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1 t allow spatial and temporal control of gene abrogation.
2 f sim1a cannot be rescued by RA biosynthesis abrogation.
3 lyses revealing a biphasic response to BRCA2 abrogation.
4 tate DNA replication in the context of BRCA2 abrogation.
6 on of WDHD1 reduced E7-induced G1 checkpoint abrogation and rereplication, demonstrating a novel func
8 cells were destroyed not by frank G2-M phase abrogation but rather by initiating a cumulative genotox
9 mouse model to an extent just shy of disease abrogation, but this remarkable observation has not been
11 tochondrial accumulation is indicated by its abrogation by dominant-negative HRES-1/Rab4(S27N) mutati
12 rence only in the presence of plasma and its abrogation by heat inactivation, EDTA, and eculizumab.
15 lls, and notably show that specific microRNA abrogation can disrupt the wild-type cellular phenotype
16 rrb transcript repression, cell-cell contact abrogation, cell survival in suspension, STAT3 phosphory
18 effect was attenuated by shRNA-mediated MUC4 abrogation, further implying that these nicotine-mediate
19 es have remained elusive in part because its abrogation has been reported without overt phenotypes in
29 liver taurine production and associates with abrogation of a growth hormone/insulin-like growth facto
30 physical security of memory devices, prompt abrogation of a memory device which stored a large numbe
31 y inducing expression of IKZF1, resulting in abrogation of adhesion and self-renewal, cell cycle arre
34 Grp78(f/f) murine uteri also corresponded to abrogation of AKT activation within the endometrium.
35 isib-mediated inhibition of PI3Kdelta led to abrogation of Akt phosphorylation in patient CLL cells a
36 ereby negating their use as anti-infectives, abrogation of alkaline signalling has, therefore, been p
37 nd airway T(H)2 cytokine levels and complete abrogation of allergen-induced airway eotaxin-2/CCL24 an
39 ion in primary exocytosis (SG-PM fusion) and abrogation of almost all sequential SG-SG fusion, togeth
41 emotherapeutics targeting DNA often involves abrogation of apoptosis and has emerged as a significant
48 induces the re-expression of E-cadherin via abrogation of autocrine EGFR signaling pathway in prosta
52 the cellular response to DNA damage whereby abrogation of AXL signaling leads to accumulation of the
55 lated alpha-DG on muscle fibers and possibly abrogation of binding from molar excess of overexpressed
57 scues lip formation and involves a localized abrogation of Bmp4-mediated repression of Pax9 Analyses
60 oietic progenitors and its deletion leads to abrogation of both adult and fetal hematopoiesis, target
70 veral recent studies have indicated that the abrogation of checkpoints in tumourigenesis through the
75 TTFL rhythms in SCN slices recorded ex vivo Abrogation of circadian competence in VPAC2 cells by del
79 at KLLN interacts with DBC1, with consequent abrogation of DBC1 inhibition of SUV39H1, a H3K9 methylt
83 elated with transmission efficiency, and the abrogation of direct contact between infected and naive
85 sruption of the aberrant immune response via abrogation of downstream Mavs or Rnasel signaling partia
93 cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implic
95 generated a Fan1 knockout mouse model, with abrogation of Fan1 expression confirmed by quantitative
98 al p53 (ATp53) mutations often result in the abrogation of full-length p53 expression, but concomitan
99 ibition rescued the gamma-H2AX induction and abrogation of G2 phase as induced by Wee1 inhibition in
100 se included several novel mechanisms such as abrogation of G2/M and mitotic spindle assembly checkpoi
101 t recipients of GFP-expressing marrow had an abrogation of gadolinium-induced pathology and displayed
103 ith a mechanistic rationale based chiefly on abrogation of gemcitabine-induced G2-M checkpoint activa
111 sitron emission tomography showed a complete abrogation of hepatic binding of labeled Myrcludex B in
113 ing extrinsic stimuli, and they suggest that abrogation of Hmga2 function in the microenvironment can
114 red lead to u(s)-driven proteotoxicity, i.e. abrogation of HRD1-mediated ER-associated degradation (E
119 NF-alpha and IL-10, (iv) a reduction but not abrogation of IL-10 and TNF-alpha by Tat-stimulated macr
120 sular macrophages (SCMsmall ef, Cyrillic) or abrogation of IL-18 signaling dramatically impairs the A
122 ode Schistosoma mansoni Here, we report that abrogation of IL-4 receptor alpha (IL-4Ralpha) signaling
126 ha-synuclein and ubiquitinated proteins, and abrogation of inflammatory responses and neuronal loss w
127 Knockdown of Axl expression resulted in abrogation of invasive and transendothelial migratory ab
129 murine models, we found that the conditional abrogation of IRE1alpha in bone marrow cells increases b
131 hways in a replication-dependent manner, and abrogation of IRF-3 function enhanced virus-mediated inj
136 of PRMT5-mediated KLF4 methylation leads to abrogation of KLF4 accumulation, which, in turn, attenua
137 Mechanisms of immune evasion can involve abrogation of leukemia cell recognition due to loss of H
138 ts in the cleavage of the signal peptide and abrogation of leukotoxin-induced cytolysis of target cel
141 ing the immunofibroblasts in vivo results in abrogation of local pathology, demonstrating the functio
143 hat has been delineated in this study is the abrogation of lytic activity of lysozyme by a novel glyc
144 graft dysfunction and structural damage with abrogation of macrophage and dendritic cell infiltration
146 lactosamine (GalNAc) salvage pathway induced abrogation of MAL-II and PNA epitopes in Jurkat cells.
147 and sensitization to tamoxifen, resulting in abrogation of mammary tumor growth and progression.
148 /NO and VISTA caused additive or synergistic abrogation of MDSC-mediated suppression of B-cell respon
150 romerization in vivo, leading to a selective abrogation of memory impairments caused by exposure to T
152 vitro and in vivo We found that concomitant abrogation of metallothioneins 1 and 2 results in activa
154 oncogene transformation resulted in a timely abrogation of miR-223 expression, likely due to activati
157 CD154(-/-) H-2(d) strains, and by selective abrogation of MPER restimulated, H-2(d)-restricted prime
158 nhibitor and rapamycin uniformly resulted in abrogation of mTOR inhibition-induced AKT activation in
161 f STAT6 to the TGF-beta promoter by NaB, and abrogation of NaB-induced expression of TGF-beta in sple
165 osteroid function and p38 MAPK inhibition to abrogation of necrotic cell death mediated by mitochondr
167 icularly, in the isolated mouse spinal cord, abrogation of neurotransmission derived by both V1 and V
168 esulted in pulmonary adaptation evidenced by abrogation of neutrophilic inflammation and airway hyper
170 responses, are particularly relevant to the abrogation of new relapsing disease activity observed in
174 creas and that overexpression may lead to an abrogation of normal cytokinesis, indicating that it sho
175 ke ligands Dll1 and Dll3 and NOTCH activity; abrogation of NOTCH activity restored LDN-enhanced myelo
181 ty of A2B5-defined glioma TPCs; as such, the abrogation of PAR1-dependent signaling pathways may prov
183 IFN-gamma expression concomitantly with the abrogation of PD-L1 expression in CMFs under homeostasis
185 MUNE are responsive to SMN restoration, and abrogation of phenotype can be achieved even after sympt
193 and leading to more efficient DNA repair and abrogation of programmed cell death under salinity and g
194 naling molecules to lipid rafts, followed by abrogation of protein tyrosine phosphorylation of ZAP70,
195 of T cell proliferation was associated with abrogation of proximal TCR signaling by inhibiting recru
196 ering SHH signaling and eye development upon abrogation of ptch1 in zebrafish for which in vivo compl
201 ion of peptidyl arginine deiminase type 4 or abrogation of reactive oxygen species (ROS) production,
202 ng titers compared with palivizumab, whereas abrogation of receptor binding led to a drastic reductio
205 ly, these effects include an almost complete abrogation of release by a single residue substitution i
210 ting motif for TMEM106B and demonstrate that abrogation of sorting to lysosomes rescues TMEM106B-indu
213 ncluding elevated osmoticum, suggesting that abrogation of stomatal function reflects a mechanical ch
214 idues caused the loss of protein solubility, abrogation of substrate binding, increased cell death, a
223 lls lacking C/EBPbeta showed nearly complete abrogation of TDB/TDM responsiveness, but also failed to
224 ody blocking this cytokine resulted from the abrogation of Teff suppression; however, T1D-derived iNK
226 aring low-affinity T cell receptors, and the abrogation of TGF-beta receptor expression led to failed
228 tumor formation and progression by targeted abrogation of TGF-beta1 expression in metastatic cells i
230 Here, we show that combined pharmacological abrogation of the cyclooxygenase-2 (COX-2) and soluble e
231 /fl) B6-transplanted recipients and observed abrogation of the deleterious effect of a HSD in the abs
232 e that had already experienced EAE symptoms, abrogation of the disease in 90% of the animals was appa
233 -251) and CRE (-308) sites led to a complete abrogation of the effect of TX on GLT-1 promoter activit
234 nhibitors, E64d plus pepstatin A, results in abrogation of the ES-62-mediated suppression of LPS-driv
236 enome repair machinery, with nearly complete abrogation of the hypomutation phenomenon in individual
238 adjuvanticity is ascertained by significant abrogation of the immunity after systemic depletion of p
242 257-mediated inhibition of Mps-1 resulted in abrogation of the mitotic checkpoint, premature progress
244 inase-dependent mechanism); and (v) complete abrogation of the normal pro-apoptotic effect of dexamet
245 Treatment with anti-IFN-gamma led to an abrogation of the NP-specific IgG2c Ab induced by P. cha
247 ervations provide a possible explanation for abrogation of the p53-mediated apoptotic pathway in mela
248 , in complementary loss of function studies, abrogation of the PAR2-Gq-calcium signaling arm failed t
253 have recently demonstrated a p53-independent abrogation of the postmitotic checkpoint by HPV E6 that
257 d by genomic instability, TP53 mutation, and abrogation of the TP53-mediated senescence program.
259 the prospective forebrain and combinatorial abrogation of their activity results in incomplete segre
261 odulating ILEI protein levels results in the abrogation of these phenotypes, promoting further invest
268 pendent group 2 ILC (ILC2) response and that abrogation of this response impairs re-epithelialization
272 -alpha by inflammatory granulocytes leads to abrogation of tolerance at the FMI and fetal rejection.
274 gic inhibition of KDM1A resulted in complete abrogation of tumor growth in an AML xenograft model har
275 est possible novel molecular targets for the abrogation of tumor microenvironment immunosuppression.
276 xenografts with a BMI1 inhibitor resulted in abrogation of tumor progression and reduced the frequenc
277 and p53 inhibition by pifithrin-alpha caused abrogation of tumor-suppressive effects of Rig-G in lung
282 lizes vinculin binding to alpha-catenin, and abrogation of vinculin in vivo and in vitro leads to unc
283 Taken together, our results suggest that abrogation of viral mRNA cap methylation can serve as an
285 l after DNA damage relies on DNA repair, the abrogation of which causes genomic instability and devel
289 we termed "p53 potentiation with checkpoint abrogation" (PPCA)] displayed therapeutic benefits in pr
290 STAT2 variant causing complete STAT2 protein abrogation presents with hemophagocytic lymphohistiocyto
292 er cells from the apoptotic effects of HSP90 abrogation, restoring blood vessel formation in two prec
293 ell genes in pluripotent cells and that TRF1 abrogation results in increased TERRA levels and in high
295 further substantiates the concept that BRCA2 abrogation triggers cell-intrinsic immune signaling.
296 6 played a role in E7-mediated G1 checkpoint abrogation under hypoxic condition, and the function cou