ライフサイエンスコーパス: abrogate

1 equences that can arise when this process is abrogated.

2 iated activation of type I IFN signaling was abrogated.

3 investigation of Nutlin-3A as an approach to abrogate acquired resistance of melanoma to MAPK inhibit

4 c as primarily nonoligomeric with completely abrogated acute synaptotoxicity; moreover, despite epiga

5 in (Tirap(-/-)), attenuated inflammation and abrogated adverse LV remodeling following I/R injury.

6 ortantly, neutrophil depletion significantly abrogated Ag-specific CD4(+) T cell proliferation in LdC

7 CCHC zinc fingers in the NC domain, does not abrogate Alix-mediated virus rescue.

8 e report that neutralization of IL-2 in mice abrogated all IL-2R signaling in Treg cells, but was wel

9 calcium signaling, whereas actin inhibition abrogated all nuclear responses and increased nuclear st

10 face residues critical for complex formation abrogated allosteric activation of LegK7 both in vitro a

11 SAFB knockdown decreased GTP loading of RAS, abrogated alternative prenylation, and sensitized RAS-mu

12 infection activates IFN-gammaR signaling and abrogates AM-dependent bacteria clearance and thereby ca

13 iguingly, glucose supplementation profoundly abrogated AMPK activation and rescued bladder cancer cel

14 ition enhanced calcium signaling and thereby abrogated an anergic response to BCR stimulation in CLL

15 instigates a fate-promoting mechanism while abrogating an innate immunity-linked, fate-suppressing m

16 trogens and antiandrogens induced anoikis by abrogating anchorage-independent growth of HR(+) cancer

17 Blockade of CXCL-11 abrogated anti-GM-CSF treatment and induced inflammatory

18 Oral administration of AS1842856 in mice abrogated apoptosis and prevented DOX-induced cardiac dy

19 nscription factor (dnTCF4) that specifically abrogates beta-catenin-TCF/LEF interaction.

20 -1 3'UTR and mutations in the seed sequences abrogate binding between the two RNA molecules.

21 e KIX domain in CBP/p300 does not completely abrogate binding of E2A and E2A-PBX1.

22 bstitution at site 3 of murine IL-23p19 that abrogates binding to murine IL-23R.

23 hFip1 to bind, while mutation of both sites abrogates binding.

24 ar CEACAM6, and that deletion of this CEACAM abrogates both bacterial adhesion and toxin delivery.

25 ted by the recipient's immune system require abrogating both T- and natural killer (NK)-cell response

26 y impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid

27 dium bicarbonate (NaHCO(3) ), and completely abrogated by a combined pretreatment with amiloride (an

28 e, secretion of IL5, IL13, IL6 and IL17A was abrogated by a mechanism involving IL33 signaling in bot

29 usly enhancing muscle regeneration, which is abrogated by adaptive transfer of normal macrophages.

30 ction in mice drives lung fibrosis, which is abrogated by administration of anti-CD47.

31 7MG (proportional to the peptide content and abrogated by anti-alpha(v)beta(3)) but not by A2780 (sam

32 f beta-catenin critical to osteogenesis were abrogated by calreticulin deficiency or NFAT blockade.

33 otection against Brucella melitensis that is abrogated by cotransfer of B cells.

34 e- and IMiD-induced SALL4 degradation can be abrogated by CRBN V388I mutation or SALL4 G416A mutation

35 dependent of IL-1beta stimulation, which was abrogated by deletion of IRAK4.

36 reducing amyloid-beta production, which are abrogated by delta-secretase cleavage of TrkB in AD.

37 antitumor activity from Mertk inhibition was abrogated by depletion of cytotoxic CD8alpha T cells by

38 Since the defect is abrogated by exogenous intrarenal cGMP, the renal cGMP p

39 ing-induced increase in LR-MSC migration was abrogated by genetic and pharmacologic targeting of ATX

40 tion in microglial synaptic phagocytosis was abrogated by global REV-ERBalpha deletion, which caused

41 and mice, and the effect of AKI on FGF23 was abrogated by GPAT inhibition or Lpar1 deletion.

42 t this co-culture-induced chemoresistance is abrogated by inhibition of the CXCR4 and hedgehog pathwa

43 t increase in male aggressiveness, an effect abrogated by interruption of pCd activity.

44 hypertension, and this protective effect was abrogated by IP antagonists.

45 INC5 on antibody-dependent virus capture was abrogated by Nef expression.

46 ion induced STAT5 phosphorylation, which was abrogated by nontoxic concentrations of the JAK1/2 inhib

47 The effect of lithium on V(m) was virtually abrogated by ouabain.

48 y, ABHD5-dependent suppression of mTORC1 was abrogated by pharmacological inhibition of DGAT1 or DGAT

49 responses to AMPA receptor agonists and was abrogated by preabsorption of CSF with HEK cells express

50 ced protease release, and this was partially abrogated by sialidase pretreatment, which removes cell

51 n of AhR is 5-HT(2B) dependent because it is abrogated by the 5-HT(2B)-specific antagonist SB204741.

52 ased growth in the presence of Cu, which was abrogated by the introduction of mntA::Tn.

53 compared with continuous feeding, an effect abrogated by treatment with atenolol.

54 APK inhibitor resistance in melanoma, can be abrogated by treatment with the MDM2 inhibitor Nutlin-3A

55 CytoD was able to abrogate C. albicans killing.

56 void of Golgi Ca(2+) and Mn(2+) transporters abrogates Ca(2+)- and Mn(2+)-induced growth defects, exc

57 p38alpha/beta MAPK inhibitor, SB202190, and abrogated cancer cell-induced muscle protein loss in C2C

58 coding secretome; improved cardiac function; abrogated cardiac arrhythmias, fibrosis, and apoptosis;

59 letion perturbed caudal fin regeneration and abrogated cardiac regeneration altogether.

60 liferative (LPR) disease in mice result from abrogated CD95-induced apoptosis.

61 y of IFN to reprogram cholesterol metabolism abrogates cellular protection and renders mice more susc

62 groove formed by the two extracellular loops abrogates channel inhibition by carbenoxolone.

63 The expression of kinase-dead DNA-PKcs abrogates cNHEJ(2).

64 line-specific differences in the mechanisms abrogating COIII mRNA editing, including the possible ut

65 mere targeting agent 6-thio-2'deoxyguanosine abrogates colony growth in these late passage cultures (

66 e behavior, reduced ethanol consumption, and abrogated compulsive consumption of ethanol with the add

67 milies, clinicians, and facilities rendering abrogating conflict a key priority for all.

68 logical blockade of Delta-like Notch ligands abrogated core-2 O-glycosylation in a dose-dependent man

69 Effective treatment largely abrogated cough aerosol culture positivity; however, thi

70 ernal supplementation with these metabolites abrogated deficiencies in fetal thalamocortical axons.

71 augments delamination, whereas decreasing it abrogates delamination.

72 rom naive and preimmune vaccinees completely abrogated DENV-2 NS1-induced hyperpermeability and cross

73 to 45% (P = 0.038) and miR-31 gene knockout abrogated development of ESCC (P = 1 x 10(-6)).

74 ta1 impairs, whereas deficiency of AMPKbeta2 abrogates differentiation into cardiomyocytes.

75 epletion by gadolinium chloride pretreatment abrogated disease development, whereas their reconstitut

76 c ablation of GM-CSF production in NK cells, abrogated disease.

77 prevention of C3a receptor (C3aR) signaling abrogates disease despite DAF deficiency, confirming com

78 R3008H abrogated DNA damage- and oxidative stress-induced activ

79 AC), a strong antioxidant and ROS scavenger, abrogated DRP1-dependent mitochondrial fragmentation and

80 of Stat3 in peripheral myeloid lineage cells abrogated EAE, which was associated with decreased antig

81 Loss of HSF1 abrogates ECM assembly by colon fibroblasts in cell-cult

82 analysis, we observed that blocking Ship1/2 abrogated EMC cell survival by exerting dual effects on

83 that loss of ANO1-dependent Cl(-) transport abrogated esophageal epithelial proliferation.

84 Furthermore, the signaling mutations abrogated established FGF-induced signal transduction pa

85 Moreover, depletion of the microbiota abrogated expression of SYNPO in the mouse colon, which

86 ce, a model of Fragile X Syndrome (FXS) with abrogated expression of the Fragile X Mental Retardation

87 n this region that either silence or largely abrogate FcgammaR binding and downstream FcgammaR effect

88 formed cells, while it weakened, but did not abrogate, formation of tumors induced by a control oncog

89 Loss of APE1 abrogated G4 structure formation in cells, which suggest

90 ant and inhibitor of NF-kappaB signaling can abrogate GEM-induced hyperexpression of GM-CSF in E0771

91 es is impaired by guides which inefficiently abrogate gene function.

92 , known to be involved in HB-EGF processing, abrogated glucose-induced beta-cell proliferation.

93 Early MDSC depletion (day 0 or 20), however, abrogated graft survival, but late depletion (day 25) di

94 CXCL12 receptor CXCR4 and integrins rapidly abrogated HSC motility and shape dynamics in real time.

95 urther showed that low-dose naltrexone (LDN) abrogates hyperinsulinemia-mediated SIRT1 repression and

96 Neutralization of IFN-gamma during infection abrogated Ido1 expression and was sufficient to restore

97 These effects were abrogated if caffeine was added after establishing the p

98 ltration into the spinal cord and completely abrogates immune responses to myelin antigen in the sple

99 tly, 2'-5'-linkages had the added benefit of abrogating immune-stimulatory activity of siRNAs.

100 in plasma, together with a potent effect on abrogating immunosuppressive properties of MDSC-like cel

101 ansferred tumor-specific CD8(+) T cells were abrogated in Batf3(-/-) mice.

102 This effect was abrogated in cells lacking Bak/Bax-two pro-apoptotic mem

103 It is largely abrogated in cells lacking the Piezo stretch-operated ch

104 ies in placebo recipients, this increase was abrogated in FMT recipients.

105 patic steatosis and glucose intolerance-were abrogated in Insp3r1 (also known as Itpr1)-knockout mice

106 4-nucleotide smRNA accumulation was severely abrogated in irAGO4 plants.

107 that NAS neuroprotective effects in EAE are abrogated in mice lacking IDO1 expression, we investigat

108 The pathogenesis of VEEV infection is abrogated in mice with deletions in Ldlrad3, and adminis

109 LPS-induced lethality was almost completely abrogated in neuronal Mfn2 overexpression mice.

110 While remyelination was completely abrogated in OSMRbeta knockout (KO) mice, OSM overexpres

111 RE module and actin colocalize, but which is abrogated in Pcare (-/-) mice.

112 iated by killer cytotoxic lymphocytes: it is abrogated in perforin-deficient mice or mice depleted of

113 Surprisingly, feedback inhibition is abrogated in phagocytic cells.

114 This increase was abrogated in Slc26a6 (-/-) mice associated with a signif

115 ukocyte adhesion and integrin activation are abrogated in the absence of receptor Notch3.

116 In H. polygyrus infection, ST2 detection is abrogated in the peritoneal cavity and lung, consistent

117 endothelial function in eNOS(-/-) mice were abrogated in the presence of 25 mm KCl, implicating enha

118 2B immunoreactivity of selected RA-rmAbs was abrogated in the VH and VL GL counterpart.

119 the fumarate-stimulating ULBP2/5 pathway is abrogated in these cells as an immune-evasive strategy.

120 nt trehalose-6,6-dibehenate was specifically abrogated in TNF-deficient mice and strongly attenuated

121 AMP-mediated adjuvanticity was substantially abrogated in vivo.

122 n, and treatments for newborns are needed to abrogate infection or limit disease progression.

123 erexpression (Nur77(tg)) in mouse thymocytes abrogates iNKT cell development.

124 uce the levels of circulating insulin and to abrogate insulin signalling in cancer cells.

125 Concordantly, gpr27 deletion in zebrafish abrogated insulin-dependent Akt phosphorylation and gluc

126 er p115 or CHC22, but not GM130 or sortilin, abrogates insulin-responsive GLUT4 release.

127 independent, but a gamma-secretase inhibitor abrogated it, and it was not found in Notch1-null CD4 T

128 profound reduction of BCCIP was required to abrogate its function in 60S biogenesis.

129 n at position 53 of the Kv7.5 amino terminus abrogated its ability to confer forskolin sensitivity to

130 NUAK2, a serine/threonine kinase, completely abrogated its catalytic activity.

131 Moreover, YY1 deletion abrogated its interaction with histone deacetylases in a

132 (-/-) ;thrab (-/-) ;thrb (-/-) ) completely abrogates its induction and the resulting conversion of

133 infection, and here, we investigated how EPS abrogates its production.

134 activity, methylation of histone H3 by PRMT5 abrogates its subsequent methylation by PRC2.

135 total of nine lysine residues in Zta largely abrogates its ubiquitination, indicating that these are

136 In contrast, Cav1.2 agonist Bay k8644 abrogates ketamine-induced smooth muscle dysfunction.

137 Abrogating LAIR1 immunosuppression through LAIR2 overexp

138 LepR neuron-specific deletion of Sh2b1 abrogates leptin-stimulated sympathetic nerve activation

139 lation is a potential therapeutic target for abrogating lethal skin SCCs in patients who have undergo

140 ctivity and siRNA-mediated knock down of HSL abrogated LH-induced progesterone production.

141 ctivates antigen-presenting cells (APC), and abrogates local and metastatic tumor growth by a T-cell-

142 l hyperinsulinemia promotes tumorigenesis by abrogating local cell competition.

143 Post-injection, both domain-specific mAbs abrogated long-term potentiation induction, and LRR-dire

144 Similarly, microtubule-destabilizing drugs abrogated LPS-induced IL18 expression, but this effect c

145 tigation to modulate the immune response and abrogate lung injury in severe COVID-19.

146 tor-3 and LTbeta receptor signaling pathways abrogated lymphoma angiogenesis, thus revealing targets

147 cytotoxicity against BTN3A1(+) cancer cells, abrogating malignant progression.

148 sion of nonglycosylatable SIRT1 in the liver abrogated metabolic flexibility, resulting in systemic i

149 xpressing breast cancer cells to anoikis and abrogated metastasis.

150 gies aimed at overcoming drug resistance and abrogating metastasis.

151 tment to tumors and depletion of these cells abrogated MI-induced tumor growth.

152 in cytoskeleton via alpha-actinin (DeltaABD) abrogated migratory responses to TGFbeta.

153 Furthermore, mutation of pUL36 Cys(131) abrogated MLKL degradation and restored necroptosis.

154 oblotted allergens with sodium metaperiodate abrogated most of the cross-reactivity of the rabbit ant

155 Indeed, infection with viruses lacking E7 abrogated most transcriptional changes.

156 sceptible P. aeruginosa isolates harbor T6SS-abrogating mutations, the repair of which, in some cases

157 astasize; whereas, blockade of Ccl2 and Il13 abrogated MYC/Twist1-HCC metastasis.

158 he C181S second-site amino acid substitution abrogated myeloid transformation by NrasG12D, which was

159 In addition to abrogating myristoylation of Src family kinases, PCLX-00

160 In this report, we studied the effects of abrogating NCS-Rapgef2 expression on cAMP-dependent ERK-

161 virus infectivity controller 2 (vic2), that abrogates neonatal immune tolerance to retroviruses.

162 ion through the administration of GSK2656157 abrogated neuronal induction of IFNbeta, switched microg

163 vinculin attenuates, but does not completely abrogate, neutrophil adhesion, spreading, and crawling u

164 talytic inhibitors of this deubiquitinase to abrogate NF-kB activity.

165 ocking TLR2 prior to DENV infection in vitro abrogates NF-kappaB activation while CD14 and TLR6 block

166 tive seed sequence in the NGF 3'UTR and also abrogated nicotine-induced increases in NGF, FN1, and ET

167 ting lactate transfer from losers to winners abrogates NMDAR-mediated cell competition.

168 eported that minocycline (MINO) co-treatment abrogates olanzapine (OLZ)-induced hyperphagia and weigh

169 uct of the gene, which is either permanently abrogated or depleted at a rate defined by the half-life

170 Our results showed that GMSC-EVs robustly abrogated oxidative stress-induced upregulation in the e

171 ifically, TRIM21-mediated p62 ubiquitination abrogates p62 oligomerization and sequestration activity

172 rough a proline-rich loop, deletion of which abrogates PFN2 binding.

173 Pharmacologically or genetically abrogating Pi transport, the impact of high Pi-induced c

174 Succinate receptor (SUCNR1) inhibition abrogated PMN priming, PMN sequestration, and ARDS.

175 epleted or pathogenic ATXN3-expressing cells abrogate polynucleotide kinase 3'-phosphatase (PNKP) act

176 ll allows IL-1beta and GSDMD processing, but abrogates pore formation, thereby preventing IL-1beta re

177 om endogenous lag-1 reduced LAG-1 levels and abrogated positive autoregulation, but did not cause hal

178 Interestingly, Mtb LAM did not abrogate priming responses elicited by Pam(3)CSK(4) Nota

179 ical or genetic inhibition of CDK4/6 or EZH2 abrogated psoriasis-related proinflammatory gene express

180 B mutations that abolish Atg16L binding also abrogate Rab33B association with the Golgi stacks.

181 The Chk1/2 inhibitor AZD7762 is used to abrogate radiation therapy (RT)-induced G2/M cell cycle

182 of injured corticospinal neurons transiently abrogated recovery.

183 TLR inhibitor together with CNI abrogated refractory B-1b cell immune responses against

184 inhibitor and histone deacetylase inhibitor abrogated refractory B-1b cell immune responses against

185 PK sensitized recovering BLBCs to AZD1775 by abrogating replication arrest, allowing replication desp

186 iltration, diminishes exhausted T cells, and abrogates resistance to anti-PD-L1.

187 acting with SLC15A4 on the lysosome' (TASL), abrogated responses to endolysosomal TLR agonists in bot

188 N-terminal or the C-terminal domain of HflX abrogates ribosome splitting and concomitantly abolishes

189 t systemic administration of hNSC-derived EV abrogates RICD and neuroinflammation in cranially irradi

190 ortantly, incorporation of 2'F modifications abrogates RNA NANP activation of TLR7 but permits RIG-I

191 Cancer-associated mutations that abrogate RNF43 phosphorylation cooperate with active Ras

192 We observed that deoxyuridine could abrogate ROS-induced ER stress to promote cancer cell su

193 Finally, we find that while abrogating RSS nicking with Ca2+ leads to substantially

194 the role of the triterpenoid CF(3)DODA-Me in abrogating several of these tumor-promoting pathways.

195 xp3 Treg (nTreg) and depletion of Foxp3 Treg abrogates skin-graft tolerance.

196 mouse model baring PlexinA1(Y1815F) mutation abrogating SlitC but not Sema3B responsiveness, manipula

197 se 3 alpha/beta (GSK3alpha/beta) efficiently abrogate SOX10 protein in human melanoma cells in vitro

198 NG-induced REG3gamma production in IECs, and abrogated STING-mediated IEC killing of C. rodentium.

199 mmunotherapy, together with interventions to abrogate stress-inflammatory responses, should be evalua

200 ng mechanisms and effective interventions to abrogate such effect remain unclear.

201 ans exposed during lysosomal membrane damage abrogate such ubiquitination responses.

202 Interestingly, the Gli1 knockout abrogated SULF2-mediated induction of several STAT3 targ

203 e extent of rosetting, but almost completely abrogated T-cell activation.

204 arise as P. aeruginosa adapts to the CF lung abrogate T6SS activity, making P. aeruginosa and its hum

205 lter the HLA Trp-167 side-chain conformation abrogated TCR binding, indicating that this indirect bin

206 cular modeling suggests that V679A and R695H abrogate the auto-cleavage function of the ICA homo-trim

207 udy embarked on determining which nsSNPs may abrogate the binding of selective ARBs.

208 Importantly, these compounds did not abrogate the cytotoxic effects of cisplatin on human can

209 o preemptively corrects pre-mRNA splicing to abrogate the disease phenotype.

210 LINE-1 shRNAs can abrogate the HUSH-dependent response, while overexpressi

211 on with anti-IL-15 antibody as a strategy to abrogate the severe exacerbations of dry eye disease obs

212 n of full donor T-cell chimerism at 3 months abrogated the adverse impact of pretransplant MRD on CIR

213 Furthermore, NOS3 knockdown abrogated the angiogenic effects of AM.

214 D73 or the inhibition of adenosine receptors abrogated the ATP effect on CXCL8 secretion.

215 a and 23b) or cycloalkane substituents (23e) abrogated the binding to Na(v)1.6.

216 Inhibition of Wnt5A abrogated the BPD transcriptomic phenotype induced by hy

217 Finally, Ifn-gamma blockade abrogated the CpG-induced but not the constitutive Il-18

218 The loss of LANCL2 in skeletal muscle abrogated the effect of ABA extract in the DIO model and

219 Serum starvation abrogated the effect of insulin on YAP phosphorylation a

220 in glutamatergic, but not GABAergic, neurons abrogated the effects of dietary protein restriction on

221 onse and, in combination with anti-CD28 dAb, abrogated the effects of selective blockade.

222 RNAi-mediated knockdown of PERK or eIF2alpha abrogated the endorepellin-mediated up-regulation of GAD

223 of SLC27A4/FATP4 but not FAT/CD36 completely abrogated the enhanced FA oxidation in RabGAP-deficient

224 Lastly, inhibition of astrocytic miR-223 abrogated the exosomal-mediated reduction in neuronal Gr

225 lation of NCOA3 at S1062/T1067 significantly abrogated the function of UHMK1 in GC development.

226 reduced vascularity of the Matrigel plug and abrogated the generation of these E* cells.

227 Loss of Kdm5b abrogated the hyperactivation of AKT signaling by decrea

228 given together with Tdap or after Tdap, BCG abrogated the immunosuppressive effects of Tdap vaccinat

229 of endometriosis showed lenvatinib treatment abrogated the increased lymphatic vessels development in

230 LON5 IgG with HEK293 cells expressing IgLON5 abrogated the indicated cytoskeletal changes.

231 ell as inhibition of PI3K, mTORC2, and PDGFR abrogated the induction of GLS1 by TGF-beta.

232 Mitochondrial antioxidant therapy abrogated the ion channel and structural remodeling and

233 we observed that ablation of CDK5 completely abrogated the metastasis, revealing that CDK5 is essenti

234 retreatment of the cells with NAC completely abrogated the NKA inhibitory activity of plumbagin and a

235 this receptor in mouse and human leukocytes abrogated the pro-resolving actions of RvD5n-3 DPA, incl

236 Depletion of periostin from the serum abrogated the proliferation of cancer cells; conversely,

237 pneumoniae lung disease, the IL-6 deficiency abrogated the protective effect of allergic inflammation

238 n vaccinated C57BL/6 mice prior to challenge abrogated the protective efficacy of GCP-rCpa1 vaccine.

239 ) T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity ag

240 nding or phosphoinositide-binding properties abrogated the regenerative effects.

241 gly, mutations in the miR-125b seed sequence abrogated the regulatory effect of the miRNA on the CPSF

242 SPT blocking key protective signaling routes abrogated the salutary effect of conditioning.

243 -1R1 in glutamatergic neurons (nIL-1R1(-/-)) abrogated the stress-induced deficits in social interact

244 Consistently, knockout of UPP1 abrogated the tumor inhibitory effect of combined CB-839

245 axis or its activated Smads/YAP/TAZ complex abrogated the tumor-promoting role of P. gingivalis.

246 ced by the vancomycin-depleted gut bacteria, abrogated the vancomycin effect.

247 -exposed ALI cultures with interferon beta-1 abrogated the viral infection, suggesting one potential

248 rmation in an oxidative cellular environment abrogates the ability of BFL-1 to bind BH3 domains.

249 Minor editing of highly active Alu elements abrogates the ability to activate both transcriptional r

250 HuR deficiency (HuR knockdown in macrophage) abrogates the above effects.

251 Remodeling of the coiled-coil domain of Smc3 abrogates the binding surface for Scc1, thus leading to

252 wise, deletion of Orai1 in GABAergic neurons abrogates the chemoconvulsant-induced burst of spontaneo

253 AD brains and 5xFAD mice, and uPA treatment abrogates the deleterious effects of Abeta on the synaps

254 , whereas genetic deletion of Syk completely abrogates the disease phenotype.

255 Leflunomide abrogates the effective transcription elongation of gene

256 HIV-1 capture and cell-to-cell transfer, and abrogates the exacerbation of HIV-1 infection induced by

257 ddition, NFATc2 deficiency almost completely abrogates the expression of IL-3 in both cell types.

258 ound that myeloid-specific deletion of Tgfb1 abrogates the fibrotic response in this injury model and

259 Mutation of a peptide that abrogates the formation of helical structure resulted in

260 rthermore, AP-1 inhibition almost completely abrogates the hepatomegaly induced by YAP overexpression

261 imultaneous disruption of fission and fusion abrogates the lifespan increase induced by mitochondrial

262 Notably, loss of Prdm14 completely abrogates the PGC program, as demonstrated by failure of

263 renine supplementation in IDO-deficient mice abrogates the protective effects of IDO deletion.

264 In vivo CXCR3 blockade partially abrogates the survival advantage of an ALK5(DeltaCD8) ho

265 t the R183W mutation in PP2A Aalpha scaffold abrogates the tumor suppressive actions of PP2A, thereby

266 Conversely, abrogating the expression of IL-17 receptor subunit a (I

267 ls without altering mRNA levels, thus mainly abrogating the increased protein degradation.

268 revealed residues critical for sustaining or abrogating the light- and stress-gated response.

269 ade of C/EBPbeta/mTOR signaling in human DCs abrogated their protumorigenic function in primary B cel

270 en CNS-specific TR1 cells away from the CNS, abrogating their antiencephalitogenic activity.

271 en and progesterone receptors, without fully abrogating them.

272 succinimidyl suberate to the VLPs completely abrogated these dynamics as observed in both localizatio

273 Depletion of the microbiome with antibiotics abrogated these effects.

274 Silencing of LAMR abrogated these effects.

275 To test this model, we have specifically abrogated these sites of daily neuronal remodeling throu

276 CNS, the first genetic background to largely abrogate this distinct APA signature.

277 in, but not the FDA-approved drug memantine, abrogated this hyperactivity.

278 A485, a p300/CBP inhibitor, abrogated this process and cut off the secretion of exos

279 P clones, genetically reduced IL-6 signaling abrogated this risk.

280 in vitro tRNase activity, and mutations that abrogated this tRNAse activity in vitro also attenuated

281 lymorphism in the NS1(RBD) (R21Q) completely abrogates this interaction.

282 required its interaction with HSP70 and that abrogating this interaction genetically or with small mo

283 genes essential for HSPC development, due to abrogated transcription.

284 We demonstrated that acute CMV infection abrogated transplantation tolerance during the maintenan

285 rectly binding to Vimentin and competitively abrogating Trim16-depedent Vimentin polyubiquitination a

286 4E impaired 5'-cap-dependent translation and abrogated tumor cell proliferation.

287 or pharmacological blockade of Nox4 activity abrogated tumor-induced cachexia in mice.

288 s (parasympathetic, sympathetic, or sensory) abrogates tumor growth in a tissue-specific manner.

289 In contrast, deletion of Max abrogates tumorigenesis in MYCL-overexpressing SCLC.

290 pression and that deletion of Gcn5 delays or abrogates tumorigenesis in the Emu-Myc mouse model of B-

291 dants N-acetylcysteine and glutathione (GSH) abrogated ULBP2/5 upregulated by DMF.

292 Bafilomycin treatment abrogated vacuole generation, indicating that H(+)-drive

293 Two repurposed FDA-approved VCP inhibitors abrogated VCP-mediated repression of NIS function, resul

294 ant-negative STAT3 mutant, but not of STAT1, abrogated VEGFR2 expression.

295 te type I TGFbeta receptor kinase inhibition abrogates VehM-/GIM- and/or TGFbeta2-induced upregulatio

296 s) at fever temperatures, the Th2 switch was abrogated via increased production of IL12 from DCs at f

297 icacy of TY014, as compared with placebo, in abrogating viremia related to the administration of live

298 g p14 mutants, we demonstrate that fusion is abrogated when binding of an adaptor protein is prevente

299 These effects were abrogated when using a mutant circSamd4 lacking the PUR

300 mTOR activation in iMCD patients, which was abrogated with JAK1/2 inhibition.