 averaged across the four injections.

26 an speeds up the guide RNA library designing about 9-12 times on a 32-process mode comparing to Guide

27 ted in the rotarod test, to be sacrificed at about 12-13 or 19 weeks of age, and their lumbar spinal

28 and 20%, respectively; and the water loss by about 5%, 15% and 0%, respectively.

29 Light commercial vehicles (LCVs) account for about 10-15% of road traffic in Europe.

30 A very low limit of detection of about 0.15 ng/mL was obtained during the detection of CR

31 trate that current N removal by US wetlands (about 860 +/- 160 kilotonnes of nitrogen per year) is li

32 than traditional CN(-) fluorescent sensors (about 0.2 mum).

33 he grip of continental ice sheets, with only about 0.2% of its overall area being ice-free.

34 Vitiligo has an estimated prevalence of about 0.2-2% in different populations and approximately

35 We find that the EU ETS saved about 1.2 billion tons of [Formula: see text] between 20

36 lectric energy cost for FG synthesis is only about 7.2 kilojoules per gram, which could render FG sui

37 sites, with a stable male-to-female ratio of about 3:2.

38 ients with MF and Sezary syndrome found that about 10-20% of stage IB patients don't survive 5 years,

39 star-forming regions, has an aspect ratio of about 1:20 and contains about three million solar masses

40 trains shared common expression patterns for about 10,200 genes, and an additional 400-600 genes were

41 eased gradually along storage and reduced by about 21.23, 47.22 and 56.65% for TRI, INI and RPF, resp

42 -1) , corresponding to a space time yield of about 30x10(3) kg m(-3) day(-1) , which is 1-2 orders of

43 tide substitution variants have error rates (about 10-3) that limit sensitive detection.

44 gnificant decrease in their melting point of about 0.3-0.4 K.

45 Here we report imaging, with a resolution of about 1.3 kiloparsecs, of the 158-micrometre emission li

46 /EG is significantly enhanced by a factor of about 32.3%; this is highest reported value for a graphe

47 ove, salt marsh, and seagrass ecosystems are about 0.33-0.39 Tmol CH(4) -C/year-an addition that incr

48 reduces heat transfer to the dough center by about 21%, 35% and 20%, respectively; and the water loss

49 nt at that time, becoming more frequent from about 1.35 Ma, as the Northern Hemisphere cooled, and pe

50 3.9 meV, another one exhibits a full gap of about 2.35 meV.

51 orphization of the empty structure occurs at about 0.4 GPa.

52 thern Hemisphere cooled, and permanent after about 0.4 Ma.

53 Rhodochrosite has a calculated bandgap of about 5.4 eV, corresponding to light energy centering ar

54 IHCs (9-12 kHz cochlear region) decreases by about 30-40% with age.

55 However, previous data show that only about 24%-45% of US adults at high risk of HBV infection

56 strom between hemes in adjacent proteins was about 10(5) s(-1), about 100-fold slower than expectatio

57 ntologic results that indicate a time gap of about 0.5 Myr between the Ries and Steinheim events.

58 2:6n-3) per 100 kcal, which is equivalent to about 0.5-1% of fatty acids (FAs) and thus higher than t

59 h genetic diagnoses (median, 31.5 years) was about 14.5 years earlier than that of patients without m

60 We also estimate that about 2.5 million new hospital beds need to be allocated

61 easures would reduce that to household size (about 2.5), we reproduce actual infection curves with re

62 ion, resolving eight colors in 300-nm width, about 37.5-nm per color.

63 nized concentrically: the excitatory center (about 4.5 degrees ) is surrounded by opponent periphery.

64 rometres), area (continuous thin films up to about 5.5 centimetres by 5.5 centimetres), and compositi

65 About 40%-50% of patients have kidney abnormalities, and

66 th e3/e3 and e4 carriers with odds ratios of about 0.50 for e3 contrasts and 0.10 for e4 contrasts.

67 We map the fine-scale structure within about 1.6 million DNase I-hypersensitive sites and show

68 gical CH(4) emissions to the atmosphere were about 1.6 teragrams CH(4) per year, with a maximum of 5.

69 emissions are underestimated by a factor of about 2.6 compared with the 2018 UK National Atmospheric

70 7 years smoke their first cigarette and that about 5.6 million adolescents alive today will die prema

71 ry syndrome have a 5-year survival chance of about 20-60%.

72 vident, both measures were found reverted to about 50-60% of control values.

73 (and genes for the biosynthesis of 2-MIB in about 50%)(7,8), suggests that the volatiles provide a s

74 Our analysis indicates that about 2.7 billion people worldwide (36% of the populatio

75 About 3.7 billion doses of ivermectin have been distribu

76 About 60%-70% of individuals with the typical 3 megabase

77 Its iron abundance is about 1/800 that of the Sun and about one-third that of

78 yr BP and maize (Zea mays) at about 6,850 cal.

79 ior to what achieved with the CRAM format by about 8-9%.

80 by a d-wave gap function with gap maximum of about 3.9 meV, another one exhibits a full gap of about

81 the predictors identify the affected sibling about 70-90% of the time across a variety of disease con

82 For a 100 MHz frequency band centered about 890-920 MHz, the maximum Youden's J index is 81.5%

83 About 594 adults were participated with a response rate

84 rmoelectric coefficient, reaching a value of about 5 amperes per kelvin per metre with a logarithmic

85 6 and 31 ka and the Ngandong terrace between about 140 and 92 ka.

86 content in the first and second harvests by about 15 and 30%, respectively.

87 ability of A(1)R-G279S(7.44) was enhanced by about 2 and 8 K when compared with wild-type A(1)-recept

88 This reduction is about 29% and 5% of total agricultural soil GHG emission

89 tration rate increases the risk of stroke by about 40% and that proteinuria increases the risk by abo

90 realistic contact networks with a degree of about 5, and assuming that lockdown measures would reduc

91 n and inserted into an acidic pocket that is about 5 angstrom away.

92 ith a maximum intracellular concentration of about 65% as early as 10 min after incubation.

93 chness potential is projected to increase by about 40% at higher latitudes under the 'no mitigation p

94 women and approximately 75% in men, up from about 45% at the start of the study.

95 tolerant and can withstand water pressure of about 20 atmospheres (atm) for the species Sepia officin

96 About 50 bilateral pairs of neurons innervating all subs

97 estimate from the ionized carbon emission of about 72 billion solar masses.

98 We observed about 700 Ca-rich particles with order parameters, L(2)'

99 We observed that ABS occurred for about 84% circRNAs.

100 Among these were about 20 columnar neurons, 33 bilateral pairs of tangent

101 n leads to an increase of the conductance by about 50 % compared to the initial state.

102 OER-active gamma-phases are characterized by about 8% contraction of the lattice spacing and switchin

103 With about 800 curated models, BioModels has become the world

104 d of crystalline STC with a cross-section of about 100 cytochromes could support the anaerobic respir

105 rcher with basic proteomics skills and takes about 4 d to complete.

106 ce most patients had an antibody response at about 10 days after onset of symptoms.

107 With a lifetime of about 130 days, the potential soft-X-ray frequency refer

108 lment and one follow-up household visit done about 60 days later (range 50-90 days) in children with

109 ly selective, reproducible and is stable for about 60 days.

110 eveal significant sound level differences of about 1 dBA, with the most-common noise level being spre

111 halves of the S6 helices bend and rotate by about 100 deg, exposing different residues to the channe

112 the temperature increased from 90 degrees to about 215 degrees C.

113 ermal treatment pathway (Acheson process) at about 3000 degrees C.

114 t environment existed at a palaeolatitude of about 82 degrees S during the Turonian-Santonian age (92

115 ads to the detection of the presence of even about 5% distribution of premalignant cells among health

116 e into substrate-specific pathways requiring about 100 enzymes per fucoidan from different species of

117 variance of genetic correlation estimates by about 60%, equivalent to a 2.5-fold increase in sample s

118 of mechanophores required to crosslinking by about 100-fold compared to previous examples of load-str

119 in adjacent proteins was about 10(5) s(-1), about 100-fold slower than expectations based on simplif

120 in Mecp2 conditional knockout mice, whereas about 12-fold decrease in Wnt6 mRNA level was found in M

121 The sequential conjugate was internalized about 13-fold more efficiently than the branched conjuga

122 .L(water)(-1)) and incubated for 21 h-showed about 15-fold lower atmospheric concentrations (3-4 pg.L

123 strated an increased bioavailability rate by about 20-fold for total quercetin.

124 h and economic benefits were estimated to be about 2-fold larger than based on consumer response alon

125 The alpha137-141 concentration was increased about 4-fold at a feed peptide concentration of 8% with

126 on from homogenization drastically enhanced (about 5-fold) bioaccessibility of carotenoids including

127 f dopamine detection (7.8 muA/muM), which is about 312 folds that of silicon electrode (0.025 muA/muM

128 activity might reduce breast cancer risk by about 20% for women across the risk continuum, including

129 alue = .023), the protective effect reaching about 40% for children with 2 or more siblings (OR = 0.6

130 pture all finger motions with an accuracy of about 99% for seven classes.

131 2 is demonstrated, with a throughput rate of about 1500 g day(-1) , corresponding to a space time yie

132 in the TM, but TM adaptation stalled within about 300 generations.

133 for rapid antibiotic susceptibility tests in about 2 h.

134 r the 1,2-IHN isomer with a time constant of about 6 h best explains our atmospheric measurements.

135 -GMIB-anti-HER2-VHH1 in healthy subjects was about 8 h.

136 About 60% HFD-fed mice were treated intragastrically wit

137 Indian dying from snakebite before age 70 is about 1 in 250, but notably higher in some areas.

138 sometimes called Edwards syndrome, occurs in about 1 in 6000 live births and causes multiple birth de

139 common craniofacial birth defects, impacting about 1 in 800 births in the USA.

140 g from <30% in normal to mild proteinuria to about 70% in severe proteinuria, and with wider predicti

141 pletely filled by newly formed bone, against about 75% in C specimens (P = 0.0015).

142 tions, respectively, and the synchronisation about 80% in both directions.

143 hat each derived allele reduces body size by about 1 inch and 5 pounds.

144 mation through a highly recurrent network of about 80 interneurons, and it produces a coordinated out

145 predominantly adhered to nearby vasculature, about 30% invaded the non-vascularized tissue, reminisce

146 ost common parallel genetic changes, whereas about 40% is attributed to the stochastic accumulation o

147 t sunlight, their loss would trigger strong (about 5 K) global warming.

148 odies by combining a low molecular weight of about 2 kDa with an antibody-like binding specificity.

149 he order of 3 mus, and a signal bandwidth of about 300 kHz.

150 rth, for which the maximum distance has been about 100 kilometres(11,12).

151 rotating disk with a rotational velocity of about 272 kilometres per second.

152 retreated to near the precipitate location, about 700 kilometres inland from the current position of

153 e of the Milky Way with an average period of about 2 kiloparsecs and a maximum amplitude of about 160

154 iles, from northern Gulf of Mexico - located about 500 km from the Chicxulub crater - offer a unique

155 ethane mixing ratios, covering a distance of about 6400 km, and sampled emission plumes from sources

156 o be in the range of 45~49 kJ/mol, which was about 20% larger than that between the water molecules (

157 udes lateral striate cortex, being therefore about 25% larger in area than the binocular region in Lo

158 FM-SECM probe was 6.2 +/- 2.2 nN, and it was about 50% less (i.e., 2.6 +/- 1.1 nN) for a negatively p

159 for (11)C-FEKAP and (11)C-GR103545 but were about 25% lower for (11)C-EKAP.

160 half of its 2015 carbon emissions at a cost about 6% lower compared to business-as-usual conditions.

161 ch, with thicknesses ranging from 12 m up to about 100 m, providing direct evidence of multiple lava-

162 s(-2) to large motions of the entire body at about 10 m s(-2), and at frequencies up to around 800 Hz

163 s of mostly live corals with a total area of about 10 m(2) and the length of the individual coral bra

164 ted, current-driven, strong (to a maximum of about 1340 m) downward displacement at depth (450, 1000

165 to plosive sounds; and 3) a distance out to about 2 m, or even farther, where sequential plosives in

166 Red Sea waters of Saudi Arabia at a depth of about 640 m.

167 The estimated maximum tolerated activity was about 1 MBq/kg.

168 Sea level estimates in excess of about 10 metres, however, have been discounted because t

169 troscopy revealed an Mg ionization energy of about 100 meV, which agrees quite well with the value of

170 escence full-width at half-maximum (FWHM) of about 120 meV throughout.

171 to less than 14 meV/[Formula: see text] from about 42 meV/[Formula: see text] for SCAN.

172 By applying about 100 MHz ac frequencies (with varying V(rms) amplit

173 heir thickness (from about 600 nanometres to about 100 micrometres), area (continuous thin films up t

174 ectrolyte/LiFePO(4)-shows a high capacity of about 164 milliampere hours per gram of LiFePO(4), and a

175 a spp. bacteria share an evolutionary origin about 110 million years ago.

176 as a 'neural fossil' within in the brain for about 25 million years.

177 pulse of the Late Ordovician mass extinction about 445 million years ago suggests that stratospheric

178 Participants completed BREASTChoice in about 27 minutes.

179 tion reached half of the overall change, was about 6 minutes.

180 elimination half-life of contrast agents is about 90 minutes, recent studies demonstrated that some

181 toward normal levels of right-side pressure (about 20 mmHg) measured by RHC.

182 elated protein insolubilization beginning at about 4-months of age.

183 A(N101D) mice developed cortical cataract at about 7-months of age relative to CRYalphaA(WT) mice.

184 end stereotyped projections to one or two of about 50 morphologically defined glomeruli [1-3].

185 s, and it produces a coordinated output from about 120 motor neurons that control the nematode's musc

186 , polycrystalline discs at 200 degrees C and about 300 MPa of uniaxial pressure.

187 ontacts with the C-terminal domain of CaM in about 2 ms.

188 the N-terminal domain of CaM more slowly, in about 8 ms.

189 osures to the nearby population of less than about 2 mSv, discernible impacts to the health of the ex

190 verall, the developed protocol consumes only about 15 mug microsomal protein per assay.

191 ple, droplets with initial radii larger than about 50 mum rapidly fall to the ground, while smaller,

192 is consistent with a mantle stirring time of about 400 My since the early Hadean.

193 Amphibians evolved in the Devonian period about 400 Mya and represent a transition step in tetrapo

194 matic morphological change from nanospheres (about 100 nanometres in diameter) into nanosheets (sever

195 sitive to MIEC material choice with channels about 100 nanometres wide and 10-100 micrometres deep.

196 t can elongate into toroids with a radius of about 13 nanometres.

197 ith precise control of their thickness (from about 600 nanometres to about 100 micrometres), area (co

198 riments on liquid samples having a volume of about 1 nL performed at 10.7 GHz(ESR)/16 MHz(NMR).

199 s display a sharp optical absorption peak at about 360 nm and are labeled MSC-360.

200 The PL emission of the LSCs is centered at about 700 nm with 99.4+/-0.4 % PLQY and narrow full widt

201 PSCs were significantly enhanced, retaining about 90 % of the initial efficiencies after more than 1

202 logical effects to Arctic warming represents about 10% of radiative forcing effects.

203 lament contribute to force development, only about 10% of the motors in each filament bear the peak f

204 ted human cells proliferated more slowly and about 10% of them were multinucleated compared with fewe

205 About 12% of the eroded organic carbon is eventually exp

206 In typical virtual screens, however, only about 12% of the top-scoring compounds actually show act

207 About 15% of adults in the United States-37 million pers

208 on protein (PrP) gene (PRNP) and account for about 15% of human prion disease cases worldwide.

209 energy consumption of buildings accounts for about 15% of national total energy consumption in the Un

210 To date, only about 17% of druggable GPCRs have had their structures c

211 The presence of syntenic orthologs to about 19% of the S. italica TPSs in related grasses supp

212 due to the aviation emission, equivalent to about 1% of the background concentration.

213 In about 20% of cases plasticity causes non-native phenotyp

214 Its substrates account for about 21% of the human proteome, including well known pr

215 Streptococcus (GBS) can be found to colonize about 25% of all healthy, adult women and is the leading

216 About 25% of pancreatic cancers harbour actionable molec

217 Overall, about 2% of cases were directly responsible for 20% of a

218 About 30% of patients with impaired cardiac function hav

219 trade-off analysis identifies that for only about 30% of students, a 1% increase in route length is

220 ly inefficient; indeed, in higher C3 plants, about 30% of the time the enzyme mistakes CO(2) for O(2)

221 serotype (HLA-A2) that has been observed in about 35% of patients with acute myeloid leukaemia (AML)

222 Alanine (Ala) accumulated to about 35% of total amino acids in nectaries and nectar d

223 About 40% of the place field edges concentrated near the

224 About 45% of 1103 United States kidneys discarded becaus

225 About 50% of AD patients will develop psychotic symptoms

226 With about 50% of human genes having more than two APA isofor

227 e, and led to complete tumour eradication in about 50% of mice with orthotopic breast tumours.

228 , normalization of acid exposure occurred in about 50% of patients and, for some modalities, long-ter

229 However, only about 50% of patients respond to treatment.

230 prostate cancer patients and is positive in about 50% of patients with a PSA level of less than 0.5

231 a large number of sugar-based glycan forms; about 50% of the Env molecular weight is composed of gly

232 The legacy PFAS accounted for about 50% of total PFAS in drinking water and 90% in ser

233 IMP was clinically distinguished from PIM in about 60% of patients while 40% remained diagnosed as fa

234 procedural stricture formation, occurring in about 6% of cases.

235 About 6% of males and <1% of females have anomalies in t

236 t in PLCD1 which is normally present in only about 6% of this population.

237 Only about 6% of transcribed enhancers defined by CAGE-tag an

238 b group) of 302 anticipated deaths observed (about 73% of the originally planned 88% power needed for

239 idence interval, 77.6%-98.4%), compared with about 80% of those occurring 1 week to 1 month after RSV

240 Overall, the model explains about 83% of the seasonal variation in C3 plant V(cmax,2

241 as much as 52-fold, raising this quantity to about 84% of the corresponding value realized for 75 muL

242 resolved infrared measurements revealed that about 90% of the photogenerated one-electron reduced com

243 2V mice) had normal follicle structures, and about 90% of them developed uterine tumors with diverse

244 About 90% of these individuals have no family history an

245 end of the fuel's useful life in a reactor, about 96% of the SNF is still UO(2).

246 ecurrent copy number aberration that defines about 9% of all primary breast cancer tumours and is ass

247 ey terminate on a particularly large number (about 460) of primary olfactory glomeruli, suggesting an

248 exhibit a low charge transfer resistance of about 20 Omega, high sensitivity of dopamine detection (

249 solubility limits, indeed exceeding them by about 10% on average.

250 [M - H](-) species of N-glycans increased by about 3 orders of magnitude.

251 out 2 kiloparsecs and a maximum amplitude of about 160 parsecs.

252 cing the number of gene copies from 10(5) to about 10 per cell revealed a transition from determinist

253 rmance (albeit below the practical limits of about 30 per cent and 35 per cent, respectively(3)) is s

254 per year during 2010 to 2016, equivalent to about 45 per cent of our estimate of annual Chinese anth

255 ing records underestimate barrier numbers by about 61 per cent.

256 efficiency of over 80 per cent (compared to about 66 per cent for pure Cu) is achieved at a current

257 major TC exceedance probability increases by about 8% per decade, with a 95% CI of 2 to 15% per decad

258 At the catchment scale, about 60 percent of the Chloride found in groundwater or

259 sured gain of 9.8 dBi and peak efficiency of about 95 percent in the X-band.

260 ated more drug reaching on average values of about 150 pg/muPL, for both CURC and DEX.

261 cedure that achieved a limit of detection of about 1 pM or 50 amol/measurement, well within the repor

262 Starting from about 4 postnatal weeks, SOD1-G93A and wild-type (WT) mi

263 It is difficult to believe that in about 1960 practically nothing was known about the thymu

264 processing network that receives input from about 90 sensory neurons, processes that information thr

265 ults indicate the conterminous US C sink was about 30% smaller than previous modeling studies, but co

266 About 1500 SNPs per family were detected across the geno

267 Pulsatilla (Ranunculaceae) consists of about 40 species, and many of them have horticultural an

268 SARS-CoV-2 virus mutations with information about 3D structures of its proteins, allowing users to v

269 m/q = 1000 with moderate magnetic fields of about 7 T.

270 of excitatory neuron-restricted precursors (about 10) that generate the excitatory neurons within a

271 cial muscles, which can lift masses that are about 110 times of their weights and biomimetic frog ton

272 About 1202 times enhancement in detection power was reco

273 e containing carbon nanotubes is improved by about 30 times at a bias voltage of 10 V.

274 integrated Cu(2)O electrodes is delayed for about 36 times; The photocurrent of bR integrated CuSCN

275 tor due to evapotranspiration was on average about 3 times more than in the natural system, with high

276 t in (BA)(2)(MA)Pb(2)I(7) is estimated to be about 7 times larger than that in MAPbI(3).

277 phenotypic potential of the compact pool is about 1000-times higher than the fully random pool.

278 robing revealed that the RNA binds amino-tSS about 100-times stronger than the cis photoisoform (amin

279 then decreased, with an inflection point at about 1 to 2 intercapillary distances.

280 elements-ranging in target copy number from about 32 to 161 000 per cell.

281 solved(3) edge-on debris disk extending from about 35 to 210 astronomical units from the star(4), and

282 g current ice volumes-would have contributed about 3 to 4 metres(13) to global sea levels.

283 entories suggest that the latter account for about 40 to 60 teragrams CH(4) per year(6,7).

284 The multi-linear regression models explain about 89% to 96% of the variation of cities' GDP across

285 rmits 2 statistically independent inferences about 1 treatment effect such that each factor is immune

286 how very low lattice thermal conductivity of about 4 W m(-1) K(-1) at room temperature, one order of

287 henotype of nondiabetic obesity beginning at about 20 weeks of age.

288 The half-life was about 2 weeks.

289 ntent of the transgenic seeds was lowered by about 3% when compared to the wild-type seeds.

290 R integrated CuSCN electrodes is enhanced by about 400%, which is attributed to the directional migra

291 ls appears at a refractive index contrast of about 2, which means that a photonic bandgap could be ac

292 About 30% with HIV-HBV coinfection had FLD including 10%

293 reproductive number reduced to below one in about 2 wk after the shelter-in-place order.

294 n concentration in the seston (respectively, about 1 x 10(6) cells.L(-1) and 2 x 10(8) pg.L(water)(-1

295 Since the discovery of mycobacterial T7SSs about 15 y ago, genetic, structural, and functional stud

296 n has been replaced by adult hemoglobin S at about 1 y after birth.

297 About 20 years after the identification of immunoglobuli

298 ce its recognition as a rotating nanomachine about 40 years ago.

299 These offspring were about 4 years younger than those without FMPD (controls;

300 It is estimated that every day about 1600 youth aged 12 to 17 years smoke their first c