ライフサイエンスコーパス: abstinence

1 me-dependent increase in drug seeking during abstinence).

2 ssment; self-reported >=12 months continuous abstinence).

3 dependent increases in heroin seeking during abstinence).

4 t substance use outcomes (opioid vs. cocaine abstinence).

5 after voluntary abstinence than after forced abstinence.

6 lex role for dynorphin in cocaine reward and abstinence.

7 promising pharmacological target in morphine abstinence.

8 , and risk of relapse among those attempting abstinence.

9 in relapse to opioid seeking after voluntary abstinence.

10 s effect was abolished after cocaine CPP and abstinence.

11 n of methamphetamine craving after voluntary abstinence.

12 relapse to fentanyl seeking after voluntary abstinence.

13 of food discovery even after periods of HFD abstinence.

14 odone seeking after voluntary but not forced abstinence.

15 ced methamphetamine seeking after 15 days of abstinence.

16 one seeking after either voluntary or forced abstinence.

17 fter palatable food choice-induced voluntary abstinence.

18 istent relapse vulnerability after prolonged abstinence.

19 tor availability following 2 weeks of forced abstinence.

20 cotine sated and another after 36 h nicotine abstinence.

21 s of relapse to drug seeking after prolonged abstinence.

22 rwent either forced or social choice-induced abstinence.

23 likely than men to achieve long-term smoking abstinence.

24 and have a harder time maintaining long-term abstinence.

25 nic ethanol self-administration and repeated abstinence.

26 e tested after voluntary, punishment-induced abstinence.

27 ug seeking is assessed after homecage forced abstinence.

28 choice-induced abstinence than after forced abstinence.

29 ice and relapse to aggression seeking during abstinence.

30 elf-administration and social choice-induced abstinence.

31 xt B, the punishment context after prolonged abstinence.

32 s is seen in AUD within the first 30 days of abstinence.

33 9.1%, 16.7%) successfully attained long-term abstinence.

34 on training, forced abstinence, or voluntary abstinence.

35 eeking behavior in Context B after prolonged abstinence.

36 r resumption of drug seeking after voluntary abstinence.

37 nt role in preventing recovery and long-term abstinence.

38 anatomical substrates of opioid vs. cocaine abstinence.

39 received a high-fat diet (HFD) after 3-week abstinence.

40 xamined relapse following acute or prolonged abstinence.

41 xt B, the punishment context after prolonged abstinence.

42 canned after 2 weeks of outpatient-monitored abstinence.

43 after 15 days of either voluntary or forced abstinence.

44 response, and is reduced following extended abstinence.

45 independent increases in drug seeking during abstinence.

46 r 5-7 days prior to the scans to standardize abstinence.

47 ly in female rodents after 20 days of forced abstinence.

48 uses alternative non-drug reward to maintain abstinence.

49 istent nicotine seeking even after prolonged abstinence.

50 ver heroin during the choice-based voluntary abstinence.

51 fusion study that followed overnight smoking abstinence.

52 as also obtained following 2 years of forced abstinence.

53 l to balancing propensity for relapse versus abstinence.

54 g a primary attentional deficit during acute abstinence.

55 (18)F]FPEB during early and extended alcohol abstinence.

56 ould help patients both achieve and maintain abstinence.

57 ehaviors in animals when given during forced abstinence.

58 e affected differentially by cocaine CPP and abstinence.

59 it strong motivation to seek the drug during abstinence.

60 expression associated with protracted forced abstinence.

61 g pathways that occurs during cocaine forced abstinence.

62 hat intensifies (or "incubates") during drug abstinence.

63 PVT in heroin seeking following a period of abstinence.

64 , and relapse-like behavior after 3 weeks of abstinence.

65 t role in risk of relapse following extended abstinence.

66 seeking after food choice-induced voluntary abstinence.

67 ciated with increased likelihood of drug use abstinence (15 trials, n = 3636; relative risk [RR], 1.6

68 xt groups differed in the rates of validated abstinence (22.5% versus 14.9%, P = 0.008; adjusted OR:

69 B PET scans were acquired first during early abstinence (6 +/- 4 days after last drink) and a second

70 The primary end point was point prevalence abstinence (7-day recall, biochemically validated using

71 ine seeking after 1 and 15 days of voluntary abstinence, achieved via a discrete choice procedure bet

72 Indeed, abstinence after repeated exposure to cocaine alters dyn

73 Results: During abstinence, alcohol-dependent patients showed sustained

74 lf-administration is followed by a period of abstinence and a subsequent test for drug seeking.

75 on was associated with fewer days of alcohol abstinence and also predicted greater number heavy drink

76 It then persists into protracted abstinence and contributes to the development and persis

77 ing after electric barrier-induced voluntary abstinence and determined whether the dopamine stabilize

78 Hyperkatifeia can extend into protracted abstinence and interact with learning processes in the f

79 n alcohol-dependent patients recovers during abstinence and is associated with reduced craving.

80 Cocaine-induced plasticity persists during abstinence and is thought to underlie cue-evoked craving

81 synaptic strength in the DH during prolonged abstinence and observed an increase in moderate long-ter

82 Relationships between abstinence and opioid and cocaine abstinence networks re

83 able food) seeking incubated over 60 days of abstinence and persisted up to 300 days.

84 fferences between opiate and psychostimulant abstinence and points to pharmacological repression of e

85 pital for 5 days (maximum 8 days) to achieve abstinence and precipitate cannabis withdrawal, after wh

86 istration procedures followed by a period of abstinence and subsequent tests for relapse to aggressio

87 The primary outcomes were end-of-study abstinence and time to relapse (defined as first use or

88 atment initiation were influenced by alcohol abstinence and were prospectively predictive of early he

89 ns are affected by number of days of alcohol abstinence and whether they influence heavy drinking dur

90 ivity within the recurrent loop accrues with abstinence and, through the activity-dependent transcrip

91 vered by Medicaid only with documentation of abstinence and/or alcohol rehabilitation.

92 t knowledge of the neurocircuitry of alcohol abstinence, and 3) discover brain regions that may be in

93 l self-administration, social choice-induced abstinence, and incubation of craving in rats trained in

94 tasks was modulated by nicotine dependence, abstinence, and pharmacological manipulation.

95 es repetitive cycles of compulsive drug use, abstinence, and relapse.

96 e preference protocol followed by 2 weeks of abstinence, and then recorded GABAergic synaptic input e

97 ity to relapse following extended periods of abstinence, and this is a critical feature preventing th

98 unishment-associated context after prolonged abstinence, and this is mediated by activity in the AI.S

99 modularity that are associated with alcohol abstinence are causal features of alcohol dependence or

100 (NAc) shell of alcohol-dependent rats during abstinence, as well as the reduction in tyrosine hydroxy

101 one significantly increased point prevalence abstinence at 12 weeks.

102 Coprimary outcomes were alcohol abstinence at 6 months and heavy drinking days between 6

103 The primary outcome was continuous abstinence at 6 months, defined as self-report (of not h

104 ctivity measured at posttreatment related to abstinence at 6-month follow-up (p < 0.009).

105 lly confirmed 7-day point prevalence tobacco abstinence at 6-month follow-up.

106 t multiple follow-ups, were point prevalence abstinence at other follow-ups, continuous abstinence, d

107 Number of days of alcohol abstinence at treatment initiation significantly affecte

108 alcohol-dependent patients normalizes during abstinence (at 2 and 6 mo of detoxification) and whether

109 ate of extinction, and administration during abstinence attenuated cue-induced cocaine-seeking.

110 obacco and Health Study to compare long-term abstinence between matched US smokers who tried to quit

111 to perform an emotional-learning task during abstinence but recover their functioning by l-3,4-dihydr

112 identify a brain-based predictor of cocaine abstinence by using connectome-based predictive modeling

113 Voluntary abstinence can be accomplished by introducing adverse co

114 Abstinence can be achieved through extinction training,

115 ronic alcohol consumption followed by forced abstinence (CDFA), prolonged alcohol abstinence increase

116 Following abstinence, changes in GMD in some regions, including th

117 er [(18)F]FPEB V(T) in AUD subjects at early abstinence compared to controls (F((1,32)) = 7.23, p = 0

118 n=43) transdermal patch following overnight abstinence completed three sessions occurring during hor

119 sessed with timeline followback method, with abstinence confirmed by urine ethyl glucuronide testing.

120 ional changes continue to evolve during drug abstinence, contributing to numerous emotional and motiv

121 e abstinence at other follow-ups, continuous abstinence, daily cigarette consumption change, serious

122 y member activin A is increased in the DH on abstinence day (AD) 30 but not AD1 following extended-ac

123 2 (7.5 and 15 mg/kg) on oxycodone seeking on abstinence day 1 or after 15 days of either voluntary or

124 elf-administration and aggression seeking on abstinence Day 1.

125 elf-administration and aggression seeking on abstinence Day 1.

126 Independent of access condition and abstinence day, cocaine seeking was higher in female rat

127 On abstinence days 1, 15, or 30, we tested the rats for oxy

128 In both sexes, cocaine seeking on both abstinence days was higher after intermittent drug acces

129 se to fentanyl seeking after 13-14 voluntary abstinence days, achieved through a discrete choice proc

130 se to methamphetamine seeking after 1 and 15 abstinence days.

131 sed relapse to heroin seeking after 1 and 15 abstinence days.

132 g under extinction conditions after 1 and 21 abstinence days.

133 eased incubated drug seeking after 15 forced abstinence days.

134 ne significantly increased the likelihood of abstinence, delayed the time to relapse, and reduced the

135 y dissociable central amygdala mechanisms of abstinence-dependent expression or inhibition of incubat

136 current alcohol consumption (i.e. active vs. abstinence, determination of abstinence period, and quan

137 nicotine products in the long term (nicotine abstinence difference: -4%; 95% CI: -7%, -1%); approxima

138 ith matched non-e-cigarette users (cigarette abstinence difference: 2%; 95% CI: -3%, 7%).

139 behavioral modification, including promoting abstinence, diminishing craving, and reducing risk of re

140 Experiment 1 showed that following abstinence, drug co-exposure reduced visceral fat and th

141 nt after experimenter-imposed abstinence, or abstinence due to extinction training.

142 ment assessment also significantly predicted abstinence during follow-up (r=0.34, df=39).

143 ess changes over time and ability to predict abstinence during follow-up.

144 ify pretreatment connections associated with abstinence during the 3-month treatment.

145 CPM predicted abstinence during treatment, as indicated by a significa

146 We found that after cocaine CPP and abstinence dynorphin attenuated inhibitory input to VP(G

147 ctions in a cell-type-specific manner; after abstinence dynorphin suppresses the inhibitory drive on

148 maintenance of drug seeking often long into abstinence, especially when presented response-contingen

149 These results suggest that with abstinence ex-smokers may recover from low striatal D2R

150 Egr3 overexpression in D2-MSNs during forced abstinence facilitated extinction and blunted drug-induc

151 The effects of protracted abstinence following long-term ethanol self-administrati

152 in relapse to alcohol seeking after extended abstinence following punishment imposed voluntary cessat

153 The primary outcome was sustained abstinence for 1 year, which was validated biochemically

154 ine the impact of decreasing drug use and of abstinence for each drug on viral suppression.

155 Point prevalence abstinence for nonnicotine e-cigarettes plus counseling

156 s delayed liver transplantation (6 months of abstinence from alcohol before transplantation) increase

157 -brain imaging approach to 1) assess whether abstinence from alcohol in an animal model of alcohol de

158 se atrial remodeling; however, the effect of abstinence from alcohol on secondary prevention of atria

159 mixed-effects model was used to model daily abstinence from alcohol over the 21 days after ketamine

160 Abstinence from alcohol reduced arrhythmia recurrences i

161 ic of this human condition: namely voluntary abstinence from alcohol use because of contingent punish

162 following differential housing during forced abstinence from cocaine self-administration for either 1

163 th PBS or G-CSF during (1) extinction or (2) abstinence from cocaine self-administration, and drug se

164 e DH in relapse behavior following prolonged abstinence from cocaine self-administration.

165 ility to relapse during periods of attempted abstinence from cocaine use is hypothesized to result fr

166 These data illustrate how after abstinence from cocaine, aversive pathways change in a m

167 ability was not altered following 2 weeks of abstinence from cocaine.

168 moting Drp1 enhances seeking after long-term abstinence from cocaine.

169 ic potassium channels in the NAc may promote abstinence from drug-taking behaviors.

170 tanding the neurobiological underpinnings of abstinence from drugs of abuse is critical to allow bett

171 enorphine-naloxone in maintaining short-term abstinence from heroin and other illicit substances and

172 t response at 18 weeks, which was defined as abstinence from illicit and non-prescribed opioids and c

173 evels in the NAc following 20 days of forced abstinence from intravenous cocaine self-administration

174 genetic changes in the brain after prolonged abstinence from noncontingent drug exposure or drug self

175 ficacy endpoint was participants' percentage abstinence from opioid use, defined as the percentage of

176 d fat content, exercise, weight control, and abstinence from smoking and opium) were delivered by the

177 , by intention to treat (ITT), was validated abstinence from smoking at the 6-month follow-up.

178 nsulin to evaluate its efficacy during acute abstinence from smoking.

179 and social interaction that causes voluntary abstinence from the drug and tests for incubation of dru

180 Following several weeks of forced abstinence, G9a knockdown attenuates extinction respondi

181 ease expected drug value acutely outweighing abstinence goals.

182 age, 62+/-9 years), 70 were assigned to the abstinence group and 70 to the control group.

183 n recurred in 37 of 70 patients (53%) in the abstinence group and in 51 of 70 patients (73%) in the c

184 The abstinence group had a longer period before recurrence o

185 Patients in the abstinence group reduced their alcohol intake from 16.8+

186 of follow-up was significantly lower in the abstinence group than in the control group (median perce

187 f the DH in cocaine seeking during prolonged abstinence has not been investigated.

188 ecreased oxycodone seeking and taking during abstinence in a partly sex-specific manner and prevented

189 Alcohol abstinence in drinkers with atrial fibrillation.

190 ohol biomarker resulted in increased alcohol abstinence in outpatients with co-occurring serious ment

191 minating between 4-week morphine and cocaine abstinence in the nucleus accumbens (NAc).

192 hanisms of relapse after forced or voluntary abstinence, including the phenomenon of "incubation of h

193 forced abstinence (CDFA), prolonged alcohol abstinence increased c-fos expression and spontaneous gl

194 tion of participants exhibiting full alcohol abstinence increased from baseline to 3, 6, and 12 month

195 showed that cocaine seeking increases during abstinence (incubation of cocaine craving).

196 ther homecage forced abstinence or voluntary abstinence induced by an electric barrier of increasing

197 Results suggest that voluntary abstinence induced by negative consequences of drug seek

198 Our findings provide evidence that targeting abstinence-induced homeostatic gene expression is a pote

199 nous cannabinoids (eCB) with JZL184 prevents abstinence-induced increases in dBNST neuronal activity,

200 High rates of relapse to drug use during abstinence is a defining feature of human drug addiction

201 -opioid receptor (MOR) availability in early abstinence is associated with greater craving.

202 signs, whereas anxiety linked to protracted abstinence is attenuated by pioglitazone injected into t

203 impact of reducing substance use, even when abstinence is not achieved, and the potential benefits o

204 However, human abstinence is often voluntary because negative consequen

205 In humans, however, abstinence is often voluntary, with drug available in th

206 uitry present in the brain at a state during abstinence, just prior to relapse to ethanol drinking.

207 transcripts between rats of different forced abstinence length and housing environment, as well as wi

208 riched based on housing condition and forced abstinence length including RELN, the Eif2 signaling pat

209 nisms driving the negative mood of prolonged abstinence likely involve the 5 main reward-aversion bra

210 Thus, cocaine CPP followed by abstinence may allow VP(VGluT2) neurons to recruit avers

211 y neural circuit adaptations during nicotine abstinence may foster maladaptive nicotine taking in add

212 on of drug craving after prolonged voluntary abstinence, mimicking the human condition of relapse aft

213 ast drink) and a second time during extended abstinence (n = 13; 27 +/- 6 days after last drink).

214 CPM identified an opioid abstinence network (p = 0.018), characterized by stronge

215 ine the specificity of the identified opioid abstinence network across different brain states (cognit

216 Structuring of the alcohol abstinence network revealed three major brain modules: 1

217 determine further clinical relevance, opioid abstinence network strength was compared with healthy su

218 This opioid abstinence network was anatomically distinct from a prev

219 istinct from a previously identified cocaine abstinence network.

220 ps between abstinence and opioid and cocaine abstinence networks replicated across multiple brain sta

221 ine use disorder, and they identify specific abstinence networks that may be targeted in novel interv

222 e inhibitory effect of social choice-induced abstinence on incubated drug seeking on day 15.

223 FDA-approved smoking cessation aids, during abstinence), on two well-established tests of inhibitory

224 e symptoms associated with prolonged alcohol abstinence, one of the leading causes of relapse.

225 r relapse to aggression seeking after forced abstinence or punishment-induced suppression of aggressi

226 then exposed them to either homecage forced abstinence or voluntary abstinence induced by an electri

227 lar risk in many studies, in comparison with abstinence or with heavier drinking.

228 i) studies related to medication, treatment, abstinence or withdrawal effects in OUD; and (iii) studi

229 ing reinstatement after experimenter-imposed abstinence, or abstinence due to extinction training.

230 achieved through extinction training, forced abstinence, or voluntary abstinence.

231 d by lay counsellors, enhanced remission and abstinence over 3 months among male primary care attende

232 individuals in the ketamine group maintained abstinence over the last 2 weeks of the trial, compared

233 were independently associated with complete abstinence (P < 0.001 and P = 0.02, respectively) during

234 dentify pretreatment networks that predicted abstinence (percent cocaine-negative urine samples durin

235 tive" (requiring documentation of a specific abstinence period and/or rehabilitation) versus "unrestr

236 s centers have adopted early (i.e., specific abstinence period not required) LT practices.

237 lastography can be repeated after a complete abstinence period of at least two weeks.

238 lastography can be repeated after a complete abstinence period of at least two weeks.

239 i.e. active vs. abstinence, determination of abstinence period, and quantification of alcohol intake)

240 outcomes included 7-day point prevalence of abstinence (PPA) and level of readiness to quit at each

241 ipients for AH with median period of alcohol abstinence pre-LT of 54 days, 74% were abstinent, 16% ha

242 eported that social choice-induced voluntary abstinence prevents incubation of methamphetamine cravin

243 that operant social choice-induced voluntary abstinence prevents incubation of methamphetamine cravin

244 o often relapse within the first few days of abstinence, primarily due to the aversive aspects of the

245 Most transplant programs require 6 months of abstinence prior to transplantation; commonly referred t

246 ed experimenter-imposed extinction or forced abstinence procedures.

247 During subsequent abstinence, PTSD-like behavior responses, GABAergic syna

248 The 1-year abstinence rate was 18.0% in the e-cigarette group, as c

249 tcomes and that cannabinoids do not increase abstinence rates (moderate SOE), reduce cannabis use (lo

250 testing had lasting or temporary effects on abstinence rates.

251 Enriched, 21-day forced abstinence rats displayed a significant reduction in coc

252 ncluding contingency management to reinforce abstinence, recovery activities, and clinic attendance)

253 t resumption of drug seeking after voluntary abstinence recruits neural circuits distinct from those

254 After an extended period of abstinence, relapse propensity is markedly increased in

255 ward seeking after a period of extinction or abstinence remains a key impediment to successful treatm

256 Reaching and maintaining abstinence represents the mainstay of managing patients

257 Alcohol abstinence resulted in the whole-brain reorganization of

258 in the placebo group had achieved continuous abstinence (risk difference 2.68%, 95% CI -0.96 to 6.33;

259 in the right habenula decreased in CD in the abstinence/saline condition vs acute cocaine and HC.

260 place preference (CPP) training followed by abstinence selectively potentiates their synapses on tar

261 rats underwent either social choice-induced abstinence (shPKCdelta groups) or homecage forced abstin

262 nence (shPKCdelta groups) or homecage forced abstinence (shSOM groups).

263 to relapse to opioid seeking after voluntary abstinence.SIGNIFICANCE STATEMENT There are few preclini

264 mounts of alcohol use after transplantation: abstinence, slip (alcohol use followed by sobriety), or

265 Treating neonatal abstinence syndrome (NAS) as a marker of opioid use duri

266 Neonatal abstinence syndrome (NAS) has increased over the last 2

267 mic, including neonates who exhibit Neonatal Abstinence Syndrome (NAS).

268 Among infants with the neonatal abstinence syndrome, treatment with sublingual buprenorp

269 s, and higher county-level rates of neonatal abstinence syndrome.

270 opioid craving) was stronger after voluntary abstinence than after forced abstinence.

271 aving) was lower after social choice-induced abstinence than after forced abstinence.

272 CI, 1.01-2.01) were associated with greater abstinence than placebo.

273 nd text groups had higher rates of validated abstinence than the control group (video group: 22.5% [7

274 istent negative emotional states during drug abstinence that drive compulsive drug taking and seeking

275 During early withdrawal and protracted abstinence, the expression of PPARgamma increased in GAB

276 Moreover, after cocaine CPP and abstinence, the VP(VGluT2) input to the aversion-related

277 s the lateral habenula, but also that, after abstinence, their synapses on aversive targets are stren

278 Among participants with 1-year abstinence, those in the e-cigarette group were more lik

279 ene expression during early and late cocaine abstinence to identify putative regulators of neural hom

280 d were able, after at least 3 days of sexual abstinence, to produce freshly ejaculated sperm for the

281 ntion of oxycodone seeking and taking during abstinence using a modified context-induced reinstatemen

282 lapse to alcohol seeking following prolonged abstinence using Fos as a marker of neuronal activation.

283 correspondence between predicted and actual abstinence values (r=0.42, df=52).

284 r hippocampal synaptic density resolves with abstinence warrants further study.

285 Mean participants' percentage abstinence was 41.3% (SD 39.7) for BUP-XR 300 mg/300 mg

286 and marijuana, regardless of whether or not abstinence was achieved.

287 ated methamphetamine seeking after voluntary abstinence was associated with a selective increase of F

288 contrast, incubation of craving after forced abstinence was associated with activation of CeL-express

289 Abstinence was associated with higher odds of viral supp

290 oth sexes, relapse after food choice-induced abstinence was associated with increased expression of t

291 pioid or methamphetamine/crystal use without abstinence was associated with lower relative VL (47%, 3

292 Abstinence was associated with viral suppression.

293 pioid or methamphetamine/crystal use without abstinence was associated with VL suppression (OR, 2.2,

294 Sustained activation of Cartpt at late abstinence was coupled with depletion of the repressive

295 excessive anxiety associated with protracted abstinence was prevented by pioglitazone microinjection

296 Point prevalence abstinence was significantly greater for nicotine e-ciga

297 Participants' percentage abstinence was significantly higher in both BUP-XR group

298 ids or methamphetamine/crystal, even without abstinence, was also associated with viral suppression.

299 ined whether social choice-induced voluntary abstinence would prevent incubation of heroin craving.

300 ften occurs in alcoholics, especially during abstinence, yet the underlying mechanisms remain elusive