ライフサイエンスコーパス: absolutely

1 e embryonic stem cells, we show that CTCF is absolutely and dose-dependently required for looping bet

2 n lysate extracted from 2 x 5 um FFPE slices absolutely and quantitatively using QDB method in 332 br

3 e been described for a century as exhibiting absolutely and relatively long clavicles.

4 ed against most recent islet transplant were absolutely associated with loss of graft function despit

5 that gE(-), gI(-), or US9(-) mutants are not absolutely blocked in axonal transport.

6 llular content of Rubisco decreased not only absolutely, but also relative to the content of PSII.

7 a four-point scale (1 = low confidence, 4 = absolutely certain) on MR angiographic and UTE images.

8 he advantage of the DropArray technology was absolutely clear when semiadherent or suspension cells w

9 f the transmembrane domain, and contains the absolutely conserved (679)LWYIK/R(683) sequence, propose

10 Of these residues, only Ile274(7.39) is absolutely conserved across the human adenosine receptor

11 a methionine residue at position 16 of GolS, absolutely conserved among GolS-like proteins but absent

12 Replacement of an absolutely conserved Asp by charge reversal (D478E), neu

13 salient features of this core structure are absolutely conserved between alphabeta and gammadelta TC

14 e their importance, these components are not absolutely conserved between parts of the tree of life,

15 active site, lined with the residues from an absolutely conserved CDP-AP signature motif (D(1)xxD(2)G

16 ntains an anti-parallel coiled-coil with two absolutely conserved cysteine residues at its apex.

17 -manno-heptose 7-phosphate kinase (HldA), an absolutely conserved enzyme in this pathway, from Burkho

18 lants, whereas the other key amino acids are absolutely conserved from bacteria to plants.

19 An absolutely conserved Gly in the middle of the alpha1-hel

20 e selectivity filter, which is lined by four absolutely conserved histidines.

21 tion between Phe(364) and Pro(357), which is absolutely conserved in enteroviral polymerases, was fou

22 Tyr54, absolutely conserved in NK2 family proteins, mediates se

23 on, and for Gly in the P1 position, which is absolutely conserved in the natural Atg8 substrates.

24 An absolutely conserved interaction between Phe(727) and a

25 vertebrate Piezo channel subunits define an absolutely conserved motif that may be involved in chann

26 P101) are trans in the S state but that two absolutely conserved residues (P14 and P101) become cis

27 Transfer RNAs (tRNAs) require the absolutely conserved sequence motif CCA at their 3'-ends

28 PilA1-A6) that, although diverse, contain an absolutely conserved signal peptide hydrophobic (H) doma

29 ition of the hydroxymethyl side chain of the absolutely conserved Thr(772) of the alpha-subunit.

30 fidence intervals are variable and cannot be absolutely constrained.

31 Pregnancy, although not absolutely contraindicated in this population, carries r

32 ent domain protein-caspase-1 inflammasome is absolutely critical for IL-1beta production in response

33 tivator positive coactivator 4 (PC4/Sub1) is absolutely critical for life, because its absence leads

34 nisms underlying these diverse phenomena are absolutely critical for the development of optimized or

35 Reconstitution of T cell immunity is absolutely critical for the effective control of virus-a

36 For all applications, it is absolutely critical that polygenic risk prediction is ap

37 further show that the presence of PARP-1 is absolutely crucial for reactivation of transcription aft

38 mological risk and to control the vector are absolutely crucial to demolishing the rise of CHIKV.

39 CLP is not absolutely crucial, however; some 5LO activity remained

40 Here we investigate annually resolved, absolutely dated and spatially explicit paleoclimatic ev

41 ocarbon reservoir age offset derived from an absolutely dated annually resolved shell chronology span

42 Here, we used absolutely dated fossil corals from the central tropical

43 f a millennial-length, annually resolved and absolutely dated marine delta(18)O archive.

44 he first high-latitude annually-resolved and absolutely dated marine record spanning the last millenn

45 Owing to the lack of absolutely dated oceanographic information before the mo

46 Using 1768 annually resolved and absolutely dated ring width measurement series from livi

47 measurements across a global network of 103 absolutely dated tree-ring chronologies.

48 t be developed to secure "floating" (not yet absolutely dated) tree-ring sequences, which cannot be a

49 Here, we present four absolutely dated, overlapping stalagmite oxygen isotopic

50 In mice, both Tfh and Tfr are absolutely dependent on B cells for their formation and

51 This emergent function is enabled by and absolutely dependent on both the supramolecular assembly

52 s demonstrate that histone H4 acetylation is absolutely dependent on CA-induced AhR and MTA2 recruitm

53 While cilia assembly is absolutely dependent on centrioles, it is not known to w

54 s as one of a very limited number of cargoes absolutely dependent on CLIP-170-mediated capture to ini

55 signaling is suppressed in a manner that is absolutely dependent on DUSP5.

56 m endogenously synthesized viral proteins is absolutely dependent on its protein half-life.

57 the human mtRNA polymerase (POLRMT) that was absolutely dependent on mitochondrial transcription fact

58 The recruitment is absolutely dependent on nuclear proteins EBNA3A and EBNA

59 an malaria parasite Plasmodium falciparum is absolutely dependent on the acquisition of host pantothe

60 ylation to CCL5, but arrestin recruitment is absolutely dependent on the arrestin tail interaction, a

61 ts revealed that silencing establishment was absolutely dependent on the cell-cycle-regulated interpl

62 G preparations, the response was found to be absolutely dependent on the presence of small numbers of

63 d compared with wild type; this increase was absolutely dependent on the presence within the flagellu

64 eceptors, RA signaling during development is absolutely dependent on the rate of RA synthesis and deg

65 nt of strategies to target pre-LSCs that are absolutely dependent on their microenvironment.

66 t synthesize the purine ring de novo and are absolutely dependent upon them to meet their purine requ

67 Fragmentation absolutely depends on both RecA-catalyzed homologous str

68 This checkpoint absolutely depends on the Gcn2 kinase.

69 These facets are absolutely different from six ({110}, {002}) equivalent

70 s with significant refractive errors and 130 absolutely emmetropic participants, were enrolled from s

71 her hand, the cleavage of linker peptide was absolutely essential and the release of cytosolic 24 kDa

72 Importantly, although VEGF was thought to be absolutely essential for arterial fates, we find that no

73 s reduced, this amino acid side chain is not absolutely essential for catalysis.

74 is of these residues confirmed that they are absolutely essential for catalytic activity.

75 Separase is absolutely essential for cohesion dissolution in organis

76 d required for efficient replication, but is absolutely essential for egress of parasites from host r

77 While these additional clusters are absolutely essential for enzyme activity, their exact ro

78 yme assays confirmed that these residues are absolutely essential for full catalytic activity.

79 the only muscle-specific protein known to be absolutely essential for fusion of embryonic and adult m

80 mal interaction of CA with CPSF6, though not absolutely essential for HIV-1 replication in physiologi

81 t that optimal binding of CA to CPSF6 is not absolutely essential for HIV-1 replication in vivo but p

82 mportantly, this platelet activation appears absolutely essential for host survival during infection

83 sex as a biological variable in research is absolutely essential for improving our understanding of

84 Therefore, while revA is not absolutely essential for infection, deletion of revA had

85 reveals that tyrosine residues 1007/1008 are absolutely essential for kinase function and signal tran

86 KO embryos, demonstrating that Myo10 is not absolutely essential for mitosis, meiosis, adult surviva

87 ntiation pathways, the miR-206 family is not absolutely essential for myogenesis and is instead a mod

88 rial synthesis of aspartate in particular is absolutely essential for staphylococcal survival in bone

89 ults indicate that neither LMP1 nor LMP2A is absolutely essential for the ability of EBV to induce B

90 ther hand, the catalytic activity of PstP is absolutely essential for the in vitro growth.

91 um-based motility is involved in, but is not absolutely essential for, B. subtilis pellicle formation

92 As a collection, they are absolutely essential genomic features, but individually

93 Neutrophils are an absolutely essential part of the innate immune system, p

94 mixtures is a redoubtable challenge that is absolutely essential to allow determination of the biolo

95 t highlight potential supporting (albeit not absolutely essential) players.

96 item were scored as 1 (not essential) to 9 (absolutely essential).

97 phomas in this model, but neither protein is absolutely essential.

98 etic diversity of the hepacivirus genera has absolutely exploded.

99 esent in the same nucleus and which can have absolutely identical sequences.

100 in the same nucleus and that can indeed have absolutely identical sequences.

101 gned and synthesized for detection of OCl(-) absolutely in aqueous medium at nanomolar level.

102 Our results are absolutely inconsistent with the model.

103 r results suggest that the Arp2/3 complex is absolutely indispensable in the melanocyte lineage in mo

104 alculations, combined with second-generation absolutely localized molecular orbital energy decomposit

105 y our energy decomposition analysis based on absolutely localized molecular orbitals.

106 3.31), though the risk of hypoglycaemia was absolutely lower (RR: 0.51, 95% CI: 0.33 to 0.80).

107 maintain blood glucose below that level and absolutely <180 mg/dL.

108 ld highly accurate CEST profiles based on an absolutely minimally sampled (AMS) data set allowing a s

109 butes only modestly to PB potency and is not absolutely necessary for activity.

110 CaM is shown to be absolutely necessary for efficient activity of eEF-2K, a

111 irmed that the ComDE two-component system is absolutely necessary for mutacin production in S. mutans

112 ade via eco-efficient processes, is becoming absolutely necessary for reasons of sustainable producti

113 Tyrosine 53 is absolutely necessary for Sprouty1 function during genito

114 ent compliance to periodontal maintenance is absolutely necessary for successful long-term therapy.

115 s present in many pathogenic bacteria and is absolutely necessary for the efficient evasion of the Br

116 data suggest that the CD8 coreceptor is not absolutely necessary for the generation of Ag-specific C

117 The NoLS motif in the SBV NSs is absolutely necessary for virus-induced inhibition of cel

118 antisense transcript of HAS2 (HAS2-AS1) was absolutely necessary to induce the transcription of the

119 ine for vesicle refilling, a process that is absolutely necessary to preserve quantal glycine content

120 Reliable estimates of correlations are absolutely necessary to protect a portfolio.

121 ability of the microcompartment shell is not absolutely necessary, but is often beneficial in establi

122 urther optimization using in vivo models was absolutely necessary, through which we were able to incr

123 hniques and optical imaging these agents are absolutely necessary.

124 etailed analysis of NREM sleep and dreams is absolutely necessary.

125 en-specific IgE test (ImmunoCAP((R))) showed absolutely negativity for all suspected foods.

126 4623 unique genes (34.6%), of which 111 have absolutely no evidence of function.

127 nts were highly satisfied and 8911 (91%) had absolutely no regret after surgery.

128 ility, whereas the dephosphomimetic provides absolutely no rescue.

129 l colonies directly from the Petri dish with absolutely no sample preparation needed.

130 amples in their native state with minimal to absolutely no sample preparation.

131 with universal prescriptions-the belief that absolutely nobody or everybody should engage in an actio

132 of on-off-keyed 10 Gbit s(-1) systems and is absolutely prohibitive for today's (>)100 Gbit s(-1) coh

133 ucose/hexose, among which 67 metabolites are absolutely quantified and 75 metabolites are semiquantif

134 h leave-one-patient-out cross-validation and absolutely quantified by selected reaction monitoring as

135 c network between 4 and 37 degrees C through absolutely quantified exo- and endometabolomics data.

136 Finally, 21 glycoproteins were absolutely quantified with high quality.

137 a selective reaction monitoring technique to absolutely quantify the four organosulfur compounds.

138 ssing, or observation of many samples in an "absolutely quiescent" state, while also removing some tr

139 We demonstrate that people consistently and absolutely (rather than relatively) match specific audit

140 strength, vinculin-dependent traction forces absolutely require a full-length and activated molecule;

141 maintained epithelium integrity but did not absolutely require Caspase-1 or Gasdermin D.

142 Moreover, cortex glia absolutely require FGF signalling, such that inhibition

143 ell edge protrusions in fibroblasts does not absolutely require kinase activity, raising the question

144 jejuni and Agrobacterium tumefaciens, which absolutely require polyamines for growth, S. aureus and

145 topoisomerase reaction; however, it does not absolutely require the non-conserved carboxyl-terminal d

146 of processing of an ICL, its bypass may not absolutely require TLS polymerases.

147 g, while Th17 and gammadelta T cells are not absolutely required and may compensate for each other.

148 erited at centromeres, and new deposition is absolutely required at each cell cycle for kinetochore f

149 However, we show here that Mef2 is absolutely required for a diverse range of Drosophila ad

150 , simple, low-cost, and portable devices are absolutely required for a fast point-of care information

151 C2 receptor accessory protein (MRAP) that is absolutely required for ACTH binding and signaling.

152 CtIP is absolutely required for activating the nuclease-dependen

153 get genes demonstrated that unbound hp53 was absolutely required for activation of the DNA-damage res

154 s have shown that the scaffold module is not absolutely required for activity, but dramatically decre

155 We found that Pyk2 is not absolutely required for adhesion of CTL to ICAM-1, but r

156 reover, we show that CBC:HapX interaction is absolutely required for all known functions of HapX.

157 Although IgE is absolutely required for allergies, it is not understood

158 olar initiation, but that neither pathway is absolutely required for alveolar fate specification; rat

159 sms raises the question as to whether SOD is absolutely required for animal life and whether the loss

160 We posit that IL-6R cis-signaling is absolutely required for appropriate ICOS expression in T

161 he source of the "mother filaments" that are absolutely required for Arp2/3 complex to nucleate actin

162 of normal size, indicating that AtpI is not absolutely required for ATP synthase function.

163 The AR1b elements are absolutely required for auto-induction of UPC2 gene expr

164 -FNIP complex deregulated in BHD syndrome is absolutely required for B-cell differentiation, and that

165 omains within the C terminus of LapA are not absolutely required for biofilm formation, export, or lo

166 This protein, together with TonB2, is absolutely required for both the uptake of endogenously

167 n EMRE was identified as a uniporter subunit absolutely required for Ca(2+) permeation.

168 MEF2A and MEF2D were absolutely required for cardiomyocyte survival, whereas

169 ate alpha-COO(-) group to the carboxamide is absolutely required for catalysis.

170 ily, including a conserved histidine that is absolutely required for catalytic activity.

171 ualitatively different CDK complexes are not absolutely required for cell cycle progression either du

172 mines are small organic polycations that are absolutely required for cell growth and proliferation; y

173 Glycine 4864 is not absolutely required for channel gating, but some flexibi

174 ins from urease expression is modest and not absolutely required for colonization, urease can contrib

175 Moreover, two TPN classes are absolutely required for conditioned taste aversion, a le

176 revealed that the prominent hook segment is absolutely required for core NEC formation and contribut

177 These data suggest that 3'RR is not absolutely required for CSR and, thus, is not essential

178 ronic long-range tertiary pseudoknot that is absolutely required for deamination of one particular ad

179 n factor expressed in dentate stem cells and absolutely required for dentate granule cell production.

180 rf2x have been shown to be the only proteins absolutely required for detectable excision.

181 indicating that GI tract inducible CYP1A1 is absolutely required for detoxication of oral BaP.

182 study, we report that N-glycan branching is absolutely required for development of mature B cells in

183 that proliferation at this step was not only absolutely required for differentiation but also that it

184 Residue S186 of ZEBRA, Z(S186), which is absolutely required for disruption of latency, participa

185 ween them, and the interacting residues were absolutely required for DksA function.

186 data demonstrated that Bax translocation is absolutely required for DR6-induced apoptosis.

187 onstration that transient ING4 expression is absolutely required for epithelial differentiation, its

188 We conclude that FMRP is absolutely required for experience-dependent changes in

189 postsynaptic density protein-95 (PSD-95) was absolutely required for experience-dependent maturation

190 ng factor AREB2/ABF4, which binds to a G-box absolutely required for expression of the COX5b-1 gene.

191 We also found that no auxiliary factor is absolutely required for flavinylation, indicating that t

192 ning the integrity of the complex but is not absolutely required for formation of the daughter filame

193 hrough the Rev1-interacting region (RIR), is absolutely required for function.

194 RalA function is absolutely required for furrow formation and initiation.

195 ngle immunoglobulin (Ig)-like domain that is absolutely required for gamete fusion [3, 4].

196 The polyamine spermidine is absolutely required for growth and cell proliferation in

197 However, T cells were not absolutely required for IL-22 production because imiquim

198 Expression of the CTLA-4 gene is absolutely required for immune homeostasis, but aspects

199 lysis demonstrated that aa 60-90 of HRS were absolutely required for in vitro as well as in vivo sign

200 ntibody-mediated effects does not seem to be absolutely required for infection or reinfection.

201 alphaherpesvirus (MDV) in chickens, CHPK is absolutely required for interindividual spread from chic

202 SCs, indicating that an accessory protein is absolutely required for its function.

203 Thus, the T2SS is absolutely required for L. pneumophila to grow to larger

204 The Scar/WAVE complex is absolutely required for lamellipodia and is a key effect

205 ylinositol (GPI) membrane anchor is also not absolutely required for LON-2 activity.

206 and in vivo data demonstrated that B7-H1 was absolutely required for MDSC to exert immune regulatory

207 These factors are not absolutely required for meiotic maturation or its negati

208 t, are mediated exclusively by Orai1 and are absolutely required for milk ejection and pup survival,

209 shown to be highly conserved in amniotes and absolutely required for myeloid-restricted expression of

210 vior, suggesting that none of these cues are absolutely required for navigation back to the food.

211 of TGFbeta superfamily signaling, SMAD4, is absolutely required for normal FSH synthesis in both mal

212 is a physiologically relevant event that is absolutely required for nuclear GRK5 localization downst

213 ividual or specific combination of NoLSs was absolutely required for nucleolar localization, we sugge

214 d not pass quality control; this function is absolutely required for oncogenic transformation.

215 te for the first time that these enzymes are absolutely required for phage reproduction.

216 onstitutive TGFbetaRI binding protein and is absolutely required for phosphorylation of STATs in a SM

217 the two-component proteins PhoR and PhoB, is absolutely required for Pi signaling in Escherichia coli

218 Whereas MEF2A is absolutely required for proper myoblast differentiation,

219 Although Hsp104 is absolutely required for proteasomal degradation of Sdj1-

220 cteria to humans, only the serine residue is absolutely required for Psd1p autocatalysis and function

221 l inhibition by MB suggests that dynactin is absolutely required for retrograde DCV transport but doe

222 Thus WD60/FAP163 is a dynein IC that is absolutely required for retrograde IFT and ciliary assem

223 lly, but not paternally, derived AtLETM2 was absolutely required for seed development.

224 orphology of their projections, and PGCs are absolutely required for SGP wrapping behaviors.

225 t binding site, but, surprisingly, it is not absolutely required for signaling.

226 We also demonstrate that type I IFNs are absolutely required for survival following intracranial

227 l line-derived neurotrophic factor (GDNF) is absolutely required for survival of dopaminergic (DA) ni

228 at the compositional characteristics are not absolutely required for T3SS targeting and that other re

229 of the ICP0 sequence (SLS4) was found to be absolutely required for targeting cellular sumoylated sp

230 n the SMAD pathway, as intact HIF sites were absolutely required for TGF-beta1 to exert its effect on

231 acute Friend Virus (FV) infection, they were absolutely required for the control of chronic infection

232 athway, genetic analysis reveals that YAP is absolutely required for the development of APC-deficient

233 Thus, IFN-gamma is absolutely required for the development of autoimmune pe

234 Caspase-1 activation and IL-1 signaling are absolutely required for the efficient control of Helicob

235 sidase and that CD1e is an accessory protein absolutely required for the generation of the lipid immu

236 However, proper phosphorylation of CBL1 is absolutely required for the in vivo activation of the AK

237 demonstrated that Lang+ dDC, but not LC, are absolutely required for the induction of a rapid and rob

238 genetic strategy, we show here that Stat5 is absolutely required for the pathogenesis of PV induced b

239 tency, is a multifunctional protein which is absolutely required for the persistence of KSHV in the h

240 ice that mTOR complex 1 (mTORC1) activity is absolutely required for the proliferation of Apc-deficie

241 Host type I IFN signaling was absolutely required for the reduced tumor growth, prolon

242 Zn(2+) is absolutely required for the S18-1/S6 interaction while i

243 that is installed posttranslationally and is absolutely required for their antibiotic activity.

244 he upstream region of 21U-RNAs, CTGTTTCA, is absolutely required for their individual expression.

245 ice, demonstrating that IFN signaling is not absolutely required for these neuroinflammatory response

246 of Vpx, implying that neither properties is absolutely required for this function and indicating tha

247 but because of functional redundancy, it is absolutely required for this process in cells deficient

248 mily effectors BAX and BAK are thought to be absolutely required for this process.

249 nstrating that adaptive immune cells are not absolutely required for this process.

250 In contrast, BIG1-4 are absolutely required for trafficking of both endocytosed

251 (cytoplasmic tail) of the S2 subunit was not absolutely required for virus entry or syncytium formati

252 Elevated cytoplasmic calcium is absolutely required for virus replication, but the under

253 They also demonstrate that the domain is not absolutely required for virus viability in cell culture

254 lying that WIP-WASp complex formation is not absolutely required for WASp localization.

255 We demonstrate that TF is not absolutely required in culture, although disrupting TF p

256 cd4 is essential in somatic cells but is not absolutely required in spermatogenesis, indicating tissu

257 lso found that a SECIS element was no longer absolutely required in such a system.

258 nous replication checkpoint but that Ddc1 is absolutely required in the absence of Mrc1.

259 a small group of organic compounds that are absolutely required in the human diet.

260 latency-associated nuclear antigen (LANA) is absolutely required in the maintenance, replication, and

261 ucing B cells in the intestine, they are not absolutely required in the setting of rotavirus infectio

262 LSO AP half-widths were also fast, but absolutely required Kv3.3 subunits for fast repolarizati

263 ding and presentation of mycoketide antigens absolutely required the unusual, mycobacteria-specific l

264 gested that pre-existing disulfide links are absolutely required to allow protein folding and, conver

265 F2-leader 3 5' untranslated region, which is absolutely required to enable IGF2-leader 3 mRNA transla

266 T deficiency targeted the Jalpha18, which is absolutely required to form the TCR with the appropriate

267 their modifications, is functionally neither absolutely required to maintain pausing in the absence o

268 However, B cells were absolutely required to provide lymphotoxin (LT) alpha1be

269 SpoIIQ is absolutely required to recruit SpoIIIAH to the sporulati

270 ur findings support a model in which TFAM is absolutely required to recruit the transcription machine

271 and recycling to the plasma membrane but is absolutely required, much like actin, for early-to-late-

272 Some of them are absolutely required, whereas others are needed only for

273 tively critical for function, only three are absolutely required.

274 romoted Th17 differentiation, but it was not absolutely required.

275 nsuring that lateral roots only develop when absolutely required.

276 ouse infection, when OspC is transiently but absolutely required.

277 everal pathways in which TRPV3 activation is absolutely required.

278 However, inter-rugal growth is not absolutely required: new stripes of Shh expression still

279 monstrate that the N7-demethylation reaction absolutely requires a unique, tightly bound protein comp

280 rmore, it is not known if proton selectivity absolutely requires all four histidines with two of the

281 ndent dendritogenesis in both neuron classes absolutely requires dfmr1 during one developmental windo

282 ions of non-physiological hypoxia the embryo absolutely requires Hif1alpha to continue normal develop

283 However, liver transplant (LT) tolerance absolutely requires interferon (IFN)-gamma, a rejection-

284 adapting early endosomes (EEs) to dynein but absolutely requires p25 in dynactin.

285 Flh function; however, parapineal migration absolutely requires Tbx2b activity.

286 naling upstream of IkappaB kinase activation absolutely requires the influx of extracellular Ca(2+) v

287 c alterations, as lymphocyte differentiation absolutely requires the introduction of indelible geneti

288 ing of the viral genome into an empty capsid absolutely requires the L4-22K protein to bind to packag

289 is instead inhibited by heterochromatin and absolutely requires the nucleosome remodeler DRD1.

290 mnose linkage in chain A of RGII and that it absolutely requires the presence of a second d-galacturo

291 More importantly, these leukocytes were absolutely resistant to leukotoxin-induced cytolysis.

292 certainty have their non-classical dynamics absolutely restricted to only the identity operation.

293 also show that expression of Atoh1 does not absolutely result in commitment to a HC fate.

294 The resulting procedure was found absolutely safe.

295 athways can be engineered without developing absolutely specific enzymes.

296 Tamoxifen-dependent recombination was absolutely specific to proximal tubule.

297 specific biomarker, no manometric pattern is absolutely specific.

298 all connected core of 124 reactions that are absolutely superessential (that is, required in all meta

299 sfavored addition to enolate acceptors to an absolutely unexpected extent.

300 e outcome of these high-risk patients is not absolutely uniform, with some patients presenting long s